KEGG   NETWORK: N01543
Entry
N01543                      Network                                
Name
TLR7/8/9-IRF5 signaling pathway
Definition
(TLR7+TLR8+TLR9) -> MYD88 -> (IRAK4+IRAK1) -> TRAF6 -> IRF5 => (IFNA,IFNB1)
  Expanded
(51284+51311+54106) -> 4615 -> (51135+3654) -> 7189 -> 3663 => ((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456)
Class
nt06517 TLR signaling
Type
Reference
Pathway
hsa04620  Toll-like receptor signaling pathway
Gene
51284  TLR7; toll like receptor 7
51311  TLR8; toll like receptor 8
54106  TLR9; toll like receptor 9
4615  MYD88; MYD88 innate immune signal transduction adaptor
51135  IRAK4; interleukin 1 receptor associated kinase 4
3654  IRAK1; interleukin 1 receptor associated kinase 1
7189  TRAF6; TNF receptor associated factor 6
3663  IRF5; interferon regulatory factor 5
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Reference
PMID:24928322
  Authors
Lazzari E, Jefferies CA
  Title
IRF5-mediated signaling and implications for SLE.
  Journal
Clin Immunol 153:343-52 (2014)
DOI:10.1016/j.clim.2014.06.001
Reference
PMID:23251221
  Authors
Cham CM, Ko K, Niewold TB
  Title
Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus.
  Journal
Clin Dev Immunol 2012:780436 (2012)
DOI:10.1155/2012/780436
Reference
PMID:29860420
  Authors
Ban T, Sato GR, Tamura T
  Title
Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus.
  Journal
Int Immunol 30:529-536 (2018)
DOI:10.1093/intimm/dxy032
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