KEGG ORTHOLOGY: K16857

ORTHOLOGY: K16857

Entry

K16857                      KO

Symbol

THBS1

Name

thrombospondin 1

Pathway

map04015

Rap1 signaling pathway

map04115

p53 signaling pathway

map04145

Phagosome

map04148

Efferocytosis

map04151

PI3K-Akt signaling pathway

map04350

TGF-beta signaling pathway

map04510

Focal adhesion

map04512

ECM-receptor interaction

map04518

Integrin signaling

map04820

Cytoskeleton in muscle cells

map05144

Malaria

map05165

Human papillomavirus infection

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

map05219

Bladder cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K16857  THBS1; thrombospondin 1
   04350 TGF-beta signaling pathway
    K16857  THBS1; thrombospondin 1
   04151 PI3K-Akt signaling pathway
    K16857  THBS1; thrombospondin 1
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K16857  THBS1; thrombospondin 1
   04518 Integrin signaling
    K16857  THBS1; thrombospondin 1
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K16857  THBS1; thrombospondin 1
   04148 Efferocytosis
    K16857  THBS1; thrombospondin 1
  09143 Cell growth and death
   04115 p53 signaling pathway
    K16857  THBS1; thrombospondin 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K16857  THBS1; thrombospondin 1
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K16857  THBS1; thrombospondin 1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K16857  THBS1; thrombospondin 1
   05205 Proteoglycans in cancer
    K16857  THBS1; thrombospondin 1
  09162 Cancer: specific types
   05219 Bladder cancer
    K16857  THBS1; thrombospondin 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K16857  THBS1; thrombospondin 1
  09174 Infectious disease: parasitic
   05144 Malaria
    K16857  THBS1; thrombospondin 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K16857  THBS1; thrombospondin 1
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K16857  THBS1; thrombospondin 1
Membrane trafficking [BR:ko04131]
Endocytosis
  Phagocytosis
   Opsonins
    K16857  THBS1; thrombospondin 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Extracellular matrix molecules
   K16857  THBS1; thrombospondin 1

Genes

HSA:	7057(THBS1)

PTR:	453319(THBS1)

PPS:	100994890(THBS1)

GGO:	101135507(THBS1)

PON:	100453386(THBS1)

PPYG:

129013959(THBS1)

NLE:	100603886(THBS1)

HMH:	116481505(THBS1)

SSYN:

129482620(THBS1)

MCC:	705413(THBS1)

MCF:	102130245(THBS1)

MTHB:

126957930

MNI:	105492481(THBS1)

CSAB:

103245860(THBS1)

CATY:

105574152(THBS1)

PANU:

101005612(THBS1)

TGE:	112628028(THBS1)

MLEU:

105546194(THBS1)

RRO:	104659681(THBS1)

RBB:	108526966(THBS1)

TFN:	117070884(THBS1)

PTEH:

111524230(THBS1)

CANG:

105504981(THBS1)

CJC:	100390178(THBS1)

SBQ:	101029602(THBS1)

CIMI:

108306127(THBS1)

ANAN:

105724157(THBS1)

CSYR:

103255767(THBS1)

MMUR:

105872421(THBS1)

LCAT:

123621930(THBS1)

ERUF:

138393562(THBS1)

PCOQ:

105814426(THBS1)

OGA:	100949247(THBS1)

MMU:	21825(Thbs1)

MCAL:

110310932(Thbs1)

MPAH:

110319023(Thbs1)

RNO:	445442(Thbs1)

MCOC:

116090684(Thbs1)

ANU:	117704005(Thbs1)

ASYL:

127685729(Thbs1)

MUN:	110564049(Thbs1)

CGE:	100760878(Thbs1)

MAUA:

101827006(Thbs1)

PROB:

127221659(Thbs1)

PLEU:

114705915(Thbs1)

PMAV:

102923190(Thbs1)

MORG:

121465637(Thbs1)

MFOT:

126496529

AAMP:

119815510(Thbs1)

CNL:	130881341(Thbs1)

NGI:	103727450(Thbs1)

HGL:	101701581(Thbs1)

CPOC:

100727882(Thbs1)

CCAN:

109700113(Thbs1)

DORD:

105981135(Thbs1)

DSP:	122114333(Thbs1)

DMER:

138816188(Thbs1)

PLOP:

125340576(Thbs1)

NCAR:

124976726

MMMA:

107138240(Thbs1)

ITI:	101955133(Thbs1)

OCU:

100350430

OPI:	101521365(THBS1)

OCZ:	121148469(THBS1)

TUP:	102497602(THBS1)

GVR:	103585203(THBS1)

CFA:	487486(THBS1)

CLUD:

112676140(THBS1)

VVP:	112919933(THBS1)

VLG:	121479866(THBS1)

NPO:	129504160(THBS1)

AML:	100465724(THBS1)

UMR:	103673473(THBS1)

UAH:	113242050(THBS1)

UAR:	123804137(THBS1)

ELK:

111161597

LLV:

125104839

MPUF:

101694197(THBS1)

MNP:	131999619(THBS1)

MLK:	131836095(THBS1)

NVS:	122894202(THBS1)

ORO:	101376329(THBS1)

EJU:	114221286(THBS1)

ZCA:	113908849(THBS1)

MLX:	118003756(THBS1)

MANO:

123861355(THBS1)

NSU:	110585587(THBS1)

LWW:	102739409(THBS1)

FCA:	101092689(THBS1)

PYU:	121041482(THBS1)

PCOO:

112855318(THBS1)

PBG:	122468795(THBS1)

PVIV:

125168227(THBS1)

LRUF:

124508718

LGF:	123583187(THBS1)

AJU:

106979757

PTG:	102969748(THBS1)

PPAD:

109263182(THBS1)

PUC:

125909843

PLEZ:

122222202(THBS1)

HHV:	120232244(THBS1)

CCRU:

144231986(THBS1)

BTA:	281530(THBS1)

BOM:	102278109(THBS1)

BIU:	109564916(THBS1)

BJV:	133256039(THBS1)

BBUB:

102401160(THBS1)

BKE:	129621200(THBS1)

BBIS:

104994392(THBS1)

CHX:	100860971(THBS1)

OAS:	101106433(THBS1)

OCAN:

138443491(THBS1)

BTAX:

128054540(THBS1)

CSUM:

138073694(THBS1)

ODA:	120853227(THBS1)

CCAD:

122443364(THBS1)

MREE:

136172382(THBS1)

OVR:	110140200(THBS1)

MBEZ:

129562363(THBS1)

SSC:	492313(THBS1)

CFR:	102519986(THBS1)

CBAI:

105076884(THBS1)

CDK:	105096896(THBS1)

VPC:	102539069(THBS1)

BACU:

103019307(THBS1)

BMUS:

118889690(THBS1)

LVE:	103080694(THBS1)

OOR:	101283920(THBS1)

LALB:

132519056(THBS1)

GMF:	115845220(THBS1)

DDP:	132420497(THBS1)

DLE:	111181763(THBS1)

PCAD:

102995420(THBS1)

PSIU:

116748587(THBS1)

PPHC:

136118049(THBS1)

NASI:

112391175(THBS1)

ECB:	100057478(THBS1)

EPZ:	103556716(THBS1)

EAI:	106835162(THBS1)

MYB:	102250983(THBS1)

MYD:	102758170(THBS1)

MMYO:

118649603(THBS1)

MLF:	102441094(THBS1)

MDT:	132239155(THBS1)

MYUM:

139017170(THBS1)

PKL:	118723784(THBS1)

EFUS:

103287300(THBS1)

MNA:	107543012(THBS1)

DRO:	112311111(THBS1)

SHON:

118993608(THBS1)

AJM:	119048145(THBS1)

PDIC:

114491731(THBS1)

PHAS:

123808233(THBS1)

MMF:	118632173(THBS1)

PPAM:

129064365(THBS1)

HAI:	109384080(THBS1)

RFQ:	117023582(THBS1)

PALE:

102898784(THBS1)

PGIG:

120587198(THBS1)

PVP:	105288620(THBS1)

RAY:	107514453(THBS1)

MJV:	108400147(THBS1)

TOD:	119238471(THBS1)

SARA:

101549465(THBS1)

SFUM:

130041584(THBS1)

SETR:

126024782(THBS1)

LAV:	100667431(THBS1)

TMU:

101344047

ETF:	101656527(THBS1)

DNM:	101424204(THBS1)

MDO:	100031767(THBS1)

GAS:	123237918(THBS1)

SHR:	100926698(THBS1)

AFZ:

127549212

PCW:	110202873(THBS1)

TVP:	118828152(THBS1)

PBRV:

138175374(THBS1)

MLAO:

141522015(THBS1)

OAA:	100092988(THBS1)

TACU:

119920810(THBS1)

GGA:	373987(THBS1)

PCOC:

116229306(THBS1)

MGP:	100542373(THBS1)

CJO:	107314919(THBS1)

TPAI:

128086613(THBS1)

LMUT:

125694377(THBS1)

NMEL:

110401369(THBS1)

APLA:

101793322(THBS1)

AACU:

137857575(THBS1)

OJA:	118168019(THBS1)

ACYG:

106031773(THBS1)

CATA:

118244741(THBS1)

AFUL:

116489983(THBS1)

TGU:	100230636(THBS1)

LSR:	110475265(THBS1)

VMC:	128808689(THBS1)

VCHA:

128789412(THBS1)

AIB:	137475630(THBS1)

SCAN:

103826589(THBS1)

PMOA:

120500320(THBS1)

OTC:	121348252(THBS1)

PRUF:

121349463(THBS1)

ATRC:

139590034(THBS1)

MATE:

118687832(THBS1)

MAEN:

136557722(THBS1)

GFR:	102031762(THBS1)

FAB:	101818592(THBS1)

OMA:	130253813(THBS1)

PHI:	102103663(THBS1)

PMAJ:

107206295(THBS1)

CCAE:

111930312(THBS1)

CCW:	104684025(THBS1)

CBRC:

103620988(THBS1)

ACOE:

138111597(THBS1)

ETL:	114063733(THBS1)

ZAB:	102071926(THBS1)

ZLE:	135448474(THBS1)

ACHL:

103808322(THBS1)

SVG:	106849064(THBS1)

MMEA:

130578754(THBS1)

HRT:	120754021(THBS1)

SATI:

136362665(THBS1)

CFAI:

136292501(THBS1)

CCIC:

134045554(THBS1)

FPG:	101915773(THBS1)

FCH:	102054866(THBS1)

FRS:	119151515(THBS1)

CCRI:

104155632(THBS1)

NNT:	104400129(THBS1)

SHAB:

115607044(THBS1)

POCC:

134163981(THBS1)

ACUN:

113480732(THBS1)

ANOC:

141962119(THBS1)

SURA:

141943234(THBS1)

TALA:

104362883(THBS1)

ACHC:

115336101(THBS1)

HALD:

104319393(THBS1)

HLE:	104835981(THBS1)

AGEN:

126049295

HHAR:

128139690(THBS1)

BBUT:

142032157(THBS1)

GCL:

127016366

CSTI:

104553637(THBS1)

LDI:	104347809(THBS1)

MNB:	103769951(THBS1)

DPUB:

104306853(THBS1)

PPUS:

135177517(THBS1)

IIN:	128981761(THBS1)

AVIT:

104275457(THBS1)

BRHI:

104492214(THBS1)

EGZ:	104122092(THBS1)

NNI:	104020294(THBS1)

PCRI:

104030852(THBS1)

PCAO:

104039883(THBS1)

PARX:

142061772(THBS1)

PADL:

103914353(THBS1)

AFOR:

103902591(THBS1)

FGA:	104070507(THBS1)

CBOR:

142083201(THBS1)

GSTE:

104258978(THBS1)

CBOY:

140653730(THBS1)

MAME:

142410443(THBS1)

CLV:	102091738(THBS1)

CNIC:

135988815(THBS1)

MUI:	104538813(THBS1)

PGUU:

104458950(THBS1)

PLET:

104621532(THBS1)

EHS:	104508727(THBS1)

CMAC:

104474140(THBS1)

CUCA:

104062852(THBS1)

PCUR:

138721289(THBS1)

TEO:	104370469(THBS1)

BREG:

104638462(THBS1)

GAME:

129206811(THBS1)

OHA:	104326976(THBS1)

ACAR:

104523798(THBS1)

CPEA:

104397730(THBS1)

CVF:	104285096(THBS1)

RTD:	128909334(THBS1)

CRID:

134514284(THBS1)

LMIC:

141742503(THBS1)

NARQ:

141465889(THBS1)

AAM:	106482797(THBS1)

AROW:

112977838(THBS1)

NPD:	112957975(THBS1)

TGT:	104578512(THBS1)

DNE:	112980711(THBS1)

SCAM:

104140229(THBS1)

ASN:	102374383(THBS1)

AMJ:	102568233(THBS1)

CPOO:

109320792(THBS1)

GGN:	109298727(THBS1)

PSS:	102447926(THBS1)

CIZ:	142014421(THBS1)

CMY:	102943153(THBS1)

CCAY:

125638126(THBS1)

LKP:	140913099(THBS1)

NDS:	141989278(THBS1)

DCC:	119857170(THBS1)

CPIC:

101940307(THBS1)

TST:	117876703(THBS1)

EOB:	135878551(THBS1)

CABI:

116837806(THBS1)

MRV:	120402916(THBS1)

EMQ:	137159565(THBS1)

ACS:	100552734(thbs1)

ASAO:

132765864(THBS1)

PVT:	110080127(THBS1)

SUND:

121929146(THBS1)

PBI:	103054107(THBS1)

PMUR:

107296464(THBS1)

CTIG:

120307674(THBS1)

TSR:	106542050(THBS1)

PGUT:

117665703(THBS1)

PCAE:

139314507(THBS1)

APRI:

131187658(THBS1)

PTEX:

113442657(THBS1)

NSS:	113410120(THBS1)

VKO:	123026431(THBS1)

PMUA:

114593635(THBS1)

PRAF:

128410615(THBS1)

ZVI:	118082968(THBS1)

HCG:	128328019(THBS1)

GJA:	107119648(THBS1)

STOW:

125426101(THBS1)

EMC:	129323749(THBS1)

XLA:	379508(thbs1.L) 779026(thbs1.S)

XTR:	100170153(thbs1)

NPR:	108796832(THBS1)

RTEM:

120920536(THBS1)

ACAT:

141116864(THBS1)

PADS:

140342599(THBS1)

BBUF:

120981693(THBS1)

BGAR:

122922235(THBS1)

DTC:	141082829(THBS1)

HSQ:	130295820(THBS1)

PCOB:

134981053(THBS1)

PWL:	138260540(THBS1)

MUO:	115477335(THBS1)

GSH:	117363527(THBS1)

DRE:	100332237(thbs1a) 561901(thbs1b)

DAES:

130244060 130247476(thbs1b)

SRX:	107719693 107721311 107743901 107756566

SANH:

107668245 107671781 107678760 107687209

SGH:	107549089 107567351(thbs1) 107568499 107601983

CCAR:

109044909 109108576 109108577 109113549

CAUA:

113062811 113063081 113086682 113117769 113120880

CGIB:

127933159 127938619 127976786 127983957

PTET:

122324771(thbs1b) 122334470

LROH:

127179534(thbs1a) 127182985(thbs1b)

GRF:	141295318(thbs1a) 141348672(thbs1b)

OMC:	131523347(thbs1a) 131527248(thbs1b)

PPRM:

120477688 120493747(thbs1b)

RKG:	130071834 130075459(thbs1b)

MAMB:

125269215(thbs1a) 125277812(thbs1b)

CIDE:

127498276 127498300 127502113

CERY:

137007076 137019006(thbs1b)

MASI:

127409861 127410690 127416379 127455166

TROS:

130559911 130565978(thbs1b)

TDW:	130434237(thbs1b) 130436698

MANU:

129416976(thbs1a) 129429438(thbs1b)

PDAB:

135738786(thbs1b) 135761037

IPU:	108257932(thbs1b) 108270370

IFU:	128601263(thbs1b) 128612280

PHYP:

113530102(thbs1) 113531877

SMEO:

124377185(thbs1b) 124389724

TFD:	113655652(thbs1b) 113660295

TVC:	132843245(thbs1b) 132852810

CGAR:

128514945(thbs1b) 128535563

NGRA:

132883801(thbs1b) 132894304

TRN:	134320115(thbs1b) 134325588

AMEX:

103029184 103031445(thbs1b)

CMAO:

118815648(thbs1b) 118823447

EEE:	113570532 113571350

CHAR:

105899428(thbs1b) 105908317

SPIL:

134067441 134097618(thbs1b)

ASAD:

121692911 121711691(thbs1b)

TRU:	101061772(thbs1) 101062487

TFS:	130516152(thbs1b) 130540033

TNG:	GSTEN00022976G001 GSTEN00032374G001

LCO:	104926707 104934764

NCC:	104957017(thbs1) 104963041

TBEN:

117476612 117486952(thbs1b)

CGOB:

115003467 115027426(thbs1)

PGEO:

117439911(thbs1b) 117467640

GACU:

117549253(thbs1b) 117550137

EMAC:

134876790(thbs1b) 134881352

ELY:	117267199(thbs1a) 117270742(thbs1b)

EFO:	125896717(thbs1b) 125900663

PLEP:

121953263 121955248(thbs1b)

SLUC:

116035434 116066182(thbs1b)

SVIT:

144533038(thbs1b) 144534958(thbs1a)

ECRA:

117935928 117961504(thbs1b)

ESP:	116670144(thbs1) 116706057

PFLV:

114546727 114573037(thbs1)

PFLT:

120546999(thbs1b) 120549428

GAT:	120808162(thbs1b) 120832521

PPUG:

119195186(thbs1b) 119227931

AFB:	129103143 129106838(thbs1b)

CLUM:

117725477 117727098(thbs1b)

PSWI:

130201662 130202755(thbs1b)

CANA:

137785543(thbs1b) 137787632

CVE:	137870916(thbs1b) 137880414

AMIR:

142941603(thbs1b) 142968105(thbs1a)

MSAM:

119909012(thbs1b) 119910151

SCHU:

122861455 122863142(thbs1b)

EARM:

139298060 139301850(thbs1b)

CUD:	121521470(thbs1b) 121526103

SPUL:

138590893 138612456(thbs1b)

LMIX:

132984790(thbs1b) 132992842

HTC:	141801782(thbs1b) 141806871(thbs1a)

ALAT:

119004792 119012924(thbs1b)

ASTR:

137610491 137613226(thbs1b)

PKLU:

139211535 139217652(thbs1b)

MZE:	101472122(thbs1b) 101487021(thbs1a)

ONL:	100533981(thbs1b) 100533982

OAU:	116322283 116325269(thbs1b)

OLA:	100302438 100302441(thbs1)

OML:	112147575 112158403

CSAI:

133418703(thbs1b) 133462795

XMA:	102222883 102236898(thbs1)

XCO:	114134229 114158629

XHE:	116709065 116734246(thbs1)

PRET:

103457638 103458518(thbs1)

PFOR:

103129990(thbs1) 103136130

PLAI:

106960034 106960788(thbs1)

PMEI:

106929407(thbs1) 106930609

GAF:	122824890(thbs1b) 122846573

PPRL:

129365360 129375324(thbs1b)

CVG:	107084065 107093665

CTUL:

119785636(thbs1b) 119787521

GMU:	124855701 124882460(thbs1b)

NFU:	107377820 107392441(thbs1)

KMR:	108233501(thbs1b) 108236340

ALIM:

106522431(thbs1) 106535463

NWH:	119418329(thbs1b) 119427410

LTU:	140266634(thbs1b) 140270019

AOCE:

111569559(thbs1b) 111588169

EJA:	138199819 138205646(thbs1b)

BFRE:

138626668(thbs1b) 138632852

MCEP:

124999037(thbs1b) 125023273

CSEM:

103381239 103393533

POV:	109627896 109636170

SSEN:

122783306 122784081(thbs1b)

SSOE:

131443827(thbs1b) 131444991

HHIP:

117755995 117758338(thbs1b)

HSP:	118099418(thbs1b) 118116277

PPLT:

128450720 128459897(thbs1b)

SMAU:

118286576 118289767(thbs1b)

LCF:	108887258 108892515

SDU:	111225391 111236186

SLAL:

111661462 111663195

XGL:	120788903(thbs1b) 120795957

HCQ:	109516072 109523753(thbs1)

SSCV:

125980427 125990012(thbs1b)

SBIA:

133496411(thbs1b) 133513050

PEE:	133412608 133416964(thbs1b)

PTAO:

133468541(thbs1b) 133487979

BPEC:

110155241 110172375

ENY:	140360486(thbs1b) 140370868

MALB:

109962404 109967980(thbs1)

BSPL:

114848130 114849528(thbs1b)

SJO:	128375196 128376979(thbs1b)

SSCO:

133997488(thbs1b) 134000500

TTY:	137168981(thbs1b) 137199176

GMH:	115534170 115543658

SASA:

106571097 106587655 106608163 106610834

STRU:

115156330 115162365 115172646 115175127

OTW:	112217958 112233141 112249819(thbs1b) 112256663

OMY:	110497949 110505508 110522588(thbs1b) 110529176

OGO:	123995408 124001730 124046433

ONE:	115138471 115146249

OKI:	109866447 109878706 109894521 109904020

OKE:	118362459 118368340 118372856 118397908

OMM:	135508241 135525905 135557937

OCLA:

139375245 139384062 139407397 139414907

SALP:

111968762 111972691 112069670 112080561

SNH:	120019198 120023096 120024499 120060229

SFON:

129811632 129812855 129817771 129825512

CCLU:

121539254 121544935 121548536(thbs1b) 121552072

ELS:	105015675 105024329

OEP:	134024506(thbs1b) 134026268

SFM:	108919589(thbs1)

PKI:	111838851(thbs1)

AANG:

118228824(thbs1b) 118231909

AROT:

135250509 135257177(thbs1b)

CCOG:

133123922 133128669(thbs1b)

LOC:	102686208(thbs1)

PSPA:

121324992 121329482

ARUT:

117421302(thbs1b)

PSEX:

120518968(thbs1b)

LCM:	102358103(THBS1)

CMK:	103175202(thbs1b)

RTP:	109918114(thbs1b)

CPLA:

122553720(thbs1b)

CPUN:

140476452(thbs1b)

HOC:	132818146(thbs1b)

SCAU:

119957562(thbs1b)

LERI:

129700340(thbs1b)

HAKA:

140725115(thbs1b)

PMRN:

116943196(THBS1) 116953931

LRJ:	133342390(THBS1) 133356245

CIN:

SCLV:

CLEP:

SPU:

LVG:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

NVE:

ATEN:

AQU:

Reference

PMID:2430973

Authors

Lawler J, Hynes RO

Title

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

Journal

J Cell Biol 103:1635-48 (1986)
DOI:10.1083/jcb.103.5.1635

Sequence

[hsa:7057]

Reference

PMID:15707899

Authors

Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA

Title

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.

Journal

Cell 120:421-33 (2005)
DOI:10.1016/j.cell.2004.12.020

LinkDB

DBGET integrated database retrieval system