KEGG   ORTHOLOGY: K03989
Entry
K03989                      KO                                     

Symbol
C4
Name
complement component 4
Pathway
map04610  Complement and coagulation cascades
map04936  Alcoholic liver disease
map05133  Pertussis
map05150  Staphylococcus aureus infection
map05171  Coronavirus disease - COVID-19
map05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H00102  Classic complement pathway component defects
H01649  Schizophrenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03989  C4; complement component 4
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03989  C4; complement component 4
  09171 Infectious disease: bacterial
   05133 Pertussis
    K03989  C4; complement component 4
   05150 Staphylococcus aureus infection
    K03989  C4; complement component 4
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K03989  C4; complement component 4
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03989  C4; complement component 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03989  C4; complement component 4
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03989  C4; complement component 4
Peptidases and inhibitors [BR:ko01002]
 Peptidase inhibitors
  Family I39: alpha2M family
   K03989  C4; complement component 4
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K03989  C4; complement component 4
  Exosomal proteins of other cancer cells
   K03989  C4; complement component 4
Genes
HSA: 720(C4A) 721(C4B)
PTR: 100616513 462577
PPS: 100988452
GGO: 101146168 101148680
PON: 100171517(C4B)
NLE: 100596445
MCC: 721200 723314
MCF: 102123546(C4A) 102132156
CSAB: 103221723(C4B) 103221732
CATY: 105583245(C4A)
PANU: 101024934
RRO: 104659391(C4A) 104678146
TFN: 117086984
PTEH: 111531048
CJC: 100411501(C4A)
SBQ: 101045782(C4A)
MMUR: 105858157
MMU: 12268(C4b) 625018(C4a)
MCAL: 110283979
MPAH: 110335909(C4a)
RNO: 24233(C4a) 406161(C4b)
MCOC: 116074977(C4a)
MUN: 110560118(C4a)
CGE: 100767983(C4a)
PLEU: 114705860
NGI: 103724415
HGL: 101719002(C4a)
CPOC: 100728345
CCAN: 109689567
OCU: 100356976(C4A)
OPI: 101518028
TUP: 102483263(C4A)
CFA: 481722
VVP: 112913631
VLG: 121500739(C4A)
AML: 100475765
UMR: 103682335(C4A)
UAH: 113243734
ORO: 101380173
ELK: 111152244
MPUF: 101688875(C4A)
EJU: 114222096
MLX: 118027309
FCA: 101094346
PYU: 121022332
PBG: 122478260
PTG: 102967020(C4A)
PPAD: 109260502
AJU: 106983498
HHV: 120221895(C4A)
BOM: 102269445(C4A) 102280288
ODA: 120859350
SSC: 445467(C4A)
CFR: 102521056
CBAI: 105074038(C4A)
CDK: 105087437(C4A)
BACU: 103015179(C4A)
LVE: 103087928(C4A)
OOR: 101279376
DLE: 111170700
PCAD: 102989916
PSIU: 116762652
ECB: 100059239
EPZ: 103563298(C4A)
EAI: 106831006
MYB: 102254455(C4A)
MYD: 102774999(C4A)
MMYO: 118679563(C4A)
MLF: 102435940
MNA: 107538990
PKL: 118705351
HAI: 109373128
DRO: 112302138
SHON: 118979529(C4A)
AJM: 119053698
PDIC: 114494413
MMF: 118621124
RFQ: 117020465
PALE: 102898626(C4A)
PGIG: 120618894(C4A)
PVP: 105305288(C4A)
RAY: 107498435(C4A)
MJV: 108393997(C4A)
TOD: 119252237
LAV: 100667171(C4A)
TMU: 101351736
MDO: 100025543(C4A)
GAS: 123245156(C4A)
SHR: 100923960
PCW: 110199439(C4A)
OAA: 103165320(C4A)
GGA: 418892(C4A) 426611(C4)
TGU: 100231134
LSR: 110468582
SCAN: 103827373
PMOA: 120496315
OTC: 121337306
PRUF: 121353296
GFR: 102032664(C4A)
FAB: 101810518(C4A)
PHI: 102114525(C4A)
PMAJ: 107210755
CCAE: 111945366
CCW: 104689934
ETL: 114063749
FPG: 101924008(C4B)
FCH: 102048743
CLV: 102094160
EGZ: 104131486
NNI: 104010873
ACUN: 113484218
TALA: 104357035
PADL: 103913434
AROW: 112974022
NPD: 112959289
ASN: 102383747
AMJ: 102568973
PSS: 102454722
CMY: 102944866
TST: 117871016
CABI: 116833560
ACS: 100554736(c4b)
PVT: 110089773
SUND: 121921798
PBI: 103063425
PMUR: 107297122
TSR: 106545859
PGUT: 117667875
ZVI: 118080967
XLA: 394275(c4a.L)
XTR: 100135012(c4a)
DRE: 566261(c4) 794635(c4b)
TRU: 101065354
LCO: 104922750
NCC: 104965571
CGOB: 115021288
PLEP: 121945174(c4b)
SLUC: 116049377(c4b)
ECRA: 117945984(c4b)
PFLV: 114556849
GAT: 120810611(c4b)
PPUG: 119197188(c4b)
CUD: 121513534(c4b)
OLA: 100049261(c4b) 110016646
OML: 112143386(c4b)
XMA: 102220196
XCO: 114140756
XHE: 116716986
PRET: 103478546
GAF: 122831411(c4b)
CTUL: 119772833(c4b)
NFU: 107372375
KMR: 108242012 108242013(c4b)
AOCE: 111588842
POV: 109633561
SSEN: 122775106(c4b)
HHIP: 117776693(c4b)
LCF: 108891077
SDU: 111238774
SLAL: 111668799
XGL: 120784515(c4b)
MALB: 109971691
AANG: 118210051(c4) 118231169(c4b)
LOC: 102691668
PSPA: 121299232(c4b) 121302941
LCM: 102346391
RTP: 109927203
 » show all
Reference
PMID:2395880
  Authors
Carroll MC, Fathallah DM, Bergamaschini L, Alicot EM, Isenman DE
  Title
Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.
  Journal
Proc Natl Acad Sci U S A 87:6868-72 (1990)
DOI:10.1073/pnas.87.17.6868
  Sequence
[hsa:720 721]
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