KEGG   DRUG: TivozanibHelp
Entry
D09683                      Drug                                   

Name
Tivozanib (USAN/INN)
Formula
C22H19ClN4O5
Exact mass
454.1044
Mol weight
454.8631
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
ATC code: L01XE34
Chemical structure group: DG01375
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
Target
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
  Pathway
hsa04010  MAPK signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE34 Tivozanib
      D09683  Tivozanib (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   VEGFR family
    VEGFR1 (FLT1)
     D09683  Tivozanib (USAN/INN)
    VEGFR2 (KDR)
     D09683  Tivozanib (USAN/INN)
    VEGFR3 (FLT4)
     D09683  Tivozanib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 475108-18-0
PubChem: 124490423
ChEMBL: CHEMBL1289494
PDB-CCD: AV9[PDBj]
LigandBox: D09683
LinkDB All DBs
KCF data Show

ATOM        32
            1   C8y C    12.8800  -20.3000
            2   C8y C    12.8800  -21.7000
            3   C8x C    14.0924  -22.4000
            4   C8y C    15.3049  -21.7000
            5   C8y C    15.3049  -20.3000
            6   C8x C    14.0924  -19.6000
            7   C8y C    16.5173  -22.4000
            8   C8x C    17.7297  -21.7000
            9   C8x C    17.7297  -20.3000
            10  N5x N    16.5173  -19.6000
            11  O2a O    16.5173  -23.8000
            12  C8y C    17.7318  -24.5012
            13  O2a O    11.6676  -19.6000
            14  C1a C    10.4721  -20.2904
            15  O2a O    11.6676  -22.4000
            16  C1a C    10.4721  -21.7096
            17  C8x C    17.7318  -25.8998
            18  C8y C    18.9442  -26.5999
            19  C8y C    20.1566  -25.8999
            20  C8x C    20.1567  -24.5012
            21  C8x C    18.9442  -23.8012
            22  N1b N    21.3716  -26.6014
            23  C5a C    22.5683  -25.9103
            24  N1b N    23.7550  -26.5955
            25  C8y C    24.9466  -25.9073
            26  O5a O    22.5685  -24.5003
            27  X   Cl   18.9442  -27.9998
            28  C8x C    24.9467  -24.5003
            29  N5x N    26.2848  -26.3422
            30  O2x O    27.1119  -25.2038
            31  C8y C    26.2849  -24.0655
            32  C1a C    26.7094  -22.7575
BOND        35
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14    1  13 1
            15   13  14 1
            16    2  15 1
            17   15  16 1
            18   12  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   12  21 1
            24   19  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   23  26 2
            29   18  27 1
            30   25  28 1
            31   25  29 2
            32   29  30 1
            33   30  31 1
            34   28  31 2
            35   31  32 1

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