KEGG   DRUG: VorinostatHelp
Entry
D06320                      Drug                                   

Name
Vorinostat (JAN/USAN);
Zolinza (TN)
Product
Formula
C14H20N2O3
Exact mass
264.1474
Mol weight
264.3202
Structure
Mol fileKCF fileDB search
Remark
Therapeutic category: 4291
ATC code: L01XX38
Product: D06320<JP/US>
Efficacy
Antineoplastic, Histone deacetylase inhibitor
  Disease
Cutaneous T-cell lymphoma [DS:H01463]
Target
HDAC1 [HSA:3065] [KO:K06067]
HDAC2 [HSA:3066] [KO:K06067]
HDAC3 [HSA:8841] [KO:K11404]
HDAC6 [HSA:10013] [KO:K11407]
  Pathway
hsa04110  Cell cycle
hsa04330  Notch signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: UGT1A1 [HSA:54658], UGT1A3 [HSA:54659], UGT1A7 [HSA:54577], UGT1A8 [HSA:54576], UGT1A9 [HSA:54600], UGT2B7 [HSA:7364], UGT2B17 [HSA:7367]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX38 Vorinostat
      D06320  Vorinostat (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Vorinostat
    D06320  Vorinostat (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D06320  Vorinostat (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Histone deacetylase
    HDAC1
     D06320  Vorinostat (JAN/USAN) <JP/US>
    HDAC2
     D06320  Vorinostat (JAN/USAN) <JP/US>
    HDAC3
     D06320  Vorinostat (JAN/USAN) <JP/US>
    HDAC6
     D06320  Vorinostat (JAN/USAN) <JP/US>
Antineoplastics [br08340.html]
 D06320
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D06320
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06320
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06320
BRITE hierarchy
Other DBs
CAS: 149647-78-9
PubChem: 47207977
ChEBI: 45716
ChEMBL: CHEMBL98
PDB-CCD: SHH[PDBj]
LigandBox: D06320
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    18.0545  -17.1308
            2   C8x C    18.0545  -18.5347
            3   C8x C    19.2703  -19.2367
            4   C8x C    20.4863  -18.5347
            5   C8y C    20.4863  -17.1308
            6   C8x C    19.2703  -16.4288
            7   O5a O    22.9179  -18.5347
            8   C5a C    22.9179  -17.1308
            9   N1b N    21.7021  -16.4288
            10  C1b C    24.1189  -16.4374
            11  C1b C    25.3106  -17.1252
            12  C1b C    26.5446  -16.4060
            13  C1b C    27.7538  -17.1042
            14  C1b C    28.9630  -16.4060
            15  C1b C    30.1721  -17.1042
            16  C5a C    31.3814  -16.4060
            17  N1b N    32.5905  -17.1042
            18  O1b O    33.7997  -16.4060
            19  O5a O    31.3814  -15.0101
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 2
            8     8   9 1
            9     5   9 1
            10    8  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   16  19 2

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