KEGG ORTHOLOGY: K14157

ORTHOLOGY: K14157

Entry

K14157                      KO

Symbol

AASS

Name

alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00032

Lysine degradation, lysine => saccharopine => acetoacetyl-CoA

Reaction

R00716

N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

R02313

N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase

N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)

Disease

H00188

Hyperlysinemia

H01242

Saccharopinuria

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K14157  AASS; alpha-aminoadipic semialdehyde synthase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.8  saccharopine dehydrogenase (NADP+, L-lysine-forming)
     K14157  AASS; alpha-aminoadipic semialdehyde synthase
    1.5.1.9  saccharopine dehydrogenase (NAD+, L-glutamate-forming)
     K14157  AASS; alpha-aminoadipic semialdehyde synthase

Other DBs

GO:	0047130 0047131

Genes

HSA:	10157(AASS)

PTR:	472493(AASS)

PPS:	100983928(AASS)

GGO:	101143865(AASS)

PON:	100454072(AASS)

NLE:	100607105(AASS)

HMH:	116814294(AASS)

MCC:	694594(AASS)

MCF:	102145151(AASS)

MTHB:

126951178

MNI:	105475252(AASS)

CSAB:

103226802(AASS)

CATY:

105598498(AASS)

PANU:

101023478(AASS)

TGE:	112621792(AASS)

MLEU:

105550927(AASS)

RRO:	104657067(AASS)

RBB:	108518504(AASS)

TFN:	117072333(AASS)

PTEH:

111550222 113219515

CANG:

105508558(AASS)

CJC:	100385723(AASS)

SBQ:	101030460(AASS)

CIMI:

108292795(AASS) 108297229

CSYR:

103266259(AASS)

MMUR:

105864150(AASS)

LCAT:

123647228(AASS)

PCOQ:

105817157(AASS)

OGA:	100943543(AASS)

MMU:	30956(Aass)

MCAL:

110296036(Aass)

MPAH:

110316418(Aass)

RNO:	296925(Aass)

MCOC:

116098018(Aass)

ANU:	117721064(Aass)

MUN:	110560725(Aass)

CGE:	100751161(Aass)

MAUA:

101831679(Aass)

PROB:

127215354(Aass)

PLEU:

114695606(Aass)

MORG:

121463453(Aass)

MFOT:

126503976

AAMP:

119806653(Aass)

NGI:	103730601(Aass)

HGL:	101707268(Aass)

CPOC:

100722098(Aass)

CCAN:

109685533(Aass)

DORD:

105988398(Aass)

DSP:	122121749(Aass)

PLOP:

125347072(Aass)

NCAR:

124990904

OCU:

100352070

OPI:	101536276(AASS)

TUP:	102489208(AASS)

GVR:	103596796(AASS)

CFA:	482429(AASS)

CLUD:

112678088(AASS)

VVP:	112910607(AASS)

VLG:	121474769(AASS)

NPO:	129502917(AASS)

AML:	100468913(AASS)

UMR:	103676605(AASS)

UAH:	113263479(AASS)

UAR:	123789016(AASS)

ELK:

111152037

LLV:

125080848

MPUF:

101682519

MNP:	132015755(AASS)

NVS:	122905024(AASS)

ORO:	101383022(AASS)

EJU:	114210641(AASS)

ZCA:	113911600(AASS)

MLX:	118021028(AASS)

NSU:	110588919(AASS)

LWW:	102739643(AASS)

FCA:	101091272(AASS)

PYU:	121028418(AASS)

PCOO:

112866648(AASS)

PBG:	122488152(AASS)

LRUF:

124523798

PTG:	102960744(AASS)

PPAD:

109268907(AASS)

PUC:

125930096

AJU:

106970654

HHV:	120236729(AASS)

BTA:	520865(AASS)

BOM:	102275417(AASS)

BIU:	109557575(AASS)

BBUB:

102394960(AASS)

BBIS:

104987236(AASS)

CHX:	102185894(AASS)

OAS:	101103973(AASS)

BTAX:

128046624(AASS)

ODA:	120877291(AASS)

CCAD:

122438583(AASS)

MBEZ:

129552599(AASS)

SSC:	100513962(AASS)

CFR:	102520837(AASS)

CBAI:

105063132(AASS)

CDK:	105085335(AASS)

VPC:	102530174(AASS)

BACU:

103016134(AASS)

LVE:	103085872(AASS)

OOR:	101285244(AASS)

DLE:	111179042(AASS)

PCAD:

102992598(AASS)

PSIU:

116759791(AASS)

NASI:

112408261(AASS)

ECB:	100056260(AASS)

EPZ:	103547307(AASS)

EAI:	106829857(AASS)

MYB:	102254732(AASS)

MYD:	102770634(AASS)

MMYO:

118666463(AASS)

MLF:	102432631(AASS)

MNA:	107537367(AASS)

PKL:	118712123(AASS)

EFUS:

103300691(AASS)

HAI:	109371287(AASS)

DRO:	112299931(AASS)

SHON:

118994001(AASS)

AJM:

119046514

PDIC:

114507757(AASS)

PHAS:

123824426(AASS)

MMF:	118619894(AASS)

RFQ:	117018160(AASS)

PALE:

102881018(AASS)

PGIG:

120601214(AASS)

PVP:	105290157(AASS)

RAY:	107500210(AASS)

MJV:	108404217(AASS)

TOD:	119246109(AASS)

SARA:

101548455(AASS)

LAV:	100665204(AASS)

TMU:

101358790

ETF:	101659941(AASS)

DNM:	101414881(AASS)

MDO:	100016400(AASS)

GAS:	123250759(AASS)

SHR:	100923009(AASS)

AFZ:

127563973

PCW:	110194178(AASS)

OAA:	100076030(AASS)

GGA:	417757(AASS)

PCOC:

116243788(AASS)

MGP:	100543809(AASS)

CJO:	107308784(AASS)

TPAI:

128073735(AASS)

LMUT:

125688366(AASS)

NMEL:

110392561(AASS)

APLA:

101793380(AASS)

ACYG:

106044525(AASS)

CATA:

118254260(AASS)

AFUL:

116491208(AASS)

TGU:	100222251(AASS)

LSR:	110483501(AASS)

SCAN:

103813475(AASS)

PMOA:

120510701(AASS)

OTC:	121336320(AASS)

PRUF:

121355789(AASS)

GFR:	102036981(AASS)

FAB:	101818954(AASS)

OMA:	130266122(AASS)

PHI:	102112915(AASS)

PMAJ:

107204864(AASS)

CCAE:

111922957(AASS)

CCW:	104686812(AASS)

CBRC:

103622077(AASS)

ETL:	114064186(AASS)

ZAB:	102066527(AASS)

ACHL:

103803905(AASS)

SVG:	106854054(AASS)

MMEA:

130580767(AASS)

HRT:	120751602(AASS)

FPG:	101923487(AASS)

FCH:	102047696(AASS)

CLV:	102094241(AASS)

EGZ:	104125682(AASS)

NNI:	104011825(AASS)

PCRI:

104029622(AASS)

PLET:

104613552(AASS)

EHS:	104513185(AASS)

PCAO:

104042521(AASS)

ACUN:

113490507(AASS)

TALA:

104369177(AASS)

PADL:

103923842(AASS)

AFOR:

103905212(AASS)

ACHC:

115341719(AASS)

HALD:

104319552(AASS)

HLE:	104840397(AASS)

AGEN:

126044299

GCL:

127014004

CCRI:

104162754(AASS)

CMAC:

104473130(AASS)

MUI:	104537916(AASS)

BREG:

104636344(AASS)

FGA:	104080942(AASS)

GSTE:

104250234(AASS)

LDI:	104342779(AASS)

MNB:

103776647

OHA:	104330036(AASS)

NNT:	104409609(AASS)

SHAB:

115605565(AASS)

DPUB:

104303122(AASS)

PGUU:

104457428(AASS)

ACAR:

104529636(AASS)

CPEA:

104394675(AASS)

AVIT:

104274653(AASS)

CVF:	104285242(AASS)

RTD:	128900827(AASS)

CUCA:

104061620(AASS)

TEO:	104378926(AASS)

BRHI:

104496765(AASS)

AAM:	106495938(AASS)

AROW:

112966683(AASS)

NPD:	112957907(AASS)

TGT:	104578451(AASS)

DNE:	112990916(AASS)

SCAM:

104152135(AASS)

ASN:	102376316(AASS)

AMJ:	102574453(AASS)

CPOO:

109315640(AASS)

GGN:	109292023(AASS)

PSS:	102454542(AASS)

CMY:	102948389(AASS)

CCAY:

125630370(AASS)

DCC:	119842928(AASS)

CPIC:

101934272(AASS)

TST:	117876370(AASS)

CABI:

116831587(AASS)

MRV:	120388288(AASS)

ACS:	100553247(aass)

PVT:	110084070(AASS)

SUND:

121930747(AASS)

PBI:	103054458(AASS)

PMUR:

107293701(AASS)

CTIG:

120301264(AASS)

TSR:	106555089(AASS)

PGUT:

117673614(AASS)

APRI:

131202393(AASS)

PTEX:

113445073(AASS)

NSS:	113413051(AASS)

VKO:	123019869(AASS)

PMUA:

114605071(AASS)

PRAF:

128422072(AASS)

ZVI:	118090844(AASS)

HCG:	128327296(AASS)

GJA:	107111118(AASS)

STOW:

125435842(AASS)

EMC:	129335988(AASS)

XLA:	444409(aass.L)

XTR:	496923(aass)

NPR:	108788040(AASS)

RTEM:

120931849(AASS)

BBUF:

120981869(AASS)

BGAR:

122927937(AASS)

MUO:	115478577(AASS)

GSH:	117367147(AASS)

DRE:	556229(aass)

SRX:	107752301 107753626

SANH:

107678990 107698474

SGH:

107575779

CCAR:

109050748(aass) 109061151

CAUA:

113066967(aass)

CGIB:

127947095 127953010

PTET:

122330775(aass)

LROH:

127157008(aass)

OMC:	131534050(aass)

PPRM:

120469052(aass)

MAMB:

125247135(aass)

CIDE:

127507189

MASI:

127435942

TROS:

130551474(aass)

MANU:

129433156(aass)

IPU:

108274751

IFU:	128618341(aass)

PHYP:

113529768(aass)

SMEO:

124392555(aass)

TFD:	113660164(aass)

AMEX:

103040216(aass)

CMAO:

118811735(aass)

EEE:	113582558(aass)

CHAR:

105901951(aass)

TRU:	101061348(aass)

TFS:	130536227(aass)

TNG:	GSTEN00019707G001

LCO:	104927983(aass)

CGOB:

115009199(aass)

ELY:	117261991(aass)

EFO:	125887417(aass)

SLUC:

116036255(aass)

ECRA:

117949029(aass)

ESP:	116693715(aass)

PFLV:

114559584(aass)

GAT:	120808988(aass)

PPUG:

119195464(aass)

AFB:	129108028(aass)

CLUM:

117732281(aass)

MSAM:

119893411(aass)

SCHU:

122874397(aass)

CUD:	121515421(aass)

ALAT:

119023863(aass)

MZE:	101483693(aass)

ONL:	100700037(aass)

OAU:	116322054(aass)

OLA:	101155996(aass)

OML:	112139570(aass)

XMA:	102235893(aass)

XCO:	114136268(aass)

XHE:	116708415(aass)

PRET:

103465787(aass)

PFOR:

103130309(aass)

PLAI:

106934445(aass)

PMEI:

106934269(aass)

GAF:	122836023(aass)

CVG:	107092787(aass)

CTUL:

119793851(aass)

GMU:	124882332(aass)

NFU:	107389491(aass)

KMR:	108247341(aass)

ALIM:

106530280(aass)

NWH:	119416419(aass)

AOCE:

111567529(aass)

MCEP:

125015290(aasS)

CSEM:

103379906(aass)

POV:	109624603(aass)

SSEN:

122775709(aass)

HHIP:

117762862(aass)

HSP:	118109577(aass)

LCF:

108902912

SDU:	111235992(aass)

SLAL:

111665076(aass)

XGL:	120793423(aass)

HCQ:	109522992(aass)

SSCV:

125970260

BPEC:

110166755(aass)

MALB:

109956395(aass)

BSPL:

114857226(aass)

SASA:

106584550

STRU:

115192728

OTW:	112220815(aass)

OMY:	100136272(aass)

OGO:	124037596(aass)

ONE:

115144791

OKI:

109897782

OKE:	118359306(aass)

SALP:

111971984

SNH:	120052382(aass)

CCLU:

121531191 121540551(aass)

ELS:	105018620(aass)

SFM:	108931602(aass)

PKI:	111851693(aass)

AANG:

118231204(aass)

LOC:	102692209(aass)

PSPA:

121319777(aass)

ARUT:

117415599(aass)

PSEX:

120533967(aass)

LCM:	102353181(AASS)

CMK:	103179368(aass)

RTP:	109937592(aass)

CPLA:

122559543(aass)

LERI:

129706180(aass)

BFO:	118415155 118415358 118415478 118427549

BBEL:

CIN:

SCLV:

SPU:

APLC:

AJC:

SKO:	100367386 102804295

DME:	Dmel_CG7144(LKRSDH)

DER:

6542219

DSE:

6611574

DSI:	Dsimw501_GD22468(Dsim_GD22468)

DYA:	Dyak_GE18334

DAN:

6505494

DSR:

110177043

DPO:

4817347

DPE:	113565906 6589787

DMN:

108163154

DWI:

6642305

DGR:

6562901

DMO:	Dmoj_GI18086

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

ECOE:

HIS:

AGA:	AgaP_AGAP008632

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ000416

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:

DPA:	109539617 109539618

SOY:

AGRG:

ATD:

CSET:

AGB:	108913067 108916332

LDC:

111517256

NVL:	108562347 108569430

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208487

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

HAW:

HZE:

TNL:	113497359 113503145

SLIU:

111348498

OFU:

114354176

PXY:	105384700 105397629

PGW:

126367999

CFEL:

113366242

CCRN:

123305173

API:	100163885 100166221

DNX:

AGS:

RMD:

ACOO:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM016080

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

FCD:	110853651 110858421

DPX:	DAPPUDRAFT_334150

DMK:	116929230 123475612

DPZ:

124352613

PVM:	113818204 113818248

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

UDV:

SDM:

PMEO:

CEL:	CELE_R02D3.1(aass-1)

CBR:

CBG_13546

CRQ:	GCK72_016303

NAI:	NECAME_02067

HRO:	HELRODRAFT_110863

LGI:	LOTGIDRAFT_218445

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

MYI:

PMAX:

MCAF:

MMER:

DPOL:

OBI:

OSN:

LAK:	106164010 106175203 106177321

OVI:	T265_08833

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_36926

AQU:

100641330

ATH:

AT4G33150

ALY:	9303270 9305293

CRB:	111829356 17877973

CSAT:

104716844 104721500 104729943 104733158

EUS:	EUTSA_v10024287mg

BRP:	103849713 103862218

BNA:	106368756 106408600 106423277 106438508

BOE:	106305178 106310570

RSZ:	108843027 108852642 130508219

THJ:

104804447

CPAP:

110812057

CIT:

102608315

CIC:	CICLE_v10007313mg

PVY:	116114036 116118520

MINC:

123194548

TCC:

18588195

GRA:

105772791

GHI:	107900997 107962841

GAB:

108486121

DZI:	111285465 111285563 111303021

EGR:

104437949

GMX:	100811246 100813294

GSJ:	114381717 114393744

PVU:	PHAVU_003G126300g

VRA:

VAR:

VUN:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

LJA:	Lj4g3v2215480.1(Lj4g3v2215480.1) Lj4g3v2215480.2(Lj4g3v2215480.2)

ADU:

107495845

AIP:

107638430

AHF:	112696156 112740737

LANG:

PCIN:

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103418228 103454158

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110636542 110636543

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:	120005172 120005358

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

CANN:

LBB:

NTA:	107798112 107827281

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

APAN:

HAN:

ECAD:

LSV:

DCR:

CSIN:

RVL:

AEW:	130756747 130789657

BVG:	104901700 104901702

SOE:

110799548

CQI:	110715969 110721851

ATRI:

MOF:

MING:

TSS:

PSOM:

113326588 113339287 113339302

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119318189 119323058

TAES:

123128669 123138725 123145804

TUA:

125514986

LPER:

127305673

LRD:	124693311 124693332

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	122000812 122005102

DCT:

PEQ:

AOF:

NCOL:

ATR:

SMO:	SELMODRAFT_103525 SELMODRAFT_173433

PPP:

112278437

GSL:	Gasu_48290

CNE:

CNA02370

CNB:

CNBA2210

CNG:	CNAG_00247

CGI:	CGB_B3130C

TMS:	TREMEDRAFT_29255

TASA:

A1Q1_07452

CCAC:

CcaHIS019_0601920(CcaverHIS019_0601920)

TVS:	TRAVEDRAFT_67257

DSQ:	DICSQDRAFT_92955

PCO:	PHACADRAFT_177943

SHS:	STEHIDRAFT_102335

HIR:	HETIRDRAFT_235542

PSQ:	PUNSTDRAFT_76716

ADL:	AURDEDRAFT_83944

FME:	FOMMEDRAFT_126943

GTR:	GLOTRDRAFT_140080

RSX:	RhiXN_07831

LBC:	LACBIDRAFT_241294

CCI:	CC1G_15806

ABP:	AGABI1DRAFT77562(AGABI1DRAFT_77562)

ABV:	AGABI2DRAFT188762(AGABI2DRAFT_188762)

MRR:	Moror_7544

E1B28_003344

SCM:	SCHCO_02629850(SCHCODRAFT_02629850)

CPUT:

CONPUDRAFT_128756 CONPUDRAFT_147051

SLA:	SERLADRAFT_350049

PTRC:

PtA15_11A440

PSTR:

Pst134EA_017495

MLR:	MELLADRAFT_90413

MBR:	MONBRDRAFT_16322

SRE:	PTSG_00811

DDI:	DDB_G0284835(aass)

DPP:	DICPUDRAFT_51448

DFA:	DFA_03752(aass)

TET:	TTHERM_00149450

PTM:	GSPATT00020034001 GSPATT00022271001 GSPATT00031371001

PTI:	PHATRDRAFT_54394(LKRSDH)

FCY:	FRACYDRAFT_264866

TPS:	THAPSDRAFT_261124

PIF:	PITG_03530

PSOJ:

PHYSODRAFT_552101

SPAR:

SPRG_16261

EHX:	EMIHUDRAFT_467888 EMIHUDRAFT_74668

NGR:	NAEGRDRAFT_79185

» show all

Reference

PMID:10775527

Authors

Sacksteder KA, Biery BJ, Morrell JC, Goodman BK, Geisbrecht BV, Cox RP, Gould SJ, Geraghty MT

Title

Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia.

Journal

Am J Hum Genet 66:1736-43 (2000)
DOI:10.1086/302919

Sequence

[hsa:10157]

LinkDB

DBGET integrated database retrieval system