Entry |
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Name |
TLR1/2/4-NFKB signaling pathway
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Definition |
(TLR1,TLR2,TLR4) -> (TIRAP+MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (TNF,IL6,IL12A,IL12B) |
Expanded |
(7096,7097,7099) -> (114609+4615) -> (51135+3654) -> (7189+6885+23118) -> (1147+3551+8517) -> 4792 -> (4790+5970) => (7124,3569,3592,3593) |
Class |
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Type |
Reference
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Pathway |
hsa04620 | Toll-like receptor signaling pathway |
|
Gene |
7096 | TLR1; toll like receptor 1 |
7097 | TLR2; toll like receptor 2 |
7099 | TLR4; toll like receptor 4 |
114609 | TIRAP; TIR domain containing adaptor protein |
4615 | MYD88; MYD88, innate immune signal transduction adaptor |
51135 | IRAK4; interleukin 1 receptor associated kinase 4 |
3654 | IRAK1; interleukin 1 receptor associated kinase 1 |
7189 | TRAF6; TNF receptor associated factor 6 |
6885 | MAP3K7; mitogen-activated protein kinase kinase kinase 7 |
23118 | TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2 |
1147 | CHUK; conserved helix-loop-helix ubiquitous kinase |
3551 | IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta |
8517 | IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma |
4792 | NFKBIA; NFKB inhibitor alpha |
4790 | NFKB1; nuclear factor kappa B subunit 1 |
5970 | RELA; RELA proto-oncogene, NF-kB subunit |
7124 | TNF; tumor necrosis factor |
3592 | IL12A; interleukin 12A |
3593 | IL12B; interleukin 12B |
|
Reference |
|
Authors |
O'Neill LA, Bowie AG. |
Title |
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. |
Journal |
|
Reference |
|
Authors |
O'Neill LA, Golenbock D, Bowie AG |
Title |
The history of Toll-like receptors - redefining innate immunity. |
Journal |
|
Reference |
|
Authors |
Yang L, Seki E |
Title |
Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms. |
Journal |
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LinkDB |
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