| Entry |
|
|---|
| Name |
Vortioxetine hydrobromide (JAN/USAN);
Brintellix (TN);
Trintellix (TN) |
|---|
| Product |
|
|---|
| Formula |
C18H22N2S. HBr
|
|---|
| Exact mass |
378.0765
|
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| Mol weight |
379.3576
|
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| Structure |
|
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| Simcomp |
|
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| Class |
|
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00965): | D10185<JP/US> |
|
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| Efficacy |
Antidepressant, Antianxiety, Serotonin reuptake inhibitor, Serotonin receptor antagonist/agonist |
|---|
| Disease |
Major depressive disorder [DS: H01646] |
|---|
| Comment |
Fluoxetine derivatives, thioether type
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX26 Vortioxetine
D10185 Vortioxetine hydrobromide (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Vortioxetine
D10185 Vortioxetine hydrobromide (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D10185 Vortioxetine hydrobromide (JAN/USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01483 5-HT1A-receptor agonist
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
DG02919 CYP2B6 substrate
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
DG02918 CYP2C8 substrate
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
DG01642 CYP2C9 substrate
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
DG01639 CYP2C19 substrate
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
DG01644 CYP2D6 substrate
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
DG02925 CYP3A5 substrate
DG00965 Vortioxetine
D10185 Vortioxetine hydrobromide
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1A
D10185 Vortioxetine hydrobromide (JAN/USAN) <JP/US>
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D10185 Vortioxetine hydrobromide (JAN/USAN) <JP/US>
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D10185 Vortioxetine hydrobromide (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D10185
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10185
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D10185
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D10185
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10185
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D10185
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01483 5-HT1A-receptor agonist
DG00965 Vortioxetine
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00965 Vortioxetine
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00965 Vortioxetine
DG02919 CYP2B6 substrate
DG00965 Vortioxetine
DG02918 CYP2C8 substrate
DG00965 Vortioxetine
DG01642 CYP2C9 substrate
DG00965 Vortioxetine
DG01639 CYP2C19 substrate
DG00965 Vortioxetine
DG01644 CYP2D6 substrate
DG00965 Vortioxetine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00965 Vortioxetine
DG02925 CYP3A5 substrate
DG00965 Vortioxetine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C8x C 21.8400 -20.0200
2 C8x C 21.8400 -21.4200
3 C8y C 23.0300 -22.1200
4 C8y C 24.2900 -21.4200
5 C8x C 24.2900 -20.0200
6 C8x C 23.0300 -19.3200
7 S2a S 23.0300 -23.5200
8 C8y C 21.8400 -24.2200
9 C8x C 20.5800 -23.5200
10 C8x C 19.3900 -24.2200
11 C8y C 19.3900 -25.6200
12 C8x C 20.5800 -26.3200
13 C8y C 21.8400 -25.6200
14 C1a C 18.2000 -26.3200
15 C1a C 23.0300 -26.3200
16 N1y N 25.4800 -22.1200
17 C1x C 25.4800 -23.5200
18 C1x C 26.6700 -24.2200
19 N1x N 27.9300 -23.5200
20 C1x C 27.9300 -22.1200
21 C1x C 26.6700 -21.4200
22 X Br 28.7000 -26.8100
BOND 23
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 3 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 11 14 1
16 13 15 1
17 4 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 19 20 1
22 20 21 1
23 16 21 1
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