KEGG ORTHOLOGY: K06450

ORTHOLOGY: K06450

Entry

K06450                      KO

Symbol

CD3D

Name

T-cell surface glycoprotein CD3 delta chain

Pathway

map04640

Hematopoietic cell lineage

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map05142

Chagas disease

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05340

Primary immunodeficiency

Disease

H00091

T-B+Severe combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04660 T cell receptor signaling pathway
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04658 Th1 and Th2 cell differentiation
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04659 Th17 cell differentiation
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05170 Human immunodeficiency virus 1 infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05162 Measles
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05169 Epstein-Barr virus infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09163 Immune disease
   05340 Primary immunodeficiency
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
CD molecules [BR:ko04090]
Proteins
  K06450  CD3d; CD3D antigen, delta polypeptide (TiT3 complex)

Genes

HSA:

915(CD3D)

PTR:	451584(CD3D)

PPS:

GGO:

PON:

PPYG:

NLE:	100603907(CD3D)

HMH:

116477008

SSYN:

129479736

MCC:	699582(CD3D)

MCF:

102133701

MTHB:

126936070

MNI:	105476413(CD3D)

CSAB:

103248585(CD3D)

CATY:

105582471(CD3D)

PANU:

101017443(CD3D)

TGE:	112606384(CD3D)

MLEU:

105528217(CD3D)

RRO:	104665574(CD3D)

RBB:	108536385(CD3D)

TFN:	117080882(CD3D)

PTEH:

111540206(CD3D)

CANG:

105501093(CD3D)

CJC:	100404313(CD3D)

SBQ:	101029738(CD3D)

CIMI:

108300597(CD3D)

ANAN:

105729556

CSYR:

103252246(CD3D)

MMUR:

105876053(CD3D)

LCAT:

123641520(CD3D)

PCOQ:

105819245(CD3D)

OGA:	100966280(CD3D)

MMU:	12500(Cd3d)

MCAL:

110302262(Cd3d)

MPAH:

110328514(Cd3d)

RNO:	25710(Cd3d)

MCOC:

116072408(Cd3d)

ANU:	117699353(Cd3d)

ASYL:

127689158

MUN:

110549118

CGE:	100756906(Cd3d)

MAUA:

101836347(Cd3d)

PROB:

127231639

PLEU:

114691294(Cd3d)

MORG:

121438266(Cd3d)

MFOT:

126510037

AAMP:

119809864(Cd3d)

NGI:	103748303(Cd3d)

HGL:	101712534(Cd3d)

CPOC:

100727506(Cd3d)

CCAN:

109699106(Cd3d)

DORD:

105980551(Cd3d)

DSP:	122110306(Cd3d)

PLOP:

125349618

NCAR:

124958813

MMMA:

107145809

ITI:	101958960(Cd3d)

OCU:

100356153

OPI:	101529860(CD3D)

TUP:	102498607(CD3D)

GVR:	103592269(CD3D)

CFA:	479419(CD3D)

CLUD:

112671248

VVP:	112920226(CD3D)

VLG:	121500522(CD3D)

NPO:

129497002

AML:	100484718(CD3D)

UMR:	103662337(CD3D)

UAH:

113260002

UAR:	123792618(CD3D)

ELK:

111153823

LLV:

125080069

MPUF:

101676392(CD3D)

MNP:

132027468

MLK:

131836621

NVS:	122912335(CD3D)

ORO:	101385969(CD3D)

EJU:	114211431(CD3D)

ZCA:	113914770(CD3D)

MLX:	118013287(CD3D)

NSU:	110586281(CD3D)

LWW:	102729861(CD3D)

FCA:	101083107(CD3D)

PYU:	121035465(CD3D)

PCOO:

112865955(CD3D)

PBG:	122483025(CD3D)

PVIV:

125176525

LRUF:

124504775

LGF:	123600744(CD3D)

AJU:

106966153

PTG:	102969057(CD3D)

PPAD:

109278564(CD3D)

PUC:

125909406

PLEZ:

122199658(CD3D)

HHV:	120229959(CD3D)

BTA:	281053(CD3D)

BOM:	102272573(CD3D)

BIU:	109569960(CD3D)

BBUB:

102390133(CD3D)

BBIS:

104981365(CD3D)

CHX:	102191154(CD3D)

OAS:	443397(CD3D)

BTAX:

128060506

CSUM:

138093162(CD3D)

ODA:	120876320(CD3D)

CCAD:

122450232(CD3D)

MREE:

136174768(CD3D)

OVR:	110133012(CD3D)

MBEZ:

129553778

SSC:	396661(CD3D)

CFR:	102505672(CD3D)

CBAI:

105067818(CD3D)

CDK:	105090171(CD3D)

VPC:	102533755(CD3D)

BACU:

103003761(CD3D)

BMUS:

118899710(CD3D)

LVE:	103069825(CD3D)

OOR:

101279567

DLE:	111166923(CD3D)

PCAD:

102979567

PSIU:

116758073(CD3D)

NASI:

112404016(CD3D)

ECB:	100062931(CD3D)

EPZ:	103546675(CD3D)

EAI:	106840277(CD3D)

MYB:	102240563(CD3D)

MYD:	102753304(CD3D)

MMYO:

118664240(CD3D)

MLF:	102436834(CD3D)

MDT:

132240484

MYUM:

139017562(CD3D)

PKL:	118710562(CD3D)

EFUS:

103293741

MNA:	107530792(CD3D)

DRO:	112314228(CD3D)

SHON:

118994764(CD3D)

AJM:

119050808

PDIC:

114500133(CD3D)

PHAS:

123819998(CD3D)

MMF:	118628139(CD3D)

PPAM:

129086044

HAI:	109385283(CD3D)

RFQ:	117029810(CD3D)

PALE:

102894486(CD3D)

PGIG:

120622049(CD3D)

PVP:	105310192(CD3D)

RAY:	107516062(CD3D)

MJV:	108385099(CD3D)

TOD:

119239888

SARA:

101545654(CD3D)

SFUM:

130016829

SETR:

126015814

LAV:	100661471(CD3D)

TMU:

101353008

ETF:	101663960(CD3D)

DNM:	101413471(CD3D)

MDO:	100031472(CD3D)

GAS:	123242099(CD3D)

SHR:

100925080

PCW:	110207189(CD3D)

TVP:	118839151(CD3D)

PBRV:

138145061(CD3D)

OAA:

100090811

TACU:

119935108(CD3D)

GGA:	396518(CD3D)

PCOC:

116233175(CD3D)

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106039849(CD3D)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

120508489(CD3D)

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

ETL:	114056275 114056276

ZAB:

102070969

ZLE:

135457479

ACHL:

103806926(CD3D)

SVG:

MMEA:

HRT:

SATI:

CCIC:

FPG:	101916542(CD3D)

FCH:	102052093(CD3D)

CCRI:

104154784(CD3D)

NNT:

SHAB:

ACUN:

TALA:

ACHC:

115344581(CD3D)

HALD:

104311029(CD3D)

HLE:	104836397(CD3D)

AGEN:

HHAR:

GCL:

CSTI:

LDI:

MNB:	103774581(CD3D)

DPUB:

104301766

PPUS:

135191118

AVIT:

104270071(CD3D)

BRHI:

104497096(CD3D)

EGZ:

104124562

NNI:	104019039(CD3D)

PCRI:

104037975(CD3D)

PCAO:

104041595(CD3D)

PADL:

103921538(CD3D)

AFOR:

103894943(CD3D)

FGA:	104073434(CD3D)

GSTE:

104260227(CD3D)

CBOY:

140661830

CLV:	102092403(CD3D)

MUI:	104533869(CD3D)

PGUU:

104462628(CD3D)

PLET:

104623866(CD3D)

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:	104332056(CD3D)

ACAR:

104521634

CPEA:

104398739

CVF:	104295032(CD3D)

RTD:

128918575

CRID:

134524909

AAM:	106491545(CD3D)

AROW:

112962044(CD3D)

NPD:	112948068(CD3D)

DNE:	112991715(CD3D)

ASN:	102382203(CD3D)

AMJ:	102572479(CD3D)

CPOO:

109315403(CD3D)

GGN:	109293913(CD3D)

CMY:	102940831(CD3G)

CCAY:

125625339

DCC:	119846672(CD3G)

CPIC:

101940477

TST:

117868715

CABI:

116822944(CD3G)

MRV:

ACS:

ASAO:

SUND:

NSS:	113420886(CD3G)

VKO:

PRAF:

ZVI:

HCG:

GJA:	107112603(CD3G)

STOW:

EMC:

PWL:

SRX:

SGH:

CAUA:

TDW:

IPU:

TVC:

TRU:	654302(cd3g/d)

TNG:	GSTEN00012261G001

MSAM:

119883393

MZE:	101473769(cd3g)

XMA:

111611912

XCO:

114133423

CVG:	107080968 107102634

NFU:

ALIM:

CSEM:

SDU:

XGL:

SASA:

100136515 100137057 106580890

OTW:

112266839

OMY:

110503669

SALP:

111957658

LOC:	107075658(cd3d)

ARUT:

RTP:

CPLA:

HOC:

LERI:

Reference

PMID:3488209

Authors

Tunnacliffe A, Sims JE, Rabbitts TH

Title

T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.

Journal

EMBO J 5:1245-52 (1986)
DOI:10.1002/j.1460-2075.1986.tb04353.x

Sequence

[hsa:915]

Reference

PMID:15546002

Authors

de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F

Title

Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.

Journal

J Clin Invest 114:1512-7 (2004)
DOI:10.1172/JCI22588

LinkDB

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