KEGG   ORTHOLOGY: K05096
Entry
K05096                      KO                                     
Symbol
FLT1, VEGFR1
Name
FMS-like tyrosine kinase 1 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04066  HIF-1 signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map05202  Transcriptional misregulation in cancer
map05323  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04014 Ras signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04015 Rap1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04066 HIF-1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04020 Calcium signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04151 PI3K-Akt signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Genes
HSA: 2321(FLT1)
PTR: 452512(FLT1)
PPS: 100977352(FLT1)
GGO: 101133492(FLT1)
PON: 100456061(FLT1)
NLE: 100590200(FLT1)
MCC: 574133(FLT1)
MCF: 102115442(FLT1)
CSAB: 103249076(FLT1)
CATY: 105597064(FLT1)
PANU: 101006510(FLT1)
TGE: 112610885(FLT1)
RRO: 104661639(FLT1)
RBB: 108512923(FLT1)
TFN: 117097913(FLT1)
PTEH: 111540453(FLT1)
CJC: 100413680(FLT1)
SBQ: 101053773(FLT1)
CSYR: 103271953
MMUR: 105858897(FLT1)
OGA: 100946241(FLT1)
MMU: 14254(Flt1)
MCAL: 110294038(Flt1)
MPAH: 110339167(Flt1)
RNO: 54251(Flt1)
MCOC: 116068780(Flt1)
CGE: 100761329(Flt1)
PLEU: 114699134(Flt1)
NGI: 103727233(Flt1)
HGL: 101711333(Flt1)
CPOC: 100732326(Flt1)
CCAN: 109694691(Flt1)
DORD: 105993915(Flt1) 105999329
DSP: 122096363 122112548(Flt1)
OCU: 100343352(FLT1) 100358984
OPI: 101519888 101533860(FLT1)
TUP: 102480253(FLT1)
CFA: 403727(FLT1)
VVP: 112918641(FLT1)
VLG: 121496478(FLT1)
AML: 100483462(FLT1)
UMR: 103664410(FLT1)
UAH: 113251212(FLT1)
UAR: 123791948(FLT1)
ELK: 111158583
LLV: 125096245
MPUF: 101689297(FLT1)
ORO: 101383542(FLT1)
EJU: 114211921(FLT1)
ZCA: 113920594(FLT1)
MLX: 118009553(FLT1)
FCA: 101088292(FLT1)
PYU: 121012786(FLT1)
PBG: 122481013(FLT1)
PTG: 102955273(FLT1)
PPAD: 109266122(FLT1)
AJU: 106985536(FLT1)
HHV: 120247154(FLT1)
BTA: 503620(FLT1)
BOM: 102269660(FLT1)
BIU: 109566823(FLT1)
BBUB: 102410059(FLT1)
CHX: 100860837(FLT1)
OAS: 443088(FLT1)
ODA: 120882914(FLT1)
CCAD: 122447130(FLT1)
SSC: 396763(FLT1)
CFR: 102508666(FLT1)
CBAI: 105066317(FLT1)
CDK: 105086584(FLT1)
VPC: 102530642(FLT1)
BACU: 103015874(FLT1)
LVE: 103079754(FLT1)
OOR: 101277470(FLT1)
DLE: 111175188(FLT1)
PCAD: 102986927(FLT1)
PSIU: 116742893(FLT1)
ECB: 100033957(FLT1)
EPZ: 103561902(FLT1)
EAI: 106832910(FLT1)
MYB: 102244559(FLT1) 102247542
MYD: 102755891 102760394(FLT1)
MMYO: 118650828(FLT1) 118654202
MLF: 102417951(FLT1) 102422327
MNA: 107534361(FLT1)
PKL: 118719986 118729025(FLT1)
HAI: 109390085 109395227(FLT1)
DRO: 112300051 112323117(FLT1)
SHON: 118986919 118995808(FLT1)
AJM: 119041773 119064949(FLT1)
PDIC: 114489006(FLT1) 114505286
PHAS: 123822657(FLT1)
MMF: 118623942(FLT1) 118635912
RFQ: 117021297(FLT1) 117026978
PALE: 102891095(FLT1) 112469042
PGIG: 120592792 120602420(FLT1)
PVP: 105292131(FLT1) 105307777
RAY: 107498919 107514322(FLT1)
MJV: 108385338
TOD: 119258799(FLT1)
SARA: 101544502(FLT1)
LAV: 100668928(FLT1)
TMU: 101352737
DNM: 101433858(FLT1)
MDO: 100017469 100025304(FLT1)
GAS: 123241274(FLT1) 123253770
SHR: 100930426(FLT1) 111721579
PCW: 110203184 110215551(FLT1)
OAA: 100090501(FLT1) 100090796
GGA: 374100(FLT1) 422316(VEGFRKDRL)
PCOC: 116229736 116244085(FLT1)
CJO: 107308289(FLT1) 107312792
NMEL: 110388861(FLT1) 110403438
APLA: 101795331(FLT1) 101797327
ACYG: 106038554 106041123(FLT1)
AFUL: 116492016(FLT1) 116494267
TGU: 100223459(FLT1) 100229347
LSR: 110467886 110476760(FLT1)
SCAN: 103816498 103827338(FLT1)
PMOA: 120506575(FLT1) 120512684
OTC: 121341965(FLT1) 121346527
PRUF: 121362872 121364149(FLT1)
GFR: 102034196 102037593(FLT1)
FAB: 101806396(FLT1) 101808610
PHI: 102108061(FLT1) 102108458
PMAJ: 107202343(FLT1) 107203705
CCW: 104689893(FLT1) 104691716
ETL: 114062430 114067520(FLT1)
ZAB: 102066332 102069571(FLT1)
FPG: 101913316 101922526(FLT1)
FCH: 102051492 102058347(FLT1)
CLV: 102087545 102094103(FLT1)
EGZ: 104126066 104133690(FLT1)
NNI: 104021082 104023019(FLT1)
ACUN: 113479969 113485269(FLT1)
TALA: 104366770(FLT1) 104367161
PADL: 103917156 103920091(FLT1)
ACHC: 115333495 115353436(FLT1)
AAM: 106489849 106500427(FLT1)
AROW: 112970206(FLT1) 112975755
NPD: 112947066 112956318(FLT1)
DNE: 112982911 112988391(FLT1)
ASN: 102368462 102372479(FLT1)
AMJ: 102561001 102566553(FLT1)
CPOO: 109305529(FLT1) 109313679
GGN: 109300700 109302231(FLT1)
PSS: 102446651 102456773(FLT1)
CMY: 102930345 102931972(FLT1)
CPIC: 101936531 101943434(FLT1)
TST: 117871080(FLT1) 117882473
CABI: 116816233(FLT1) 116819796
MRV: 120371478 120383535(FLT1)
ACS: 100556703(flt1) 100563056
PVT: 110074293 110076449(FLT1)
SUND: 121925433(FLT1) 121936578
PBI: 103048455(FLT1) 103057723
PMUR: 107282917 107294150(FLT1)
TSR: 106546359(FLT1) 106550713
PGUT: 117661708(FLT1) 117675990
VKO: 123021962 123028973(FLT1)
PMUA: 114588860 114595760(FLT1)
ZVI: 118084151 118084634(FLT1)
GJA: 107105448(FLT1) 107121841
XLA: 108698372(kdrl.L) 108700541(kdrl.S) 373789(flt1.L) 379546(flt1.S)
XTR: 100492992(flt1) 100495109(kdrl)
NPR: 108791089 108796337(FLT1)
RTEM: 120913770 120929198(FLT1)
BBUF: 120977993 120996322(FLT1)
BGAR: 122930927(FLT1) 122946033
DRE: 544667(flt1) 796537(kdrl)
IPU: 108256487(flt1) 108269076(kdrl)
PHYP: 113528886 113541212(flt1)
SMEO: 124375383(flt1) 124385940(kdrl)
AMEX: 103032355(flt1) 103038588
TRU: 101071220 101071361(flt1)
LCO: 104923474
CGOB: 115014595 115025365(flt1)
ELY: 117255381(kdrl) 117264653(flt1)
PLEP: 121947692(kdrl) 121960979(flt1)
SLUC: 116037936(flt1) 116052518(kdrl)
ECRA: 117938210(flt1) 117951764(kdrl)
PFLV: 114549359(flt1) 114562330
GAT: 120811852(flt1) 120817726(kdrl)
PPUG: 119198803(flt1) 119210622(kdrl)
MSAM: 119888301(kdrl) 119909684(flt1)
CUD: 121516665(kdrl) 121527176(flt1)
MZE: 101478748 101479515(flt1)
ONL: 100701270(flt1) 100707615
OAU: 116319752(flt1) 116324255(kdrl)
OLA: 100049480 101172940(flt1)
OML: 112151381(flt1) 112153421(kdrl)
XMA: 102219213(flt1) 102221726
XCO: 114136904(flt1) 114139259
XHE: 116711908(flt1) 116714458
PRET: 103456619(flt1) 103471632
PFOR: 103139803(flt1) 103140126
GAF: 122824253(flt1) 122837171(kdrl)
CVG: 107090808(flt1) 107092557
CTUL: 119789068(flt1) 119795774(kdrl)
GMU: 124858000(flt1) 124860351(kdrl)
NFU: 107378530 107382874(flt1)
KMR: 108230231(flt1) 108231416(kdrl)
ALIM: 106513437(flt1) 106515430
NWH: 119408904(kdrl) 119426533(flt1)
SSEN: 122778409(kdrl)
HHIP: 117753707(flt1) 117769340(kdrl)
LCF: 108872510 108881770(flt1)
SDU: 111221028(flt1) 111232404
SLAL: 111662923(flt1) 111666345
XGL: 120785138(kdrl) 120789678(flt1)
MALB: 109952200 109960158(flt1)
ELS: 105021948(flt1) 105029482
AANG: 118223172(kdrl) 118225407(flt1)
LOC: 102683866 102685646(flt1)
LCM: 102345121(FLT1) 102365485
CMK: 103178759(kdrl) 103183246(flt1)
BFO: 118419709
BBEL: 109466500
CIN: 778954
SCLV: 120341244
APLC: 110982549
DME: Dmel_CG8222(Pvr)
DER: 6543482
DSE: 6611642
DSI: Dsimw501_GD22428(Dsim_GD22428)
DSR: 110176819
DPE: 6589575
DMN: 108163426
DWI: 6641517
DGR: 6561707
DAZ: 108610455
DNV: 115563483
DHE: 111596228
DVI: 6628383
CCAT: 101462378
BOD: 106615299
MDE: 101895886
SCAC: 106082738
LCQ: 111685234
ACOZ: 120955167
AARA: 120900592
AAG: 5563777
AME: 413303
ACER: 107994676
ALAB: 122712978
BIM: 100741439
BBIF: 117215673
BVK: 117238328
BVAN: 117164708
BTER: 100646978
BPYO: 122567051
OBB: 114880994
NMEA: 116425246
CGIG: 122399641
SOC: 105207136
MPHA: 105828561
AEC: 105149416
ACEP: 105627372
PBAR: 105423752
VEM: 105563797
HST: 105190724
DQU: 106742591
CFO: 105257298
FEX: 115238084
PGC: 109851977
OBO: 105280097
PCF: 106789615
PFUC: 122516114
VPS: 122628092
NVI: 100116425
CSOL: 105364449
TPRE: 106653230
MDL: 103570507
CGLO: 123272112
FAS: 105264444
DAM: 107043041
CCIN: 107272921
TCA: 662470
SOY: 115881768
NVL: 108569966
APLN: 108737760
OTU: 111421295
BMOR: 101745869
BMAN: 114249695
MSEX: 115442606
BANY: 112056304
PMAC: 106708843
PPOT: 106100371
PXU: 106123226
PRAP: 110997017
ZCE: 119833434
HAW: 110383235
TNL: 113508407
OFU: 114351194
API: 100159169
DNX: 107173314
AGS: 114131520
RMD: 113551843
BTAB: 109032088
DCI: 103513240
CLEC: 106670705
HHAL: 106688748
FOC: 113203112
DSV: 119450045
DFR: 124500602
SDM: 118199018
CEL: CELE_F59F3.1(ver-3) CELE_T17A3.1(ver-1)
CBR: CBG_17535 CBG_17536(Cbr-ver-3)
BMY: BM_BM5314(Bm5314)
TSP: Tsp_00087
PCAN: 112559656
GAE: 121376104
HRF: 124132649
HRJ: 124274313
CRG: 105348465
MYI: 110447179
PMAX: 117329218
MMER: 123557632
OBI: 106877728
OSN: 115218235
LAK: 106159770
ATEN: 116300809
AMIL: 114973625
DGT: 114529432
HMG: 100209153
 » show all
Reference
  Authors
Habeck H, Odenthal J, Walderich B, Maischein H, Schulte-Merker S
  Title
Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis.
  Journal
Curr Biol 12:1405-12 (2002)
DOI:10.1016/s0960-9822(02)01044-8
  Sequence
[dre:796537]
Reference
  Authors
Wiesmann C, Muller YA, de Vos AM.
  Title
Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.
  Journal
J Mol Med 78:247-60 (2000)
DOI:10.1007/s001090000082
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234
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