Entry
Name
ECM-receptor interaction
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Other DBs
Orthology
K03900 VWF; von Willebrand factor
K04659 THBS2S; thrombospondin 2/3/4/5
K05635 LAMC1; laminin, gamma 1
K05637 LAMA1_2; laminin, alpha 1/2
K05719 ITGB1, CD29; integrin beta 1
K06236 COL1A; collagen type I alpha
K06237 COL4A; collagen type IV alpha
K06238 COL6A; collagen type VI alpha
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K06249 RELN; reelin [EC:3.4.21.-]
K06250 SPP1, BNSP, OPN; secreted phosphoprotein 1
K06253 IBSP; integrin binding sialoprotein
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
K06257 SDC1, CD138; syndecan 1
K06258 SV2; MFS transporter, VNT family, synaptic vesicle glycoprotein 2
K06260 GP5, CD42d; platelet glycoprotein V
K06261 GP1BA, CD42b; platelet glycoprotein Ib alpha chain
K06262 GP1BB, CD42c; platelet glycoprotein Ib beta chain
K06263 GP9, CD42a; platelet glycoprotein IX
K06264 GP6; platelet glycoprotein VI
K06266 CD47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
K06267 HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor
K06476 ITGA2B, CD41; integrin alpha 2B
K06480 ITGA1, CD49a; integrin alpha 1
K06481 ITGA2, CD49b; integrin alpha 2
K06482 ITGA3, CD49c; integrin alpha 3
K06483 ITGA4, CD49d; integrin alpha 4
K06484 ITGA5, CD49e; integrin alpha 5
K06485 ITGA6, CD49f; integrin alpha 6
K06487 ITGAV, CD51; integrin alpha V
K06493 ITGB3, CD61; integrin beta 3
K06525 ITGB4, CD104; integrin beta 4
K06583 ITGA7; integrin alpha 7
K06584 ITGA8; integrin alpha 8
K06585 ITGA9; integrin alpha 9
K06586 ITGA10; integrin alpha 10
K06587 ITGA11; integrin alpha 11
K08131 COL9A; collagen type IX alpha
K16857 THBS1; thrombospondin 1
K19719 COL2A; collagen type II alpha
K23328 DMP1; dentin matrix acidic phosphoprotein 1
K23379 FRAS1; extracelluar matrix protein FRAS1
K23380 FREM1_2; FRAS1-related extracelluar matrix protein 1/2
K23573 DSPP; dentin sialophosphoprotein
K26442 MEPE; matrix extracellular phosphoglycoprotein
Compound
Reference
Authors
van der Flier A, Sonnenberg A.
Title
Function and interactions of integrins.
Journal
Reference
Authors
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Title
Integrin receptors: the dynamic modulators of endometrial function.
Journal
Reference
Authors
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Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
Journal
Reference
Authors
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Title
The liberation of CD44.
Journal
Reference
Authors
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Title
Function of the syndecans--a family of cell surface proteoglycans.
Journal
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Reference
Authors
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Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Journal
Reference
Authors
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Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
Journal
Reference
Authors
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Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
Journal
Reference
Authors
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Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Journal
Reference
Authors
Martin PT.
Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
Journal
Reference
Authors
Toole BP.
Title
Hyaluronan: from extracellular glue to pericellular cue.
Journal
Reference
Authors
Bosman FT, Stamenkovic I.
Title
Functional structure and composition of the extracellular matrix.
Journal
Reference
Authors
van der Ven AT, Vivante A, Hildebrandt F
Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Journal
Related pathway