| Entry |
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| Name |
Sitravatinib malate (USAN) |
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| Formula |
C33H29F2N5O4S. C4H6O5
|
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| Exact mass |
763.2124
|
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| Mol weight |
763.76
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| Structure |
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| Simcomp |
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| Class |
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
|
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| Remark |
|
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| Efficacy |
Antineoplastic, Receptor tyrosine kinase inhibitor |
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| Target |
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| Pathway |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EX Other protein kinase inhibitors
L01EX26 Sitravatinib
D11541 Sitravatinib malate (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03045 Sitravatinib
D11541 Sitravatinib malate
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
PDGFR family
PDGFR
D11541 Sitravatinib malate (USAN)
VEGFR family
VEGFR1 (FLT1)
D11541 Sitravatinib malate (USAN)
VEGFR2 (KDR)
D11541 Sitravatinib malate (USAN)
VEGFR3 (FLT4)
D11541 Sitravatinib malate (USAN)
MET family
MET
D11541 Sitravatinib malate (USAN)
EPH family
EPHA1
D11541 Sitravatinib malate (USAN)
EPHA2
D11541 Sitravatinib malate (USAN)
EPHB1
D11541 Sitravatinib malate (USAN)
EPHB2
D11541 Sitravatinib malate (USAN)
EPHB4
D11541 Sitravatinib malate (USAN)
AXL family
AXL
D11541 Sitravatinib malate (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03045 Sitravatinib
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 54
1 C8x C 21.4647 -19.2346
2 C8y C 21.4647 -20.6284
3 C8x C 20.2800 -21.3950
4 C8y C 19.0256 -20.6284
5 C8y C 19.0256 -19.2346
6 C8x C 20.2800 -18.5377
7 O2a O 17.7711 -18.5377
8 C8y C 16.5864 -19.2346
9 C8x C 16.5864 -20.6284
10 C8x C 15.3321 -21.3950
11 N5x N 14.1474 -20.6284
12 C8y C 14.1474 -19.2346
13 C8y C 15.3321 -18.5377
14 N1b N 22.6494 -21.3950
15 C5a C 23.8340 -20.6284
16 C1z C 25.0188 -21.3950
17 O5a O 23.8340 -19.2346
18 C5a C 26.2035 -20.6284
19 C1x C 25.7156 -22.5797
20 C1x C 24.3219 -22.5797
21 N1b N 27.3882 -21.3950
22 O5a O 26.2035 -19.2346
23 C8y C 28.5729 -20.6284
24 C8x C 28.5729 -19.2346
25 C8x C 29.7575 -18.5377
26 C8y C 31.0120 -19.2346
27 C8x C 31.0120 -20.6284
28 C8x C 29.8272 -21.3950
29 X F 32.1270 -18.5377
30 X F 17.7711 -21.3253
31 S2x S 15.0534 -17.2136
32 C8y C 13.6596 -17.0742
33 C8x C 13.1020 -18.3287
34 C8y C 12.9627 -15.8896
35 C8x C 13.6596 -14.7049
36 C8x C 12.9627 -13.5202
37 C8y C 11.5689 -13.5202
38 C8x C 10.8720 -14.7049
39 N5x N 11.5689 -15.8896
40 C1b C 10.8720 -12.3355
41 N1b N 9.4086 -12.3355
42 C1b C 8.7117 -11.0810
43 C1b C 7.2789 -11.0580
44 O2a O 6.5988 -9.8348
45 C1a C 5.1804 -9.8815
46 O6a O 21.5566 -12.9483
47 C6a C 22.7688 -13.6482
48 C1c C 23.9641 -12.9579
49 O6a O 22.7689 -15.0478
50 C1b C 25.1513 -13.6433
51 C6a C 26.3423 -12.9554
52 O6a O 27.5317 -13.6420
53 O6a O 26.3423 -11.5488
54 O1a O 23.9642 -11.5488
BOND 58
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 2 14 1
16 14 15 1
17 15 16 1
18 15 17 2
19 16 18 1
20 19 20 1
21 20 16 1
22 16 19 1
23 18 21 1
24 18 22 2
25 21 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 26 27 1
30 27 28 2
31 23 28 1
32 26 29 1
33 4 30 1
34 13 31 1
35 31 32 1
36 32 33 2
37 12 33 1
38 32 34 1
39 34 35 2
40 35 36 1
41 36 37 2
42 37 38 1
43 38 39 2
44 34 39 1
45 37 40 1
46 40 41 1
47 41 42 1
48 42 43 1
49 43 44 1
50 44 45 1
51 46 47 1
52 47 48 1
53 47 49 2
54 48 50 1
55 50 51 1
56 51 52 1
57 51 53 2
58 48 54 1 #Up
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