KEGG   DRUG: MianserinHelp
Entry
D08216                      Drug                                   

Name
Mianserin (INN);
Tolvon (TN)
Formula
C18H20N2
Exact mass
264.1626
Mol weight
264.3648
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01729  Tetracyclic antidepressant
Enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
ATC code: N06AX03
Chemical structure group: DG00951
Product (DG00951): D01358<JP>
Efficacy
Antidepressant
Comment
tetracyclic antidepressants
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07027  Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX03 Mianserin
      D08216  Mianserin (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D08216  Mianserin (INN)
BRITE hierarchy
Other DBs
CAS: 24219-97-4
PubChem: 96024904
ChEMBL: CHEMBL6437
DrugBank: DB06148
LigandBox: D08216
NIKKAJI: J16.389I
LinkDB All DBs
KCF data Show

ATOM        20
            1   C8y C    20.1600  -15.0500
            2   N1y N    19.2500  -16.1000
            3   C1y C    17.8500  -16.1000
            4   C8y C    17.0100  -14.9800
            5   C8y C    19.8800  -13.6500
            6   C8y C    17.3600  -13.6500
            7   C1x C    18.6200  -13.0200
            8   C8x C    16.3800  -12.6700
            9   C8x C    14.9800  -13.0900
            10  C8x C    14.7000  -14.4200
            11  C8x C    15.6800  -15.4000
            12  C8x C    21.4900  -15.4700
            13  C8x C    22.5400  -14.5600
            14  C8x C    22.2600  -13.1600
            15  C8x C    20.9300  -12.7400
            16  C1x C    17.1500  -17.2900
            17  N1y N    17.8500  -18.5500
            18  C1x C    19.2500  -18.5500
            19  C1x C    19.9500  -17.3600
            20  C1a C    17.1500  -19.7400
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    4  11 2
            13    1  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    5  15 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22    2  19 1
            23   17  20 1

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