Entry Name ECM-receptor interaction
Description The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Other DBs Orthology K03900 VWF; von Willebrand factor
K04659 THBS2S; thrombospondin 2/3/4/5
K05635 LAMC1; laminin, gamma 1
K05637 LAMA1_2; laminin, alpha 1/2
K05719 ITGB1, CD29; integrin beta 1
K06236 COL1A; collagen type I alpha
K06237 COL4A; collagen type IV alpha
K06238 COL6A; collagen type VI alpha
K06240 LAMA3_5; laminin, alpha 3/5
K06241 LAMA4; laminin, alpha 4
K06246 LAMC2; laminin, gamma 2
K06247 LAMC3; laminin, gamma 3
K06249 RELN; reelin [EC:3.4.21.-]
K06250 SPP1, BNSP, OPN; secreted phosphoprotein 1
K06253 IBSP; integrin binding sialoprotein
K06255 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
K06257 SDC1, CD138; syndecan 1
K06258 SV2; MFS transporter, VNT family, synaptic vesicle glycoprotein 2
K06260 GP5, CD42d; platelet glycoprotein V
K06261 GP1BA, CD42b; platelet glycoprotein Ib alpha chain
K06262 GP1BB, CD42c; platelet glycoprotein Ib beta chain
K06263 GP9, CD42a; platelet glycoprotein IX
K06264 GP6; platelet glycoprotein VI
K06266 CD47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
K06267 HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor
K06476 ITGA2B, CD41; integrin alpha 2B
K06480 ITGA1, CD49a; integrin alpha 1
K06481 ITGA2, CD49b; integrin alpha 2
K06482 ITGA3, CD49c; integrin alpha 3
K06483 ITGA4, CD49d; integrin alpha 4
K06484 ITGA5, CD49e; integrin alpha 5
K06485 ITGA6, CD49f; integrin alpha 6
K06487 ITGAV, CD51; integrin alpha V
K06493 ITGB3, CD61; integrin beta 3
K06525 ITGB4, CD104; integrin beta 4
K06583 ITGA7; integrin alpha 7
K06584 ITGA8; integrin alpha 8
K06585 ITGA9; integrin alpha 9
K06586 ITGA10; integrin alpha 10
K06587 ITGA11; integrin alpha 11
K08131 COL9A; collagen type IX alpha
K16857 THBS1; thrombospondin 1
K19719 COL2A; collagen type II alpha
K23328 DMP1; dentin matrix acidic phosphoprotein 1
K23379 FRAS1; extracelluar matrix protein FRAS1
K23380 FREM1_2; FRAS1-related extracelluar matrix protein 1/2
K23573 DSPP; dentin sialophosphoprotein
K26442 MEPE; matrix extracellular phosphoglycoprotein
Compound Reference Authors van der Flier A, Sonnenberg A.
Title Function and interactions of integrins.
Journal Reference Authors Reddy KV, Mangale SS.
Title Integrin receptors: the dynamic modulators of endometrial function.
Journal Reference Authors Milner R, Campbell IL.
Title The integrin family of cell adhesion molecules has multiple functions within the CNS.
Journal Reference Authors Cichy J, Pure E.
Title The liberation of CD44.
Journal Reference Authors Elenius K, Jalkanen M.
Title Function of the syndecans--a family of cell surface proteoglycans.
Journal J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference Authors Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
Title The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Journal Reference Authors Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
Title Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
Journal Reference Authors Canobbio I, Balduini C, Torti M.
Title Signalling through the platelet glycoprotein Ib-V-IX complex.
Journal Reference Authors Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
Title Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Journal Reference Authors Martin PT.
Title Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
Journal Reference Authors Toole BP.
Title Hyaluronan: from extracellular glue to pericellular cue.
Journal Reference Authors Bosman FT, Stamenkovic I.
Title Functional structure and composition of the extracellular matrix.
Journal Reference Authors van der Ven AT, Vivante A, Hildebrandt F
Title Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Journal Related
