Entry |
|
Name |
Lapatinib (INN) |
Formula |
C29H26ClFN4O4S
|
Exact mass |
580.1347
|
Mol weight |
581.06
|
Structure |

|
Class |
|
Remark |
Product (DG00715): | D04024<JP/US> |
|
Efficacy |
Antineoplastic, Receptor tyrosine kinase inhibitor |
Target |
|
Pathway |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]; CYP2C19 [HSA: 1557], CYP2C8 [HSA: 1558]
Transporter: ABCB1 [HSA: 5243], ABCG2 [HSA: 9429]
|
Interaction |
|
Structure map |
map07045 | Antineoplastics - protein kinase inhibitors |
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Other map |
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Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EH Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors
L01EH01 Lapatinib
D08108 Lapatinib (INN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03158 HER2 inhibitor
DG00715 Lapatinib
D08108 Lapatinib
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00715 Lapatinib
D08108 Lapatinib
DG01639 CYP2C19 substrate
DG00715 Lapatinib
D08108 Lapatinib
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00715 Lapatinib
D08108 Lapatinib
DG02925 CYP3A5 substrate
DG00715 Lapatinib
D08108 Lapatinib
Transporter substrate
DG01665 ABCB1 substrate
DG00715 Lapatinib
D08108 Lapatinib
DG01913 ABCG2 substrate
DG00715 Lapatinib
D08108 Lapatinib
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
EGFR family
EGFR
D08108 Lapatinib (INN)
ERBB2 (HER2, CD340)
D08108 Lapatinib (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08108
Drug transporters
D08108
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03158 HER2 inhibitor
DG00715 Lapatinib
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00715 Lapatinib
DG01639 CYP2C19 substrate
DG00715 Lapatinib
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00715 Lapatinib
DG02925 CYP3A5 substrate
DG00715 Lapatinib
Transporter substrate
DG01665 ABCB1 substrate
DG00715 Lapatinib
DG01913 ABCG2 substrate
DG00715 Lapatinib
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Other DBs |
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LinkDB |
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KCF data |
ATOM 40
1 C8x C 16.4054 -14.0918
2 N5x N 16.4054 -15.4940
3 C8y C 17.5972 -16.1950
4 C8y C 18.8592 -15.4940
5 C8y C 18.8592 -14.0918
6 N5x N 17.5972 -13.3907
7 C8x C 20.0510 -16.1950
8 C8y C 21.2428 -15.4940
9 C8x C 21.2428 -14.0918
10 C8x C 20.0510 -13.3907
11 N1b N 17.5972 -17.5972
12 C8y C 18.7890 -18.2983
13 C8x C 18.7890 -19.7005
14 C8y C 20.0510 -20.4015
15 C8y C 21.2428 -19.7005
16 C8x C 21.2428 -18.2983
17 C8x C 20.0510 -17.5972
18 X Cl 20.0510 -21.8037
19 O2a O 22.4347 -20.4015
20 C1b C 23.6265 -19.7005
21 C8y C 24.8184 -20.4015
22 C8x C 24.8184 -21.8037
23 C8x C 26.0803 -22.5048
24 C8x C 27.2722 -21.8037
25 C8y C 27.2722 -20.4015
26 C8x C 26.0803 -19.7005
27 X F 28.4640 -19.7005
28 C8y C 22.4347 -16.1950
29 C8x C 22.8553 -17.5271
30 C8x C 24.2575 -17.5271
31 C8y C 24.6782 -16.1950
32 O2x O 23.5564 -15.3537
33 C1b C 25.9401 -15.4940
34 N1b N 27.1319 -16.1950
35 C1b C 28.3238 -15.4940
36 C1b C 29.5857 -16.1950
37 S4a S 30.7776 -15.4940
38 C1a C 31.9694 -16.1950
39 O3c O 31.7591 -14.5124
40 O3c O 29.7961 -14.5124
BOND 44
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 2
8 7 8 1
9 8 9 2
10 9 10 1
11 5 10 2
12 3 11 1
13 11 12 1
14 12 13 2
15 13 14 1
16 14 15 2
17 15 16 1
18 16 17 2
19 12 17 1
20 14 18 1
21 15 19 1
22 19 20 1
23 20 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 21 26 1
30 25 27 1
31 8 28 1
32 29 30 1
33 30 31 2
34 31 32 1
35 32 28 1
36 29 28 2
37 31 33 1
38 33 34 1
39 34 35 1
40 35 36 1
41 36 37 1
42 37 38 1
43 37 39 2
44 37 40 2
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