KEGG   DRUG: ClopidogrelHelp
Entry
D07729                      Drug                                   

Name
Clopidogrel (USP/INN);
Clopidogrel (TN);
Plavix (TN)
Formula
C16H16ClNO2S
Exact mass
321.059
Mol weight
321.8217
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
 DG01809  P2Y12 receptor antagonist
  DG01808  Thienopyridine
Enzyme substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A substrate
Enzyme inhibitor
 DG01641  CYP2C8 inhibitor
Remark
ATC code: B01AC04
Chemical structure group: DG00155
Product (DG00155): D00769<JP/US>
Product (mixture): D10513<JP>
Efficacy
Anticoagulant, Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist
Comment
Thienopyridine derivative
CYP2C19 poor metabolizer status is associated with diminished response to Clopidogrel.
Target
P2RY12 [HSA:64805] [KO:K04298]
Metabolism
Enzyme: CYP2C19 [HSA:1557]; CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2B6 [HSA:1555]
Interaction
CYP inhibition: CYP2C8 [HSA:1558]
Drug interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC04 Clopidogrel
      D07729  Clopidogrel (USP/INN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Platelet Modifying Agents
   Clopidogrel
    D07729  Clopidogrel (USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Purine / pyrimidine
    P2RY12
     D07729  Clopidogrel (USP/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07729
BRITE hierarchy
Other DBs
CAS: 113665-84-2
PubChem: 51092025
ChEMBL: CHEMBL1771
DrugBank: DB00758
PDB-CCD: CGE[PDBj]
LigandBox: D07729
NIKKAJI: J691.232J
LinkDB All DBs
KCF data Show

ATOM        21
            1   N1y N    24.2900  -17.5700
            2   C1c C    23.1000  -18.2700
            3   C1x C    25.4800  -18.2700
            4   C1x C    24.2900  -16.1700
            5   C8y C    21.9100  -17.5700
            6   C7a C    23.1000  -19.6700
            7   C8y C    26.7400  -17.5700
            8   C1x C    25.4800  -15.4700
            9   C8y C    21.9100  -16.1700
            10  C8x C    20.6500  -18.2700
            11  O7a O    21.9100  -20.3700
            12  O6a O    24.2900  -20.3700
            13  C8y C    26.7400  -16.1700
            14  C8x C    28.0700  -17.9900
            15  C8x C    20.6500  -15.4700
            16  X   Cl   23.1000  -15.4700
            17  C8x C    19.4600  -17.5700
            18  C1a C    20.6500  -19.6700
            19  S2x S    28.0700  -15.7500
            20  C8x C    28.9100  -16.8700
            21  C8x C    19.4600  -16.1700
BOND        23
            1     2   5 1
            2     2   6 1 #Down
            3     3   7 1
            4     4   8 1
            5     5   9 1
            6     5  10 2
            7     6  11 1
            8     6  12 2
            9     7  13 2
            10    7  14 1
            11    9  15 2
            12    9  16 1
            13   10  17 1
            14   11  18 1
            15   13  19 1
            16   14  20 2
            17   15  21 1
            18    8  13 1
            19   17  21 2
            20   19  20 1
            21    1   2 1
            22    1   3 1
            23    1   4 1

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