心筋梗塞

Myocardial infarction (MI) or acute myocardial infarction (AMI) is a term for an event of heart attack. It is due to formation of plaques in the interior walls of the arteries resulting in reduced blood flow to the heart and injuring heart muscles because of lack of oxygen supply. The symptoms of MI include chest pain, which travels from left arm to neck, shortness of breath, nausea, epigastric discomfort, syncope, diaphoresis, and other factors. The diagnosis of MI is dependent on the sensitivity and specificity of the clinical criteria, electrocardiographic (ECG) findings, imaging studies and biomarkers used to detect death of cardiomyocytes. The treatment of MI includes, aspirin tablets, and to dissolve arterial blockage injection of thrombolytic or clot dissolving drugs such as tissue plasminogen activator, streptokinase or urokinase in blood within 3 h of the onset of a heart attack. Nitroglycerin and antihypertensive drugs such as beta-blockers and ACE inhibitors may also be used to lower blood pressure and to improve the oxygen demand of heart.

循環器疾患

ESR1 [HSA:2099] [KO:K08550]
F13A1 [HSA:2162] [KO:K03917]
F7 [HSA:2155] [KO:K01320]
GCLC [HSA:2729] [KO:K11204]
GCLM [HSA:2730] [KO:K11205]
ITGB3 [HSA:3690] [KO:K06493]
LRP8 [HSA:7804] [KO:K20052]
LTA [HSA:4049] [KO:K05468]
OLR1 [HSA:4973] [KO:K08763]
PSMA6 [HSA:5687] [KO:K02730]
TNFSF4 [HSA:7292] [KO:K05469]

Old age
Tobacco smoking
High blood pressure
High levels of LDL
High cholesterol and fat
Diabetes
Obesity
Chronic kidney disease
Alcohol
Cocaine
Amphetamines

ベラパミル塩酸塩 [DR:D00619]
ニトログリセリン [DR:D00515]
硝酸イソソルビド [DR:D00516]
ノルアドレナリン [DR:D00076]
ヘパリンナトリウム [DR:D02112]
プラスグレル塩酸塩 [DR:D05597]
アスピリン・ランソプラゾール [DR:D10527]

PMID:25638347 (definition, env_factor, drug)

Lu L, Liu M, Sun R, Zheng Y, Zhang P

Myocardial Infarction: Symptoms and Treatments.

Cell Biochem Biophys 72:865-7 (2015)
DOI:10.1007/s12013-015-0553-4

PMID:22922597 (description, marker)

Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD

Third universal definition of myocardial infarction.

Nat Rev Cardiol 9:620-33 (2012)
DOI:10.1038/nrcardio.2012.122

PMID:26426469 (description, drug)

Frangogiannis NG

Pathophysiology of Myocardial Infarction.

Compr Physiol 5:1841-75 (2015)
DOI:10.1002/cphy.c150006

PMID:22061094

Puzianowska-Kuznicka M

ESR1 in myocardial infarction.

Clin Chim Acta 413:81-7 (2012)
DOI:10.1016/j.cca.2011.10.028

PMID:30972713

Ambroziak M, Kurylowicz A, Budaj A

Increased coagulation factor XIII activity but not genetic variants of coagulation factors is associated with myocardial infarction in young patients.

J Thromb Thrombolysis 48:519-527 (2019)
DOI:10.1007/s11239-019-01856-3

PMID:10984565

Girelli D, Russo C, Ferraresi P, Olivieri O, Pinotti M, Friso S, Manzato F, Mazzucco A, Bernardi F, Corrocher R

Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease.

N Engl J Med 343:774-80 (2000)
DOI:10.1056/NEJM200009143431104

PMID:12598062

Koide S, Kugiyama K, Sugiyama S, Nakamura S, Fukushima H, Honda O, Yoshimura M, Ogawa H

Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction.

J Am Coll Cardiol 41:539-45 (2003)
DOI:10.1016/s0735-1097(02)02866-8

PMID:12081989

Nakamura S, Kugiyama K, Sugiyama S, Miyamoto S, Koide S, Fukushima H, Honda O, Yoshimura M, Ogawa H

Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.

Circulation 105:2968-73 (2002)
DOI:10.1161/01.cir.0000019739.66514.1e

PMID:31457051

Sheikhvatan M, Boroumand MA, Behmanesh M, Ziaee S, Cheraghee S

Integrin Beta-3 Gene Polymorphism and Risk for Myocardial Infarction in Premature Coronary Disease.

Iran J Biotechnol 17:e1921 (2019)
DOI:10.21859/ijb.1921

PMID:34122585

Ghorbani MJ, Razmi N, Tabei SMB, Zibaeenezhad MJ, Goodarzi HR

A substitution mutation in LRP8 gene is significantly associated with susceptibility to familial myocardial infarction.

ARYA Atheroscler 16:301-305 (2020)
DOI:10.22122/arya.v16i6.1797

PMID:12426569

Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, Sato H, Sato H, Hori M, Nakamura Y, Tanaka T

Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction.

Nat Genet 32:650-4 (2002)
DOI:10.1038/ng1047

PMID:12646194

Tatsuguchi M, Furutani M, Hinagata J, Tanaka T, Furutani Y, Imamura S, Kawana M, Masaki T, Kasanuki H, Sawamura T, Matsuoka R

Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction.

Biochem Biophys Res Commun 303:247-50 (2003)
DOI:10.1016/s0006-291x(03)00326-7

PMID:16845397

Ozaki K, Sato H, Iida A, Mizuno H, Nakamura T, Miyamoto Y, Takahashi A, Tsunoda T, Ikegawa S, Kamatani N, Hori M, Nakamura Y, Tanaka T

A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population.

Nat Genet 38:921-5 (2006)
DOI:10.1038/ng1846

PMID:15750594

Wang X, Ria M, Kelmenson PM, Eriksson P, Higgins DC, Samnegard A, Petros C, Rollins J, Bennet AM, Wiman B, de Faire U, Wennberg C, Olsson PG, Ishii N, Sugamura K, Hamsten A, Forsman-Semb K, Lagercrantz J, Paigen B

Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.

Nat Genet 37:365-72 (2005)
DOI:10.1038/ng1524