KEGG   DRUG: Tivozanib hydrochloride
Entry
D10190                      Drug                                   

Name
Tivozanib hydrochloride (USAN);
Tivozanib hydrochloride monohydrate;
Fotivda (TN)
Product
Formula
C22H19ClN4O5. HCl. H2O
Exact mass
508.0916
Mol weight
509.3393
Structure
Simcomp
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
ATC code: L01EK03
Chemical structure group: DG01375
Product (DG01375): D10190<US>
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
  Disease
Renal cell carcinoma [DS:H00021]
Target
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
PDGFRB [HSA:5159] [KO:K05089]
  Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EK Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors
     L01EK03 Tivozanib
      D10190  Tivozanib hydrochloride (USAN) <US>
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFRB
     D10190  Tivozanib hydrochloride (USAN) <US>
    KIT (CD117)
     D10190  Tivozanib hydrochloride (USAN) <US>
   VEGFR family
    VEGFR1 (FLT1)
     D10190  Tivozanib hydrochloride (USAN) <US>
    VEGFR2 (KDR)
     D10190  Tivozanib hydrochloride (USAN) <US>
    VEGFR3 (FLT4)
     D10190  Tivozanib hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10190
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10190
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10190
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10190
Other DBs
CAS: 682745-41-1
PubChem: 135626908
ChEMBL: CHEMBL2105756
LigandBox: D10190
LinkDB
KCF data

ATOM        34
            1   C8y C    17.0800  -19.3200
            2   C8y C    17.0800  -20.7200
            3   C8x C    18.3400  -21.4200
            4   C8y C    19.5300  -20.7200
            5   C8y C    19.5300  -19.3200
            6   C8x C    18.3400  -18.6200
            7   C8y C    20.7200  -21.4200
            8   C8x C    21.9800  -20.7200
            9   C8x C    21.9800  -19.3200
            10  N5x N    20.7200  -18.6200
            11  O2a O    20.7200  -22.8200
            12  C8y C    21.9800  -23.5200
            13  O2a O    15.8900  -18.6200
            14  C1a C    14.7000  -19.2500
            15  O2a O    15.8900  -21.4200
            16  C1a C    14.7000  -20.7200
            17  C8x C    21.9800  -24.9200
            18  C8y C    23.1700  -25.6200
            19  C8y C    24.3600  -24.9200
            20  C8x C    24.3600  -23.5200
            21  C8x C    23.1700  -22.8200
            22  N1b N    25.6200  -25.6200
            23  C5a C    26.8100  -24.9200
            24  N1b N    28.0000  -25.6200
            25  C8y C    29.1900  -24.9200
            26  O5a O    26.8100  -23.5200
            27  X   Cl   23.1700  -27.0200
            28  C8x C    29.1900  -23.5200
            29  N5x N    30.5200  -25.3400
            30  O2x O    31.3600  -24.2200
            31  C8y C    30.5200  -23.0300
            32  C1a C    30.9400  -21.7700
            33  X   Cl   26.1800  -18.8300
            34  O0  O    29.4000  -18.8300
BOND        35
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14    1  13 1
            15   13  14 1
            16    2  15 1
            17   15  16 1
            18   12  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   12  21 1
            24   19  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   23  26 2
            29   18  27 1
            30   25  28 1
            31   25  29 2
            32   29  30 1
            33   30  31 1
            34   28  31 2
            35   31  32 1

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