| Entry |
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| Name |
Naratriptan hydrochloride (JAN/USP);
Amerge (TN) |
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| Product |
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| Generic |
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| Formula |
C17H25N3O2S. HCl
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| Exact mass |
371.1434
|
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| Mol weight |
371.93
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| Structure |
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| Simcomp |
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| Class |
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| Remark |
| Therapeutic category: | 2160 |
| Product (DG00837): | D00674<JP/US> |
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| Efficacy |
Antimigraine, Vasoconstrictor, Serotonin receptor agonist |
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| Comment |
Sumatriptan derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2C9 [HSA: 1559], CYP2D6 [HSA: 1565], CYP2E1 [HSA: 1571], CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02C ANTIMIGRAINE PREPARATIONS
N02CC Selective serotonin (5HT1) agonists
N02CC02 Naratriptan
D00674 Naratriptan hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antimigraine Agents
Serotonin (5-HT) Receptor Agonists
Naratriptan
D00674 Naratriptan hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
216 Vasoconstrictors
2160 Vasoconstrictors
D00674 Naratriptan hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01483 5-HT1A-receptor agonist
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
Analgesic
DG01484 5-HT1B-receptor agonist
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
DG01485 5-HT1D-receptor agonist
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
DG01518 5-HT1B/1D-receptor agonist
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
DG01943 Triptan
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
DG01642 CYP2C9 substrate
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
DG01644 CYP2D6 substrate
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
DG02855 CYP2E1 substrate
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
DG02925 CYP3A5 substrate
DG00837 Naratriptan
D00674 Naratriptan hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1B
D00674 Naratriptan hydrochloride (JAN/USP) <JP/US>
HTR1D
D00674 Naratriptan hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00674
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00674
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01483 5-HT1A-receptor agonist
DG00837 Naratriptan
Analgesic
DG01484 5-HT1B-receptor agonist
DG00837 Naratriptan
DG01485 5-HT1D-receptor agonist
DG00837 Naratriptan
DG01518 5-HT1B/1D-receptor agonist
DG00837 Naratriptan
DG01943 Triptan
DG00837 Naratriptan
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00837 Naratriptan
DG01642 CYP2C9 substrate
DG00837 Naratriptan
DG01644 CYP2D6 substrate
DG00837 Naratriptan
DG02855 CYP2E1 substrate
DG00837 Naratriptan
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00837 Naratriptan
DG02925 CYP3A5 substrate
DG00837 Naratriptan
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 24
1 C8y C 33.6700 -19.1800
2 C8y C 35.0000 -18.6900
3 C8y C 33.6700 -20.5800
4 C8x C 32.4100 -18.4800
5 C8x C 35.8400 -19.8800
6 N4x N 35.0000 -21.0000
7 C8x C 32.4100 -21.2800
8 C8y C 31.2200 -19.1800
9 C8x C 31.2200 -20.5800
10 C1b C 30.0300 -18.4800
11 C1b C 28.8400 -19.1800
12 S4a S 27.5800 -18.4800
13 N1b N 26.3900 -19.1800
14 O3c O 28.8400 -17.7800
15 O3c O 26.3900 -17.7800
16 C1a C 25.2000 -18.4800
17 C1y C 35.0000 -17.2900
18 C1x C 36.1900 -16.5900
19 C1x C 36.1900 -15.1900
20 N1y N 35.0000 -14.4900
21 C1x C 33.8100 -15.1900
22 C1x C 33.8100 -16.5900
23 C1a C 35.0000 -13.0900
24 X Cl 38.9900 -19.8800
BOND 25
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 3 6 1
6 3 7 1
7 4 8 2
8 7 9 2
9 8 10 1
10 10 11 1
11 11 12 1
12 12 13 1
13 12 14 2
14 12 15 2
15 13 16 1
16 5 6 1
17 8 9 1
18 2 17 1
19 17 18 1
20 18 19 1
21 19 20 1
22 20 21 1
23 21 22 1
24 17 22 1
25 20 23 1
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