KEGG ORTHOLOGY: K03989

ORTHOLOGY: K03989

Entry

K03989                      KO

Symbol

Name

complement component 4

Pathway

map04610

Complement and coagulation cascades

map04936

Alcoholic liver disease

map05133

Pertussis

map05150

Staphylococcus aureus infection

map05171

Coronavirus disease - COVID-19

map05322

Systemic lupus erythematosus

Disease

H00080

Systemic lupus erythematosus

H00102

Classic complement pathway component defects

H01649

Schizophrenia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03989  C4; complement component 4
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03989  C4; complement component 4
  09171 Infectious disease: bacterial
   05133 Pertussis
    K03989  C4; complement component 4
   05150 Staphylococcus aureus infection
    K03989  C4; complement component 4
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K03989  C4; complement component 4
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03989  C4; complement component 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03989  C4; complement component 4
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03989  C4; complement component 4
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I39: alpha2M family
   K03989  C4; complement component 4
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of hepatic cells
   K03989  C4; complement component 4
  Exosomal proteins of other cancer cells
   K03989  C4; complement component 4

Genes

HSA:	720(C4A) 721(C4B)

PTR:	100616513 462577

PPS:

100988452

GGO:	101146168 101148680

PON:	100171517(C4B)

NLE:

100596445

MCC:	721200 723314

MCF:	102123546(C4A) 102132156

MTHB:

126953210 126953211

MNI:	105497592(C4A)

CSAB:

103221723(C4B) 103221732

CATY:

105583245(C4A)

PANU:

101024934

TGE:

112622247

RRO:	104659391(C4A) 104678146

TFN:

117086984

PTEH:

111531048

CANG:

105513813

CJC:	100411501(C4A)

SBQ:	101045782(C4A)

CSYR:

MMUR:

LCAT:

OGA:

MMU:	12268(C4b) 625018(C4a)

MCAL:

110283979

MPAH:

110335909(C4a)

RNO:	24233(C4a) 406161(C4b)

MCOC:

116074977(C4a)

MUN:	110560118(C4a)

CGE:	100767983(C4a)

MAUA:

101830930(C4a)

PLEU:

MORG:

AAMP:

NGI:

HGL:	101719002(C4a)

CPOC:

100728345

CCAN:

109689567

DORD:

105999823(C4a)

DSP:	122111109(C4a)

NCAR:

124988769

OCU:

100356976

OPI:

101518028

TUP:	102483263(C4A)

GVR:	103592343(C4A)

CFA:

481722

CLUD:

112641333

VVP:

112913631

VLG:	121500739(C4A)

AML:

100475765

UMR:	103682335(C4A)

UAH:

113243734

UAR:	123790971(C4A)

ELK:

111152244

LLV:

125101520

MPUF:

101688875(C4A)

NVS:	122911388(C4A)

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:

PYU:

PBG:

LRUF:

PTG:	102967020(C4A)

PPAD:

109260502

AJU:

106983498

HHV:	120221895(C4A)

BTA:	107131209 280678(C4A) 781663

BOM:	102269445(C4A) 102280288

BIU:	109576672 109576941 109576944

BBUB:

102402713 102403881 112577762

BBIS:

104983996

CHX:	102170693 102172711 102188588 102189753

OAS:	101112891 101123419 101123672

ODA:

120859350

CCAD:

122429227 122429824

SSC:	445467(C4A)

CFR:

102521056

CBAI:

105074038(C4A)

CDK:	105087437(C4A)

VPC:

102526087

BACU:

103015179(C4A)

LVE:	103087928(C4A)

OOR:

DLE:

PCAD:

PSIU:

ECB:

EPZ:	103563298(C4A)

EAI:

106831006

MYB:	102254455(C4A)

MYD:	102774999(C4A)

MMYO:

118679563(C4A)

MLF:

MNA:

PKL:

HAI:

DRO:

SHON:

118979529(C4A)

AJM:

PDIC:

PHAS:

MMF:

RFQ:

PALE:

102898626(C4A)

PGIG:

120618894(C4A)

PVP:	105305288(C4A)

RAY:	107498435(C4A)

MJV:	108393997(C4A)

TOD:

119252237

SARA:

101550122

LAV:	100667171(C4A)

TMU:

101351736

ETF:

101645127

DNM:	101436657(C4A)

MDO:	100025543(C4A)

GAS:	123245156(C4A)

SHR:

100923960

PCW:	110199439(C4A)

OAA:	103165320(C4A)

GGA:	418892(C4A) 426611(C4)

PCOC:

116236738 116244169

MGP:	100538976 100549188 104909337

CJO:	107308202 107321557

NMEL:

APLA:

ACYG:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:	102032664(C4A)

FAB:	101810518(C4A)

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ACHL:

FPG:	101924008(C4B)

FCH:

CLV:

EGZ:

NNI:

PLET:

PCRI:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

ACAR:

CPEA:

AVIT:

CVF:

CUCA:

TEO:

AAM:	106489156 106494493

AROW:

112974022

NPD:

112959289

TGT:

104570586

DNE:	112988150 112996251

SCAM:

ASN:

AMJ:

PSS:

CMY:

CPIC:

TST:

CABI:

MRV:	120391193 120392331

ACS:	100554736(c4b)

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

VKO:	123017777 123035079

PMUA:

114592138 114592148

ZVI:

118080967

GJA:	107107890 107109836 107114004

STOW:

125427681

XLA:	394275(c4a.L)

XTR:	100135012(c4a)

NPR:	108786514 108786515

RTEM:

120913235

BBUF:

120977034

BGAR:

122945987

DRE:	566261(c4) 794635(c4b)

SRX:	107752837 107756256

SANH:

107662667 107682925

SGH:	107559007 107581612

CCAR:

109061229 109104568

CAUA:

113058647 113116298

PPRM:

120478561(c4) 120481135(c4b)

MAMB:

125243333 125243336(c4b) 125249565(c4)

IPU:	108267218(c4b) 108277767(c4)

PHYP:

113539200 113542362

SMEO:

124384992(c4b) 124394140(c4)

TFD:	113644338(c4b) 113649413(c4)

AMEX:

103038938 103045695

EEE:	113570684 113582264

TRU:

LCO:

NCC:

CGOB:

ELY:	117265845(c4b) 117265846 117265847

EFO:	125892560 125893644 125893645(c4b)

PLEP:

121945174(c4b)

SLUC:

116049377(c4b)

ECRA:

117945984(c4b)

ESP:

116691000

PFLV:

114556849

GAT:	120810611(c4b)

PPUG:

119197188(c4b)

MSAM:

119897763 119897764 119897765 119898284

CUD:	121513534(c4b)

ALAT:

119006500(c4b)

MZE:	101471515 101471809

ONL:	100703919 100704190

OAU:	116319800 116325358

OLA:	100049261(c4b) 110016646

OML:	112143386(c4b)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122831411(c4b)

CVG:	107102532 107103181

CTUL:

119772833(c4b)

GMU:	124865993(c4b)

NFU:

107372375

KMR:	108242012 108242013(c4b)

ALIM:

106517686 106517729

NWH:	119409458 119410121

AOCE:

111588842

MCEP:

125016912(c4b)

POV:

109633561

SSEN:

122775106(c4b)

HHIP:

117776693(c4b)

HSP:	118114200(c4b)

LCF:	108891077(c4b)

SDU:

111238774

SLAL:

111668799

XGL:	120784515(c4b)

MALB:

109971691

BSPL:

114842463(c4b)

SASA:

106581002 106605920 106612870

STRU:

115163315 115177503 115186072 115206254

OTW:	112225300(c4b) 112234724 112267007

OMY:	100136078(c4b) 110503832 110506677 110507666

OGO:	123992818 124006156 124024361 124024604

ONE:	115136834 115141754

SALP:

111949975 111956815

SNH:	120018256 120028678 120031505(c4b)

CCLU:

121555551(c4b) 121567886 123483544

ELS:	105010521 105018835

SFM:	108927450 108941674

PKI:	111839016 111851310

AANG:

118210051(c4) 118231169(c4b)

LOC:

102691668

PSPA:

121299232(c4b) 121302941

ARUT:

117405439(c4) 117433774 117964834

PSEX:

120539035(c4b)

LCM:

102346391

CMK:	103189476 103189738

RTP:

109927203

RSAN:

119407057 119407256

RMP:	119163486 119164934 119176497

DFR:

124495393

» show all

Reference

PMID:2395880

Authors

Carroll MC, Fathallah DM, Bergamaschini L, Alicot EM, Isenman DE

Title

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

Journal

Proc Natl Acad Sci U S A 87:6868-72 (1990)
DOI:10.1073/pnas.87.17.6868

Sequence

[hsa:720 721]

LinkDB

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