KEGG   DRUG: Propafenone
Entry
D08435                      Drug                                   

Name
Propafenone (INN);
Propafenon hexal (TN)
Formula
C21H27NO3
Exact mass
341.1991
Mol weight
341.444
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07381
ATC code: C01BC03
Chemical structure group: DG00200
Product (DG00200): D00640<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC03 Propafenone
      D08435  Propafenone (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00200  Propafenone
      D08435  Propafenone
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00200  Propafenone
    D08435  Propafenone
  DG01644  CYP2D6 substrate
   DG00200  Propafenone
    D08435  Propafenone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00200  Propafenone
     D08435  Propafenone
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08435  Propafenone (INN)
    SCN2A
     D08435  Propafenone (INN)
    SCN3A
     D08435  Propafenone (INN)
    SCN4A
     D08435  Propafenone (INN)
    SCN5A
     D08435  Propafenone (INN)
    SCN8A
     D08435  Propafenone (INN)
    SCN9A
     D08435  Propafenone (INN)
    SCN10A
     D08435  Propafenone (INN)
    SCN11A
     D08435  Propafenone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08435
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00200  Propafenone
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00200  Propafenone
  DG01644  CYP2D6 substrate
   DG00200  Propafenone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00200  Propafenone
Other DBs
CAS: 54063-53-5
PubChem: 96025121
ChEBI: 63619
ChEMBL: CHEMBL631
DrugBank: DB01182
LigandBox: D08435
NIKKAJI: J12.333A
LinkDB
KCF data

ATOM        25
            1   C8y C    27.2300  -18.2700
            2   C8y C    27.2300  -19.6700
            3   O2a O    25.9700  -17.5700
            4   C8x C    28.4200  -17.5700
            5   C5a C    25.9700  -20.3700
            6   C8x C    28.4200  -20.3700
            7   C1b C    25.9700  -16.1700
            8   C8x C    29.6100  -18.2700
            9   C1b C    24.7800  -19.6700
            10  O5a O    25.9700  -21.7700
            11  C8x C    29.6100  -19.6700
            12  C1c C    24.7800  -15.4700
            13  C1b C    23.5900  -20.4400
            14  C1b C    23.5900  -16.1700
            15  O1a O    24.7800  -14.0700
            16  C8y C    22.4000  -19.7400
            17  N1b N    22.4000  -15.4700
            18  C8x C    22.4000  -18.3400
            19  C8x C    21.1400  -20.4400
            20  C1b C    21.1400  -16.2400
            21  C8x C    21.1400  -17.6400
            22  C8x C    19.9500  -19.7400
            23  C1b C    19.9500  -15.5400
            24  C8x C    19.9500  -18.3400
            25  C1a C    18.7600  -16.2400
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   16  18 2
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21   19  22 2
            22   20  23 1
            23   21  24 2
            24   23  25 1
            25    8  11 2
            26   22  24 1

» Japanese version   » Back

KEGG   DRUG: Propafenone hydrochloride
Entry
D00640                      Drug                                   

Name
Propafenone hydrochloride (JP18/USP);
Rythmol (TN)
Product
  Generic
PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Proficient Rx LP), PROPAFENONE HYDROCHLORIDE (TWi Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Vitruvias Therapeutics), PROPAFENONE HYDROCHLORIDE (A-S Medication Solutions), PROPAFENONE HYDROCHLORIDE (A-S Medication Solutions), PROPAFENONE HCL (A-S Medication Solutions), PROPAFENONE HYDROCHLORIDE (ANI Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Actavis Pharma), PROPAFENONE HCL (Actavis Pharma), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (Aurobindo Pharma Limited), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Glenmark Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Northstar Rx LLC), PROPAFENONE HYDROCHLORIDE (Par Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Par Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Prasco Laboratories), PROPAFENONE HYDROCHLORIDE (Rising Pharma Holdings), PROPAFENONE HYDROCHLORIDE (Sun Pharmaceutical Industries), PROPAFENONE HYDROCHLORIDE (Upsher-Smith Laboratories)
Formula
C21H27NO3. HCl
Exact mass
377.1758
Mol weight
377.9049
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2129
ATC code: C01BC03
Chemical structure group: DG00200
Product (DG00200): D00640<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC03 Propafenone
      D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class I
    Propafenone
     D00640  Propafenone hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00640  Propafenone hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00200  Propafenone
      D00640  Propafenone hydrochloride
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00200  Propafenone
    D00640  Propafenone hydrochloride
  DG01644  CYP2D6 substrate
   DG00200  Propafenone
    D00640  Propafenone hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00200  Propafenone
     D00640  Propafenone hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN2A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN3A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN4A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN5A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN8A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN9A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN10A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN11A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00640  Propafenone hydrochloride
  D00640  Propafenone hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00640
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00640
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00200  Propafenone
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00200  Propafenone
  DG01644  CYP2D6 substrate
   DG00200  Propafenone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00200  Propafenone
Other DBs
CAS: 34183-22-7
PubChem: 7847706
ChEBI: 8466
ChEMBL: CHEMBL1201063
DrugBank: DB01182
LigandBox: D00640
NIKKAJI: J252.813D
LinkDB
KCF data

ATOM        26
            1   C8y C    27.3415  -18.7772
            2   C8y C    27.3474  -20.1862
            3   O2a O    26.1247  -18.0844
            4   C8x C    28.5641  -18.0785
            5   C5a C    26.1363  -20.8906
            6   C8x C    28.5641  -20.8849
            7   C1b C    26.1363  -16.6871
            8   C8x C    29.7753  -18.7772
            9   C1b C    24.9311  -20.1919
            10  O5a O    26.1422  -22.2880
            11  C8x C    29.7693  -20.1803
            12  C1c C    24.9311  -15.9825
            13  C1b C    23.7259  -20.8965
            14  C1b C    23.7259  -16.6928
            15  O1a O    24.9253  -14.5851
            16  C8y C    22.5090  -20.2036
            17  N1b N    22.5149  -15.9941
            18  C8x C    22.5090  -18.8005
            19  C8x C    21.3097  -20.9082
            20  C1b C    21.3097  -16.6987
            21  C8x C    21.2921  -18.1135
            22  C8x C    20.0869  -20.2212
            23  C1b C    20.0928  -16.0000
            24  C8x C    20.0754  -18.8121
            25  C1a C    18.8819  -16.7045
            26  X   Cl   31.8596  -18.4395
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   16  18 2
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21   19  22 2
            22   20  23 1
            23   21  24 2
            24   23  25 1
            25    8  11 2
            26   22  24 1

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