KEGG ORTHOLOGY: K09278

ORTHOLOGY: K09278

Entry

K09278                      KO

Symbol

RUNX2, AML3

Name

runt-related transcription factor 2

Pathway

map04928

Parathyroid hormone synthesis, secretion and action

map05202

Transcriptional misregulation in cancer

Disease

H00479

Metaphyseal dysplasias

H00521

Cleidocranial dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K09278  RUNX2, AML3; runt-related transcription factor 2
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09278  RUNX2, AML3; runt-related transcription factor 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09278  RUNX2, AML3; runt-related transcription factor 2
Transcription factors [BR:ko03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   Runt
    K09278  RUNX2, AML3; runt-related transcription factor 2

Genes

HSA:	860(RUNX2)

PTR:	472017(RUNX2)

PPS:	100970671(RUNX2)

GGO:	101147953(RUNX2)

PON:	100453201(RUNX2)

PPYG:

129037896(RUNX2)

NLE:	100588616(RUNX2)

HMH:	116460259(RUNX2)

SSYN:

129473452(RUNX2) 129473775

MCC:	703331(RUNX2)

MCF:	102124310(RUNX2)

MTHB:

126953010

MNI:	105489529(RUNX2)

CSAB:

103221423(RUNX2)

CATY:

105590944(RUNX2)

PANU:

101005700(RUNX2)

TGE:	112623412(RUNX2)

MLEU:

105544366(RUNX2)

RRO:	104669542(RUNX2)

RBB:	108533434(RUNX2)

TFN:	117087302(RUNX2)

PTEH:

111543105(RUNX2)

CANG:

105524875(RUNX2)

CJC:	100406564(RUNX2)

SBQ:	101034272(RUNX2)

CIMI:

108286968(RUNX2)

ANAN:

105714691(RUNX2)

CSYR:

103259536(RUNX2)

MMUR:

105859527(RUNX2)

LCAT:

123631944(RUNX2)

PCOQ:

105826653(RUNX2)

OGA:	100962162(RUNX2)

MMU:	12393(Runx2)

MCAL:

110312495(Runx2)

MPAH:

110335449(Runx2)

RNO:	367218(Runx2)

MCOC:

116075311(Runx2)

ANU:	117722418(Runx2)

ASYL:

127692153(Runx2)

MUN:	110555956(Runx2)

CGE:	100753922(Runx2)

MAUA:

101835587(Runx2)

PROB:

127236527(Runx2)

PLEU:

114707829(Runx2)

MORG:

121450837(Runx2)

MFOT:

126486857

AAMP:

119822669(Runx2)

NGI:	103730759(Runx2)

HGL:	101724767(Runx2)

CPOC:

100734175(Runx2)

CCAN:

109676134 109682118(Runx2)

DORD:

105987726(Runx2)

DSP:	122101608(Runx2)

DMER:

138828016(Runx2)

PLOP:

125352523(Runx2)

NCAR:

124989118

MMMA:

107143653(Runx2)

ITI:	101972533(Runx2)

OCU:

100008943

OPI:	101525925(RUNX2)

OCZ:	121158621(RUNX2)

TUP:	102494351(RUNX2)

GVR:	103581869(RUNX2)

CFA:	449531(RUNX2)

CLUD:

112641666(RUNX2)

VVP:	112914043(RUNX2)

VLG:	121488278(RUNX2)

NPO:	129512579(RUNX2)

AML:	100481039(RUNX2)

UMR:	103664043(RUNX2)

UAH:	113261240(RUNX2)

UAR:	123795112(RUNX2)

ELK:

111147562

LLV:

125102232

MPUF:

101681651(RUNX2)

MNP:	132018000(RUNX2)

MLK:	131834045(RUNX2)

NVS:	122908797(RUNX2)

ORO:	101372800(RUNX2)

EJU:	114204642(RUNX2)

ZCA:	113926433(RUNX2)

MLX:	118001492(RUNX2)

NSU:	110581964(RUNX2)

LWW:	102727912(RUNX2)

FCA:	101089612(RUNX2)

PYU:	121029244(RUNX2)

PCOO:

112862781(RUNX2)

PBG:	122489581(RUNX2)

PVIV:

125165320(RUNX2)

LRUF:

124528193

LGF:	123608450(RUNX2)

AJU:

106973952

PTG:	102956197(RUNX2)

PPAD:

109271691(RUNX2)

PUC:

125937879

PLEZ:

122219978(RUNX2)

HHV:	120231215(RUNX2)

BTA:	536911(RUNX2)

BOM:	102275238(RUNX2)

BIU:	109577177(RUNX2)

BBUB:

102416200(RUNX2)

BBIS:

105005187(RUNX2)

CHX:	102183278(RUNX2)

OAS:	101115489(RUNX2)

BTAX:

128055309(RUNX2)

CSUM:

138069353(RUNX2)

ODA:	120870053(RUNX2)

CCAD:

122429548(RUNX2)

MREE:

136151303(RUNX2)

OVR:	110131899(RUNX2)

MBEZ:

129543186(RUNX2)

SSC:	100737965(RUNX2)

CFR:	102518703(RUNX2)

CBAI:

105083833(RUNX2)

CDK:	105088103(RUNX2)

VPC:	102532256(RUNX2)

BACU:

103013421(RUNX2)

BMUS:

118904096(RUNX2)

LVE:	103071306(RUNX2)

OOR:	101276079(RUNX2)

LALB:

132527394(RUNX2)

GMF:	115860631(RUNX2)

DDP:	132431956(RUNX2)

DLE:	111178880(RUNX2)

PCAD:

102973449(RUNX2)

PSIU:

116762666(RUNX2)

PPHC:

136130033(RUNX2)

NASI:

112413812(RUNX2)

ECB:	100033890(RUNX2)

EPZ:	103565981(RUNX2)

EAI:	106828760(RUNX2)

MYB:	102258581(RUNX2)

MYD:	102766309(RUNX2)

MMYO:

118659733(RUNX2)

MLF:	102423415(RUNX2)

MDT:	132237271(RUNX2)

MYUM:

139012468(RUNX2)

PKL:	118705191(RUNX2)

EFUS:

103296614(RUNX2)

MNA:	107536840(RUNX2)

DRO:	112302373(RUNX2)

SHON:

118992272(RUNX2)

AJM:	119047190(RUNX2)

PDIC:

114493813(RUNX2)

PHAS:

123821528(RUNX2)

MMF:	118621644(RUNX2)

PPAM:

129067498(RUNX2)

HAI:	109382927(RUNX2)

RFQ:	117019177(RUNX2)

PALE:

102886724(RUNX2)

PGIG:

120596023(RUNX2)

PVP:	105288506(RUNX2)

RAY:	107503218(RUNX2)

MJV:	108403615(RUNX2)

TOD:	119252525(RUNX2)

SFUM:

130034426(RUNX2)

SETR:

125996600(RUNX2)

LAV:	100658815(RUNX2)

TMU:

101345377

ETF:	101650778(RUNX2)

DNM:	101429569(RUNX2)

MDO:	100619969(RUNX2)

GAS:	123246430(RUNX2)

SHR:	100917959(RUNX2)

AFZ:

127561808

PCW:	110213479(RUNX2)

TVP:	118856948(RUNX2)

PBRV:

138144531(RUNX2)

MLAO:

141523693(RUNX2)

OAA:	100080409(RUNX2)

TACU:

119932119(RUNX2)

GGA:	373919(RUNX2)

PCOC:

116236340(RUNX2)

MGP:	100549663(RUNX2)

CJO:	107312455(RUNX2)

TPAI:

128085294(RUNX2)

LMUT:

125688832(RUNX2)

NMEL:

110396414(RUNX2)

APLA:

101803341(RUNX2)

ACYG:

106038170(RUNX2)

CATA:

118254683(RUNX2)

AFUL:

116487703(RUNX2)

TGU:	100222668(RUNX2)

LSR:	110468943(RUNX2)

SCAN:

103823178(RUNX2)

PMOA:

120496008(RUNX2)

OTC:	121347496(RUNX2)

PRUF:

121360832(RUNX2)

ATRC:

139599687(RUNX2)

GFR:	102032615(RUNX2)

FAB:	101819157(RUNX2)

OMA:	130251135(RUNX2)

PHI:

102099411

PMAJ:

107202143(RUNX2)

CCAE:

111927494(RUNX2)

CCW:	104685481(RUNX2)

CBRC:

103622886(RUNX2)

ACOE:

138108726(RUNX2)

ETL:	114058832(RUNX2)

ZAB:	102068819(RUNX2)

ZLE:	135446222(RUNX2)

SVG:	106851158(RUNX2)

MMEA:

130578969(RUNX2)

HRT:	120750285(RUNX2)

SATI:

136358727(RUNX2)

CCIC:

134042385(RUNX2)

FPG:	101924686(RUNX2)

FCH:	102057313(RUNX2)

CCRI:

104157912

NNT:	104404098(RUNX2)

SHAB:

115609240(RUNX2)

ACUN:

113478892(RUNX2)

TALA:

104358392(RUNX2)

ACHC:

115351032(RUNX2)

HLE:	104841492(RUNX2)

AGEN:

126046648

HHAR:

128151721(RUNX2)

GCL:

127014681

CSTI:

104554695(RUNX2)

LDI:	104354887(RUNX2)

MNB:	103771962(RUNX2)

DPUB:

104304566(RUNX2)

PPUS:

135176640(RUNX2)

AVIT:

104280617(RUNX2)

BRHI:

104492883(RUNX2)

EGZ:	104127018(RUNX2)

NNI:	104014742(RUNX2)

PCRI:

104036972

PCAO:

104041258

PADL:

103913261(RUNX2)

AFOR:

103906944(RUNX2)

FGA:

104077451

CBOR:

142080068(RUNX2)

GSTE:

104264323

CBOY:

140650254(RUNX2)

MAME:

142407970(RUNX2)

CLV:	102096882(RUNX2)

CNIC:

135986587(RUNX2)

MUI:	104540769(RUNX2)

CMAC:

104479028(RUNX2)

CUCA:

104057117(RUNX2)

TEO:	104377022(RUNX2)

OHA:	104332768(RUNX2)

ACAR:

104530982(RUNX2)

CPEA:

104395225(RUNX2)

CVF:	104286898(RUNX2)

RTD:	128906775(RUNX2)

CRID:

134513630(RUNX2)

LMIC:

141741404(RUNX2)

AAM:	106495205(RUNX2)

AROW:

112962876(RUNX2)

NPD:	112947829(RUNX2)

TGT:	104579793(RUNX2)

DNE:	112979537(RUNX2)

SCAM:

104139687(RUNX2)

ASN:	102386680(RUNX2)

AMJ:	102577398(RUNX2)

CPOO:

109311481(RUNX2)

GGN:	109300279(RUNX2)

PSS:	102461064(RUNX2)

CIZ:	142011610(RUNX2)

CMY:	102944969(RUNX2)

CCAY:

125634662(RUNX2)

DCC:	119853844(RUNX2)

CPIC:

101939013(RUNX2)

TST:	117875377(RUNX2)

CABI:

116837553(RUNX2)

MRV:	120400657(RUNX2)

ACS:	100555776(runx2)

ASAO:

132781272(RUNX2)

PVT:	110083231(RUNX2)

SUND:

121935451(RUNX2)

PBI:	103052745(RUNX2)

PMUR:

107284274(RUNX2)

CTIG:

120300336(RUNX2)

TSR:	106545883(RUNX2)

PGUT:

117671107(RUNX2)

PCAE:

139326879(RUNX2)

APRI:

131198618(RUNX2)

PTEX:

113441047(RUNX2)

NSS:	113422632(RUNX2)

VKO:	123017724(RUNX2)

PMUA:

114593480(RUNX2)

PRAF:

128409857(RUNX2)

ZVI:	118082590(RUNX2)

HCG:	128339736(RUNX2)

GJA:	107123757(RUNX2)

STOW:

125436172(RUNX2)

EMC:	129340625(RUNX2)

XLA:	100037059(runx2.L) 108718280

XTR:	100189546(runx2)

NPR:	108802224(RUNX2)

RTEM:

120936233(RUNX2)

ACAT:

141139283(RUNX2)

BBUF:

120997267(RUNX2)

BGAR:

122934367(RUNX2)

DTC:	141098599(RUNX2)

PWL:	138296710(RUNX2)

MUO:	115467080(RUNX2)

GSH:	117357015(RUNX2)

DRE:	405784(runx2a) 405788(runx2b)

SRX:	107717234 107726745 107733444 107743311

SANH:

107653853 107678859 107692356 107697170

SGH:	107549686 107552040 107594081 107603075

CCAR:

109106865 109113109 109113629

CAUA:

113080575 113092580 113095478 113095480 113117801 113120485

CGIB:

127933302 127938991 127976153 127983596

PTET:

122324345(runx2b) 122361760(runx2a)

LROH:

127179530(runx2a) 127183297(runx2b)

GRF:	141295268(runx2a) 141295316 141348661(runx2b)

OMC:	131523068(runx2a) 131527571(runx2b)

PPRM:

120471116(runx2a) 120491955(runx2b)

RKG:	130088933(runx2a) 130103108(runx2b)

MAMB:

125268306(runx2a) 125278438(runx2b)

CIDE:

127498481 127502591

CERY:

137006193(runx2a) 137018545(runx2b)

MASI:

127409856 127410717 127415663 127455192

TROS:

130560856(runx2a) 130565493(runx2b)

TDW:	130434874(runx2b) 130436510(runx2a)

MANU:

129417210(runx2a) 129430013(runx2b)

PDAB:

135736230(runx2a) 135738328(runx2b)

IPU:	108258149(runx2b) 108270157(runx2a)

IFU:	128601228(runx2b) 128613211(runx2a)

PHYP:

113538700(runx2) 113545368

SMEO:

124377425(runx2b) 124389883(runx2a)

TFD:	113644195(runx2b) 113659389(runx2a)

TVC:	132843301(runx2b) 132852353(runx2a)

CGAR:

128515230(runx2b) 128535532(runx2a)

NGRA:

132883753(runx2b) 132894561(runx2a)

TRN:	134320064(runx2b) 134324949(runx2a)

AMEX:

103028241(runx2b) 103042599(runx2a)

CMAO:

118815548(runx2b) 118823627(runx2a)

EEE:	113572678(runx2) 113588113

CHAR:

105897746 105909466(runx2a)

SPIL:

134067358(runx2a) 134098146

ASAD:

121693054(runx2a) 121712017

TRU:	445986(runx2)

TFS:	130515762(runx2b)

TNG:	GSTEN00018383G001

LCO:

104930001

NCC:	104958974(runx2)

TBEN:

117498484(runx2b)

CGOB:

115003446(runx2)

PGEO:

117439471(runx2b)

GACU:

117554373(runx2b)

EMAC:

134877030(runx2b)

ELY:	117271082(runx2b)

EFO:	125897084(runx2b)

PLEP:

121955414(runx2b)

SLUC:

116041957(runx2b)

ECRA:

117961116(runx2b)

ESP:	116706449(runx2)

PFLV:

114573304(runx2)

GAT:	120808333(runx2b)

AFB:	129107020(runx2b)

PSWI:

130202511(runx2b)

CANA:

137785499(runx2b)

CVE:

137887265

MSAM:

119909300(runx2b)

SCHU:

122863286(runx2b)

CUD:	121520888(runx2b)

SPUL:

138583954(runx2b)

LMIX:

132985220(runx2b)

HTC:	141801832(runx2b)

ALAT:

119013102(runx2b)

ASTR:

137613493(runx2b)

MZE:	101474902(runx2)

ONL:	100709317(runx2)

OAU:	116332248(runx2b)

OLA:	100049495(runx2)

OML:	112157729(runx2b)

CSAI:

133464596(runx2b)

XMA:	102216610 102236639

XCO:	114137946 114158594(runx2)

XHE:	116734168(runx2)

PRET:

103457845 103476608

PFOR:

103148026(runx2)

PLAI:

106964170(runx2)

PMEI:

106927107

GAF:	122825239(runx2b)

PPRL:

129368963(runx2b)

CVG:	107097507(runx2)

CTUL:

119784143(runx2b)

GMU:	124882028(runx2b)

NFU:

107378134

KMR:	108231786(runx2b)

ALIM:

106530950

NWH:	119418071(runx2b)

AOCE:

111573513(runx2b)

EJA:	138203598(runx2b)

BFRE:

138630104(runx2b)

MCEP:

124999357(runx2b)

CSEM:

103381039

POV:	109632346 109645274

SSEN:

122783641(runx2b)

SSOE:

131443868(runx2b)

HHIP:

117758157(runx2b)

HSP:	118099582(runx2b)

PPLT:

128460535(runx2b)

SMAU:

118290514(runx2b)

LCF:	108898077(runx2b)

SDU:	111237516(runx2)

SLAL:

111672707(runx2)

XGL:	120788977(runx2b)

HCQ:

109507234

SSCV:

125989912(runx2b)

SBIA:

133496374(runx2b)

PEE:	133417162(runx2b)

PTAO:

133468611(runx2b)

BPEC:

110173900(runx2)

ENY:	140355240(runx2b)

MALB:

109962211

BSPL:

114849536(runx2b)

SJO:	128376730(runx2b)

SSCO:

133998077(runx2b)

TTY:	137168876(runx2b)

GMH:	115534715(runx2)

SASA:

100286411 106592413

STRU:

115184136

OTW:

112239220

OMY:	110521125 110530744

OGO:	123990452 123995754 124046938

ONE:	115125436 115126411

OKI:	109882544(runx2) 109886710

OKE:	118369073 118383487 118387162

OMM:	135505616 135558021

OCLA:

SALP:

SNH:

SFON:

CCLU:

ELS:

OEP:	134007913(runx2a) 134025087(runx2b)

SFM:	108922388(runx2) 108929217

PKI:	111837672 111857910

AANG:

118234872(runx2a)

AROT:

135252525(runx2a) 135257702

CCOG:

133127313 133128414

LOC:	102697337(runx2)

PSPA:

121315621 121317431

ARUT:

117403041 117411045

PSEX:

120526314(runx2a)

LCM:	102349738(RUNX2)

CMK:	103184986(runx2a)

CPLA:

122543810(runx2a)

HOC:	132833237(runx2a)

SCAU:

119967411(runx2a)

LERI:

129697219(runx2a)

HAKA:

140733623

PMRN:

116955533

LPIC:

129259455

LVG:	121413870 121414003

PJA:

MAEA:

OBI:

HMG:

Reference

PMID:20580290

Authors

Blyth K, Vaillant F, Jenkins A, McDonald L, Pringle MA, Huser C, Stein T, Neil J, Cameron ER

Title

Runx2 in normal tissues and cancer cells: A developing story.

Journal

Blood Cells Mol Dis 45:117-23 (2010)
DOI:10.1016/j.bcmd.2010.05.007

Reference

PMID:10911365

Authors

Drissi H, Luc Q, Shakoori R, Chuva De Sousa Lopes S, Choi JY, Terry A, Hu M, Jones S, Neil JC, Lian JB, Stein JL, Van Wijnen AJ, Stein GS

Title

Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene.

Journal

J Cell Physiol 184:341-50 (2000)
DOI:10.1002/1097-4652(200009)184:3<341::AID-JCP8>3.0.CO;2-Z

Sequence

[hsa:860]

LinkDB

DBGET integrated database retrieval system