KEGG   COMPOUND: C00752
Entry
C00752                      Compound                               
Name
Thrombin;
Coagulation factor IIa
Sequence
(A chain)
TFGSGEADCG LRPLFEKKSL EDKTERELLE SYIDGR
(B chain)
VEGSDAEIG MSPWQVMLFR KSPQELLCGA SLISDRWVLT AAHCLLYPPW DKNFTENDLL
VRIGKHSRTR YERNIEKISM LEKIYIHPRY NWRENLDRDI ALMKLKKPVA FSDYIHPVCL
PDRETAASLL QAGYKGRVTG WGNLKETWTA NVGKGQPSVL QVVNLPIVER PVCKDSTRIR
ITDNMFCAGY KPDEGKRGDA CEGDSGGPFV MKSPFNNRWY QMGIVSWGEG CDRDGKYGFY
THVFRLKKWI QKVIDQFGE
(Disulfide bridge: A9-B119)
  Organism
Homo sapiens [HSA:2147]
  Type
Peptide
Remark
Same as: D00090
Comment
active form [EC:3.4.21.5] of prothrombin [KO:K01313]
Pathway
map04610  Complement and coagulation cascades
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06514  Coagulation cascade
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC06 Thrombin
      D00090  Thrombin (JP18/USP/INN) <JP/US>
    B02BD Blood coagulation factors
     B02BD30 Thrombin
      D00090  Thrombin (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   332  Hemostatics
    3323  Hemostatics for organs
     D00090  Thrombin (JP18/USP/INN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG00169  Thrombin
     D00090  Thrombin
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00090  Thrombin
Other DBs
CAS: 9002-04-4
PubChem: 4014
NIKKAJI: J247.643F
LinkDB

» Japanese version

KEGG   Homo sapiens (human): 7056
Entry
7056              CDS       T01001                                 
Symbol
THBD, AHUS6, BDCA-3, BDCA3, CD141, THPH12, THRM, TM
Name
(RefSeq) thrombomodulin
  KO
K03907  thrombomodulin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06514  Coagulation cascade
  Element
N01515  Regulation of coagulation cascade, protein C system
Disease
H00223  Inherited thrombophilia
H01434  Atypical hemolytic uremic syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    7056 (THBD)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    7056 (THBD)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    7056 (THBD)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    7056 (THBD)
   00535 Proteoglycans [BR:hsa00535]
    7056 (THBD)
   04091 Lectins [BR:hsa04091]
    7056 (THBD)
CD molecules [BR:hsa04090]
 Proteins
  7056 (THBD)
Proteoglycans [BR:hsa00535]
 Cell surface proteoglycans
  Others
   7056 (THBD)
Lectins [BR:hsa04091]
 C-Type lectins
  Others
   7056 (THBD)
SSDB
Motif
Pfam: THBD FXa_inhibition cEGF EGF_Tme5 EGF_CA EGF Lectin_C hEGF EGF_LRP2
Other DBs
NCBI-GeneID: 7056
NCBI-ProteinID: NP_000352
OMIM: 188040
HGNC: 11784
Ensembl: ENSG00000178726
UniProt: P07204
Structure
LinkDB
Position
20:complement(23045633..23049672)
AA seq 575 aa
MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM
TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS
RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV
EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP
GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP
DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG
ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN
TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC
DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR
KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
NT seq 1728 nt   +upstreamnt  +downstreamnt
atgcttggggtcctggtccttggcgcgctggccctggccggcctggggttccccgcaccc
gcagagccgcagccgggtggcagccagtgcgtcgagcacgactgcttcgcgctctacccg
ggccccgcgaccttcctcaatgccagtcagatctgcgacggactgcggggccacctaatg
acagtgcgctcctcggtggctgccgatgtcatttccttgctactgaacggcgacggcggc
gttggccgccggcgcctctggatcggcctgcagctgccacccggctgcggcgaccccaag
cgcctcgggcccctgcgcggcttccagtgggttacgggagacaacaacaccagctatagc
aggtgggcacggctcgacctcaatggggctcccctctgcggcccgttgtgcgtcgctgtc
tccgctgctgaggccactgtgcccagcgagccgatctgggaggagcagcagtgcgaagtg
aaggccgatggcttcctctgcgagttccacttcccagccacctgcaggccactggctgtg
gagcccggcgccgcggctgccgccgtctcgatcacctacggcaccccgttcgcggcccgc
ggagcggacttccaggcgctgccggtgggcagctccgccgcggtggctcccctcggctta
cagctaatgtgcaccgcgccgcccggagcggtccaggggcactgggccagggaggcgccg
ggcgcttgggactgcagcgtggagaacggcggctgcgagcacgcgtgcaatgcgatccct
ggggctccccgctgccagtgcccagccggcgccgccctgcaggcagacgggcgctcctgc
accgcatccgcgacgcagtcctgcaacgacctctgcgagcacttctgcgttcccaacccc
gaccagccgggctcctactcgtgcatgtgcgagaccggctaccggctggcggccgaccaa
caccggtgcgaggacgtggatgactgcatactggagcccagtccgtgtccgcagcgctgt
gtcaacacacagggtggcttcgagtgccactgctaccctaactacgacctggtggacggc
gagtgtgtggagcccgtggacccgtgcttcagagccaactgcgagtaccagtgccagccc
ctgaaccaaactagctacctctgcgtctgcgccgagggcttcgcgcccattccccacgag
ccgcacaggtgccagatgttttgcaaccagactgcctgtccagccgactgcgaccccaac
acccaggctagctgtgagtgccctgaaggctacatcctggacgacggtttcatctgcacg
gacatcgacgagtgcgaaaacggcggcttctgctccggggtgtgccacaacctccccggt
accttcgagtgcatctgcgggcccgactcggcccttgcccgccacattggcaccgactgt
gactccggcaaggtggacggtggcgacagcggctctggcgagcccccgcccagcccgacg
cccggctccaccttgactcctccggccgtggggctcgtgcattcgggcttgctcataggc
atctccatcgcgagcctgtgcctggtggtggcgcttttggcgctcctctgccacctgcgc
aagaagcagggcgccgccagggccaagatggagtacaagtgcgcggccccttccaaggag
gtagtgctgcagcacgtgcggaccgagcggacgccgcagagactctga

KEGG   Homo sapiens (human): 10544
Entry
10544             CDS       T01001                                 
Symbol
PROCR, CCCA, CCD41, EPCR
Name
(RefSeq) protein C receptor
  KO
K06557  protein C receptor, endothelial (EPCR)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Network
nt06514  Coagulation cascade
  Element
N01515  Regulation of coagulation cascade, protein C system
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    10544 (PROCR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    10544 (PROCR)
CD molecules [BR:hsa04090]
 Proteins
  10544 (PROCR)
SSDB
Motif
Pfam: MHC_I_3 MHC_I
Other DBs
NCBI-GeneID: 10544
NCBI-ProteinID: NP_006395
OMIM: 600646
HGNC: 9452
Ensembl: ENSG00000101000
UniProt: Q9UNN8
Structure
LinkDB
Position
20:35171096..35216259
AA seq 238 aa
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEG
PDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCEL
PPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELRE
FLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
NT seq 717 nt   +upstreamnt  +downstreamnt
atgttgacaacattgctgccgatactgctgctgtctggctgggccttttgtagccaagac
gcctcagatggcctccaaagacttcatatgctccagatctcctacttccgcgacccctat
cacgtgtggtaccagggcaacgcgtcgctggggggacacctaacgcacgtgctggaaggc
ccagacaccaacaccacgatcattcagctgcagcccttgcaggagcccgagagctgggcg
cgcacgcagagtggcctgcagtcctacctgctccagttccacggcctcgtgcgcctggtg
caccaggagcggaccttggcctttcctctgaccatccgctgcttcctgggctgtgagctg
cctcccgagggctctagagcccatgtcttcttcgaagtggctgtgaatgggagctccttt
gtgagtttccggccggagagagccttgtggcaggcagacacccaggtcacctccggagtg
gtcaccttcaccctgcagcagctcaatgcctacaaccgcactcggtatgaactgcgggaa
ttcctggaggacacctgtgtgcagtatgtgcagaaacatatttccgcggaaaacacgaaa
gggagccaaacaagccgctcctacacttcgctggtcctgggcgtcctggtgggcagtttc
atcattgctggtgtggctgtaggcatcttcctgtgcacaggtggacggcgatgttaa

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