KEGG   PATHWAY: ko04512
Entry
ko04512                     Pathway                                
Name
ECM-receptor interaction
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ko04512  ECM-receptor interaction
ko04512

Other DBs
GO: 0005201
Orthology
K03900  VWF; von Willebrand factor
K04659  THBS2S; thrombospondin 2/3/4/5
K05635  LAMC1; laminin, gamma 1
K05636  LAMB1; laminin, beta 1
K05637  LAMA1_2; laminin, alpha 1/2
K05717  FN1; fibronectin 1
K05719  ITGB1, CD29; integrin beta 1
K06236  COL1A; collagen type I alpha
K06237  COL4A; collagen type IV alpha
K06238  COL6A; collagen type VI alpha
K06240  LAMA3_5; laminin, alpha 3/5
K06241  LAMA4; laminin, alpha 4
K06243  LAMB2; laminin, beta 2
K06244  LAMB3; laminin, beta 3
K06245  LAMB4; laminin, beta 4
K06246  LAMC2; laminin, gamma 2
K06247  LAMC3; laminin, gamma 3
K06248  CHAD; chondroadherin
K06249  RELN; reelin [EC:3.4.21.-]
K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
K06251  VTN; vitronectin
K06252  TN; tenascin
K06253  IBSP; integrin binding sialoprotein
K06254  AGRN; agrin
K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
K06256  CD44; CD44 antigen
K06257  SDC1, CD138; syndecan 1
K06258  SV2; MFS transporter, VNT family, synaptic vesicle glycoprotein 2
K06259  CD36; CD36 antigen
K06260  GP5, CD42d; platelet glycoprotein V
K06261  GP1BA, CD42b; platelet glycoprotein Ib alpha chain
K06262  GP1BB, CD42c; platelet glycoprotein Ib beta chain
K06263  GP9, CD42a; platelet glycoprotein IX
K06264  GP6; platelet glycoprotein VI
K06265  DAG1; dystroglycan 1
K06266  CD47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
K06267  HMMR, RHAMM, CD168; hyaluronan-mediated motility receptor
K06476  ITGA2B, CD41; integrin alpha 2B
K06480  ITGA1, CD49a; integrin alpha 1
K06481  ITGA2, CD49b; integrin alpha 2
K06482  ITGA3, CD49c; integrin alpha 3
K06483  ITGA4, CD49d; integrin alpha 4
K06484  ITGA5, CD49e; integrin alpha 5
K06485  ITGA6, CD49f; integrin alpha 6
K06487  ITGAV, CD51; integrin alpha V
K06493  ITGB3, CD61; integrin beta 3
K06525  ITGB4, CD104; integrin beta 4
K06583  ITGA7; integrin alpha 7
K06584  ITGA8; integrin alpha 8
K06585  ITGA9; integrin alpha 9
K06586  ITGA10; integrin alpha 10
K06587  ITGA11; integrin alpha 11
K06588  ITGB5; integrin beta 5
K06589  ITGB6; integrin beta 6
K06590  ITGB7; integrin beta 7
K06591  ITGB8; integrin beta 8
K06824  NPNT; nephronectin
K08131  COL9A; collagen type IX alpha
K16338  SDC4; syndecan 4
K16857  THBS1; thrombospondin 1
K19719  COL2A; collagen type II alpha
K23328  DMP1; dentin matrix acidic phosphoprotein 1
K23379  FRAS1; extracelluar matrix protein FRAS1
K23380  FREM1_2; FRAS1-related extracelluar matrix protein 1/2
K23573  DSPP; dentin sialophosphoprotein
K26442  MEPE; matrix extracellular phosphoglycoprotein
Compound
G10505  Hyaluronic acid
Reference
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
ko04510  Focal adhesion

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