KEGG   ORTHOLOGY: K03146
Entry
K03146                      KO                                     
Symbol
THI4, THI1
Name
cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
Pathway
map00730  Thiamine metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
Reaction
R10685  NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    K03146  THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.60  cysteine-dependent adenosine diphosphate thiazole synthase
     K03146  THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase
Other DBs
COG: COG1635
Genes
ATH: AT5G54770(THI1)
ALY: 9300430
CRB: 17876896
CSAT: 104726000 104731059 104763460
EUS: EUTSA_v10013978mg
BRP: 103844930 103851941 103857026
BNA: 106346007 106347311 106366413 106371241 106402237 106420919 125601255
BOE: 106318832 106327201 106335239
RSZ: 108836615 108837050 108844151 130501203
THJ: 104817652
CPAP: 110810965
CIT: 102626594(thi) 102629135
CIC: CICLE_v10008765mg CICLE_v10015727mg CICLE_v10024231mg
PVY: 116123427
MINC: 123202328 123225908
TCC: 18593644 18597097
GRA: 105769824 105773933 105780320
GHI: 107901923 107917921 107928645 107958248 107961959 121217764
GAB: 108453783 108482152 108486471
HSYR: 120126604 120147008 120160341 120179475 120189402 120197833 120209583
DZI: 111280819 111301627 111318798
EGR: 104450213
GMX: 100775614 100788953 100794288 547461(SC-04) 547462(SC-03)
GSJ: 114372051 114380540 114403613 114404912 114417056
PVU: PHAVU_007G052900g PHAVU_011G139100g
VRA: 106754377 106755182
VAR: 108325373 108339541
VUN: 114168645 114192234
VUM: 124843922 124843926
CCAJ: 109795024 109808173
APRC: 113872364
MTR: 11446281 25485243
TPRA: 123882686
CAM: 101491901 101507074 101511321 101512227
PSAT: 127097128
VVO: 131607286 131643448
LJA: 130718164 130743625
ADU: 107477997 107488645
AIP: 107630145 107643278
AHF: 112737808 112749911 112789941 112801227
LANG: 109331169 109332649 109348532 109351883
PCIN: 129286736 129298471 129298852 129315109
QSA: O6P43_011880 O6P43_028946 O6P43_031212
FVE: 101298688 101299651
RCN: 112168087 112201505 112201899
PPER: 18780719
PMUM: 103342510
PDUL: 117623858
MDM: 103429668 103448581
MSYL: 126589528 126615015
PXB: 103948770 103967326
ZJU: 107407137 107420469
MNT: 21395127
CSAV: 115717421
CSV: 101211553
CMO: 103501605
BHJ: 120091480
CMAX: 111483293 111487533
CMOS: 111438464 111448035
CPEP: 111783834 111785935 111788519
RCU: 8280736
MEAN: 126670687
JCU: 105632894
HBR: 110647144
MESC: 110601845 110611614
POP: 7470933 7479083 7485534
PEU: 105108187 105130169 105134848
PALZ: 118035853 118047445 118059587
JRE: 108983682 108993518 109022013
CILL: 122277821 122282819 122289841
CAVE: 132170520 132173535 132176015
QSU: 111989411 112016278
QLO: 115956034 115956545 115972735 115988494
TWL: 119988758 119988861
VVI: 100260728(THI1-1) 100265774(THI1-2)
VRI: 117909200 117923467
SLY: 101257192
SPEN: 107025837
SOT: 102598996
SSTN: 125856795
SDUL: 129892560
CANN: 107856341
LBB: 132620419
NTA: 107797059(ThiI) 107798781
NSY: 104224143
NTO: 104087540
NAU: 109232136
INI: 109167290 109187908
ITR: 116005701 116028414
SIND: 105167970 105175375
OEU: 111383503 111389379
EGT: 105948772 105962248
SSPL: 121740783 121742722 121743409 121757713 121775363 121800880
SMIL: 130985758
SHIS: 125188752 125202496
APAN: 127247867 127249630
HAN: 110890327 110912864
ECAD: 122591292 122611091
LSV: 111877285 111914386
CCAV: 112507403 112514948
DCR: 108199579 108204812 108211831
CSIN: 114275070 114297269
RVL: 131322345 131330436
AEW: 130751513 130751909 130754280 130789884
BVG: 104887771 104887775
SOE: 110795721
CQI: 110721030 110723750
ATRI: 130818300
MOF: 131145521
NNU: 104604883
MING: 122078253 122091022
TSS: 122640918
PSOM: 113279575 113284440 113287867 113288375
OSA: 4343443
OBR: 102709384
OGL: 127779938
BDI: 100841709
ATS: 109771029
TDC: 119281869 119330895 119338169
TAES: 123066078 123148177 123160697 123169109
TUA: 125525971
LPER: 127313554 127333271
LRD: 124669313 124679092 124689497 124695681
SBI: 8063504 8078187
ZMA: 542714 542715
SITA: 101752840 101774400
SVS: 117842602 117853273
PVIR: 120671321 120704075
PHAI: 112889419
PDA: 103716822 103721429 120107672
EGU: 105046898 105051965
MUS: 103975582 103991030
ZOF: 121967276 122021558 122025718 122052496
DCT: 110108175
PEQ: 110031149
AOF: 109827745 109834756
MSIN: 131221413 131239167
NCOL: 116249223
ATR: 18435056
SMO: SELMODRAFT_163429 SELMODRAFT_271002
PPP: 112273035 112273481 112275550 112276032 112276579
CRE: CHLRE_04g214150v5
VCN: VOLCADRAFT_74899 VOLCADRAFT_74900
MNG: MNEG_15292 MNEG_7985
CSL: COCSUDRAFT_14398
CVR: CHLNCDRAFT_22703
APRO: F751_1708
SCE: YGR144W(THI4)
SEUB: DI49_2107
SPAO: SPAR_G03600
AGO: AGOS_AAL137W
ERC: Ecym_6012
KLA: KLLA0_A00198g
KMX: KLMA_40625(THI4)
LTH: KLTH0B03916g
VPO: Kpol_1050p31
ZRO: ZYRO0G11726g
CGR: 2891165(GVI51_M01067)
NCS: NCAS_0D01750(NCAS0D01750)
NDI: NDAI_0C02860(NDAI0C02860)
TPF: TPHA_0A04790(TPHA0A04790)
TBL: TBLA_0B09390(TBLA0B09390) TBLA_0H00760(TBLA0H00760)
TGB: HG536_0A04825 HG536_0F00230
TDL: TDEL_0H00200(TDEL0H00200)
KNG: KNAG_0E03150(KNAG0E03150)
ZMK: HG535_0B00510
PPA: PAS_chr3_0648
DHA: DEHA2F16654g
PIC: PICST_50942
PGU: PGUG_04211
SPAA: SPAPADRAFT_51398
LEL: PVL30_003709(THI4)
CAL: CAALFM_C305130CA(THI4)
CTP: CTRG_02525
COT: CORT_0C04770
CDU: CD36_85100
YLI: 2905790(YALI2_A00151g)
CLU: CLUG_04547
CLUS: A9F13_11g02431
CAUR: CJI96_0001634
SLB: AWJ20_4223(THI4)
PKZ: C5L36_0C00170
BNN: FOA43_001955(STI35)
BBRX: BRETT_001261(THI4)
OPA: HPODL_03615
SLUD: SCDLUD_003155
NCR: NCU06110
NTE: NEUTE1DRAFT95662(NEUTE1DRAFT_95662)
SMP: SMAC_06409
PAN: PODANSg1687
PBEL: QC761_508470(THI4)
PPSD: QC762_508470(THI4)
PPSP: QC763_508470(THI4)
PPSA: QC764_508470(THI4)
TTT: THITE_2117402
MTM: MYCTH_2315910
CTHR: CTHT_0017160
MGR: MGG_03098
PPEI: PpBr36_09505
PGRI: PgNI_10244
TMN: UCRPA7_2510
SSCK: SPSK_07738
FGR: FGSG_02469
FPU: FPSE_01936
FPOA: FPOAC1_002586(STI35)
FVN: FVRRES_02879
FVR: FVEG_09077
FOX: FOXG_10428
NHE: NECHADRAFT_61890
FFC: NCS54_00810500
FKR: NCS57_00853700
FMU: J7337_005314(STI35)
TRE: TRIREDRAFT_68608(thi4)
TRR: M419DRAFT_89757
TATV: 25781467(TrAtP1_003045)
MAW: 19245497(THI4_1)
MAJ: MAA_05549
MBRN: 26238893(sti35)
PCHM: VFPPC_03188
CMT: CCM_01639
AMUS: LMH87_003448
PLJ: 28891457(PLICBS_010469)
PTKZ: JDV02_002359(THI4)
VAL: VDBG_03908
VDA: VDAG_01137
CFJ: CFIO01_04759
CLUP: CLUP02_16278
CHIG: CH63R_12560
SAPO: SAPIO_CDS2560
ELA: UCREL1_6105
PFY: PFICI_09188
SSL: SS1G_09727
BFU: BCIN_07g06010(Bcthi4)
MBE: MBM_01288
PSCO: LY89DRAFT_683526
GLZ: GLAREA_02091
ANI: ANIA_03928(thiF)
AFM: AFUA_6G08360
ACT: ACLA_082310
NFI: NFIA_054010
AOR: AO090003000090
ANG: An11g01630
AFV: AFLA_001605
ALUC: AKAW2_80142S(THI4)
ACHE: ACHE_80625S(THI4)
APUU: APUU_40431S(THI4)
PCS: N7525_005441
PDP: PDIP_32520
POU: POX_d05776
TMF: EYB26_005937
TRG: TRUGW13939_06486
CIM: CIMG_01115
CPW: CPC735_052570
URE: UREG_01058
PBL: PAAG_01125
PBN: PADG_03708
ABE: ARB_07940
TVE: TRV_04098
AJE: HCAG_05915
BGH: BDBG_03342
PNO: SNOG_05965
PTE: PTT_08482
PTRR: 6343353(PtrM4_121390)
BZE: COCCADRAFT_27023
BSC: COCSADRAFT_38262
BOR: COCMIDRAFT_30031
AALT: CC77DRAFT_1021441
ARAB: EKO05_0000764
ZTR: MYCGRDRAFT_44262
PFJ: MYCFIDRAFT_211863
FFU: CLAFUR5_09695
CBET: CB0940_10496
BCOM: BAUCODRAFT_62660
NPA: UCRNP2_7340
SPO: 2540526(thi2)
SOM: SOMG_00517(thi2)
TVS: TRAVEDRAFT_71517
DSQ: DICSQDRAFT_134894
PCO: PHACADRAFT_177254
SHS: STEHIDRAFT_111603
HIR: HETIRDRAFT_440039
PSQ: PUNSTDRAFT_42416
ADL: AURDEDRAFT_139075
FME: FOMMEDRAFT_23696
GTR: GLOTRDRAFT_77212
RSX: RhiXN_04607
CCI: CC1G_04976
ABP: AGABI1DRAFT40074(AGABI1DRAFT_40074)
ABV: AGABI2DRAFT72787(AGABI2DRAFT_72787)
PCUB: JR316_0006998
MRR: Moror_11852
MORE: E1B28_012388
SCM: SCHCO_02490971(SCHCODRAFT_02490971)
CPUT: CONPUDRAFT_104209
SLA: SERLADRAFT_470126
WSE: WALSEDRAFT_32181(CYPBP37)
WIC: J056_001533
UMA: UMAG_11400
PFP: PFL1_06351
SGRA: EX895_003350
MGL: MGL_1314
MSYM: MSY001_3139
PGR: PGTG_01304
PTRC: PtA15_7A55
PSTR: Pst134EA_013047
MLR: MELLADRAFT_53832
SMIN: v1.2.003820.t1(symbB.v1.2.003820.t1)
SPAR: SPRG_04526
GTT: GUITHDRAFT_93981
 » show all
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
  Sequence
[sce:YGR144W]
LinkDB

KEGG   ORTHOLOGY: K22699
Entry
K22699                      KO                                     
Symbol
thi4
Name
sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
Pathway
map00730  Thiamine metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
Reaction
R12026  NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    K22699  thi4; sulfide-dependent adenosine diphosphate thiazole synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.59  sulfide-dependent adenosine diphosphate thiazole synthase
     K22699  thi4; sulfide-dependent adenosine diphosphate thiazole synthase
Other DBs
COG: COG1635
Genes
BBAR: RHAL1_03078
CAUL: KCG34_24290
MALU: KU6B_16750
HMR: Hipma_0421
DAV: DESACE_08810
DMA: DMR_31420
DCB: C3Y92_06440
DGG: DGI_1133
DMS: E8L03_06730
DAF: Desaf_0994
DSX: GD604_13095
DSD: GD606_19515
DLM: DPPLL_35930
DOL: Dole_2426
DAL: Dalk_2394
DOV: DSCO28_45120
DLI: dnl_00920(thiG)
DMM: dnm_073520(thiG)
DAO: Desac_0998
DAX: FDQ92_03460
DBR: Deba_1981
DMP: FAK_22910
TID: Thein_1804
TOP: TOPB45_0915
TCM: HL41_01820
THET: F1847_03705
CTHI: THC_0653
TAV: G4V39_01630
TMAI: FVE67_08730
DAW: HS1_000304
MZL: GKS04_01765
DHR: LGS26_09060
CLJ: CLJU_c30580
CSQ: CSCA_1812
CDRK: B9W14_10240
CFER: D4Z93_11890
CLOS: DMR38_15480
DKU: Desku_1659
DAU: Daud_0859
TJR: TherJR_1442
ADG: Adeg_0421 Adeg_1609
GEK: kuro4_04070
MBX: BCGT_0584
MPHL: MPHLCCUG_05062(ksdD_3)
SLK: SLUN_34370
TNR: Thena_0778
TACI: TDSAC_0747
HBS: IPV69_04150
VAI: BU251_06310 BU251_06360
TAI: Taci_1358
TLI: Tlie_1851
AMO: Anamo_0225
BCEL: BcellWH2_01838
BIS: DXK01_001245
PSOE: CE91St14_02970
PDI: BDI_1609
PARC: CI960_06610
PMER: INE87_00229
PGOL: K6V26_06880
PJO: LK449_05640
PFAI: NXY11_05335
PMZ: HMPREF0659_A5800
PIT: PIN17_A0608
PNI: J5A59_03980
PHER: prwr041_11060
PSCJ: J4856_09105
PBIV: QP022_05995
RBC: BN938_1539
TTZ: FHG85_07515
MBAS: ALGA_3764
PAA: Paes_1007
PROC: Ptc2401_01068
PRS: B9H02_06355
PROS: CHL67_06345
TAM: Theam_0077
DTE: Dester_1473
TTK: TST_0727(thi1)
TMA: TM0787
TMM: Tmari_0788
TMI: THEMA_00715
TMW: THMA_0806
TMQ: THMB_0806
TMX: THMC_0806
TPT: Tpet_0142
TNP: Tnap_0143
TRQ: TRQ2_0140
TNA: CTN_1791
THQ: T2812B_00715
THZ: CELL2_00740
THR: TRQ7_00715
TLE: Tlet_1750
TTA: Theth_1374
TME: Tmel_1590
TAF: THA_1798
THP: BG95_08660
THER: Y592_08765
FNO: Fnod_1422
FPE: Ferpe_0640
FIA: NA23_03490
FRR: IB67_05365
NDE: NIDE1062
NMV: NITMOv2_0947
NIO: NITINOP_1921
NJA: NSJP_2079
NKF: Nkreftii_003088
NIF: W02_33410
NTI: DNFV4_01351
NALL: PP769_00420
NNEO: PQG83_11585
FSH: Q2T83_00155
MJA: MJ_0601
MFE: Mefer_1385
MVU: Metvu_1585
MFS: MFS40622_1580
MIF: Metin_1281
MJH: JH146_0825
MESG: MLAUSG7_1377(thi)
MESA: MLASG1_0803(thi)
MIG: Metig_0735 Metig_1112
MMP: MMP1352
MMQ: MmarC5_0226
MMX: MmarC6_1321
MMZ: MmarC7_0597
MMAK: MMKA1_15750
MMAO: MMOS7_14560
MMAD: MMJJ_14870
MAE: Maeo_0798
MVN: Mevan_0663
MVO: Mvol_0738
MOK: Metok_0500
METF: CFE53_00030
MTH: MTH_1620
MMG: MTBMA_c02060
MWO: MWSIV6_0166(Thi4)
MTEE: MTTB_13720
METC: MTCT_1479
METE: tca_01569
METZ: METMT2_1460
METK: FVF72_03520
MTHM: FZP57_00720
METJ: FZP68_05735
MEB: Abm4_1461
MEL: Metbo_0536 Metbo_1265
MEW: MSWAN_0974 MSWAN_1853
METH: MBMB1_1137 MBMB1_1486
MFC: BRM9_0713 BRM9_1347
MFI: DSM1535_0665 DSM1535_2031
MCUB: MCBB_1020 MCBB_1725
MSUB: BK009_06380
METN: BK008_01970
METT: CIT01_06780
METO: CIT02_02510 CIT02_10600
MEME: HYG87_01485 HYG87_07505
MFEG: GCM10025860_28950
MFV: Mfer_0175
MKA: MK0430
AFU: AF_0702
AFG: AFULGI_00007840
APO: Arcpr_1423
AVE: Arcve_1405
AST: Asulf_00980
FPL: Ferp_0628
GAC: GACE_0145
GAH: GAH_01007
PFU: PF1530
PFI: PFC_06880
PHO: PH1357(PH1357)
PAB: PAB0536(thi1)
PYN: PNA2_1583 PNA2_1941
PYA: PYCH_06240 PYCH_08650
PYS: Py04_1231
PYC: TQ32_10505
TKO: TK0434
TGA: TGAM_1270
THE: GQS_02015
THM: CL1_0036
TLT: OCC_06556
THS: TES1_1982
TNU: BD01_0513
TEU: TEU_09505
TGY: X802_10050
THV: ADU37_CDS17350 ADU37_CDS22280
TCH: CHITON_1554
TPEP: A0127_02260
TPIE: A7C91_09070
TCE: A3L02_01985
TTD: A3L14_05500
TPRF: A3L09_06395
TPAF: A3L08_06895
THY: A3L12_03095
TIC: FH039_06460
TCQ: TIRI35C_0994(thi)
THEM: FPV09_02920
PPAC: PAP_08770
MBA: Mbar_A2100
MBY: MSBRM_2409
MBW: MSBRW_2643
MBAR: MSBR2_2375
MBAK: MSBR3_2431
MAC: MA_2851
MMA: MM_0222
MMAZ: MmTuc01_0227
MMJ: MSMAS_1078
MMAC: MSMAC_2441
MVC: MSVAZ_1117
MEK: MSKOL_1072
MLS: MSLAZ_1169
METM: MSMTP_1119
MEF: MSWH1_1762
MEQ: MSWHS_1554
MSJ: MSSAC_2840
MSZ: MSSIH_2497
MSW: MSSIT_2540
MTHR: MSTHT_0054
MTHE: MSTHC_0676
MHOR: MSHOH_1299
MFZ: AOB57_002245
MBU: Mbur_2109
MMET: MCMEM_0306 MCMEM_0840
MELO: J7W08_02430 J7W08_11625
MMH: Mmah_0298
MHAZ: BHR79_02030
MPOT: BKM01_06375
MEV: Metev_0188
MZH: Mzhil_1372
MZI: HWN40_08730
MMAV: RE476_01435
MSEB: RE474_11125
MTP: Mthe_1121
MCJ: MCON_3229
MHI: Mhar_2378
MHU: Mhun_1935
MRTJ: KHC33_14740
MLA: Mlab_0277
MEM: Memar_2251
MBG: BN140_1460(thi1)
MEMA: MMAB1_1869
MCHK: MchiMG62_25690
MSUM: OH143_05540
MRC: R6Y96_03785
MPI: Mpet_0116
MEND: L6E24_07545
MEFW: F1737_10475
MAQE: RJ40_07140
MFK: E2N92_07295
MOU: OU421_07750
MESB: L1S32_11135
MANQ: L1994_01520
MFO: Metfor_0238
MEZ: Mtc_1604(thi4-1) Mtc_2398(thi4-2)
MJK: N2V74_02430 N2V74_03430
HAL: VNG_2604G(thi1)
HSL: OE_4651F(thi4)
HANR: LJ422_10530
HHB: Hhub_1122(thi4)
HAGS: JT689_11965
HABO: JRZ79_10305
HNO: LT974_00705
HLU: LT972_12875
HSU: HLASF_0331
HSF: HLASA_0330
SALR: FQU85_03530
HALR: EFA46_011875
HJE: HacjB3_12970
HDO: MUK72_07875
HALX: M0R89_10525
HAXZ: M0R88_11005
HAYC: NGM10_05370
HAXY: NGM07_01030
SALI: L593_09560
SAIM: K0C01_03160
HARA: AArcS_1966(thi4)
HMA: rrnAC1782(thi1)
HHI: HAH_2313(thi1)
HHN: HISP_11780
HAB: SG26_04110
HTA: BVU17_11255
HALJ: G9465_07010
HSIN: KDQ40_01865
NPH: NP_5174A(thi4)
NMO: Nmlp_3882(thi4)
NHO: HWV23_12010
NSAL: HWV07_14560
HUT: Huta_2718
HTI: HTIA_2465
HALA: Hrd1104_02040
HASV: SVXHr_1858(thi4)
HABN: HBNXHr_1846(thi4)
HMU: Hmuk_0002
HALZ: E5139_03335
HALL: LC1Hm_2563(thi4)
HAZP: GBQ70_03335
HALI: BV210_05585
HSN: DV733_09670
HDS: HSR122_2321(thi4)
HRR: HZS55_08655
HPEL: HZS54_09780
HLT: I7X12_05325
HARC: HARCEL1_09615
HAAD: MW046_08650
HWA: HQ_1276A(thi4)
HWC: Hqrw_1306(thi4)
HVO: HVO_0665(thi4)
HALE: G3A49_03390
HLN: SVXHx_0624(thi4)
HME: HFX_0634
HGI: ABY42_03175
HLS: KU306_07905
HBO: Hbor_25460
HAQ: DU484_06390
HAJ: DU500_06660
HAER: DU502_04335
HRA: EI982_09275
HLM: DV707_12630
HLA: Hlac_2980
HALB: EKH57_08560
HEZZ: EO776_03960
HALQ: Hrr1229_002890
HSS: J7656_12905
HSAI: HPS36_03250
HAZZ: KI388_01415
SRUB: C2R22_02145
HAE: halTADL_1093
HALN: B4589_006725
HALG: HUG10_03970
HALU: HUG12_12960
HMP: K6T50_02080
HRE: K6T36_01900
HRM: K6T25_14540
HACB: Hbl1158_08970
HDF: AArcSl_1355(thi4)
HAH: Halar_3704
HTU: Htur_1462
HSAL: JMJ58_01385
HAKZ: J0X25_14155
NMG: Nmag_2419(thi4)
HXA: Halxa_2863
NAT: NJ7G_3680
NPE: Natpe_2830
NVR: FEJ81_13195
NPL: FGF80_13125
NAY: HYG81_16885
HALY: HYG82_19015
HJT: DVR14_04265
HLO: J0X27_03870
NGE: Natgr_0926
HRU: Halru_1150
SAWL: NGM29_17530
HALV: NGM15_08750
NOU: Natoc_0532
HLR: HALLA_10200
HLC: CHINAEXTREME16945
NAJ: B1756_03455
NAG: AArcMg_1121
NAN: AArc1_2501
NARA: QQ977_09420
NBG: DV706_12525
NAS: GCU68_13250
HDA: BB347_01930
MELU: MTLP_07010
MEAM: MU439_01690
MEAE: QEN48_00685
ABI: Aboo_0963
ACF: AciM339_1016
APE: APE_2149.1
ACJ: ACAM_1344
SMR: Smar_0052 Smar_0180
SHC: Shell_0764
IHO: Igni_0560
IIS: EYM_05510
IPC: IPA_05695
DKA: DKAM_0713
DFD: Desfe_0795
IAG: Igag_0295
THG: TCELL_1023
HBU: Hbut_0253
PFM: Pyrfu_0366
PDL: Pyrde_0220 Pyrde_0347
PABI: PABY_00710
STO: STK_03610
SOH: D1869_01525
SSO: SSO0436
SOL: Ssol_1411
SSOA: SULA_1456
SSOL: SULB_1457
SSOF: SULC_1455
SSHI: J5U23_03002
SCAS: SACC_05940
SAI: Saci_0854(thi)
SACN: SacN8_04145
SACR: SacRon12I_04135
SACS: SUSAZ_03885
SIS: LS215_1798
SIA: M1425_1670
SIM: M1627_1786
SID: M164_1717
SIY: YG5714_1786
SIN: YN1551_1140
SII: LD85_1927
SIH: SiH_1645
SIR: SiRe_1566
SIC: SiL_1558
SULA: BFU36_03640
SULE: GFS03_09395
SULO: GFS33_01210
SULL: EWF20_02995
MSE: Msed_2221
MEMJ: MJ1HA_2541
MCN: Mcup_0086
MHK: DFR87_07430
MPRU: DFR88_07115
MTEN: GWK48_04735
MJN: MjAS7_0513
AHO: Ahos_0692
AMAN: B6F84_06895
ABRI: DFR85_08045
ASUL: DFR86_05955
AAMB: D1866_11245
ACIH: HS5_20660
SACD: HS1genome_2409
SAZO: D1868_02625
CSTY: KN1_20130
STEP: IC006_1529
SMET: RQ359_000407
SAHS: HS7_05390
PAI: PAE0175
PIS: Pisl_1998
PCL: Pcal_1555
PAS: Pars_1498
PYR: P186_0936
POG: Pogu_0708
TNE: Tneu_1052
PYW: PYWP30_02101
CMA: Cmaq_1420
TUZ: TUZN_0079
VDI: Vdis_2373
VMO: VMUT_0723
VSO: Vsou_21150
FFO: FFONT_0392
NMR: Nmar_0678
NIR: NSED_03435
NKR: NKOR_03495
NID: NPIRD3C_1584
NIN: NADRNF5_1474
NIW: Nisw_01510
NCL: C5F47_05695
NOX: C5F49_05585
NUE: C5F50_04895
NIP: NsoK4_05025
NZT: NZOSNM25_001293
NCT: NMSP_1025
NIC: DSQ20_03585
NGA: Ngar_c21660
NVN: NVIE_008130
NEV: NTE_02257
TAA: NMY3_02935
NFN: NFRAN_0414(thi)
NCV: NCAV_0396(thi)
CSY: CENSYa_0361
NBV: T478_0555
TAH: SU86_002805
NIU: DSQ19_03795
NDV: NDEV_0758
CCAI: NAS2_0821
KCR: Kcr_0795
BARB: AOA66_0043
FLT: Sv326_1000
 » show all
Reference
PMID:26928142
  Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
  Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
  Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:10.1021/jacs.6b00445
  Sequence
[mja:MJ_0601]
Reference
PMID:25348237
  Authors
Hwang S, Cordova B, Chavarria N, Elbanna D, McHugh S, Rojas J, Pfeiffer F, Maupin-Furlow JA
  Title
Conserved active site cysteine residue of archaeal THI4 homolog is essential for thiamine biosynthesis in Haloferax volcanii.
  Journal
BMC Microbiol 14:260 (2014)
DOI:10.1186/s12866-014-0260-0
  Sequence
[hvo:HVO_0665]
LinkDB

KEGG   ENZYME: 2.4.2.59
Entry
EC 2.4.2.59                 Enzyme                                 
Name
sulfide-dependent adenosine diphosphate thiazole synthase;
Thi4 (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Reaction(IUBMB)
NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O [RN:R12026]
Reaction(KEGG)
R12026
Substrate
NAD+ [CPD:C00003];
glycine [CPD:C00037];
sulfide [CPD:C00283]
Product
nicotinamide [CPD:C00153];
ADP-5-ethyl-4-methylthiazole-2-carboxylate [CPD:C20784];
H2O [CPD:C00001]
Comment
This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
History
EC 2.4.2.59 created 2018
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K22699  sulfide-dependent adenosine diphosphate thiazole synthase
Genes
BBAR: RHAL1_03078
CAUL: KCG34_24290
MALU: KU6B_16750
HMR: Hipma_0421
DAV: DESACE_08810
DMA: DMR_31420
DCB: C3Y92_06440
DGG: DGI_1133
DMS: E8L03_06730
DAF: Desaf_0994
DSX: GD604_13095
DSD: GD606_19515
DLM: DPPLL_35930
DOL: Dole_2426
DAL: Dalk_2394
DOV: DSCO28_45120
DLI: dnl_00920(thiG)
DMM: dnm_073520(thiG)
DAO: Desac_0998
DAX: FDQ92_03460
DBR: Deba_1981
DMP: FAK_22910
TID: Thein_1804
TOP: TOPB45_0915
TCM: HL41_01820
THET: F1847_03705
CTHI: THC_0653
TAV: G4V39_01630
TMAI: FVE67_08730
DAW: HS1_000304
MZL: GKS04_01765
DHR: LGS26_09060
CLJ: CLJU_c30580
CSQ: CSCA_1812
CDRK: B9W14_10240
CFER: D4Z93_11890
CLOS: DMR38_15480
DKU: Desku_1659
DAU: Daud_0859
TJR: TherJR_1442
ADG: Adeg_0421 Adeg_1609
GEK: kuro4_04070
MBX: BCGT_0584
MPHL: MPHLCCUG_05062(ksdD_3)
SLK: SLUN_34370
TNR: Thena_0778
TACI: TDSAC_0747
HBS: IPV69_04150
VAI: BU251_06310 BU251_06360
TAI: Taci_1358
TLI: Tlie_1851
AMO: Anamo_0225
BCEL: BcellWH2_01838
BIS: DXK01_001245
PSOE: CE91St14_02970
PDI: BDI_1609
PARC: CI960_06610
PMER: INE87_00229
PGOL: K6V26_06880
PJO: LK449_05640
PFAI: NXY11_05335
PMZ: HMPREF0659_A5800
PIT: PIN17_A0608
PNI: J5A59_03980
PHER: prwr041_11060
PSCJ: J4856_09105
PBIV: QP022_05995
RBC: BN938_1539
TTZ: FHG85_07515
MBAS: ALGA_3764
PAA: Paes_1007
PROC: Ptc2401_01068
PRS: B9H02_06355
PROS: CHL67_06345
TAM: Theam_0077
DTE: Dester_1473
TTK: TST_0727(thi1)
TMA: TM0787
TMM: Tmari_0788
TMI: THEMA_00715
TMW: THMA_0806
TMQ: THMB_0806
TMX: THMC_0806
TPT: Tpet_0142
TNP: Tnap_0143
TRQ: TRQ2_0140
TNA: CTN_1791
THQ: T2812B_00715
THZ: CELL2_00740
THR: TRQ7_00715
TLE: Tlet_1750
TTA: Theth_1374
TME: Tmel_1590
TAF: THA_1798
THP: BG95_08660
THER: Y592_08765
FNO: Fnod_1422
FPE: Ferpe_0640
FIA: NA23_03490
FRR: IB67_05365
NDE: NIDE1062
NMV: NITMOv2_0947
NIO: NITINOP_1921
NJA: NSJP_2079
NKF: Nkreftii_003088
NIF: W02_33410
NTI: DNFV4_01351
NALL: PP769_00420
NNEO: PQG83_11585
FSH: Q2T83_00155
MJA: MJ_0601
MFE: Mefer_1385
MVU: Metvu_1585
MFS: MFS40622_1580
MIF: Metin_1281
MJH: JH146_0825
MESG: MLAUSG7_1377(thi)
MESA: MLASG1_0803(thi)
MIG: Metig_0735 Metig_1112
MMP: MMP1352
MMQ: MmarC5_0226
MMX: MmarC6_1321
MMZ: MmarC7_0597
MMAK: MMKA1_15750
MMAO: MMOS7_14560
MMAD: MMJJ_14870
MAE: Maeo_0798
MVN: Mevan_0663
MVO: Mvol_0738
MOK: Metok_0500
METF: CFE53_00030
MTH: MTH_1620
MMG: MTBMA_c02060
MWO: MWSIV6_0166(Thi4)
MTEE: MTTB_13720
METC: MTCT_1479
METE: tca_01569
METZ: METMT2_1460
METK: FVF72_03520
MTHM: FZP57_00720
METJ: FZP68_05735
MEB: Abm4_1461
MEL: Metbo_0536 Metbo_1265
MEW: MSWAN_0974 MSWAN_1853
METH: MBMB1_1137 MBMB1_1486
MFC: BRM9_0713 BRM9_1347
MFI: DSM1535_0665 DSM1535_2031
MCUB: MCBB_1020 MCBB_1725
MSUB: BK009_06380
METN: BK008_01970
METT: CIT01_06780
METO: CIT02_02510 CIT02_10600
MEME: HYG87_01485 HYG87_07505
MFEG: GCM10025860_28950
MFV: Mfer_0175
MKA: MK0430
AFU: AF_0702
AFG: AFULGI_00007840
APO: Arcpr_1423
AVE: Arcve_1405
AST: Asulf_00980
FPL: Ferp_0628
GAC: GACE_0145
GAH: GAH_01007
PFU: PF1530
PFI: PFC_06880
PHO: PH1357(PH1357)
PAB: PAB0536(thi1)
PYN: PNA2_1583 PNA2_1941
PYA: PYCH_06240 PYCH_08650
PYS: Py04_1231
PYC: TQ32_10505
TKO: TK0434
TGA: TGAM_1270
THE: GQS_02015
THM: CL1_0036
TLT: OCC_06556
THS: TES1_1982
TNU: BD01_0513
TEU: TEU_09505
TGY: X802_10050
THV: ADU37_CDS17350 ADU37_CDS22280
TCH: CHITON_1554
TPEP: A0127_02260
TPIE: A7C91_09070
TCE: A3L02_01985
TTD: A3L14_05500
TPRF: A3L09_06395
TPAF: A3L08_06895
THY: A3L12_03095
TIC: FH039_06460
TCQ: TIRI35C_0994(thi)
THEM: FPV09_02920
PPAC: PAP_08770
MBA: Mbar_A2100
MBY: MSBRM_2409
MBW: MSBRW_2643
MBAR: MSBR2_2375
MBAK: MSBR3_2431
MAC: MA_2851
MMA: MM_0222
MMAZ: MmTuc01_0227
MMJ: MSMAS_1078
MMAC: MSMAC_2441
MVC: MSVAZ_1117
MEK: MSKOL_1072
MLS: MSLAZ_1169
METM: MSMTP_1119
MEF: MSWH1_1762
MEQ: MSWHS_1554
MSJ: MSSAC_2840
MSZ: MSSIH_2497
MSW: MSSIT_2540
MTHR: MSTHT_0054
MTHE: MSTHC_0676
MHOR: MSHOH_1299
MFZ: AOB57_002245
MBU: Mbur_2109
MMET: MCMEM_0306 MCMEM_0840
MELO: J7W08_02430 J7W08_11625
MMH: Mmah_0298
MHAZ: BHR79_02030
MPOT: BKM01_06375
MEV: Metev_0188
MZH: Mzhil_1372
MZI: HWN40_08730
MMAV: RE476_01435
MSEB: RE474_11125
MTP: Mthe_1121
MCJ: MCON_3229
MHI: Mhar_2378
MHU: Mhun_1935
MRTJ: KHC33_14740
MLA: Mlab_0277
MEM: Memar_2251
MBG: BN140_1460(thi1)
MEMA: MMAB1_1869
MCHK: MchiMG62_25690
MSUM: OH143_05540
MRC: R6Y96_03785
MPI: Mpet_0116
MEND: L6E24_07545
MEFW: F1737_10475
MAQE: RJ40_07140
MFK: E2N92_07295
MOU: OU421_07750
MESB: L1S32_11135
MANQ: L1994_01520
MFO: Metfor_0238
MEZ: Mtc_1604(thi4-1) Mtc_2398(thi4-2)
MJK: N2V74_02430 N2V74_03430
HAL: VNG_2604G(thi1)
HSL: OE_4651F(thi4)
HANR: LJ422_10530
HHB: Hhub_1122(thi4)
HAGS: JT689_11965
HABO: JRZ79_10305
HNO: LT974_00705
HLU: LT972_12875
HSU: HLASF_0331
HSF: HLASA_0330
SALR: FQU85_03530
HALR: EFA46_011875
HJE: HacjB3_12970
HDO: MUK72_07875
HALX: M0R89_10525
HAXZ: M0R88_11005
HAYC: NGM10_05370
HAXY: NGM07_01030
SALI: L593_09560
SAIM: K0C01_03160
HARA: AArcS_1966(thi4)
HMA: rrnAC1782(thi1)
HHI: HAH_2313(thi1)
HHN: HISP_11780
HAB: SG26_04110
HTA: BVU17_11255
HALJ: G9465_07010
HSIN: KDQ40_01865
NPH: NP_5174A(thi4)
NMO: Nmlp_3882(thi4)
NHO: HWV23_12010
NSAL: HWV07_14560
HUT: Huta_2718
HTI: HTIA_2465
HALA: Hrd1104_02040
HASV: SVXHr_1858(thi4)
HABN: HBNXHr_1846(thi4)
HMU: Hmuk_0002
HALZ: E5139_03335
HALL: LC1Hm_2563(thi4)
HAZP: GBQ70_03335
HALI: BV210_05585
HSN: DV733_09670
HDS: HSR122_2321(thi4)
HRR: HZS55_08655
HPEL: HZS54_09780
HLT: I7X12_05325
HARC: HARCEL1_09615
HAAD: MW046_08650
HWA: HQ_1276A(thi4)
HWC: Hqrw_1306(thi4)
HVO: HVO_0665(thi4)
HALE: G3A49_03390
HLN: SVXHx_0624(thi4)
HME: HFX_0634
HGI: ABY42_03175
HLS: KU306_07905
HBO: Hbor_25460
HAQ: DU484_06390
HAJ: DU500_06660
HAER: DU502_04335
HRA: EI982_09275
HLM: DV707_12630
HLA: Hlac_2980
HALB: EKH57_08560
HEZZ: EO776_03960
HALQ: Hrr1229_002890
HSS: J7656_12905
HSAI: HPS36_03250
HAZZ: KI388_01415
SRUB: C2R22_02145
HAE: halTADL_1093
HALN: B4589_006725
HALG: HUG10_03970
HALU: HUG12_12960
HMP: K6T50_02080
HRE: K6T36_01900
HRM: K6T25_14540
HACB: Hbl1158_08970
HDF: AArcSl_1355(thi4)
HAH: Halar_3704
HTU: Htur_1462
HSAL: JMJ58_01385
HAKZ: J0X25_14155
NMG: Nmag_2419(thi4)
HXA: Halxa_2863
NAT: NJ7G_3680
NPE: Natpe_2830
NVR: FEJ81_13195
NPL: FGF80_13125
NAY: HYG81_16885
HALY: HYG82_19015
HJT: DVR14_04265
HLO: J0X27_03870
NGE: Natgr_0926
HRU: Halru_1150
SAWL: NGM29_17530
HALV: NGM15_08750
NOU: Natoc_0532
HLR: HALLA_10200
HLC: CHINAEXTREME16945
NAJ: B1756_03455
NAG: AArcMg_1121
NAN: AArc1_2501
NARA: QQ977_09420
NBG: DV706_12525
NAS: GCU68_13250
HDA: BB347_01930
MELU: MTLP_07010
MEAM: MU439_01690
MEAE: QEN48_00685
ABI: Aboo_0963
ACF: AciM339_1016
APE: APE_2149.1
ACJ: ACAM_1344
SMR: Smar_0052 Smar_0180
SHC: Shell_0764
IHO: Igni_0560
IIS: EYM_05510
IPC: IPA_05695
DKA: DKAM_0713
DFD: Desfe_0795
IAG: Igag_0295
THG: TCELL_1023
HBU: Hbut_0253
PFM: Pyrfu_0366
PDL: Pyrde_0220 Pyrde_0347
PABI: PABY_00710
STO: STK_03610
SOH: D1869_01525
SSO: SSO0436
SOL: Ssol_1411
SSOA: SULA_1456
SSOL: SULB_1457
SSOF: SULC_1455
SSHI: J5U23_03002
SCAS: SACC_05940
SAI: Saci_0854(thi)
SACN: SacN8_04145
SACR: SacRon12I_04135
SACS: SUSAZ_03885
SIS: LS215_1798
SIA: M1425_1670
SIM: M1627_1786
SID: M164_1717
SIY: YG5714_1786
SIN: YN1551_1140
SII: LD85_1927
SIH: SiH_1645
SIR: SiRe_1566
SIC: SiL_1558
SULA: BFU36_03640
SULE: GFS03_09395
SULO: GFS33_01210
SULL: EWF20_02995
MSE: Msed_2221
MEMJ: MJ1HA_2541
MCN: Mcup_0086
MHK: DFR87_07430
MPRU: DFR88_07115
MTEN: GWK48_04735
MJN: MjAS7_0513
AHO: Ahos_0692
AMAN: B6F84_06895
ABRI: DFR85_08045
ASUL: DFR86_05955
AAMB: D1866_11245
ACIH: HS5_20660
SACD: HS1genome_2409
SAZO: D1868_02625
CSTY: KN1_20130
STEP: IC006_1529
SMET: RQ359_000407
SAHS: HS7_05390
PAI: PAE0175
PIS: Pisl_1998
PCL: Pcal_1555
PAS: Pars_1498
PYR: P186_0936
POG: Pogu_0708
TNE: Tneu_1052
PYW: PYWP30_02101
CMA: Cmaq_1420
TUZ: TUZN_0079
VDI: Vdis_2373
VMO: VMUT_0723
VSO: Vsou_21150
FFO: FFONT_0392
NMR: Nmar_0678
NIR: NSED_03435
NKR: NKOR_03495
NID: NPIRD3C_1584
NIN: NADRNF5_1474
NIW: Nisw_01510
NCL: C5F47_05695
NOX: C5F49_05585
NUE: C5F50_04895
NIP: NsoK4_05025
NZT: NZOSNM25_001293
NCT: NMSP_1025
NIC: DSQ20_03585
NGA: Ngar_c21660
NVN: NVIE_008130
NEV: NTE_02257
TAA: NMY3_02935
NFN: NFRAN_0414(thi)
NCV: NCAV_0396(thi)
CSY: CENSYa_0361
NBV: T478_0555
TAH: SU86_002805
NIU: DSQ19_03795
NDV: NDEV_0758
CCAI: NAS2_0821
KCR: Kcr_0795
BARB: AOA66_0043
FLT: Sv326_1000
 » show all
Reference
1  [PMID:26919468]
  Authors
Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE
  Title
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole  Synthases.
  Journal
Biochemistry 55:1826-38 (2016)
DOI:10.1021/acs.biochem.6b00030
  Sequence
[mja:MJ_0601] [mig:Metig_0735]
Reference
2  [PMID:26928142]
  Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
  Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
  Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:10.1021/jacs.6b00445
  Sequence
[mja:MJ_0601]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.59
IUBMB Enzyme Nomenclature: 2.4.2.59
ExPASy - ENZYME nomenclature database: 2.4.2.59
BRENDA, the Enzyme Database: 2.4.2.59
LinkDB

KEGG   ENZYME: 2.4.2.60
Entry
EC 2.4.2.60                 Enzyme                                 
Name
cysteine-dependent adenosine diphosphate thiazole synthase;
THI4 (gene name) (ambiguous);
THI1 (gene name);
ADP-thiazole synthase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
Reaction(IUBMB)
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O [RN:R10685]
Reaction(KEGG)
R10685
Substrate
NAD+ [CPD:C00003];
glycine [CPD:C00037];
[ADP-thiazole synthase]-L-cysteine
Product
nicotinamide [CPD:C00153];
ADP-5-ethyl-4-methylthiazole-2-carboxylate [CPD:C20784];
[ADP-thiazole synthase]-dehydroalanine;
H2O [CPD:C00001]
Comment
This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway. It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo [3]. The homologous enzyme in archaea (EC 2.4.2.59, sulfide-dependent adenosine diphosphate thiazole synthase) uses sulfide as sulfur donor.
History
EC 2.4.2.60 created 2018
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K03146  cysteine-dependent adenosine diphosphate thiazole synthase
Genes
ATH: AT5G54770(THI1)
ALY: 9300430
CRB: 17876896
CSAT: 104726000 104731059 104763460
EUS: EUTSA_v10013978mg
BRP: 103844930 103851941 103857026
BNA: 106346007 106347311 106366413 106371241 106402237 106420919 125601255
BOE: 106318832 106327201 106335239
RSZ: 108836615 108837050 108844151 130501203
THJ: 104817652
CPAP: 110810965
CIT: 102626594(thi) 102629135
CIC: CICLE_v10008765mg CICLE_v10015727mg CICLE_v10024231mg
PVY: 116123427
MINC: 123202328 123225908
TCC: 18593644 18597097
GRA: 105769824 105773933 105780320
GHI: 107901923 107917921 107928645 107958248 107961959 121217764
GAB: 108453783 108482152 108486471
HSYR: 120126604 120147008 120160341 120179475 120189402 120197833 120209583
DZI: 111280819 111301627 111318798
EGR: 104450213
GMX: 100775614 100788953 100794288 547461(SC-04) 547462(SC-03)
GSJ: 114372051 114380540 114403613 114404912 114417056
PVU: PHAVU_007G052900g PHAVU_011G139100g
VRA: 106754377 106755182
VAR: 108325373 108339541
VUN: 114168645 114192234
VUM: 124843922 124843926
CCAJ: 109795024 109808173
APRC: 113872364
MTR: 11446281 25485243
TPRA: 123882686
CAM: 101491901 101507074 101511321 101512227
PSAT: 127097128
VVO: 131607286 131643448
LJA: 130718164 130743625
ADU: 107477997 107488645
AIP: 107630145 107643278
AHF: 112737808 112749911 112789941 112801227
LANG: 109331169 109332649 109348532 109351883
PCIN: 129286736 129298471 129298852 129315109
QSA: O6P43_011880 O6P43_028946 O6P43_031212
FVE: 101298688 101299651
RCN: 112168087 112201505 112201899
PPER: 18780719
PMUM: 103342510
PDUL: 117623858
MDM: 103429668 103448581
MSYL: 126589528 126615015
PXB: 103948770 103967326
ZJU: 107407137 107420469
MNT: 21395127
CSAV: 115717421
CSV: 101211553
CMO: 103501605
BHJ: 120091480
CMAX: 111483293 111487533
CMOS: 111438464 111448035
CPEP: 111783834 111785935 111788519
RCU: 8280736
MEAN: 126670687
JCU: 105632894
HBR: 110647144
MESC: 110601845 110611614
POP: 7470933 7479083 7485534
PEU: 105108187 105130169 105134848
PALZ: 118035853 118047445 118059587
JRE: 108983682 108993518 109022013
CILL: 122277821 122282819 122289841
CAVE: 132170520 132173535 132176015
QSU: 111989411 112016278
QLO: 115956034 115956545 115972735 115988494
TWL: 119988758 119988861
VVI: 100260728(THI1-1) 100265774(THI1-2)
VRI: 117909200 117923467
SLY: 101257192
SPEN: 107025837
SOT: 102598996
SSTN: 125856795
SDUL: 129892560
CANN: 107856341
LBB: 132620419
NTA: 107797059(ThiI) 107798781
NSY: 104224143
NTO: 104087540
NAU: 109232136
INI: 109167290 109187908
ITR: 116005701 116028414
SIND: 105167970 105175375
OEU: 111383503 111389379
EGT: 105948772 105962248
SSPL: 121740783 121742722 121743409 121757713 121775363 121800880
SMIL: 130985758
SHIS: 125188752 125202496
APAN: 127247867 127249630
HAN: 110890327 110912864
ECAD: 122591292 122611091
LSV: 111877285 111914386
CCAV: 112507403 112514948
DCR: 108199579 108204812 108211831
CSIN: 114275070 114297269
RVL: 131322345 131330436
AEW: 130751513 130751909 130754280 130789884
BVG: 104887771 104887775
SOE: 110795721
CQI: 110721030 110723750
ATRI: 130818300
MOF: 131145521
NNU: 104604883
MING: 122078253 122091022
TSS: 122640918
PSOM: 113279575 113284440 113287867 113288375
OSA: 4343443
OBR: 102709384
OGL: 127779938
BDI: 100841709
ATS: 109771029
TDC: 119281869 119330895 119338169
TAES: 123066078 123148177 123160697 123169109
TUA: 125525971
LPER: 127313554 127333271
LRD: 124669313 124679092 124689497 124695681
SBI: 8063504 8078187
ZMA: 542714 542715
SITA: 101752840 101774400
SVS: 117842602 117853273
PVIR: 120671321 120704075
PHAI: 112889419
PDA: 103716822 103721429 120107672
EGU: 105046898 105051965
MUS: 103975582 103991030
ZOF: 121967276 122021558 122025718 122052496
DCT: 110108175
PEQ: 110031149
AOF: 109827745 109834756
MSIN: 131221413 131239167
NCOL: 116249223
ATR: 18435056
SMO: SELMODRAFT_163429 SELMODRAFT_271002
PPP: 112273035 112273481 112275550 112276032 112276579
CRE: CHLRE_04g214150v5
VCN: VOLCADRAFT_74899 VOLCADRAFT_74900
MNG: MNEG_15292 MNEG_7985
CSL: COCSUDRAFT_14398
CVR: CHLNCDRAFT_22703
APRO: F751_1708
SCE: YGR144W(THI4)
SEUB: DI49_2107
SPAO: SPAR_G03600
AGO: AGOS_AAL137W
ERC: Ecym_6012
KLA: KLLA0_A00198g
KMX: KLMA_40625(THI4)
LTH: KLTH0B03916g
VPO: Kpol_1050p31
ZRO: ZYRO0G11726g
CGR: 2891165(GVI51_M01067)
NCS: NCAS_0D01750(NCAS0D01750)
NDI: NDAI_0C02860(NDAI0C02860)
TPF: TPHA_0A04790(TPHA0A04790)
TBL: TBLA_0B09390(TBLA0B09390) TBLA_0H00760(TBLA0H00760)
TGB: HG536_0A04825 HG536_0F00230
TDL: TDEL_0H00200(TDEL0H00200)
KNG: KNAG_0E03150(KNAG0E03150)
ZMK: HG535_0B00510
PPA: PAS_chr3_0648
DHA: DEHA2F16654g
PIC: PICST_50942
PGU: PGUG_04211
SPAA: SPAPADRAFT_51398
LEL: PVL30_003709(THI4)
CAL: CAALFM_C305130CA(THI4)
CTP: CTRG_02525
COT: CORT_0C04770
CDU: CD36_85100
YLI: 2905790(YALI2_A00151g)
CLU: CLUG_04547
CLUS: A9F13_11g02431
CAUR: CJI96_0001634
SLB: AWJ20_4223(THI4)
PKZ: C5L36_0C00170
BNN: FOA43_001955(STI35)
BBRX: BRETT_001261(THI4)
OPA: HPODL_03615
SLUD: SCDLUD_003155
NCR: NCU06110
NTE: NEUTE1DRAFT95662(NEUTE1DRAFT_95662)
SMP: SMAC_06409
PAN: PODANSg1687
PBEL: QC761_508470(THI4)
PPSD: QC762_508470(THI4)
PPSP: QC763_508470(THI4)
PPSA: QC764_508470(THI4)
TTT: THITE_2117402
MTM: MYCTH_2315910
CTHR: CTHT_0017160
MGR: MGG_03098
PPEI: PpBr36_09505
PGRI: PgNI_10244
TMN: UCRPA7_2510
SSCK: SPSK_07738
FGR: FGSG_02469
FPU: FPSE_01936
FPOA: FPOAC1_002586(STI35)
FVN: FVRRES_02879
FVR: FVEG_09077
FOX: FOXG_10428
NHE: NECHADRAFT_61890
FFC: NCS54_00810500
FKR: NCS57_00853700
FMU: J7337_005314(STI35)
TRE: TRIREDRAFT_68608(thi4)
TRR: M419DRAFT_89757
TATV: 25781467(TrAtP1_003045)
MAW: 19245497(THI4_1)
MAJ: MAA_05549
MBRN: 26238893(sti35)
PCHM: VFPPC_03188
CMT: CCM_01639
AMUS: LMH87_003448
PLJ: 28891457(PLICBS_010469)
PTKZ: JDV02_002359(THI4)
VAL: VDBG_03908
VDA: VDAG_01137
CFJ: CFIO01_04759
CLUP: CLUP02_16278
CHIG: CH63R_12560
SAPO: SAPIO_CDS2560
ELA: UCREL1_6105
PFY: PFICI_09188
SSL: SS1G_09727
BFU: BCIN_07g06010(Bcthi4)
MBE: MBM_01288
PSCO: LY89DRAFT_683526
GLZ: GLAREA_02091
ANI: ANIA_03928(thiF)
AFM: AFUA_6G08360
ACT: ACLA_082310
NFI: NFIA_054010
AOR: AO090003000090
ANG: An11g01630
AFV: AFLA_001605
ALUC: AKAW2_80142S(THI4)
ACHE: ACHE_80625S(THI4)
APUU: APUU_40431S(THI4)
PCS: N7525_005441
PDP: PDIP_32520
POU: POX_d05776
TMF: EYB26_005937
TRG: TRUGW13939_06486
CIM: CIMG_01115
CPW: CPC735_052570
URE: UREG_01058
PBL: PAAG_01125
PBN: PADG_03708
ABE: ARB_07940
TVE: TRV_04098
AJE: HCAG_05915
BGH: BDBG_03342
PNO: SNOG_05965
PTE: PTT_08482
PTRR: 6343353(PtrM4_121390)
BZE: COCCADRAFT_27023
BSC: COCSADRAFT_38262
BOR: COCMIDRAFT_30031
AALT: CC77DRAFT_1021441
ARAB: EKO05_0000764
ZTR: MYCGRDRAFT_44262
PFJ: MYCFIDRAFT_211863
FFU: CLAFUR5_09695
CBET: CB0940_10496
BCOM: BAUCODRAFT_62660
NPA: UCRNP2_7340
SPO: 2540526(thi2)
SOM: SOMG_00517(thi2)
TVS: TRAVEDRAFT_71517
DSQ: DICSQDRAFT_134894
PCO: PHACADRAFT_177254
SHS: STEHIDRAFT_111603
HIR: HETIRDRAFT_440039
PSQ: PUNSTDRAFT_42416
ADL: AURDEDRAFT_139075
FME: FOMMEDRAFT_23696
GTR: GLOTRDRAFT_77212
RSX: RhiXN_04607
CCI: CC1G_04976
ABP: AGABI1DRAFT40074(AGABI1DRAFT_40074)
ABV: AGABI2DRAFT72787(AGABI2DRAFT_72787)
PCUB: JR316_0006998
MRR: Moror_11852
MORE: E1B28_012388
SCM: SCHCO_02490971(SCHCODRAFT_02490971)
CPUT: CONPUDRAFT_104209
SLA: SERLADRAFT_470126
WSE: WALSEDRAFT_32181(CYPBP37)
WIC: J056_001533
UMA: UMAG_11400
PFP: PFL1_06351
SGRA: EX895_003350
MGL: MGL_1314
MSYM: MSY001_3139
PGR: PGTG_01304
PTRC: PtA15_7A55
PSTR: Pst134EA_013047
MLR: MELLADRAFT_53832
SMIN: v1.2.003820.t1(symbB.v1.2.003820.t1)
SPAR: SPRG_04526
GTT: GUITHDRAFT_93981
 » show all
Reference
1  [PMID:16912043]
  Authors
Godoi PH, Galhardo RS, Luche DD, Van Sluys MA, Menck CF, Oliva G
  Title
Structure of the thiazole biosynthetic enzyme THI1 from Arabidopsis thaliana.
  Journal
J Biol Chem 281:30957-66 (2006)
DOI:10.1074/jbc.M604469200
  Sequence
[ath:AT5G54770]
Reference
2  [PMID:22031445]
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
  Sequence
[sce:YGR144W]
Reference
3  [PMID:26919468]
  Authors
Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE
  Title
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole  Synthases.
  Journal
Biochemistry 55:1826-38 (2016)
DOI:10.1021/acs.biochem.6b00030
  Sequence
[sce:YGR144W]
Reference
4  [PMID:25348237]
  Authors
Hwang S, Cordova B, Chavarria N, Elbanna D, McHugh S, Rojas J, Pfeiffer F, Maupin-Furlow JA
  Title
Conserved active site cysteine residue of archaeal THI4 homolog is essential for thiamine biosynthesis in Haloferax volcanii.
  Journal
BMC Microbiol 14:260 (2014)
DOI:10.1186/s12866-014-0260-0
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.60
IUBMB Enzyme Nomenclature: 2.4.2.60
ExPASy - ENZYME nomenclature database: 2.4.2.60
BRENDA, the Enzyme Database: 2.4.2.60
LinkDB

KEGG   REACTION: R10685
Entry
R10685                      Reaction                               
Name
NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
Definition
NAD+ + Glycine + [Protein]-L-cysteine <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + [Protein]-dehydroalanine + 3 H2O
Equation
C00003 + C00037 + C02743 <=> C20784 + C00153 + C21861 + 3 C00001
Comment
thiamine thiazole synthase
multi-step reaction
Sulfur donor is enzyme itself (one cystein residue looses H2S to form dehydroalanie residue)
Reaction class
RC00033  C00003_C00153
RC03253  C00003_C20784
RC03254  C00037_C20784
Enzyme
2.4.2.60
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.60
     R10685  NAD+ + Glycine + [Protein]-L-cysteine <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + Nicotinamide + [Protein]-dehydroalanine + 3 H2O
Orthology
K03146  cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
Other DBs
RHEA: 55711
LinkDB

KEGG   REACTION: R12026
Entry
R12026                      Reaction                               
Name
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Definition
NAD+ + Glycine + Hydrogen sulfide <=> Nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
Equation
C00003 + C00037 + C00283 <=> C00153 + C20784 + 3 C00001
Reaction class
RC00033  C00003_C00153
RC03253  C00003_C20784
RC03254  C00037_C20784
Enzyme
2.4.2.59
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.59
     R12026  NAD+ + Glycine + Hydrogen sulfide <=> Nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
Orthology
K22699  sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
Other DBs
RHEA: 55707
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