KEGG ORTHOLOGY: K13158

ORTHOLOGY: K13158

Entry

K13158                      KO

Symbol

HNRNPA2B1

Name

heterogeneous nuclear ribonucleoprotein A2/B1

Pathway

map05014

Amyotrophic lateral sclerosis

Disease

H00704

Oculopharyngeal muscular dystrophy

H02031

Inclusion body myopathy with Paget disease of bone and frontotemporal dementia

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
   03041 Spliceosome
    K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Trans-acting binding proteins
     K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
Spliceosome [BR:ko03041]
Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   hnRNP proteins
    K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
  Exosomal proteins of colorectal cancer cells
   K13158  HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1

Genes

HSA:	3181(HNRNPA2B1)

PTR:	463299(HNRNPA2B1)

PPS:	100984266(HNRNPA2B1)

GGO:	101138593(HNRNPA2B1)

PON:	100174392(HNRNPA2B1)

NLE:	100583405(HNRNPA2B1)

HMH:	116812956(HNRNPA2B1)

MCC:	701821(HNRNPA2B1)

MCF:	101925647(HNRNPA2B1)

MTHB:

126951374

MNI:	105475729(HNRNPA2B1)

CSAB:

103226345(HNRNPA2B1)

CATY:

105595704(HNRNPA2B1)

PANU:

101019588(HNRNPA2B1)

TGE:	112620808(HNRNPA2B1)

MLEU:

105533746(HNRNPA2B1)

RRO:	104656829(HNRNPA2B1)

RBB:	108517879(HNRNPA2B1)

TFN:	117067990 117072870(HNRNPA2B1)

PTEH:

111551855(HNRNPA2B1)

CANG:

105509359(HNRNPA2B1)

CJC:	100399278 100401647(HNRNPA2B1)

SBQ:	101045505(HNRNPA2B1)

CIMI:

108290413 108303240(HNRNPA2B1)

CSYR:

103265132(HNRNPA2B1)

MMUR:

105875912(HNRNPA2B1)

LCAT:

123647215(HNRNPA2B1)

PCOQ:

105807347

OGA:	100944929(HNRNPA2B1)

MMU:	53379(Hnrnpa2b1)

MCAL:

110296059(Hnrnpa2b1)

MPAH:

110315903(Hnrnpa2b1)

RNO:	362361(Hnrnpa2b1)

MCOC:

116098903(Hnrnpa2b1)

ANU:	117720423(Hnrnpa2b1)

MUN:	110546150(Hnrnpa2b1)

CGE:	100759302(Hnrnpa2b1)

MAUA:

101830122(Hnrnpa2b1) 121142672

PROB:

127235508(Hnrnpa2b1)

PLEU:

114689744(Hnrnpa2b1) 114696289

MORG:

121440005(Hnrnpa2b1)

MFOT:

126494778 126509573

AAMP:

119808454(Hnrnpa2b1)

NGI:	103740807(Hnrnpa2b1)

HGL:	101715990(Hnrnpa2b1)

CPOC:

100715127(Hnrnpa2b1)

CCAN:

109698307(Hnrnpa2b1)

DORD:

105991748(Hnrnpa2b1)

DSP:	122112098(Hnrnpa2b1)

PLOP:

125346804(Hnrnpa2b1) 125350001

NCAR:

124991022

MMMA:

107134334 107137092 107144041 107146119(Hnrnpa2b1) 107148292 107148505 107160818

OCU:	100342633 100353281

OPI:	101518374(HNRNPA2B1)

TUP:	102486160 102497907(HNRNPA2B1)

GVR:	103603907(HNRNPA2B1)

CFA:	475260(HNRNPA2B1)

CLUD:

112670605(HNRNPA2B1)

VVP:	112915703(HNRNPA2B1)

VLG:	121474483(HNRNPA2B1)

NPO:	129502873(HNRNPA2B1) 129510237 129514689

AML:	100470912(HNRNPA2B1)

UMR:	103658910(HNRNPA2B1)

UAH:	113261750(HNRNPA2B1)

UAR:	123789153(HNRNPA2B1)

ELK:

111147225

LLV:

125081077

MPUF:

101692078 101692283(HNRNPA2B1)

MNP:	132015872(HNRNPA2B1)

MLK:	131829526(HNRNPA2B1)

NVS:	122904920(HNRNPA2B1)

ORO:	101363492(HNRNPA2B1) 101373032

EJU:	114221164(HNRNPA2B1)

ZCA:	113911265(HNRNPA2B1) 113929170

MLX:	118020888(HNRNPA2B1)

NSU:	110580147(HNRNPA2B1)

LWW:	102751098(HNRNPA2B1)

FCA:	101098942(HNRNPA2B1)

PYU:	121028594(HNRNPA2B1)

PCOO:

112866868(HNRNPA2B1)

PBG:	122488019(HNRNPA2B1)

PVIV:

125161205(HNRNPA2B1)

LRUF:

124524646

PTG:	102953654(HNRNPA2B1)

PPAD:

109263857(HNRNPA2B1)

PUC:

125930000

AJU:

106985503

HHV:	120230302(HNRNPA2B1)

BTA:	101904796 112443416 507564(HNRNPA2B1) 538435

BOM:	102269300 102276625 102285365(HNRNPA2B1)

BIU:	109557510(HNRNPA2B1)

BBUB:

102389038 102401754(HNRNPA2B1) 102403366 102405428

BBIS:

104979949 104999780(HNRNPA2B1)

CHX:	102172032(HNRNPA2B1)

OAS:	101103383 101107187(HNRNPA2B1) 101108009 101123446 101123501 105609437

BTAX:

128043406 128046466(HNRNPA2B1) 128051002 128051453 128059177 128066496 128066517

ODA:	120855021 120863254 120864505 120864563 120864571 120877443(HNRNPA2B1) 120883002

CCAD:

122426588 122438470(HNRNPA2B1)

MBEZ:

129537104 129547538 129551948 129552524(HNRNPA2B1) 129558884 129559223 129561170

SSC:	100521762(HNRNPA2B1)

CFR:	102504126(HNRNPA2B1) 102510499 102522398

CBAI:

105078415 105079822(HNRNPA2B1)

CDK:	105102130(HNRNPA2B1)

VPC:	102536640(HNRNPA2B1) 102543479

BACU:

103004846(HNRNPA2B1)

BMUS:

118881921 118892647 118900628(HNRNPA2B1)

LVE:	103076317(HNRNPA2B1) 103089048

OOR:	101270382 101283805(HNRNPA2B1) 117202385

DLE:	111163330 111180415(HNRNPA2B1)

PCAD:

102979157 102982273(HNRNPA2B1)

PSIU:

116745733 116754084 116759078(HNRNPA2B1) 116760701

NASI:

112406259(HNRNPA2B1) 112408071

ECB:	100068539(HNRNPA2B1)

EPZ:	103552128(HNRNPA2B1)

EAI:	106823218(HNRNPA2B1)

MYB:	102241247 102247146(HNRNPA2B1) 102263405

MYD:	102774084(HNRNPA2B1)

MMYO:

118666106(HNRNPA2B1) 118676660

MLF:	102420393 102421258(HNRNPA2B1) 102430786

PKL:	118727851(HNRNPA2B1)

EFUS:

103284788 103291839(HNRNPA2B1)

MNA:	107540326(HNRNPA2B1)

DRO:	112306913(HNRNPA2B1)

SHON:

118983599(HNRNPA2B1)

AJM:	119035235(HNRNPA2B1)

PDIC:

114507552(HNRNPA2B1)

PHAS:

123812044(HNRNPA2B1)

MMF:	118619583(HNRNPA2B1)

PPAM:

129063320(HNRNPA2B1)

HAI:	109381340(HNRNPA2B1)

RFQ:	117012078(HNRNPA2B1)

PALE:

102880339(HNRNPA2B1)

PGIG:

120602365(HNRNPA2B1)

PVP:	105293167(HNRNPA2B1)

RAY:	107505661(HNRNPA2B1)

MJV:	108393983(HNRNPA2B1)

TOD:	119241076 119243554(HNRNPA2B1)

SARA:

101542297(HNRNPA2B1)

SETR:

125999098 126020519(HNRNPA2B1)

LAV:	100676491(HNRNPA2B1)

TMU:

101352367

ETF:	101642446(HNRNPA2B1) 101657911

DNM:	101410896 101434008

MDO:	100013908(HNRNPA2B1)

GAS:	123249730(HNRNPA2B1)

SHR:	100924943(HNRNPA2B1) 116423065

AFZ:

127539333

PCW:	110213141(HNRNPA2B1)

OAA:	100079036(HNRNPA2B1)

GGA:	420627(HNRNPA2B1)

PCOC:

116227053(HNRNPA2B1)

MGP:	100551212(HNRNPA2B1)

CJO:	107309159(HNRNPA2B1)

TPAI:

128085751(HNRNPA2B1)

LMUT:

125695716(HNRNPA2B1)

NMEL:

110393029(HNRNPA2B1)

APLA:

101789543(HNRNPA2B1)

ACYG:

106030227(HNRNPA2B1)

CATA:

118252819(HNRNPA2B1)

AFUL:

116486071(HNRNPA2B1)

TGU:	100229286(HNRNPA2B1)

LSR:	110474646(HNRNPA2B1)

SCAN:

103812891(HNRNPA2B1)

PMOA:

120503705(HNRNPA2B1)

OTC:	121339639(HNRNPA2B1)

PRUF:

121353193(HNRNPA2B1)

GFR:	102033108(HNRNPA2B1)

FAB:	101811049(HNRNPA2B1)

OMA:	130250090(HNRNPA2B1)

PHI:	102099131(HNRNPA2B1)

PMAJ:

107199825(HNRNPA2B1)

CCAE:

111924326(HNRNPA2B1)

CCW:	104689096(HNRNPA2B1)

CBRC:

103613525(HNRNPA2B1)

ETL:	114063730(HNRNPA2B1)

ZAB:	102070691(HNRNPA2B1)

ACHL:

103807389(HNRNPA2B1)

SVG:	106864659(HNRNPA2B1)

MMEA:

130573201(HNRNPA2B1)

HRT:	120759617(HNRNPA2B1)

FPG:	101923293(HNRNPA2B1)

FCH:	102046392(HNRNPA2B1)

CLV:	102086186(HNRNPA2B1)

EGZ:	104126142(HNRNPA2B1)

NNI:	104013929(HNRNPA2B1)

PCRI:

104036730(HNRNPA2B1)

PLET:

104620485(HNRNPA2B1)

EHS:	104503961(HNRNPA2B1)

PCAO:

104041564(HNRNPA2B1)

ACUN:

113477313(HNRNPA2B1)

TALA:

104364838(HNRNPA2B1)

PADL:

103918414(HNRNPA2B1)

AFOR:

103901189(HNRNPA2B1)

ACHC:

115339477(HNRNPA2B1)

HALD:

104322600(HNRNPA2B1)

HLE:	104838057(HNRNPA2B1)

AGEN:

126038087

GCL:

127012887

CCRI:

104162503(HNRNPA2B1)

CSTI:

104562283(HNRNPA2B1)

CMAC:

104476198(HNRNPA2B1)

MUI:	104541163(HNRNPA2B1)

BREG:

104639771(HNRNPA2B1)

FGA:	104075596(HNRNPA2B1)

GSTE:

104261828(HNRNPA2B1)

LDI:	104340887(HNRNPA2B1)

MNB:	103782142(HNRNPA2B1)

OHA:	104335600(HNRNPA2B1)

NNT:	104403484(HNRNPA2B1)

SHAB:

115609063(HNRNPA2B1)

DPUB:

104307619(HNRNPA2B1)

ACAR:

104527870(HNRNPA2B1)

CPEA:

104397575(HNRNPA2B1)

AVIT:

104269433(HNRNPA2B1)

CVF:	104281521(HNRNPA2B1)

RTD:	128905887(HNRNPA2B1)

CUCA:

104059027(HNRNPA2B1)

TEO:	104383330(HNRNPA2B1)

BRHI:

104494068(HNRNPA2B1)

AAM:	106483453(HNRNPA2B1)

AROW:

112966550(HNRNPA2B1)

NPD:	112942434(HNRNPA2B1)

TGT:	104573682(HNRNPA2B1)

DNE:	112985282(HNRNPA2B1)

SCAM:

104145099(HNRNPA2B1)

ASN:	102372733(HNRNPA2B1)

AMJ:	102575612(HNRNPA2B1)

CPOO:

109309977(HNRNPA2B1)

GGN:	109291568(HNRNPA2B1)

PSS:	102456185(HNRNPA2B1)

CMY:	102938160(HNRNPA2B1)

CCAY:

125631550(HNRNPA2B1)

DCC:	119851283(HNRNPA2B1)

CPIC:

101950102(HNRNPA2B1)

TST:	117872320(HNRNPA2B1)

CABI:

116820992(HNRNPA2B1)

MRV:	120396346(HNRNPA2B1)

ACS:	100561250(hnrnpa2b1)

ASAO:

132778753(HNRNPA2B1)

PVT:	110072440(HNRNPA2B1)

SUND:

121934844(HNRNPA2B1)

PBI:	103053337(HNRNPA2B1)

PMUR:

107282766(HNRNPA2B1)

CTIG:

120307350(HNRNPA2B1)

TSR:	106550105(HNRNPA2B1)

PGUT:

117654932(HNRNPA2B1)

APRI:

131198453(HNRNPA2B1)

PTEX:

113441315(HNRNPA2B1)

NSS:	113415974(HNRNPA2B1)

VKO:	123033844(HNRNPA2B1)

PMUA:

114607259(HNRNPA2B1)

PRAF:

128424139(HNRNPA2B1)

ZVI:	118091695(HNRNPA2B1)

HCG:	128330670(HNRNPA2B1)

GJA:	107116636(HNRNPA2B1)

STOW:

125440926(HNRNPA2B1)

EMC:	129337547(HNRNPA2B1)

XLA:	379158(hnrnpa2b1.L) 380082(hnrnpa2b1.S)

XTR:	549680(hnrnpa2b1)

NPR:	108804433(HNRNPA2B1)

RTEM:

120940193(HNRNPA2B1)

BBUF:

121002246(HNRNPA2B1)

BGAR:

122922392(HNRNPA2B1)

MUO:

115458632

GSH:	117354046(HNRNPA2B1)

LCM:	102356472(HNRNPA2B1)

CMK:

RTP:

CPLA:

HOC:

LERI:

SCAC:

AGS:

VDE:

VJA:

PTEP:

ABRU:

SDM:

GAE:	121380583 121380965 121381112 121385317 121385324

HRJ:

124277865

CRG:

105333434

CVN:	111108192 111138166

CANU:

OED:

MMER:

RPHI:

DPOL:

OBI:

OSN:	115212793 115212911 115214028 115214029 115221315

SMM:	Smp_053940.1

OVI:	T265_01280 T265_05290

HSY:	130622496 130636754 130645375

APRO:

F751_3246

» show all

Reference

PMID:24356509

Authors

Villarroya-Beltri C, Gutierrez-Vazquez C, Sanchez-Cabo F, Perez-Hernandez D, Vazquez J, Martin-Cofreces N, Martinez-Herrera DJ, Pascual-Montano A, Mittelbrunn M, Sanchez-Madrid F

Title

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.

Journal

Nat Commun 4:2980 (2013)
DOI:10.1038/ncomms3980

Sequence

[hsa:3181]

Reference

PMID:2557628

Authors

Burd CG, Swanson MS, Gorlach M, Dreyfuss G

Title

Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.

Journal

Proc Natl Acad Sci U S A 86:9788-92 (1989)
DOI:10.1073/pnas.86.24.9788

Sequence

[hsa:3181]

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