KEGG   ORTHOLOGY: K03907
Entry
K03907                      KO                                     

Symbol
THBD, CD141
Name
thrombomodulin
Pathway
map04610  Complement and coagulation cascades
map04933  AGE-RAGE signaling pathway in diabetic complications
map05418  Fluid shear stress and atherosclerosis
Disease
H00223  Inherited thrombophilia
H01434  Atypical hemolytic uremic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03907  THBD, CD141; thrombomodulin
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K03907  THBD, CD141; thrombomodulin
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K03907  THBD, CD141; thrombomodulin
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K03907  THBD, CD141; thrombomodulin
   00535 Proteoglycans
    K03907  THBD, CD141; thrombomodulin
   04091 Lectins
    K03907  THBD, CD141; thrombomodulin
CD molecules [BR:ko04090]
 Proteins
  K03907  CD141, THBD; thrombomodulin
Proteoglycans [BR:ko00535]
 Cell surface proteoglycans
  Others
   K03907  THBD, CD141; thrombomodulin
Lectins [BR:ko04091]
 C-Type lectins
  Group 14: Thrombomodulin
   K03907  THBD, CD141; thrombomodulin
Genes
HSA: 7056(THBD)
PTR: 469898(THBD)
PPS: 100971543(THBD)
GGO: 109025156(THBD)
PON: 100443362(THBD)
NLE: 100600139(THBD)
MCC: 702132(THBD)
MCF: 102125064(THBD)
CSAB: 103215390(THBD)
CATY: 105581992(THBD)
PANU: 101014198(THBD)
RRO: 104666929(THBD)
RBB: 108520664(THBD)
TFN: 117068372(THBD)
PTEH: 111526269(THBD)
CJC: 100390722(THBD)
SBQ: 101028591(THBD)
MMUR: 105857103(THBD)
MMU: 21824(Thbd)
MCAL: 110289967(Thbd)
MPAH: 110318522(Thbd)
RNO: 83580(Thbd)
MCOC: 116091098(Thbd)
MUN: 110555879(Thbd)
CGE: 100765076(Thbd)
PLEU: 114701694(Thbd)
NGI: 103737551(Thbd)
HGL: 101700359(Thbd)
CPOC: 100723479(Thbd)
CCAN: 109695757(Thbd)
OCU: 100008887(THBD)
OPI: 101516184(THBD)
TUP: 102478284(THBD)
CFA: 474355(THBD)
VVP: 112922667(THBD)
VLG: 121477882(THBD)
AML: 100467359(THBD)
UMR: 103677878(THBD)
UAH: 113246768(THBD)
ORO: 101384524(THBD)
ELK: 111141662
MPUF: 101680062(THBD)
EJU: 114224507(THBD)
MLX: 118011182(THBD)
FCA: 100049012(THBD)
PYU: 121012563(THBD)
PBG: 122496635(THBD)
PTG: 102952222(THBD)
PPAD: 109274650(THBD)
AJU: 106988194(THBD)
HHV: 120222957(THBD)
BTA: 281529(THBD)
BOM: 102277164(THBD)
BIU: 109568053(THBD)
BBUB: 102408111(THBD)
CHX: 102182609(THBD)
OAS: 101103256(THBD)
ODA: 120869507(THBD)
CCAD: 122448458(THBD)
SSC: 100157642(THBD)
CFR: 116657896(THBD)
CBAI: 105083203(THBD)
CDK: 105106290(THBD)
BACU: 103012848(THBD)
LVE: 103086739(THBD)
OOR: 101284582(THBD)
DLE: 111185044(THBD)
PCAD: 102973124(THBD)
PSIU: 116740802(THBD)
ECB: 100146206(THBD)
EPZ: 103565362(THBD)
EAI: 106841803(THBD)
MYB: 102242682(THBD)
MYD: 102761233(THBD)
MMYO: 118663077(THBD)
MLF: 102427878(THBD)
MNA: 107536268(THBD)
PKL: 118707756(THBD)
HAI: 109390443(THBD)
DRO: 112304194(THBD)
SHON: 118994364(THBD)
AJM: 119057518(THBD)
PDIC: 114506716(THBD)
MMF: 118618914(THBD)
RFQ: 117016159(THBD)
PALE: 102892208(THBD)
PGIG: 120611835(THBD)
RAY: 107516388(THBD)
MJV: 108396921(THBD)
TOD: 119231989(THBD)
LAV: 100666649(THBD)
TMU: 101353397
MDO: 100033239(THBD)
GAS: 123234778(THBD)
SHR: 100916254(THBD)
PCW: 110208810(THBD)
OAA: 100078930(THBD)
GGA: 101752029(THBD)
PCOC: 116231835(THBD)
MGP: 104909486
CJO: 107310744(THBD)
NMEL: 110396122(THBD)
APLA: 110352606(THBD)
ACYG: 106042246(THBD)
TGU: 115494442(THBD)
LSR: 110474315(THBD)
SCAN: 115484935(THBD)
PMOA: 120505982(THBD)
OTC: 121342643(THBD)
PRUF: 121357121(THBD)
FAB: 101820274(THBD)
PHI: 102101341(THBD)
PMAJ: 107201363(THBD)
CCW: 120411742(THBD)
ETL: 114071383(THBD)
FPG: 106112352(THBD)
FCH: 102053084(THBD)
CLV: 102092796(THBD)
NNI: 104022458(THBD)
AAM: 106487077
AROW: 112963288(THBD)
NPD: 112947219(THBD)
DNE: 112986660
ASN: 102380951(THBD) 102381191
AMJ: 102573031(THBD) 106738222
CPOO: 109316197(THBD)
GGN: 109296460(THBD) 109296633
CMY: 114021528(THBD)
CPIC: 101951481(THBD)
TST: 117874200(THBD)
CABI: 116834064(THBD)
MRV: 120400119(THBD)
PVT: 110089605
SUND: 121929963(THBD)
PBI: 103055128(THBD)
PMUR: 107297751(THBD)
PGUT: 117662372(THBD)
PMUA: 114601211(THBD)
ZVI: 118077647(THBD)
GJA: 107116082(THBD)
XLA: 108716407(thbd.S) 108717752
XTR: 100485229(thbd) 100497748
NPR: 108795275(THBD) 108795284
DRE: 108180329(thbd)
IPU: 108274163
AMEX: 103037465(thbd)
ELY: 117270315 117270453(thbd)
PLEP: 121955596(thbd) 121955631
PFLV: 114573286(thbd) 114573289
GAT: 120808236 120808237(thbd)
PPUG: 119194867 119194868(thbd)
CUD: 121521028(thbd) 121521281
ONL: 102081914
OAU: 116325910(thbd)
OLA: 110017766
CTUL: 119772549(thbd)
NFU: 107378228
SSEN: 122784244 122784245(thbd)
HHIP: 117758467 117758546(thbd)
MALB: 109969811
OTW: 112217654(thbd) 112256943
OMY: 110505908
AANG: 118223227 118228796(thbd)
CMK: 103179315
 » show all
Reference
PMID:2820710
  Authors
Suzuki K, Kusumoto H, Deyashiki Y, Nishioka J, Maruyama I, Zushi M, Kawahara S, Honda G, Yamamoto S, Horiguchi S
  Title
Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.
  Journal
EMBO J 6:1891-7 (1987)
DOI:10.1002/j.1460-2075.1987.tb02448.x
  Sequence
[hsa:7056]
Reference
  Authors
Mosnier LO
  Title
Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin.
  Journal
J Biol Chem 286:502-10 (2011)
DOI:10.1074/jbc.M110.147959
  Sequence
[hsa:7056]
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