KEGG   ENZYME: 1.5.1.7
Entry
EC 1.5.1.7                  Enzyme                                 
Name
saccharopine dehydrogenase (NAD+, L-lysine-forming);
lysine-2-oxoglutarate reductase;
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming);
epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming);
N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming);
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ [RN:R00715]
Reaction(KEGG)
R00715
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.5.1.7 created 1972
Pathway
ec00300  Lysine biosynthesis
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00290  saccharopine dehydrogenase (NAD+, L-lysine forming)
Genes
NVE5513834
EPA110253051
ATEN116297853 116298760 116300891 116300965
ADF107350380
AMIL114957762
PDAM113665974 113665975
SPIS111333439 111333523 111335282 111337694
SCEYIR034C(LYS1)
SEUBDI49_2813
SPAOSPAR_I01890
AGOAGOS_ACR167C
ERCEcym_5636
KLAKLLA0_E07987g
KMXKLMA_40368(LYS1)
LTHKLTH0C00594g
VPOKpol_1057p13
ZROZYRO0D00594g
CGRCAGL0F06875g
NCSNCAS_0A08650(NCAS0A08650)
NDINDAI_0G05090(NDAI0G05090)
TPFTPHA_0N01860(TPHA0N01860)
TBLTBLA_0C01000(TBLA0C01000)
TGBHG536_0G00200
TDLTDEL_0B07590(TDEL0B07590)
KAFKAFR_0A00160(KAFR0A00160)
KNGKNAG_0H00170(KNAG0H00170) KNAG_0M02400(KNAG0M02400)
ZMKHG535_0H00220
PPAPAS_chr1-1_0447
DHADEHA2C07018g
PICPICST_86170(LYS1)
PGUPGUG_05365
SPAASPAPADRAFT_147229(LYS1)
LELPVL30_004380(LYS1_2)
CALCAALFM_C405320WA(LYS1)
CTPCTRG_03875
COTCORT_0B00970
CDUCD36_44980
CTENCANTEDRAFT_113510 CANTEDRAFT_115850
YLIYALI0B15444g
CLUCLUG_04507
CLUSA9F13_25g00627
CAURCJI96_0001742
SLBAWJ20_1568(LYS1)
PKZC5L36_0C04460
BNNFOA43_002432(LYS1)
BBRXBRETT_000252(LYS1)
OPAHPODL_00111
SLUDSCDLUD_003070
NCRNCU03118
NTENEUTE1DRAFT91293(NEUTE1DRAFT_91293)
SMPSMAC_02849
PANPODANSg5796
PBELQC761_110980(LYS1)
PPSDQC762_110980(LYS1)
PPSPQC763_110980(LYS1)
PPSAQC764_110980(LYS1)
TTTTHITE_2113543
MTMMYCTH_2088454
CTHRCTHT_0060440
MGRMGG_01359
PPEIPpBr36_00869
PGRIPgNI_04166
TMNUCRPA7_104
SSCKSPSK_03427
FGRFGSG_10925
FPUFPSE_11246
FPOAFPOAC1_009666
FVNFVRRES_10306
FVRFVEG_11605 FVEG_16154
FOXFOXG_12862
NHENECHADRAFT_93245
FFCNCS54_00646800
FKRNCS57_00687100
FMUJ7337_010011 J7337_010372
TRETRIREDRAFT_119788
TRRM419DRAFT_135482
MAWMAC_09690
MAJMAA_06003
PCHMVFPPC_07774
CMTCCM_03749 CCM_04910
AMUSLMH87_004323
PLJVFPFJ_01828
PTKZJDV02_004112(LYS1)
VALVDBG_07364
VDAVDAG_06069
CFJCFIO01_08377
CLUPCLUP02_13705
CHIGCH63R_05808
SAPOSAPIO_CDS0173
ELAUCREL1_5874
PFYPFICI_00199
SSLSS1G_06166
BFUBCIN_05g04270(Bclys1)
MBEMBM_03432
PSCOLY89DRAFT_604497 LY89DRAFT_651629
GLZGLAREA_10832
ANIANIA_02873
AFMAFUA_3G11710
ACTACLA_039590
NFINFIA_065620
AORAO090003000729
ANGAn02g07500
AFVAFLA_000953
ALUCAKAW2_10619A(LYS1_1)
ACHEACHE_21163A(LYS1_2)
APUUAPUU_30693A(LYS1_2)
PCSN7525_000851
PDPPDIP_74380
POUPOX_b03123
TMFEYB26_000569
TRGTRUGW13939_04035
CIMCIMG_00116
CPWCPC735_060200
UREUREG_00224
PBLPAAG_05847
PBNPADG_06144
ABEARB_05726
TVETRV_03009
AJEHCAG_01145
BGHBDBG_06619
PNOSNOG_13323
PTEPTT_12058
BZECOCCADRAFT_9863
BSCCOCSADRAFT_38405
BORCOCMIDRAFT_104289
AALTCC77DRAFT_171007
ARABEKO05_0000880
ZTRMYCGRDRAFT_60912
PFJMYCFIDRAFT_49771
FFUCLAFUR5_05047
CBETCB0940_11237
BCOMBAUCODRAFT_152629
NPAUCRNP2_8755
TMLGSTUM_00005842001
SPOSPAC227.18(lys3)
SOMSOMG_01598(lys3)
CNECND06290
CNBCNBD0140
CNGCNAG_06849
CGICGB_I0170W
CDEUCNBG_5912
TMSTREMEDRAFT_37417
TASAA1Q1_01558
CCACCcaHIS019_0608570(LYS1)
TVSTRAVEDRAFT_55646
DSQDICSQDRAFT_95061
PCOPHACADRAFT_84219
SHSSTEHIDRAFT_123797
HIRHETIRDRAFT_437937
PSQPUNSTDRAFT_48486
ADLAURDEDRAFT_111611
FMEFOMMEDRAFT_129025
GTRGLOTRDRAFT_68913
RSXRhiXN_11432
LBCLACBIDRAFT_228788
CCICC1G_03693
ABPAGABI1DRAFT96692(AGABI1DRAFT_96692)
ABVAGABI2DRAFT133180(AGABI2DRAFT_133180)
PCUBJR316_0000810
MPRMPER_10902
MRRMoror_145
MOREE1B28_001264
SCMSCHCO_02612998(SCHCODRAFT_02612998)
CPUTCONPUDRAFT_86509
SLASERLADRAFT_480237
WSEWALSEDRAFT_59278
WICJ056_002071
UMAUMAG_04268
PFPPFL1_03275
SGRAEX895_002018
MGLMGL_0554
MRTMRET_4335
MSYMMSY001_3457
PGRPGTG_12721
PTRCPtA15_6A217
PSTRPst134EA_003218
MLRMELLADRAFT_117783
MBRMONBRDRAFT_32342
SREPTSG_00686
ACANACA1_399240
NGRNAEGRDRAFT_78399
VBRA6E01_07465
PPRPBPRB1102(SAV1788)
PGBH744_1c1753
SVOSVI_3927
SPSWSps_03208
SEURFM038_002230
CBERB5D82_14350
LSDEMK97_10165
MMAAFR932_02790
GAIIMCC3135_26915
BGEBC1002_6948
PSPWBJG93_27770
PSAAQEN71_40330
SILSPO3307(lkr)
SITTM1040_0107
RUAD1823_16465
RUTFIU92_14995(ald2)
RCONK3740_16350
JANJann_4015
RDERD1_0698
RLIRLO149_c038450
RPONG3256_01760
PGAPGA1_c32690
PGLPGA2_c30960
PGDGal_03330
PHPPhaeoP97_03177
PPICPhaeoP14_03069
PHQD1820_11140
OATOAN307_c45970
OAROA238_c40540
OTMOSB_29950(ald_3)
OCTFTO60_14855
LMDMETH_00175
LEJETW24_00170
LAQUR2C4_17070
LEVETW23_19120
LCAEK3721_00175
REDroselon_00774
MALGMALG_00109
YPACCEW88_14660
YANAYJ57_17005
TPROGa0080559_TMP3190
PABYGa0080574_TMP1229
SULZC1J03_20910
SULIC1J05_00895
SULDB5M07_02275
SPOTG6548_00495
SMEDJNX03_15105
SINLDSM14862_00456
SFAVPL335_02115
SDUBR1T39_12530
SPSESULPSESMR1_02884
TOMBWR18_18240
RMMROSMUCSMR3_00818(ald)
ROKRAK1035_3690
RIDRIdsm_04909
ROMEI983_01020
ROHFIU89_01100
RPELN7U68_11230
AHTANTHELSMS3_00159
SAGUCDO87_06655
THAACFI11_21225
OCDFHY55_20110
MALUKU6B_07830 KU6B_07840
TGLHFZ77_09150
HATRC74_05215
PALXGQA70_03565
LSALKBK07_00185
LALGLentiSH36_02331
TRYQF118_04975
MARUFIU81_14385
RSPRSP_1086(sdh)
RSHRsph17029_2749
RSQRsph17025_2942
RSKRSKD131_2484
CAZTLV780_13175
RBLB6K69_08800
FYTQF092_13805
PDEPden_2709
PYEA6J80_08360
PCONB0A89_05955
PZHCX676_12800
PAROCUV01_08965
PARSDRW48_02850
PARREOJ32_01205
PAAKFIU66_12690
PKDF8A10_10780
PPANESD82_10970
PLIAE4191_00265
PSANHGN31_07870
PMAUCP157_00222(ald2)
PFISJHX87_11615
PAEXJHW48_01060
PSTLJHW45_02550
PVERE3U25_20890
PAEZPAE61_16360
PDIMPAF18_13035
PFEOE3U26_09160
PTPRCA23_c28820
RMBK529_000605
TSCOR1T40_15095
DONBSK21_12700
RBZB9057_12425
LVSLOKVESSMR4R_03787(ald)
GEHHYN69_16605
TAWEI545_09415
SEDIEBB79_19195
PPSOQPJ95_09065
PSEBEOK75_10440
PAEDG5B38_12720
PAMOBAR1_02320
PPAFI8N54_00780
CACTHZ995_08090
THASC6Y53_08610
GCEKYE46_02815
NSMJO391_17545
ACROK3J57_12315
AMYLQBD29_07465
RHOCQTA57_03865
PBAEP8S53_01660
RBXI3V23_07855
ECOGFIV45_07485
PAQIKW060_12350
BMXBMS_1042 BMS_3023
HAXBALOs_2120 BALOs_2686
SMASAVERM_1788
SGRFSGFS_028790
SCBSCAB_15871
SHYSHJG_7558
SHOSHJGH_7319
SDVBN159_1824
SCIB446_30345
SCXAS200_10130
SRWTUE45_07193
STSIA4E84_34035
SGMGCM10017557_34240(sdh)
SPHWNFX46_11815
SLSSLINC_7047
SLXSLAV_08715 SLAV_39975
SNZDC008_29075
SGEDWG14_01558
SQZFQU76_11665
SCYAEJ357_39670
SHAWCEB94_34915
SGALCP966_30450
SVRCP971_29815
SFYGFH48_08890
SAQUEJC51_38675
SPHVF9278_40085
STSUB7R87_11310
SCHACP983_07345
SCOECP976_36405
STUIGCM10017668_59820(sdh)
SCYGS1361_32840
SROIIAG44_06805
SLFJEQ17_09520
SDECL3078_38375
SAKBK1J60_06845
SCAEIHE65_06390
SCIRSTRCI_006728
SARGHKX69_04965
SJNRI060_06475
SCYNN8I84_33580
SHAUK9S39_10125
SKGKJK29_04865
SCOAQU709_05970
JMEEEW87_004530
PHWG7075_01900
PEIH9L10_09510
SERJSGUI_2172
SERWFY030_15380
ORNDV701_10960
NSNEXE58_03105
NPIG7071_01015
NROK8W59_18355
NPSKRR39_09915
MGGMPLG2_1577
ACYNORV05_12950
APRECNX65_17945
AMIAmir_3541
KBUQ4V64_46265
UMERM788_44440
SAQSare_1048
PLKCIK06_17705
NAVJQS30_08335
EKEEK0264_08680
 » show all
Reference
1  [PMID:4339117]
  Authors
Fujioka M, Nakatani Y.
  Title
Saccharopine dehydrogenase. Interaction with substrate analogues.
  Journal
Eur J Biochem 25:301-7 (1972)
DOI:10.1111/j.1432-1033.1972.tb01697.x
Reference
2  [PMID:4287986]
  Authors
Saunders PP, Broquist HP
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase.
  Journal
J Biol Chem 241:3435-40 (1966)
  Sequence
[sce:YIR034C]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.7
IUBMB Enzyme Nomenclature: 1.5.1.7
ExPASy - ENZYME nomenclature database: 1.5.1.7
BRENDA, the Enzyme Database: 1.5.1.7
CAS: 9073-96-5
LinkDB

DBGET integrated database retrieval system