KEGG   DISEASE: 心筋梗塞
エントリ  
H01730                                                             

名称    
心筋梗塞
概要    
Myocardial infarction (MI) or acute myocardial infarction (AMI) is a term for an event of heart attack. It is due to formation of plaques in the interior walls of the arteries resulting in reduced blood flow to the heart and injuring heart muscles because of lack of oxygen supply. The symptoms of MI include chest pain, which travels from left arm to neck, shortness of breath, nausea, epigastric discomfort, syncope, diaphoresis, and other factors. The diagnosis of MI is dependent on the sensitivity and specificity of the clinical criteria, electrocardiographic (ECG) findings, imaging studies and biomarkers used to detect death of cardiomyocytes. The treatment of MI includes, aspirin tablets, and to dissolve arterial blockage injection of thrombolytic or clot dissolving drugs such as tissue plasminogen activator, streptokinase or urokinase in blood within 3 h of the onset of a heart attack. Nitroglycerin and antihypertensive drugs such as beta-blockers and ACE inhibitors may also be used to lower blood pressure and to improve the oxygen demand of heart.
カテゴリ  
循環器疾患
階層分類  
ヒト疾患 [BR:jp08402]
 循環器系疾患
  心疾患
   H01730  心筋梗塞
ICD-11 による疾患分類 [BR:jp08403]
 11 循環器系の疾患
  虚血性心疾患
   急性虚血性心疾患
    BA41  急性心筋梗塞
     H01730  心筋梗塞
病因遺伝子 
ESR1 [HSA:2099] [KO:K08550]
F13A1 [HSA:2162] [KO:K03917]
F7 [HSA:2155] [KO:K01320]
GCLC [HSA:2729] [KO:K11204]
GCLM [HSA:2730] [KO:K11205]
ITGB3 [HSA:3690] [KO:K06493]
LRP8 [HSA:7804] [KO:K20052]
LTA [HSA:4049] [KO:K05468]
OLR1 [HSA:4973] [KO:K08763]
PSMA6 [HSA:5687] [KO:K02730]
TNFSF4 [HSA:7292] [KO:K05469]
環境要因  
Old age
Tobacco smoking
High blood pressure
High levels of LDL
High cholesterol and fat
Diabetes
Obesity
Chronic kidney disease
Alcohol
Cocaine
Amphetamines
治療薬   
ベラパミル塩酸塩 [DR:D00619]
ニトログリセリン [DR:D00515]
硝酸イソソルビド [DR:D00516]
ノルアドレナリン [DR:D00076]
ヘパリンナトリウム [DR:D02112]
プラスグレル塩酸塩 [DR:D05597]
アスピリン・ランソプラゾール [DR:D10527]
リンク   
ICD-11: BA41
ICD-10: I21
MeSH: D009203
OMIM: 608446
文献    
PMID:25638347 (definition, env_factor, drug)
  著者
Lu L, Liu M, Sun R, Zheng Y, Zhang P
  タイトル
Myocardial Infarction: Symptoms and Treatments.
  雑誌
Cell Biochem Biophys 72:865-7 (2015)
DOI:10.1007/s12013-015-0553-4
文献    
PMID:22922597 (description, marker)
  著者
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD
  タイトル
Third universal definition of myocardial infarction.
  雑誌
Nat Rev Cardiol 9:620-33 (2012)
DOI:10.1038/nrcardio.2012.122
文献    
PMID:26426469 (description, drug)
  著者
Frangogiannis NG
  タイトル
Pathophysiology of Myocardial Infarction.
  雑誌
Compr Physiol 5:1841-75 (2015)
DOI:10.1002/cphy.c150006
文献    
  著者
Puzianowska-Kuznicka M
  タイトル
ESR1 in myocardial infarction.
  雑誌
Clin Chim Acta 413:81-7 (2012)
DOI:10.1016/j.cca.2011.10.028
文献    
  著者
Ambroziak M, Kurylowicz A, Budaj A
  タイトル
Increased coagulation factor XIII activity but not genetic variants of coagulation factors is associated with myocardial infarction in young patients.
  雑誌
J Thromb Thrombolysis 48:519-527 (2019)
DOI:10.1007/s11239-019-01856-3
文献    
  著者
Girelli D, Russo C, Ferraresi P, Olivieri O, Pinotti M, Friso S, Manzato F, Mazzucco A, Bernardi F, Corrocher R
  タイトル
Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease.
  雑誌
N Engl J Med 343:774-80 (2000)
DOI:10.1056/NEJM200009143431104
文献    
  著者
Koide S, Kugiyama K, Sugiyama S, Nakamura S, Fukushima H, Honda O, Yoshimura M, Ogawa H
  タイトル
Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction.
  雑誌
J Am Coll Cardiol 41:539-45 (2003)
DOI:10.1016/s0735-1097(02)02866-8
文献    
  著者
Nakamura S, Kugiyama K, Sugiyama S, Miyamoto S, Koide S, Fukushima H, Honda O, Yoshimura M, Ogawa H
  タイトル
Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.
  雑誌
Circulation 105:2968-73 (2002)
DOI:10.1161/01.cir.0000019739.66514.1e
文献    
  著者
Sheikhvatan M, Boroumand MA, Behmanesh M, Ziaee S, Cheraghee S
  タイトル
Integrin Beta-3 Gene Polymorphism and Risk for Myocardial Infarction in Premature Coronary Disease.
  雑誌
Iran J Biotechnol 17:e1921 (2019)
DOI:10.21859/ijb.1921
文献    
  著者
Ghorbani MJ, Razmi N, Tabei SMB, Zibaeenezhad MJ, Goodarzi HR
  タイトル
A substitution mutation in LRP8 gene is significantly associated with susceptibility to familial myocardial infarction.
  雑誌
ARYA Atheroscler 16:301-305 (2020)
DOI:10.22122/arya.v16i6.1797
文献    
  著者
Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, Sato H, Sato H, Hori M, Nakamura Y, Tanaka T
  タイトル
Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction.
  雑誌
Nat Genet 32:650-4 (2002)
DOI:10.1038/ng1047
文献    
  著者
Tatsuguchi M, Furutani M, Hinagata J, Tanaka T, Furutani Y, Imamura S, Kawana M, Masaki T, Kasanuki H, Sawamura T, Matsuoka R
  タイトル
Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction.
  雑誌
Biochem Biophys Res Commun 303:247-50 (2003)
DOI:10.1016/s0006-291x(03)00326-7
文献    
  著者
Ozaki K, Sato H, Iida A, Mizuno H, Nakamura T, Miyamoto Y, Takahashi A, Tsunoda T, Ikegawa S, Kamatani N, Hori M, Nakamura Y, Tanaka T
  タイトル
A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population.
  雑誌
Nat Genet 38:921-5 (2006)
DOI:10.1038/ng1846
文献    
  著者
Wang X, Ria M, Kelmenson PM, Eriksson P, Higgins DC, Samnegard A, Petros C, Rollins J, Bennet AM, Wiman B, de Faire U, Wennberg C, Olsson PG, Ishii N, Sugamura K, Hamsten A, Forsman-Semb K, Lagercrantz J, Paigen B
  タイトル
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.
  雑誌
Nat Genet 37:365-72 (2005)
DOI:10.1038/ng1524
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