KEGG ORTHOLOGY: K02367

ORTHOLOGY: K02367

Entry

K02367                      KO

Symbol

EXT2

Name

glucuronyl/N-acetylglucosaminyl transferase EXT2 [EC:2.4.1.224 2.4.1.225]

Pathway

map00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

map01100

Metabolic pathways

Module

M00059

Glycosaminoglycan biosynthesis, heparan sulfate backbone

Reaction

R05935

R10138

R10139

Disease

H00122

Multiple exostoses

H00493

Heparan sulfate proteoglycan gene defects

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.224  glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
     K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
    2.4.1.225  N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
     K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
Glycosyltransferases [BR:ko01003]
Glycan extension
  O-Glycan
   K02367  EXT2; glucuronyl/N-acetylglucosaminyl transferase EXT2
Glycosyltransferase reactions [br08203.html]
N-Acetylglucosaminyltransferase reactions
  K02367
Glucuronyltransferase reactions
  K02367

Other DBs

GO:	0050508 0050509

CAZy:

GT47 GT64

Genes

HSA:	2132(EXT2)

PTR:	451140(EXT2)

PPS:	100975712(EXT2)

GGO:	101130563(EXT2)

PON:	100436160(EXT2)

PPYG:

129007272(EXT2)

NLE:	100604250(EXT2)

HMH:	116476325(EXT2)

SSYN:

129484203(EXT2)

MCC:	715975(EXT2)

MCF:	102136104(EXT2)

MTHB:

126936267

MNI:	105471617(EXT2)

CSAB:

103236980

CATY:

105586840(EXT2)

PANU:

101019229(EXT2)

TGE:	112606187(EXT2)

MLEU:

105554777(EXT2)

RRO:	104673882(EXT2)

RBB:	108519255(EXT2)

TFN:	117081393(EXT2)

PTEH:

111544934(EXT2)

CANG:

105527086(EXT2)

CJC:	100400679(EXT2)

SBQ:	101039408(EXT2)

CIMI:

108304907(EXT2)

ANAN:

105717305

CSYR:

103260803 103264178 103272774

MMUR:

105885490(EXT2)

LCAT:

123642622(EXT2)

PCOQ:

105819145(EXT2)

OGA:	100949922(EXT2)

MMU:	14043(Ext2)

MCAL:

110311448(Ext2)

MPAH:

110317782(Ext2)

RNO:	311215(Ext2)

MCOC:

116090518(Ext2)

ANU:	117703415(Ext2)

ASYL:

127685648(Ext2)

MUN:	110540376(Ext2)

CGE:	100751585(Ext2)

MAUA:

101842118(Ext2)

PROB:

127222213(Ext2)

PLEU:

114699729(Ext2)

MORG:

121440558(Ext2)

MFOT:

126504517

AAMP:

119814179(Ext2)

NGI:	103751554(Ext2)

HGL:	101715817(Ext2)

CPOC:

100712625(Ext2)

CCAN:

109686418

DORD:

105996073(Ext2)

DSP:	122100734(Ext2)

PLOP:

125362321(Ext2)

NCAR:

124960112

MMMA:

107135778(Ext2)

ITI:	101964761(Ext2)

OCU:

100343697

OPI:	101536088(EXT2)

TUP:	102487057(EXT2)

GVR:	103596582(EXT2)

CFA:	475989(EXT2)

CLUD:

112663258(EXT2)

VVP:	112924118(EXT2)

VLG:	121501521(EXT2)

NPO:	129501308(EXT2)

AML:	105242037(EXT2)

UMR:	103672344(EXT2)

UAH:

113265012

UAR:	123799595(EXT2)

ELK:

111150031

LLV:

125078631

MPUF:

101672930(EXT2)

MNP:	132008192 132008356

MLK:	131811678(EXT2)

NVS:	122912861(EXT2)

ORO:	101366478(EXT2)

EJU:	114215287(EXT2)

ZCA:	113914556(EXT2)

MLX:	118015783(EXT2)

NSU:	110576283(EXT2)

LWW:	102744900(EXT2)

FCA:	101083620(EXT2)

PYU:	121043515(EXT2)

PCOO:

112865217(EXT2)

PBG:	122483728(EXT2)

PVIV:

125176532(EXT2)

LRUF:

124504734

LGF:	123601619(EXT2)

AJU:

106978049

PTG:	102964333(EXT2)

PPAD:

109279210 109279211(EXT2)

PUC:

125928865

PLEZ:

122201128(EXT2)

HHV:	120228461(EXT2)

BTA:	281151(EXT2)

BOM:	102275740(EXT2)

BIU:	109569634(EXT2)

BBUB:

102389161(EXT2)

BBIS:

104982778(EXT2)

CHX:	102182243(EXT2)

OAS:	101110867(EXT2)

BTAX:

128060107(EXT2)

CSUM:

138092456(EXT2)

ODA:	120876908(EXT2)

CCAD:

122449196(EXT2)

MREE:

136174348(EXT2)

OVR:	110143371(EXT2)

MBEZ:

129554774(EXT2)

SSC:	100522362(EXT2)

CFR:	102514905(EXT2)

CBAI:

105076487(EXT2)

CDK:	105106838(EXT2)

VPC:	102542570(EXT2)

BACU:

102999728(EXT2)

BMUS:

118899308(EXT2)

LVE:	103091009(EXT2)

OOR:	101280958(EXT2)

LALB:

132525841(EXT2)

DLE:	111184011(EXT2)

PCAD:

102979294

PSIU:

116758175(EXT2)

PPHC:

136126635(EXT2)

NASI:

112402430(EXT2)

ECB:	100055879(EXT2)

EPZ:	103556459(EXT2)

EAI:	106843971(EXT2)

MYB:	102238781(EXT2)

MYD:	102767712(EXT2)

MMYO:

118665109(EXT2)

MLF:	102422014(EXT2)

MDT:	132241238(EXT2)

MYUM:

139018886(EXT2)

PKL:

118712503

EFUS:

103290862(EXT2)

MNA:	107525491(EXT2)

DRO:	112303473(EXT2)

SHON:

119002984(EXT2)

AJM:	119064418(EXT2)

PDIC:

114499874(EXT2)

PHAS:

123810129(EXT2)

MMF:	118627865(EXT2)

PPAM:

129081459(EXT2)

HAI:	109391972(EXT2)

RFQ:	117029882(EXT2)

PALE:

102890634(EXT2)

PGIG:

120606317

PVP:	105290068(EXT2)

RAY:	107511887(EXT2)

MJV:	108394755(EXT2)

TOD:	119255341(EXT2)

SARA:

101551336(EXT2)

SFUM:

130039404(EXT2)

SETR:

126017607(EXT2)

LAV:	100656016(EXT2)

TMU:

101361975

ETF:	101662457(EXT2)

DNM:	101436915(EXT2)

MDO:	100010947(EXT2)

GAS:	123252570 123252571

SHR:	105750949(EXT2)

AFZ:

127541352

PCW:	110223945(EXT2)

TVP:	118854074(EXT2)

PBRV:

138163852(EXT2)

OAA:	100079286(EXT2)

TACU:

119943353(EXT2)

GGA:	425859(EXT2)

PCOC:

116229130(EXT2)

MGP:

100545109

CJO:	107314816(EXT2)

TPAI:

128085844(EXT2)

LMUT:

125694790(EXT2)

NMEL:

110401311(EXT2)

APLA:

101790687(EXT2)

ACYG:

106044125(EXT2)

CATA:

118250771(EXT2)

AFUL:

116489660(EXT2)

TGU:	100231605(EXT2)

LSR:	110472037(EXT2)

SCAN:

103826716(EXT2)

PMOA:

120512558(EXT2)

OTC:	121333361(EXT2)

PRUF:

121349516(EXT2)

ATRC:

139590224(EXT2)

GFR:	102040196(EXT2)

FAB:	101814666(EXT2)

OMA:	130253844(EXT2)

PHI:	102107359(EXT2)

PMAJ:

107205846(EXT2)

CCAE:

111930141(EXT2)

CCW:	104695274(EXT2)

CBRC:

103620718(EXT2)

ACOE:

138111423(EXT2)

ETL:	114064860(EXT2)

ZAB:	102062154(EXT2)

ZLE:	135448536(EXT2)

SVG:	106851532(EXT2)

MMEA:

130572519(EXT2)

HRT:	120753978(EXT2)

SATI:

136362492(EXT2)

CCIC:

134045040(EXT2)

FPG:	101923547(EXT2)

FCH:	102054426(EXT2)

CCRI:

104157610(EXT2)

NNT:	104409474(EXT2)

SHAB:

115606439(EXT2)

ACUN:

113480641(EXT2)

TALA:

104367927(EXT2)

ACHC:

115333408(EXT2)

HLE:	104839720(EXT2)

AGEN:

126049243

HHAR:

128139481(EXT2)

GCL:

127017427

CSTI:

104550813(EXT2)

LDI:	104342773(EXT2)

DPUB:

104297453(EXT2)

PPUS:

135180185(EXT2)

AVIT:

104275926(EXT2)

BRHI:

104494174(EXT2)

EGZ:	104134053(EXT2)

NNI:	104019563(EXT2)

PCRI:

104037223(EXT2)

PCAO:

104039550(EXT2)

PADL:

103921685(EXT2)

AFOR:

103897455(EXT2)

FGA:	104079754(EXT2)

GSTE:

104250591(EXT2)

CBOY:

140652706(EXT2)

CLV:	102085197(EXT2)

CNIC:

135989572(EXT2)

MUI:	104538279(EXT2)

PLET:

104619405(EXT2)

EHS:	104506250(EXT2)

CMAC:

104482061

CUCA:

104067268(EXT2)

TEO:	104374413(EXT2)

BREG:

104639655

OHA:	104330168(EXT2)

CPEA:

104390387(EXT2)

CVF:	104295831(EXT2)

RTD:	128908421(EXT2)

CRID:

134514692(EXT2)

AAM:	106498294(EXT2)

AROW:

112978433(EXT2)

NPD:	112943491(EXT2)

TGT:	104565017(EXT2)

DNE:	112979229(EXT2)

SCAM:

104149258(EXT2)

ASN:	102379048(EXT2)

AMJ:	102562202(EXT2)

CPOO:

109321140(EXT2)

GGN:	109298936(EXT2)

PSS:	102446763(EXT2)

CMY:	102938478(EXT2)

CCAY:

125638325(EXT2)

DCC:	119857262(EXT2)

CPIC:

101949276(EXT2)

TST:	117876973(EXT2)

CABI:

116830766(EXT2)

MRV:	120404543(EXT2)

ACS:	100555771(ext2)

ASAO:

132768475(EXT2)

PVT:	110081549(EXT2)

SUND:

121933481(EXT2)

PBI:	103062807(EXT2)

PMUR:

107302595(EXT2)

CTIG:

120307969(EXT2)

TSR:	106545012(EXT2)

PGUT:

117665492(EXT2)

PCAE:

139311547(EXT2)

APRI:

131187435(EXT2)

PTEX:

113440794(EXT2)

NSS:	113410220(EXT2)

VKO:	123026241(EXT2)

PMUA:

114596253(EXT2)

PRAF:

128413518(EXT2)

ZVI:	118085381(EXT2)

HCG:	128334415(EXT2)

GJA:	107122615(EXT2)

STOW:

125426333(EXT2)

EMC:	129324507(EXT2)

XLA:	380140(ext2.L) 398750(ext2.S)

XTR:	100151709(ext2)

NPR:	108786158(EXT2)

RTEM:

120917049(EXT2)

ACAT:

141111936(EXT2)

BBUF:

120980295(EXT2)

BGAR:

122920720(EXT2)

DTC:	141092424(EXT2)

PWL:	138283745(EXT2)

MUO:	115468808(EXT2)

GSH:	117352242(EXT2)

DRE:	493780(ext2)

SRX:	107750554 107754691

SANH:

107671371 107683605 107688159(ext2)

SGH:	107586005 107593432

CCAR:

109072430 109074535(ext2)

CAUA:

113052033 113105758

CGIB:

127962006 128017046

PTET:

122349070(ext2)

LROH:

127168414(ext2)

GRF:	141332070(ext2)

OMC:	131544219(ext2)

PPRM:

120468007(ext2)

RKG:	130102576(ext2)

MAMB:

125264629(ext2)

CIDE:

127515571

CERY:

137029879(ext2)

MASI:

127454839

TROS:

130556169(ext2)

TDW:	130425151(ext2)

MANU:

129441614(ext2)

PDAB:

135730873(ext2)

IPU:

108271344

IFU:	128613387(ext2)

PHYP:

113536365(ext2)

SMEO:

124390802(ext2)

TFD:	113663258(ext2)

TVC:	132845376(ext2)

CGAR:

128543008(ext2)

NGRA:

132899122(ext2)

TRN:	134331470(ext2)

AMEX:

103046596(ext2)

CMAO:

118818835(ext2)

EEE:	113575759(ext2)

CHAR:

105907228(ext2)

SPIL:

134068817(ext2)

TRU:	101066048(ext2)

TFS:	130521281(ext2)

TNG:	GSTEN00017827G001

LCO:	104919199(ext2)

NCC:	104963025(ext2)

TBEN:

117471545(ext2)

CGOB:

115006327(ext2)

PGEO:

117467212(ext2)

GACU:

117547083(ext2)

EMAC:

134863486(ext2)

ELY:	117258719(ext2)

EFO:	125881736(ext2)

PLEP:

121960250(ext2)

SLUC:

116034014(ext2)

ECRA:

117943850(ext2)

ESP:	116688651(ext2)

PFLV:

114553112(ext2)

GAT:	120808600(ext2)

PPUG:

119229335(ext2)

AFB:	129101386(ext2)

CLUM:

117725979(ext2)

PSWI:

130192468(ext2)

CANA:

137803781(ext2)

CVE:	137887787(ext2)

MSAM:

119890106(ext2)

SCHU:

122875957(ext2)

CUD:	121513674(ext2)

SPUL:

138585160(ext2)

LMIX:

132973701(ext2)

ALAT:

119017615(ext2)

ASTR:

137592938(ext2)

MZE:	101473582(ext2)

ONL:	100695641(ext2)

OAU:	116327190(ext2)

OLA:	101163398(ext2)

OML:	112160904(ext2)

CSAI:

133461580(ext2)

XMA:	102234444(ext2)

XCO:	114142777(ext2)

XHE:	116718349(ext2)

PRET:

103462432(ext2)

PFOR:

103139431(ext2)

PLAI:

106958190(ext2)

PMEI:

106926106(ext2)

GAF:	122821865(ext2)

PPRL:

129357919 129369640(ext2)

CVG:	107085591(ext2)

CTUL:

119782724(ext2)

GMU:	124866743(ext2)

NFU:	107381443(ext2)

KMR:	108228674(ext2)

ALIM:

106530767(ext2)

NWH:	119427822(ext2)

AOCE:

111574611(ext2)

EJA:	138213084(ext2)

BFRE:

138620427(ext2)

MCEP:

125005111(ext2)

CSEM:

103378751(ext2)

POV:	109636768(ext2)

SSEN:

122772353(ext2)

SSOE:

131459935(ext2)

HHIP:

117758296(ext2)

HSP:	118109144(ext2)

PPLT:

128440274(ext2)

SMAU:

118302515(ext2)

LCF:

108889668

SDU:	111238419(ext2)

SLAL:

111654812(ext2)

XGL:	120794269(ext2)

HCQ:	109514394(ext2)

SSCV:

125967040(ext2)

SBIA:

133498500(ext2)

PEE:	133399176(ext2)

PTAO:

133470770(ext2)

BPEC:

110172856(ext2)

ENY:	140380875(ext2)

MALB:

109965798(ext2)

BSPL:

114852235(ext2)

SJO:	128357971(ext2)

SSCO:

133984017(ext2)

GMH:	115558722(ext2)

SASA:

100380322(ext2)

STRU:

115167097(ext2)

OTW:	112247034 112264222

OMY:	110506669 110526537

OGO:	124033638 124035622

ONE:	115112435(ext2)

OKI:	109881440 109888434

OKE:	118360328 118394191

OMM:	135550395 135557936

OCLA:

SALP:

SNH:

CCLU:

ELS:	105022258(ext2)

OEP:	134028538(ext2)

SFM:	108934682(ext2)

PKI:	111840708(ext2)

AANG:

118215430(ext2)

AROT:

135241673(ext2)

CCOG:

133111858(ext2)

LOC:	102689027(ext2)

PSPA:

121294359 121329636

ARUT:

117432282 117435140

PSEX:

120517016(ext2)

LCM:	102363354(EXT2)

CMK:	103174976(ext2)

CPLA:

122558076(ext2)

HOC:	132824498(ext2)

LERI:

129705551(ext2)

HAKA:

140729660(ext2)

PMRN:

116945549(EXT2)

LRJ:	133351349(EXT2)

BFO:

BBEL:

CIN:

SCLV:

SPU:	100893938 115918716

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:	100372539 102809744

PFLL:

139116267

DME:	Dmel_CG8433(sotv)

DER:

6548926

DSE:

6609382

DSI:	Dsimw501_GD25567(Dsim_GD25567)

DYA:	Dyak_GE14097

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI20737

DAZ:

108615183

DNV:

108652943

DHE:

111600127

DVI:	6627192(sotv)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135960464(sotv)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ012734

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139107146(Sotv)

TLN:	139810702(Sotv)

HST:

DQU:

CFO:

FEX:

PMEC:

138936147(Sotv)

LHU:	105673709(sotv)

PGC:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124217576(sotv)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138134409(sotv)

DPA:

109539467

ESIM:

136410316(sotv)

EFOR:

136345830(sotv)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_214517

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137933708(sotv)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106678975(sotv)

NLU:

111056777

HVI:	124360669 124373510

MQU:

128991922

PHU:	Phum_PHUM488440

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138703622(sotv)

SGRE:

126297625

BROR:

134538741

IEL:

124157943

HAMR:

139691358(sotv)

FCD:

110859221

DPX:	DAPPUDRAFT_307216

DMK:

116934955

DPZ:	124328499 124340498

AFRA:

136029889

PVM:	113824640(sotv)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123758376(sotv)

PTRU:

123501664

ESN:

126984445

MNZ:

135223631

MRJ:	136842590(sotv)

PORN:

139746603(sotv)

HAZT:

108677950

EAF:

111696021

LSM:	121117496(sotv)

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136972765(sotv)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

NAI:	NECAME_04728

BMY:	BM_BM10349(Bma-rib-2)

LOA:	LOAG_05822

HRO:	HELRODRAFT_186788

LGI:	LOTGIDRAFT_124977

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:	124276925 124282773

HASI:

HCRA:

CRG:

CANU:

CVN:	111104029 111104189

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106155252 106181741

SMM:	Smp_146320.1

SHX:	MS3_00006818(EXT2_1)

OVI:	T265_05932

LLON:

NVE:

EPA:

ATEN:

ADF:	107336652 107358713

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_24279

AQU:

100636774

FPU:	FPSE_06328

FVR:	FVEG_11257

FOX:	FOXG_13828

NHE:	NECHADRAFT_84083

PTI:	PHATRDRAFT_11259

FCY:	FRACYDRAFT_160829

TPS:	THAPSDRAFT_263396

» show all

Reference

PMID:9756849

Authors

Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K

Title

The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate.

Journal

J Biol Chem 273:26265-8 (1998)
DOI:10.1074/jbc.273.41.26265

Sequence

[bta:281151]

LinkDB

DBGET integrated database retrieval system