KEGG   PATHWAY: ko04512Help
Entry
ko04512                     Pathway                                

Name
ECM-receptor interaction
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
09130 Environmental Information Processing; 09133 Signaling molecules and interaction
BRITE hierarchy
Pathway map
ko04512  ECM-receptor interaction
ko04512

Ortholog table
Disease
H00219  Hemophilia
H00224  Bernard-Soulier syndrome
H00226  Glanzmann thrombasthenia
H00520  Type II collagenopathies
H00576  Pierson syndrome
H00579  Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
H00581  Alport syndrome
H00582  Benign familial hematuria
H00586  Epidermolysis bullosa, junctional
H00770  Congenital myasthenic syndrome
H00802  Ehlers-Danlos syndrome (EDS)
H00805  Vitreoretinal degeneration
H00813  Laryngo onycho cutaneous syndrome
H00839  Porencephaly
H00877  Brain small vessel disease with hemorrhage
H01260  Glomerulopathy with fibronectin deposits (GFND)
H01338  Myosclerosis
H01340  Bethlem myopathy
H01341  Collagen VI myopathy
H01526  Legg-Calve-Perthes Disease
H01777  Schwartz-Jampel syndrome
H01778  Ullrich disease
H01958  Merosin-deficient congenital muscular dystrophy
H02066  Achondrogenesis type II
H02070  Kniest dysplasia
H02071  Czech dysplasia
H02072  Stickler syndrome
Other DBs
BSID: 479
GO: 0005201
Orthology
K06236  collagen, type I, alpha
K19719  collagen, type II, alpha
K06237  collagen, type IV, alpha
K06238  collagen, type VI, alpha
K08131  collagen, type IX, alpha
K05637  laminin, alpha 1/2
K06240  laminin, alpha 3/5
K06241  laminin, alpha 4
K05636  laminin, beta 1
K06243  laminin, beta 2
K06244  laminin, beta 3
K06245  laminin, beta 4
K05635  laminin, gamma 1
K06246  laminin, gamma 2
K06247  laminin, gamma 3
K06248  chondroadherin
K06249  reelin [EC:3.4.21.-]
K16857  thrombospondin 1
K04659  thrombospondin 2/3/4/5
K05717  fibronectin 1
K06250  secreted phosphoprotein 1
K06251  vitronectin
K06252  tenascin
K03900  von Willebrand factor
K06253  integrin binding sialoprotein
K06254  agrin
K06255  heparan sulfate proteoglycan 2 (perlecan)
K06480  integrin alpha 1
K06481  integrin alpha 2
K06476  integrin alpha 2B
K06482  integrin alpha 3
K06483  integrin alpha 4
K06484  integrin alpha 5
K06485  integrin alpha 6
K06583  integrin alpha 7
K06584  integrin alpha 8
K06585  integrin alpha 9
K06586  integrin alpha 10
K06587  integrin alpha 11
K06487  integrin alpha V
K05719  integrin beta 1
K06493  integrin beta 3
K06525  integrin beta 4
K06588  integrin beta 5
K06589  integrin beta 6
K06590  integrin beta 7
K06591  integrin beta 8
K06256  CD44 antigen
K06257  syndecan 1
K16338  syndecan 4
K06258  MFS transporter, VNT family, synaptic vesicle glycoprotein 2
K06259  CD36 antigen
K06260  platelet glycoprotein V
K06261  platelet glycoprotein Ib alpha chain
K06262  platelet glycoprotein Ib beta chain
K06263  platelet glycoprotein IX
K06264  platelet glycoprotein VI
K06265  dystroglycan 1
K06266  CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
K06267  hyaluronan-mediated motility receptor
Compound
G10505  Hyaluronic acid
Reference
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
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