KEGG ORTHOLOGY: K16857

ORTHOLOGY: K16857

Entry

K16857                      KO

Symbol

THBS1

Name

thrombospondin 1

Pathway

map04015

Rap1 signaling pathway

map04115

p53 signaling pathway

map04145

Phagosome

map04148

Efferocytosis

map04151

PI3K-Akt signaling pathway

map04350

TGF-beta signaling pathway

map04510

Focal adhesion

map04512

ECM-receptor interaction

map04820

Cytoskeleton in muscle cells

map05144

Malaria

map05165

Human papillomavirus infection

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

map05219

Bladder cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K16857  THBS1; thrombospondin 1
   04350 TGF-beta signaling pathway
    K16857  THBS1; thrombospondin 1
   04151 PI3K-Akt signaling pathway
    K16857  THBS1; thrombospondin 1
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K16857  THBS1; thrombospondin 1
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K16857  THBS1; thrombospondin 1
   04148 Efferocytosis
    K16857  THBS1; thrombospondin 1
  09143 Cell growth and death
   04115 p53 signaling pathway
    K16857  THBS1; thrombospondin 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K16857  THBS1; thrombospondin 1
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K16857  THBS1; thrombospondin 1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K16857  THBS1; thrombospondin 1
   05205 Proteoglycans in cancer
    K16857  THBS1; thrombospondin 1
  09162 Cancer: specific types
   05219 Bladder cancer
    K16857  THBS1; thrombospondin 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K16857  THBS1; thrombospondin 1
  09174 Infectious disease: parasitic
   05144 Malaria
    K16857  THBS1; thrombospondin 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K16857  THBS1; thrombospondin 1
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K16857  THBS1; thrombospondin 1
Membrane trafficking [BR:ko04131]
Endocytosis
  Phagocytosis
   Opsonins
    K16857  THBS1; thrombospondin 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Extracellular matrix molecules
   K16857  THBS1; thrombospondin 1

Genes

HSA:	7057(THBS1)

PTR:	453319(THBS1)

PPS:	100994890(THBS1)

GGO:	101135507(THBS1)

PON:	100453386(THBS1)

PPYG:

129013959(THBS1)

NLE:	100603886(THBS1)

HMH:	116481505(THBS1)

SSYN:

129482620(THBS1)

MCC:	705413(THBS1)

MCF:	102130245(THBS1)

MTHB:

126957930

MNI:	105492481(THBS1)

CSAB:

103245860(THBS1)

CATY:

105574152(THBS1)

PANU:

101005612(THBS1)

TGE:	112628028(THBS1)

MLEU:

105546194(THBS1)

RRO:	104659681(THBS1)

RBB:	108526966(THBS1)

TFN:	117070884(THBS1)

PTEH:

111524230(THBS1)

CANG:

105504981(THBS1)

CJC:	100390178(THBS1)

SBQ:	101029602(THBS1)

CIMI:

108306127(THBS1)

ANAN:

105724157(THBS1)

CSYR:

103255767(THBS1)

MMUR:

105872421(THBS1)

LCAT:

123621930(THBS1)

PCOQ:

105814426(THBS1)

OGA:	100949247(THBS1)

MMU:	21825(Thbs1)

MCAL:

110310932(Thbs1)

MPAH:

110319023(Thbs1)

RNO:	445442(Thbs1)

MCOC:

116090684(Thbs1)

ANU:	117704005(Thbs1)

ASYL:

127685729(Thbs1)

MUN:	110564049(Thbs1)

CGE:	100760878(Thbs1)

MAUA:

101827006(Thbs1)

PROB:

127221659(Thbs1)

PLEU:

114705915(Thbs1)

MORG:

121465637(Thbs1)

MFOT:

126496529

AAMP:

119815510(Thbs1)

NGI:	103727450(Thbs1)

HGL:	101701581(Thbs1)

CPOC:

100727882(Thbs1)

CCAN:

109700113(Thbs1)

DORD:

105981135(Thbs1)

DSP:	122114333(Thbs1)

PLOP:

125340576(Thbs1)

NCAR:

124976726

MMMA:

107138240(Thbs1)

ITI:	101955133(Thbs1)

OCU:

100350430

OPI:	101521365(THBS1)

TUP:	102497602(THBS1)

GVR:	103585203(THBS1)

CFA:	487486(THBS1)

CLUD:

112676140(THBS1)

VVP:	112919933(THBS1)

VLG:	121479866(THBS1)

NPO:	129504160(THBS1)

AML:	100465724(THBS1)

UMR:	103673473(THBS1)

UAH:	113242050(THBS1)

UAR:	123804137(THBS1)

ELK:

111161597

LLV:

125104839

MPUF:

101694197(THBS1)

MNP:	131999619(THBS1)

MLK:	131836095(THBS1)

NVS:	122894202(THBS1)

ORO:	101376329(THBS1)

EJU:	114221286(THBS1)

ZCA:	113908849(THBS1)

MLX:	118003756(THBS1)

NSU:	110585587(THBS1)

LWW:	102739409(THBS1)

FCA:	101092689(THBS1)

PYU:	121041482(THBS1)

PCOO:

112855318(THBS1)

PBG:	122468795(THBS1)

PVIV:

125168227(THBS1)

LRUF:

124508718

LGF:	123583187(THBS1)

AJU:

106979757

PTG:	102969748(THBS1)

PPAD:

109263182(THBS1)

PUC:

125909843

PLEZ:

122222202(THBS1)

HHV:	120232244(THBS1)

BTA:	281530(THBS1)

BOM:	102278109(THBS1)

BIU:	109564916(THBS1)

BBUB:

102401160(THBS1)

BBIS:

104994392(THBS1)

CHX:	100860971(THBS1)

OAS:	101106433(THBS1)

BTAX:

128054540(THBS1)

CSUM:

138073694(THBS1)

ODA:	120853227(THBS1)

CCAD:

122443364(THBS1)

MREE:

136172382(THBS1)

OVR:	110140200(THBS1)

MBEZ:

129562363(THBS1)

SSC:	492313(THBS1)

CFR:	102519986(THBS1)

CBAI:

105076884(THBS1)

CDK:	105096896(THBS1)

VPC:	102539069(THBS1)

BACU:

103019307(THBS1)

BMUS:

118889690(THBS1)

LVE:	103080694(THBS1)

OOR:	101283920(THBS1)

LALB:

132519056(THBS1)

DLE:	111181763(THBS1)

PCAD:

102995420(THBS1)

PSIU:

116748587(THBS1)

NASI:

112391175(THBS1)

ECB:	100057478(THBS1)

EPZ:	103556716(THBS1)

EAI:	106835162(THBS1)

MYB:	102250983(THBS1)

MYD:	102758170(THBS1)

MMYO:

118649603(THBS1)

MLF:	102441094(THBS1)

MDT:	132239155(THBS1)

MYUM:

139017170(THBS1)

PKL:	118723784(THBS1)

EFUS:

103287300(THBS1)

MNA:	107543012(THBS1)

DRO:	112311111(THBS1)

SHON:

118993608(THBS1)

AJM:	119048145(THBS1)

PDIC:

114491731(THBS1)

PHAS:

123808233(THBS1)

MMF:	118632173(THBS1)

PPAM:

129064365(THBS1)

HAI:	109384080(THBS1)

RFQ:	117023582(THBS1)

PALE:

102898784(THBS1)

PGIG:

120587198(THBS1)

PVP:	105288620(THBS1)

RAY:	107514453(THBS1)

MJV:	108400147(THBS1)

TOD:	119238471(THBS1)

SARA:

101549465(THBS1)

SFUM:

130041584(THBS1)

SETR:

126024782(THBS1)

LAV:	100667431(THBS1)

TMU:

101344047

ETF:	101656527(THBS1)

DNM:	101424204(THBS1)

MDO:	100031767(THBS1)

GAS:	123237918(THBS1)

SHR:	100926698(THBS1)

AFZ:

127549212

PCW:	110202873(THBS1)

TVP:	118828152(THBS1)

PBRV:

138175374(THBS1)

OAA:	100092988(THBS1)

TACU:

119920810(THBS1)

GGA:	373987(THBS1)

PCOC:

116229306(THBS1)

MGP:	100542373(THBS1)

CJO:	107314919(THBS1)

TPAI:

128086613(THBS1)

LMUT:

125694377(THBS1)

NMEL:

110401369(THBS1)

APLA:

101793322(THBS1)

ACYG:

106031773(THBS1)

CATA:

118244741(THBS1)

AFUL:

116489983(THBS1)

TGU:	100230636(THBS1)

LSR:	110475265(THBS1)

SCAN:

103826589(THBS1)

PMOA:

120500320(THBS1)

OTC:	121348252(THBS1)

PRUF:

121349463(THBS1)

ATRC:

139590034(THBS1)

GFR:	102031762(THBS1)

FAB:	101818592(THBS1)

OMA:	130253813(THBS1)

PHI:	102103663(THBS1)

PMAJ:

107206295(THBS1)

CCAE:

111930312(THBS1)

CCW:	104684025(THBS1)

CBRC:

103620988(THBS1)

ACOE:

138111597(THBS1)

ETL:	114063733(THBS1)

ZAB:	102071926(THBS1)

ZLE:	135448474(THBS1)

ACHL:

103808322(THBS1)

SVG:	106849064(THBS1)

MMEA:

130578754(THBS1)

HRT:	120754021(THBS1)

SATI:

136362665(THBS1)

CCIC:

134045554(THBS1)

FPG:	101915773(THBS1)

FCH:	102054866(THBS1)

CCRI:

104155632(THBS1)

NNT:	104400129(THBS1)

SHAB:

115607044(THBS1)

ACUN:

113480732(THBS1)

TALA:

104362883(THBS1)

ACHC:

115336101(THBS1)

HALD:

104319393(THBS1)

HLE:	104835981(THBS1)

AGEN:

126049295

HHAR:

128139690(THBS1)

GCL:

127016366

CSTI:

104553637(THBS1)

LDI:	104347809(THBS1)

MNB:	103769951(THBS1)

DPUB:

104306853(THBS1)

PPUS:

135177517(THBS1)

AVIT:

104275457(THBS1)

BRHI:

104492214(THBS1)

EGZ:	104122092(THBS1)

NNI:	104020294(THBS1)

PCRI:

104030852(THBS1)

PCAO:

104039883(THBS1)

PADL:

103914353(THBS1)

AFOR:

103902591(THBS1)

FGA:	104070507(THBS1)

GSTE:

104258978(THBS1)

CLV:	102091738(THBS1)

MUI:	104538813(THBS1)

PGUU:

104458950(THBS1)

PLET:

104621532(THBS1)

EHS:	104508727(THBS1)

CMAC:

104474140(THBS1)

CUCA:

104062852(THBS1)

TEO:	104370469(THBS1)

BREG:

104638462(THBS1)

OHA:	104326976(THBS1)

ACAR:

104523798(THBS1)

CPEA:

104397730(THBS1)

CVF:	104285096(THBS1)

RTD:	128909334(THBS1)

CRID:

134514284(THBS1)

AAM:	106482797(THBS1)

AROW:

112977838(THBS1)

NPD:	112957975(THBS1)

TGT:	104578512(THBS1)

DNE:	112980711(THBS1)

SCAM:

104140229(THBS1)

ASN:	102374383(THBS1)

AMJ:	102568233(THBS1)

CPOO:

109320792(THBS1)

GGN:	109298727(THBS1)

PSS:	102447926(THBS1)

CMY:	102943153(THBS1)

CCAY:

125638126(THBS1)

DCC:	119857170(THBS1)

CPIC:

101940307(THBS1)

TST:	117876703(THBS1)

CABI:

116837806(THBS1)

MRV:	120402916(THBS1)

ACS:	100552734(thbs1)

ASAO:

132765864(THBS1)

PVT:	110080127(THBS1)

SUND:

121929146(THBS1)

PBI:	103054107(THBS1)

PMUR:

107296464(THBS1)

CTIG:

120307674(THBS1)

TSR:	106542050(THBS1)

PGUT:

117665703(THBS1)

APRI:

131187658(THBS1)

PTEX:

113442657(THBS1)

NSS:	113410120(THBS1)

VKO:	123026431(THBS1)

PMUA:

114593635(THBS1)

PRAF:

128410615(THBS1)

ZVI:	118082968(THBS1)

HCG:	128328019(THBS1)

GJA:	107119648(THBS1)

STOW:

125426101(THBS1)

EMC:	129323749(THBS1)

XLA:	379508(thbs1.L) 779026(thbs1.S)

XTR:	100170153(thbs1)

NPR:	108796832(THBS1)

RTEM:

120920536(THBS1)

BBUF:

120981693(THBS1)

BGAR:

122922235(THBS1)

PWL:	138260540(THBS1)

MUO:	115477335(THBS1)

GSH:	117363527(THBS1)

DRE:	100332237(thbs1a) 561901(thbs1b)

SRX:	107719693 107721311 107743901 107756566

SANH:

107668245 107671781 107678760 107687209

SGH:	107549089 107567351(thbs1) 107568499 107601983

CCAR:

109044909 109108576 109108577 109113549

CAUA:

113062811 113063081 113086682 113117769 113120880

CGIB:

127933159 127938619 127976786 127983957

PTET:

122324771(thbs1b) 122334470

LROH:

127179534(thbs1a) 127182985(thbs1b)

OMC:	131523347(thbs1a) 131527248(thbs1b)

PPRM:

120477688 120493747(thbs1b)

RKG:	130071834 130075459(thbs1b)

MAMB:

125269215(thbs1a) 125277812(thbs1b)

CIDE:

127498276 127498300 127502113

CERY:

137007076 137019006(thbs1b)

MASI:

127409861 127410690 127416379 127455166

TROS:

130559911 130565978(thbs1b)

TDW:	130434237(thbs1b) 130436698

MANU:

129416976(thbs1a) 129429438(thbs1b)

PDAB:

135738012 135738786 135761037

IPU:	108257932(thbs1b) 108270370

IFU:	128601263(thbs1b) 128612280

PHYP:

113530102(thbs1) 113531877

SMEO:

124377185(thbs1b) 124389724

TFD:	113655652(thbs1b) 113660295

TVC:	132843245(thbs1b) 132852810

CGAR:

128514945(thbs1b) 128535563

NGRA:

132883801(thbs1b) 132894304

TRN:	134320115(thbs1b) 134325588

AMEX:

103029184 103031445(thbs1b)

CMAO:

118815648(thbs1b) 118823447

EEE:	113570532 113571350

CHAR:

105899428(thbs1b) 105908317

SPIL:

134067441 134097618(thbs1b)

TRU:	101061772(thbs1) 101062487

TFS:	130516152(thbs1b) 130540033

TNG:	GSTEN00022976G001 GSTEN00032374G001

LCO:	104926707 104934764

NCC:	104957017(thbs1) 104963041

TBEN:

117476612 117486952(thbs1b)

CGOB:

115003467 115027426(thbs1)

PGEO:

117439911(thbs1b) 117467640

GACU:

117549253(thbs1b) 117550137

EMAC:

134876790(thbs1b) 134881352

ELY:	117267199 117270742(thbs1b)

EFO:	125896717(thbs1b) 125900663

PLEP:

121953263 121955248(thbs1b)

SLUC:

116035434 116066182(thbs1b)

ECRA:

117935928 117961504(thbs1b)

ESP:	116670144(thbs1) 116706057

PFLV:

114546727 114573037(thbs1)

GAT:	120808162(thbs1b) 120832521

PPUG:

119195186(thbs1b) 119227931

AFB:	129103143 129106838(thbs1b)

CLUM:

117725477 117727098(thbs1b)

PSWI:

130201662 130202755(thbs1b)

CANA:

137785543(thbs1b) 137787632

CVE:	137870916(thbs1b) 137880414

MSAM:

119909012(thbs1b) 119910151

SCHU:

122861455 122863142(thbs1b)

CUD:	121521470(thbs1b) 121526103

SPUL:

138590893 138612456(thbs1b)

LMIX:

132984790(thbs1b) 132992842

ALAT:

119004792 119012924(thbs1b)

ASTR:

137610491 137613226(thbs1b)

MZE:	101472122 101487021

ONL:	100533981(thbs1b) 100533982

OAU:	116322283 116325269(thbs1b)

OLA:	100302438 100302441(thbs1)

OML:	112147575 112158403

CSAI:

133418703(thbs1b) 133462795

XMA:	102222883 102236898(thbs1)

XCO:	114134229 114158629

XHE:	116709065 116734246(thbs1)

PRET:

103457638 103458518(thbs1)

PFOR:

103129990(thbs1) 103136130

PLAI:

106960034 106960788(thbs1)

PMEI:

106929407(thbs1) 106930609

GAF:	122824890(thbs1b) 122846573

PPRL:

129365360 129375324(thbs1b)

CVG:	107084065 107093665

CTUL:

119785636(thbs1b) 119787521

GMU:	124855701 124882460(thbs1b)

NFU:	107377820 107392441(thbs1)

KMR:	108233501(thbs1b) 108236340

ALIM:

106522431(thbs1) 106535463

NWH:	119418329(thbs1b) 119427410

AOCE:

111569559(thbs1b) 111588169

EJA:	138199819 138205646(thbs1b)

BFRE:

138626668(thbs1b) 138632852

MCEP:

124999037(thbs1b) 125023273

CSEM:

103381239 103393533

POV:	109627896 109636170

SSEN:

122783306 122784081(thbs1b)

SSOE:

131443827(thbs1b) 131444991

HHIP:

117755995 117758338(thbs1b)

HSP:	118099418(thbs1b) 118116277

PPLT:

128450720 128459897(thbs1b)

SMAU:

118286576 118289767(thbs1b)

LCF:	108887258 108892515

SDU:	111225391 111236186

SLAL:

111661462 111663195

XGL:	120788903(thbs1b) 120795957

HCQ:	109516072 109523753(thbs1)

SSCV:

125980427 125990012(thbs1b)

SBIA:

133496411(thbs1b) 133513050

PEE:	133412608 133416964(thbs1b)

PTAO:

133468541(thbs1b) 133487979

BPEC:

110155241 110172375

ENY:	140360486(thbs1b) 140370868

MALB:

109962404 109967980(thbs1)

BSPL:

114848130 114849528(thbs1b)

SJO:	128375196 128376979(thbs1b)

SSCO:

133997488(thbs1b) 134000500

GMH:	115534170 115543658

SASA:

106571097 106587655 106608163 106610834

STRU:

115156330 115162365 115172646 115175127

OTW:	112217958 112233141 112249819(thbs1b) 112256663

OMY:	110497949 110505508 110522588(thbs1b) 110529176

OGO:	123995408 124001730 124046433

ONE:	115138471 115146249

OKI:	109866447 109878706 109894521 109904020

OKE:	118362459 118368340 118372856 118397908

OMM:	135508241 135525905 135557937

OCLA:

139375245 139384062 139407397 139414907

SALP:

111968762 111972691 112069670 112080561

SNH:	120019198 120023096 120024499 120060229

CCLU:

121539254 121544935 121548536(thbs1b) 121552072

ELS:	105015675 105024329

OEP:	134024506(thbs1b) 134026268

SFM:	108919589(thbs1)

PKI:	111838851(thbs1)

AANG:

118228824(thbs1b) 118231909

AROT:

135250509 135257177(thbs1b)

CCOG:

133123922 133128669(thbs1b)

LOC:	102686208(thbs1)

PSPA:

121324992 121329482

ARUT:

117421302(thbs1b)

PSEX:

120518968(thbs1b)

LCM:	102358103(THBS1)

CMK:	103175202(thbs1b)

RTP:	109918114(thbs1b)

CPLA:

122553720(thbs1b)

HOC:	132818146(thbs1b)

LERI:

129700340(thbs1b)

PMRN:

116943196(THBS1) 116953931

LRJ:	133342390(THBS1) 133356245

CIN:

SCLV:

SPU:

APLC:

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Reference

PMID:2430973

Authors

Lawler J, Hynes RO

Title

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

Journal

J Cell Biol 103:1635-48 (1986)
DOI:10.1083/jcb.103.5.1635

Sequence

[hsa:7057]

Reference

PMID:15707899

Authors

Christopherson KS, Ullian EM, Stokes CC, Mullowney CE, Hell JW, Agah A, Lawler J, Mosher DF, Bornstein P, Barres BA

Title

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.

Journal

Cell 120:421-33 (2005)
DOI:10.1016/j.cell.2004.12.020

LinkDB

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