KEGG   ORTHOLOGY: K04127
Entry
K04127                      KO                                     
Symbol
cefD
Name
isopenicillin-N epimerase [EC:5.1.1.17]
Pathway
map00311  Penicillin and cephalosporin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00673  Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C
Reaction
R04147  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K04127  cefD; isopenicillin-N epimerase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K04127  cefD; isopenicillin-N epimerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.1  Acting on amino acids and derivatives
    5.1.1.17  isopenicillin-N epimerase
     K04127  cefD; isopenicillin-N epimerase
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide tailoring proteins
  Others
   K04127  cefD; isopenicillin-N epimerase
Other DBs
GO: 0045439
Genes
XCC: XCC1212(nifS)
XCB: XC_3030
XCA: xcc-b100_3093(cefD)
XCP: XCR_1454
XAX: XACM_1285
XPE: BJD13_10100
XDY: NYR95_07600
XRY: QN244_11760
RSO: RSp0696
RSE: F504_4019 F504_4523
RPU: CDC45_21100
RNC: GO999_17565
RSC: RCFBP_10279
RSL: RPSI07_mp0854(cefD)
RSN: RSPO_c00320(cefD)
RSM: CMR15_mp10667
RSY: RSUY_02990(cefD)
BMA: BMAA0692
BML: BMA10229_0775
BMN: BMA10247_A1739
BMAL: DM55_4745
BMAE: DM78_3245
BMAQ: DM76_3699
BMAI: DM57_12105
BMAF: DM51_4398
BMAZ: BM44_4735
BMAB: BM45_4997
BPS: BPSS0826
BPM: BURPS1710b_A2417(cefD)
BPL: BURPS1106A_A1140(cefD)
BPD: BURPS668_A1215
BPSE: BDL_4112
BPSM: BBQ_5312
BPSU: BBN_4284
BPSD: BBX_5952
BPZ: BP1026B_II0908
BPQ: BPC006_II1157
BPK: BBK_3615
BPSH: DR55_4511
BPSA: BBU_5206
BPSO: X996_4060
BUT: X994_3738
BTD: BTI_5642
BHG: I6G56_23855
BUD: AQ610_26555
BUL: BW21_5329
RGE: RGE_38680
RBN: RBXJA2T_10891
SMIO: CATMQ487_06660
MPAU: ZMTM_08360(cefD)
DEQ: XM25_21970
DEI: C4375_02015
DEA: FPZ08_09510
DSAL: K1X15_04340
DEVO: H4N61_13030
DOY: JI749_08445
YTI: FNA67_03420
MEY: TM49_09960
PPAF: I8N54_06570
CBOT: ATE48_18515
RAP: RHOA_1134
SHUM: STHU_41780(cefD)
SVC: STVA_45250(nifS)
STEL: STAQ_06800(nifS_2)
HTQ: FRZ44_45180(nifS)
HADH: FRZ61_42820(nifS)
THAR: T8K17_17400
MXA: MXAN_5758(cefD)
MSD: MYSTI_06344
MYM: A176_001151
MFB: MFUL124B02_33455
MYX: QEG98_31635
MLAN: JY572_35280
CCX: COCOR_06250(cefD)
MMAS: MYMAC_005550
PPAK: JY651_02520
SUR: STAUR_6423(cefD)
AGE: AA314_08250
AVM: JQX13_27415
MBD: MEBOL_001410
CFUS: CYFUS_008015
SCL: sce8130
SCU: SCE1572_47340
CCRO: CMC5_004080
PAUU: E8A73_014625
MRM: A7982_01717
SAMY: DB32_008262
NANN: O0S08_20395
PCAY: FRD00_09290
MMAG: MMAD_03810(cefD)
SGB: WQO_32335
SVL: Strvi_7696
SRC: M271_39675
SMAL: SMALA_2490
SSOI: I1A49_15905
SBH: SBI_00921
STRM: M444_06915
SCX: AS200_38920
STRF: ASR50_18190
STRT: A8713_30255
SCLF: BB341_07745
SGM: GCM10017557_05590(nifS)
SCAD: DN051_04840
SPHW: NFX46_16550
SAUO: BV401_15975
SLAU: SLA_7034
SLX: SLAV_07070(cefD2)
SFK: KY5_0714
SNZ: DC008_32885
SGE: DWG14_07627(cefD_2)
SCYA: EJ357_00895
SAST: CD934_13720
STIR: DDW44_23120
SKA: CP970_39425
SGZ: C0216_11470
SVN: CP980_05600
SVR: CP971_26680
SSUB: CP968_06165
SFUG: CNQ36_15950
SCHA: CP983_42365
SGX: H4W23_37025
SNF: JYK04_06931(cefD)
SCHF: IPT68_00485
SFEU: IM697_21765
SPRA: CP972_16780
SLF: JEQ17_04340
SYAN: NRK68_29015
STAA: LDH80_35675
STUB: MMF93_07995
SXT: KPP03845_106182(cefD_2)
SLON: LGI35_03655
STEE: F3L20_30335
SGK: PET44_05500
SANT: QR300_14510
SROC: RGF97_02650
STTN: BSL84_28655
SLUO: PS467_14415
SCT: SCAT_5686(cefD)
SCY: SCATT_56860
KSK: KSE_61030 KSE_67160
KAU: B6264_21240
KIT: CFP65_1261
KIS: HUT16_28860 HUT16_31665
KCH: O1G21_30720
MIM: AKG07_10945
MIX: AB663_000507
MIP: AXH82_04565
MICR: BMW26_15685
MFOL: DXT68_15110
MOY: CVS54_03345(cefD)
MLIQ: NMQ05_16130
MPAO: IZR02_15015
MAZA: NFX31_15115
MSUW: GCM10025863_29000
MEST: PTQ19_13950
MAUG: KV397_01800
MSUF: KV394_03220
MVD: AWU67_11780
SALA: ESZ53_08205
PLAP: EAO79_07900
PFLU: BWO91_03995
LYH: FrondiHNR_12415
ARM: ART_1339
AAQ: AOC05_09685
ARW: MB46_10130
APOA: J0916_09220
PNV: JMY29_01460
BHQ: BRM3_00490
YIM: J5M86_05170
ICA: Intca_2268
PEI: H9L10_13110
TED: U5C87_18950
SERW: FY030_12905
HALT: IM660_18840
RHAL: LQF10_18445
RSUA: LQF12_15750
MIK: FOE78_15590
MICG: GJV80_09610
TEZ: BKM78_07710
TLA: TLA_TLA_01558(cefD)
TEJ: KDB89_13755
TLS: QH948_00940
NMES: H9L09_05140
SGRG: L0C25_21415
KFL: Kfla_3594
KQI: F1D05_04065
KSL: OG809_32655
KRI: OX958_18130
SRO: Sros_3487
NAK: EH165_10100
KRA: Krad_0174
AAB: A4R43_03210
AMYY: YIM_39195(cefD)
MAU: Micau_1400
MIL: ML5_1645
MICB: MicB006_1421
MTUA: CSH63_17225
MICH: FJK98_07455
MTEM: GCE86_01155
MCAB: HXZ27_08180
MSAG: GCM10017556_39760
VMA: VAB18032_11635
MCRA: ID554_04995
VER: HUT12_07990
MCHL: PVK74_28195
MFEU: H1D33_13810
MPRN: Q3V37_00100
MHAW: RMN56_04410
MCAY: PVK37_14095
MICF: QQG74_07460
ASE: ACPL_7270(cefD)
AMS: AMIS_70160
ACTN: L083_6863(cefD)
ACTS: ACWT_7140
AIH: Aiant_31070
ACTR: Asp14428_61970
ACTL: L3i22_095920
ASIC: Q0Z83_099930
AOU: ACTOB_007551
ACTE: ACTI_10340
AFS: AFR_36275
PLK: CIK06_07210
PLAB: C6361_16300
PLAT: C6W10_13995
PFLA: Pflav_086350
PSUU: Psuf_049280 Psuf_059680
ATL: Athai_23090
ASER: Asera_51820
PRY: Prubr_39970
CATI: CS0771_23670
DVC: Dvina_08360
DFU: Dfulv_07810
DROS: Drose_08095
DAUR: Daura_07780
DMAT: Dmats_07870
DACT: KZZ52_07640
CCAZ: COUCH_08195
CAI: Caci_5559
SNA: Snas_2195
MCU: HMPREF0573_11857
BSCA: BBSC_0334 BBSC_0361
CYA: CYA_0818(cefD)
CYB: CYB_1874(cefD)
CYN: Cyan7425_0721
LEN: LEP3755_56000
LET: O77CONTIG1_02952(cefD_2)
LBO: LBWT_6690
KOV: K9N68_00020
LSC: KIK02_18180
LSK: J5X98_02080
PSEU: Pse7367_0560
THEU: HPC62_17260
TOG: HNI00_21275
TSIN: OXH18_24755
MAR: MAE_52910
MPK: VL20_1539
MIQ: B5D77_20865
MVZ: myaer102_25690
CYC: PCC7424_2941
CYJ: Cyan7822_0165
PAGH: NIES204_01190
PPSU: NO713_03427(cefD)
PRUN: PCC7821_04246(cefD)
OXY: HCG48_13595
MVAG: D0A34_08910
OAC: Oscil6304_1893
ONI: Osc7112_1264
MIC: Mic7113_6306
GEI: GEI7407_2493
NOS: Nos7107_3892
NOP: Nos7524_1419
NFL: COO91_06390
NSH: GXM_02799
NPZ: ACX27_12290
NCW: NIES2107_54930
CALT: Cal6303_1535
CALH: IJ00_06455
CALN: NIES2098_14720
CALS: NIES3974_08800
MDP: NIES3275_41990
STOQ: K2F26_09420
SKV: NIES73_17550
TOQ: HCG51_18985
TTQ: NIES37_54700
ALAX: NIES50_31850
SCYS: NIES4073_38250
PLP: Ple7327_4280
RRS: RoseRS_1377
RCA: Rcas_3584
CAU: Caur_1659
CHL: Chy400_1800
CAG: Cagg_2502
CALL: OZ401_003486
ATM: ANT_18540
CAP: CLDAP_22540
PBF: CFX0092_A1218
KBS: EPA93_01175
PMET: G4Y79_02185
MRB: Mrub_1746
MRE: K649_13825
MTAI: Mtai_v1c12130
LAMB: KBB96_08940
RBA: RB7564(cefD)
PSL: Psta_2194
PIR: VN12_10170(cefD)
RML: FF011L_05920(cefD)
MFF: MFFC18_08200(cefD)
ROL: CA51_19080(cefD)
RUV: EC9_16400(cefD)
RCF: Poly24_22620(cefD)
LCRE: Pla8534_29080(cefD)
AAGG: ETAA8_46010(cefD_1)
BVO: Pan97_28140(cefD)
BREM: PSR63_25235
RLC: K227x_38360(cefD)
SMAM: Mal15_34460(cefD_2)
SNEP: Enr13x_47230(cefD)
AMUC: Pan181_34570(cefD)
PLM: Plim_1607
PEH: Spb1_24620(cefD)
PBS: Plabr_2872
PLS: VT03_15840(cefD)
FMR: Fuma_05761(cefD)
MRI: Mal4_46350(cefD)
SDYN: Mal52_22760(cefD)
PLON: Pla110_41390(cefD)
ACAF: CA12_17910(cefD)
SVP: Pan189_33820(cefD)
TPOL: Mal48_03320(cefD)
CHYA: V22_06160(cefD)
CCOS: Pan44_24230(cefD)
PVAR: SH412_001124
GES: VT84_18005(cefD)
GOG: C1280_18815
GMS: SOIL9_20600
TIM: GMBLW1_51170
LRS: PX52LOC_01421
FTJ: FTUN_5065
ULI: ETAA1_15630(cefD)
TSPH: KIH39_02625
IPA: Isop_2866
TPLA: ElP_18640(cefD_1)
HBS: IPV69_22455
PBAP: Pla133_49220(cefD_3)
ABAC: LuPra_04390(cefD_4)
LUB: TBR22_A33070(nifS)
SEDT: TEGAF0_09370
FBR: FBFL15_2075
FPAL: HYN49_06285
FMG: HYN48_05940
FSN: GS03_01086(cefD)
FNK: E1750_07650
FSD: LXD69_03430
FTE: Fluta_3137
FLU: CHH17_06265
CRM: K6119_12295
AG: AAA26714(cefD)
 » show all
Reference
PMID:1694525
  Authors
Kovacevic S, Tobin MB, Miller JR
  Title
The beta-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerus.
  Journal
J Bacteriol 172:3952-8 (1990)
DOI:10.1128/JB.172.7.3952-3958.1990
  Sequence
[ag:AAA26714]
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