| Entry |
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| Name |
Chlorpromazine phenolphthalinate (JAN);
Wintermin (TN) |
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| Formula |
C20H16O4. C17H19ClN2S
|
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| Exact mass |
638.2006
|
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| Mol weight |
639.20
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG01491 Muscarinic cholinergic receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
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| Remark |
| Therapeutic category: | 1171 |
| Product (DG00867): | D00789<JP/US> D04034<JP> |
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| Efficacy |
Antipsychotic |
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| Comment |
Phenothiazine derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
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| Structure map |
| map07029 | Antipsychotics - phenothiazines |
| map07212 | Histamine H1 receptor antagonists |
| map07213 | Dopamine receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AA Phenothiazines with aliphatic side-chain
N05AA01 Chlorpromazine
D04034 Chlorpromazine phenolphthalinate (JAN) <JP>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Chlorpromazine
D04034 Chlorpromazine phenolphthalinate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1171 Chlorpromazines
D04034 Chlorpromazine phenolphthalinate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG00867 Chlorpromazine
D04034 Chlorpromazine phenolphthalinate
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00867 Chlorpromazine
D04034 Chlorpromazine phenolphthalinate
DG01491 Muscarinic cholinergic receptor antagonist
DG00867 Chlorpromazine
D04034 Chlorpromazine phenolphthalinate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00867 Chlorpromazine
D04034 Chlorpromazine phenolphthalinate
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00867 Chlorpromazine
D04034 Chlorpromazine phenolphthalinate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00867 Chlorpromazine
D04034 Chlorpromazine phenolphthalinate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00867 Chlorpromazine
D04034 Chlorpromazine phenolphthalinate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D04034 Chlorpromazine phenolphthalinate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D04034 Chlorpromazine phenolphthalinate (JAN) <JP>
Adrenaline
ADRA2
D04034 Chlorpromazine phenolphthalinate (JAN) <JP>
Dopamine
DRD2
D04034 Chlorpromazine phenolphthalinate (JAN) <JP>
Histamine
HRH1
D04034 Chlorpromazine phenolphthalinate (JAN) <JP>
Serotonin
HTR2
D04034 Chlorpromazine phenolphthalinate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04034
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG00867 Chlorpromazine
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00867 Chlorpromazine
DG01491 Muscarinic cholinergic receptor antagonist
DG00867 Chlorpromazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00867 Chlorpromazine
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00867 Chlorpromazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00867 Chlorpromazine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00867 Chlorpromazine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 45
1 C8x C 1.7565 -18.6515
2 C8x C 1.7565 -20.0541
3 C8x C 2.9711 -20.7554
4 C8y C 4.1859 -20.0541
5 C8y C 4.1859 -18.6515
6 C8x C 2.9711 -17.9502
7 S2x S 5.4006 -20.7554
8 C8y C 6.6153 -20.0541
9 C8y C 6.6153 -18.6515
10 N4y N 5.4006 -17.9502
11 C8x C 7.8301 -20.7554
12 C8x C 9.0447 -20.0541
13 C8y C 9.0447 -18.6515
14 C8x C 7.8301 -17.9502
15 C1b C 5.4006 -16.5475
16 C1b C 6.6174 -15.8450
17 C1b C 7.8161 -16.5373
18 N1c N 9.0052 -15.8508
19 C1a C 10.1989 -16.5403
20 C1a C 9.0054 -14.4438
21 X Cl 10.2635 -17.9479
22 C8x C 13.3000 -18.5500
23 C8y C 13.3000 -19.9500
24 C8x C 14.5124 -20.6500
25 C8x C 15.7249 -19.9500
26 C8y C 15.7249 -18.5500
27 C8x C 14.5124 -17.8500
28 C8x C 18.1497 -19.9500
29 C8y C 18.1497 -18.5500
30 C1c C 16.9373 -17.8500
31 C8x C 19.3622 -20.6500
32 C8y C 20.5746 -19.9500
33 C8x C 20.5746 -18.5500
34 C8x C 19.3622 -17.8500
35 C8y C 16.9373 -16.4500
36 C8y C 18.1518 -15.7488
37 C8x C 18.1518 -14.3488
38 C8x C 16.9393 -13.6488
39 C8x C 15.7249 -14.3500
40 C8x C 15.7249 -15.7500
41 O1a O 12.0876 -20.6500
42 O1a O 21.7911 -20.6523
43 C6a C 19.5518 -15.7488
44 O6a O 20.2466 -16.9527
45 O6a O 20.2457 -14.5468
BOND 49
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 18 20 1
23 13 21 1
24 22 23 2
25 23 24 1
26 24 25 2
27 25 26 1
28 26 27 2
29 22 27 1
30 28 29 1
31 29 30 1
32 26 30 1
33 28 31 2
34 31 32 1
35 32 33 2
36 33 34 1
37 29 34 2
38 30 35 1
39 35 36 2
40 36 37 1
41 37 38 2
42 38 39 1
43 39 40 2
44 35 40 1
45 23 41 1
46 32 42 1
47 36 43 1
48 43 44 2
49 43 45 1
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