KEGG   COMPOUND: C22547
Entry
C22547                      Compound                               
Name
APC;
Activated protein C
Sequence
(Light chain)
ANSFLEELRH SSLERECIEE ICDFEEAKEI FQNVDDTLAF WSKHVDGDQC LVLPLEHPCA
SLCCGHGTCI DGIGSFSCDC RSGWEGRFCQ REVSFLNCSL DNGGCTHYCL EEVGWRRCSC
APGYKLGDDL LQCHPAVKFP CGRPWKRMEK KRSHL
(Heavy chain)
DTEDQEDQVD PRLIDGKMTR RGDSPWQVVL LDSKKKLACG AVLIHPSWVL TAAHCMDESK
KLLVRLGEYD LRRWEKWELD LDIKEVFVHP NYSKSTTDND IALLHLAQPA TLSQTIVPIC
LPDSGLAERE LNQAGQETLV TGWGYHSSRE KEAKRNRTFV LNFIKIPVVP HNECSEVMSN
MVSENMLCAG ILGDRQDACE GDSGGPMVAS FHGTWFLVGL VSWGEGCGLL HNYGVYTKVS
RYLDWIHGHI RDKEAPQKSW AP
(Disulfide bridge: L141-H120)
  Organism
Homo sapiens [HSA:5624]
  Type
Peptide
Pathway
map04610  Complement and coagulation cascades
Network
nt06514  Coagulation cascade
Other DBs
PubChem: 497619906
LinkDB

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KEGG   Homo sapiens (human): 5627
Entry
5627              CDS       T01001                                 
Symbol
PROS1, PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
Name
(RefSeq) protein S
  KO
K03908  protein S
Organism
hsa  Homo sapiens (human)
Pathway
hsa04148  Efferocytosis
hsa04610  Complement and coagulation cascades
Network
nt06514  Coagulation cascade
nt06535  Efferocytosis
  Element
N01515  Regulation of coagulation cascade, protein C system
N01762  MERTK-mediated recognition and engulfment
Disease
H00223  Inherited thrombophilia
H01723  Deep vein thrombosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    5627 (PROS1)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5627 (PROS1)
SSDB
Motif
Pfam: Laminin_G_1 Laminin_G_2 EGF_CA FXa_inhibition cEGF Gla EGF EGF_3 hEGF EGF_Teneurin EGF_LRP2
Other DBs
NCBI-GeneID: 5627
NCBI-ProteinID: NP_000304
OMIM: 176880
HGNC: 9456
Ensembl: ENSG00000184500
UniProt: P07225 A0A0S2Z4K3
Structure
LinkDB
Position
3:complement(93873051..93973896)
AA seq 676 aa
MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIE
ELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQ
CSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPG
SYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKS
CEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELL
YLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIE
VQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGL
LETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVE
KGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLV
DSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDL
QRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHND
IRAHSCPSVWKKTKNS
NT seq 2031 nt   +upstreamnt  +downstreamnt
atgagggtcctgggtgggcgctgcggggcgctgctggcgtgtctcctcctagtgcttccc
gtctcagaggcaaactttttgtcaaagcaacaggcttcacaagtcctggttaggaagcgt
cgtgcaaattctttacttgaagaaaccaaacagggtaatcttgaaagagaatgcatcgaa
gaactgtgcaataaagaagaagccagggaggtctttgaaaatgacccggaaacggattat
ttttatccaaaatacttagtttgtcttcgctcttttcaaactgggttattcactgctgca
cgtcagtcaactaatgcttatcctgacctaagaagctgtgtcaatgccattccagaccag
tgtagtcctctgccatgcaatgaagatggatatatgagctgcaaagatggaaaagcttct
tttacttgcacttgtaaaccaggttggcaaggagaaaagtgtgaatttgacataaatgaa
tgcaaagatccctcaaatataaatggaggttgcagtcaaatttgtgataatacacctgga
agttaccactgttcctgtaaaaatggttttgttatgctttcaaataagaaagattgtaaa
gatgtggatgaatgctctttgaagccaagcatttgtggcacagctgtgtgcaagaacatc
ccaggagattttgaatgtgaatgccccgaaggctacagatataatctcaaatcaaagtct
tgtgaagatatagatgaatgctctgagaacatgtgtgctcagctttgtgtcaattaccct
ggaggttacacttgctattgtgatgggaagaaaggattcaaacttgcccaagatcagaag
agttgtgaggttgtttcagtgtgccttcccttgaaccttgacacaaagtatgaattactt
tacttggcggagcagtttgcaggggttgttttatatttaaaatttcgtttgccagaaatc
agcagattttcagcagaatttgatttccggacatatgattcagaaggcgtgatactgtac
gcagaatctatcgatcactcagcgtggctcctgattgcacttcgtggtggaaagattgaa
gttcagcttaagaatgaacatacatccaaaatcacaactggaggtgatgttattaataat
ggtctatggaatatggtgtctgtggaagaattagaacatagtattagcattaaaatagct
aaagaagctgtgatggatataaataaacctggacccctttttaagccggaaaatggattg
ctggaaaccaaagtatactttgcaggattccctcggaaagtggaaagtgaactcattaaa
ccgattaaccctcgtctagatggatgtatacgaagctggaatttgatgaagcaaggagct
tctggaataaaggaaattattcaagaaaaacaaaataagcattgcctggttactgtggag
aagggctcctactatcctggttctggaattgctcaatttcacatagattataataatgta
tccagtgctgagggttggcatgtaaatgtgaccttgaatattcgtccatccacgggcact
ggtgttatgcttgccttggtttctggtaacaacacagtgccctttgctgtgtccttggtg
gactccacctctgaaaaatcacaggatattctgttatctgttgaaaatactgtaatatat
cggatacaggccctaagtctatgttccgatcaacaatctcatctggaatttagagtcaac
agaaacaatctggagttgtcgacaccacttaaaatagaaaccatctcccatgaagacctt
caaagacaacttgccgtcttggacaaagcaatgaaagcaaaagtggccacatacctgggt
ggccttccagatgttccattcagtgccacaccagtgaatgccttttataatggctgcatg
gaagtgaatattaatggtgtacagttggatctggatgaagccatttctaaacataatgat
attagagctcactcatgtccatcagtttggaaaaagacaaagaattcttaa

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