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| Name |
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| Description |
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
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| Class |
Environmental Information Processing; Signaling molecules and interaction
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| Pathway map |
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| Disease |
| H00224 | Bernard-Soulier syndrome |
| H00226 | Glanzmann thrombasthenia |
| H00520 | Type II collagenopathies |
| H00579 | Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) |
| H00582 | Benign familial hematuria |
| H00586 | Epidermolysis bullosa, junctional |
| H00770 | Congenital myasthenic syndrome |
| H00805 | Vitreoretinal degeneration |
| H00813 | Laryngo onycho cutaneous syndrome |
| H00877 | Brain small vessel disease with hemorrhage |
| H01260 | Glomerulopathy with fibronectin deposits |
| H01526 | Legg-Calve-Perthes Disease |
| H01777 | Schwartz-Jampel syndrome |
| H01958 | Merosin-deficient congenital muscular dystrophy |
| H02066 | Achondrogenesis type II |
| H02241 | Ehlers-Danlos syndrome cardiac valvular type |
| H02243 | Ehlers-Danlos syndrome arthrochalasia type |
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| Other DBs |
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| Orthology |
| K06250 | secreted phosphoprotein 1 |
| K23379 | extracelluar matrix protein FRAS1 |
| K23380 | FRAS1-related extracelluar matrix protein 1/2 |
| K23573 | dentin sialophosphoprotein |
| K06253 | integrin binding sialoprotein |
| K23328 | dentin matrix acidic phosphoprotein 1 |
| K06255 | basement membrane-specific heparan sulfate proteoglycan core protein |
| K06258 | MFS transporter, VNT family, synaptic vesicle glycoprotein 2 |
| K06260 | platelet glycoprotein V |
| K06261 | platelet glycoprotein Ib alpha chain |
| K06262 | platelet glycoprotein Ib beta chain |
| K06263 | platelet glycoprotein IX |
| K06264 | platelet glycoprotein VI |
| K06266 | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) |
| K06267 | hyaluronan-mediated motility receptor |
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| Compound |
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| Reference |
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| Authors |
van der Flier A, Sonnenberg A. |
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| Title |
Function and interactions of integrins. |
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| Journal |
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| Reference |
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| Authors |
Reddy KV, Mangale SS. |
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| Title |
Integrin receptors: the dynamic modulators of endometrial function. |
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| Authors |
Milner R, Campbell IL. |
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| Title |
The integrin family of cell adhesion molecules has multiple functions within the CNS. |
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| Authors |
Cichy J, Pure E. |
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| Title |
The liberation of CD44. |
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| Journal |
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| Reference |
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| Authors |
Elenius K, Jalkanen M. |
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| Title |
Function of the syndecans--a family of cell surface proteoglycans. |
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| Journal |
J Cell Sci 107 ( Pt 11):2975-82 (1994) |
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| Reference |
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| Authors |
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS. |
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The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface. |
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| Authors |
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L. |
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| Title |
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth. |
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| Authors |
Canobbio I, Balduini C, Torti M. |
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Signalling through the platelet glycoprotein Ib-V-IX complex. |
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| Reference |
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| Authors |
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R. |
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Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. |
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| Reference |
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| Authors |
Martin PT. |
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Dystroglycan glycosylation and its role in matrix binding in skeletal muscle. |
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| Reference |
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| Authors |
Toole BP. |
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Hyaluronan: from extracellular glue to pericellular cue. |
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| Reference |
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| Authors |
Bosman FT, Stamenkovic I. |
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Functional structure and composition of the extracellular matrix. |
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| Reference |
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| Authors |
van der Ven AT, Vivante A, Hildebrandt F |
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Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract. |
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| Journal |
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Related
pathway |
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| LinkDB |
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