| Entry |
|
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| Name |
Clopidogrel (USP/INN);
Clopidogrel (TN);
Plavix (TN) |
|---|
| Formula |
C16H16ClNO2S
|
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| Exact mass |
321.0590
|
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| Mol weight |
321.82
|
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| Structure |
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| Simcomp |
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| Class |
|
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| Remark |
| Product (DG00155): | D00769<JP/US> |
| Product (mixture): | D10513<JP> |
|
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| Efficacy |
Anticoagulant, Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist |
|---|
| Comment |
Thienopyridine derivative
CYP2C19 poor metabolizer status is associated with diminished response to Clopidogrel.
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]; CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544], CYP2B6 [HSA: 1555]
|
|---|
| Interaction |
CYP inhibition: CYP2C8 [HSA: 1558]
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AC Platelet aggregation inhibitors excl. heparin
B01AC04 Clopidogrel
D07729 Clopidogrel (USP/INN)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01808 Thienopyridine
DG00155 Clopidogrel
D07729 Clopidogrel
DG01809 P2Y12 receptor antagonist
DG01808 Thienopyridine
DG00155 Clopidogrel
D07729 Clopidogrel
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00155 Clopidogrel
D07729 Clopidogrel
DG02919 CYP2B6 substrate
DG00155 Clopidogrel
D07729 Clopidogrel
DG01639 CYP2C19 substrate
DG00155 Clopidogrel
D07729 Clopidogrel
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00155 Clopidogrel
D07729 Clopidogrel
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG00155 Clopidogrel
D07729 Clopidogrel
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Purine / pyrimidine
P2RY12
D07729 Clopidogrel (USP/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D07729
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07729
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01808 Thienopyridine
DG00155 Clopidogrel
DG01809 P2Y12 receptor antagonist
DG01808 Thienopyridine
DG00155 Clopidogrel
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00155 Clopidogrel
DG02919 CYP2B6 substrate
DG00155 Clopidogrel
DG01639 CYP2C19 substrate
DG00155 Clopidogrel
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00155 Clopidogrel
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG00155 Clopidogrel
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 21
1 N1y N 24.2900 -17.5700
2 C1c C 23.1000 -18.2700
3 C1x C 25.4800 -18.2700
4 C1x C 24.2900 -16.1700
5 C8y C 21.9100 -17.5700
6 C7a C 23.1000 -19.6700
7 C8y C 26.7400 -17.5700
8 C1x C 25.4800 -15.4700
9 C8y C 21.9100 -16.1700
10 C8x C 20.6500 -18.2700
11 O7a O 21.9100 -20.3700
12 O6a O 24.2900 -20.3700
13 C8y C 26.7400 -16.1700
14 C8x C 28.0700 -17.9900
15 C8x C 20.6500 -15.4700
16 X Cl 23.1000 -15.4700
17 C8x C 19.4600 -17.5700
18 C1a C 20.6500 -19.6700
19 S2x S 28.0700 -15.7500
20 C8x C 28.9100 -16.8700
21 C8x C 19.4600 -16.1700
BOND 23
1 2 5 1
2 2 6 1 #Down
3 3 7 1
4 4 8 1
5 5 9 1
6 5 10 2
7 6 11 1
8 6 12 2
9 7 13 2
10 7 14 1
11 9 15 2
12 9 16 1
13 10 17 1
14 11 18 1
15 13 19 1
16 14 20 2
17 15 21 1
18 8 13 1
19 17 21 2
20 19 20 1
21 1 2 1
22 1 3 1
23 1 4 1
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