KEGG   PATHWAY: sinb03410Help
Entry
sinb03410                   Pathway                                

Name
Base excision repair - Sphingobium indicum
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
sinb03410  Base excision repair
sinb03410

Ortholog table
Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Sphingobium indicum [GN:sinb]
Gene
SIDU_09720  formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
SIDU_05155  endonuclease III [KO:K10773] [EC:4.2.99.18]
SIDU_09810  DNA glycosylase [KO:K01247] [EC:3.2.2.21]
SIDU_15530  hypothetical protein [KO:K01246] [EC:3.2.2.20]
SIDU_04410  uracil-DNA glycosylase [KO:K21929] [EC:3.2.2.27]
SIDU_10490  DNA polymerase [KO:K21929] [EC:3.2.2.27]
SIDU_05670  uracil-DNA glycosylase [KO:K21929] [EC:3.2.2.27]
SIDU_12885  uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
SIDU_15335  A/G-specific adenine glycosylase [KO:K03575] [EC:3.2.2.31]
SIDU_01485  exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
SIDU_15860  exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
SIDU_13505  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SIDU_13045  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
SIDU_06470  aromatic ring-opening dioxygenase LigA [KO:K01972] [EC:6.5.1.2]
SIDU_05735  ATP-dependent DNA ligase [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   
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