| Entry |
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| Name |
Chlorpromazine hibenzate (JAN);
Contomin (TN) |
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| Formula |
C17H19ClN2S. C14H10O4
|
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| Exact mass |
560.1537
|
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| Mol weight |
561.09
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG01491 Muscarinic cholinergic receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
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| Remark |
| Product (DG00867): | D00789<JP/US> D04034<JP> |
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| Efficacy |
Antipsychotic |
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| Comment |
Phenothiazine derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
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| Structure map |
| map07029 | Antipsychotics - phenothiazines |
| map07212 | Histamine H1 receptor antagonists |
| map07213 | Dopamine receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AA Phenothiazines with aliphatic side-chain
N05AA01 Chlorpromazine
D03274 Chlorpromazine hibenzate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG00867 Chlorpromazine
D03274 Chlorpromazine hibenzate
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00867 Chlorpromazine
D03274 Chlorpromazine hibenzate
DG01491 Muscarinic cholinergic receptor antagonist
DG00867 Chlorpromazine
D03274 Chlorpromazine hibenzate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00867 Chlorpromazine
D03274 Chlorpromazine hibenzate
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00867 Chlorpromazine
D03274 Chlorpromazine hibenzate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00867 Chlorpromazine
D03274 Chlorpromazine hibenzate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00867 Chlorpromazine
D03274 Chlorpromazine hibenzate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D03274 Chlorpromazine hibenzate (JAN)
Adrenaline
ADRA2
D03274 Chlorpromazine hibenzate (JAN)
Dopamine
DRD2
D03274 Chlorpromazine hibenzate (JAN)
Histamine
HRH1
D03274 Chlorpromazine hibenzate (JAN)
Serotonin
HTR2
D03274 Chlorpromazine hibenzate (JAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03274
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG00867 Chlorpromazine
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00867 Chlorpromazine
DG01491 Muscarinic cholinergic receptor antagonist
DG00867 Chlorpromazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00867 Chlorpromazine
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00867 Chlorpromazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00867 Chlorpromazine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00867 Chlorpromazine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 39
1 C8x C 18.0665 -18.4415
2 C8x C 18.0665 -19.8441
3 C8x C 19.2811 -20.5454
4 C8y C 20.4959 -19.8441
5 C8y C 20.4959 -18.4415
6 C8x C 19.2811 -17.7402
7 S2x S 21.7106 -20.5454
8 C8y C 22.9253 -19.8441
9 C8y C 22.9253 -18.4415
10 N4y N 21.7106 -17.7402
11 C8x C 24.1401 -20.5454
12 C8x C 25.3547 -19.8441
13 C8y C 25.3547 -18.4415
14 C8x C 24.1401 -17.7402
15 C1b C 21.7106 -16.3375
16 C1b C 22.9274 -15.6350
17 C1b C 24.1261 -16.3273
18 N1c N 25.3152 -15.6408
19 C1a C 26.5089 -16.3303
20 C1a C 25.3154 -14.2338
21 X Cl 26.5735 -17.7379
22 C8x C 29.6100 -18.3400
23 C8y C 29.6100 -19.7400
24 C8x C 30.8224 -20.4400
25 C8x C 32.0349 -19.7400
26 C8y C 32.0349 -18.3400
27 C8x C 30.8224 -17.6400
28 C8x C 34.4597 -19.7400
29 C8y C 34.4597 -18.3400
30 C5a C 33.2473 -17.6400
31 C8x C 35.6722 -20.4400
32 C8x C 36.8846 -19.7400
33 C8x C 36.8846 -18.3400
34 C8y C 35.6722 -17.6400
35 O1a O 28.3976 -20.4400
36 O5a O 33.2473 -16.2400
37 C6a C 35.6722 -16.2403
38 O6a O 36.9054 -15.5280
39 O6a O 34.4806 -15.5522
BOND 42
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 18 20 1
23 13 21 1
24 22 23 2
25 23 24 1
26 24 25 2
27 25 26 1
28 26 27 2
29 22 27 1
30 28 29 1
31 29 30 1
32 26 30 1
33 28 31 2
34 31 32 1
35 32 33 2
36 33 34 1
37 29 34 2
38 23 35 1
39 30 36 2
40 34 37 1
41 37 38 1
42 37 39 2
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