KEGG ORTHOLOGY: K16269

ORTHOLOGY: K16269

Entry

K16269            Tight     KO

Symbol

todD, tcbB

Name

cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase [EC:1.3.1.19 1.3.1.119]

Pathway

map00361

Chlorocyclohexane and chlorobenzene degradation

map00362

Benzoate degradation

map00623

Toluene degradation

map00624

Polycyclic aromatic hydrocarbon degradation

map00643

Styrene degradation

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01220

Degradation of aromatic compounds

Module

M00547

Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol

Reaction

R00812

cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase

R04088

toluene-cis-1,2-dihydrodiol:NAD+ oxidoreductase

R05354

styrene cis-glycol:NAD+ oxidoreductase

R05397

3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene:NAD+ oxidoreductase

R06832

3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene:NAD+ oxidoreductase

R06857

(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase

R07703

1,2-dihydrophthalic acid:NAD+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00623 Toluene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00643 Styrene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00624 Polycyclic aromatic hydrocarbon degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.19  cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
    1.3.1.119  chlorobenzene dihydrodiol dehydrogenase
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
Dioxygenases [br01602.html]
Dioxygenases in aromatic ring cleavage
  K16269

Other DBs

COG:

COG1028

GO:	0018504 0018501

Genes

PPF:

Pput_2877

PPX:	T1E_4270(tobD)

PMON:

X969_10950

PMOT:

X970_10605

PASI:

LG197_17470(bphB)

BPT:	Bpet3742(hcaB)

ATEM:

PQV96_18690(bphB)

AG:	AAC43636(tcbB)

Reference

PMID:2670929

Authors

Zylstra GJ, Gibson DT

Title

Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli.

Journal

J Biol Chem 264:14940-6 (1989)

Sequence

[ppf:Pput_2877]

Reference

PMID:8626733

Authors

Werlen C, Kohler HP, van der Meer JR

Title

The broad substrate chlorobenzene dioxygenase and cis-chlorobenzene dihydrodiol dehydrogenase of Pseudomonas sp. strain P51 are linked evolutionarily to the enzymes for benzene and toluene degradation.

Journal

J Biol Chem 271:4009-16 (1996)
DOI:10.1074/jbc.271.8.4009

Sequence

[ag:AAC43636]

LinkDB

ENZYME: 1.3.1.19

Entry

EC 1.3.1.19                 Enzyme

Name

cis-1,2-dihydrobenzene-1,2-diol dehydrogenase;
cis-benzene glycol dehydrogenase;
cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase

Reaction(IUBMB)

cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+ [RN:R00812]

Reaction(KEGG)

R00812;
(other) R04088 R05354 R07703

Substrate

cis-1,2-dihydrobenzene-1,2-diol [CPD:C04091];
NAD+ [CPD:C00003]

Product

catechol [CPD:C00090];
NADH [CPD:C00004];
H+ [CPD:C00080]

History

EC 1.3.1.19 created 1972

Pathway

ec00361

Chlorocyclohexane and chlorobenzene degradation

ec00362

Benzoate degradation

ec00623

Toluene degradation

ec00624

Polycyclic aromatic hydrocarbon degradation

ec00643

Styrene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K16269

cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase

Genes

PPF:

Pput_2877

PPX:	T1E_4270(tobD)

PMON:

X969_10950

PMOT:

X970_10605

PASI:

LG197_17470(bphB)

BPT:	Bpet3742(hcaB)

ATEM:

PQV96_18690(bphB)

Reference

1 [PMID:4362337]

Authors

Axcell BC, Geary PJ.

Title

The metabolism of benzene by bacteria. Purification and some properties of the enzyme cis-1,2-dihydroxycyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase (cis-benzene glycol dehydrogenase).

Journal

Biochem J 136:927-34 (1973)
DOI:10.1042/bj1360927

Reference

2 [PMID:4298226]

Authors

Gibson DT, Koch JR, Kallio RE.

Title

Oxidative degradation of aromatic hydrocarbons by microorganisms. I. Enzymatic formation of catechol from benzene.

Journal

Biochemistry 7:2653-62 (1968)
DOI:10.1021/bi00847a031

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.19

IUBMB Enzyme Nomenclature:

1.3.1.19

ExPASy - ENZYME nomenclature database:

1.3.1.19

UM-BBD (Biocatalysis/Biodegradation Database):

1.3.1.19

BRENDA, the Enzyme Database:

1.3.1.19

CAS:	51923-03-6

LinkDB

REACTION: R00812

Entry

R00812                      Reaction

Name

cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase

Definition

cis-1,2-Dihydrobenzene-1,2-diol + NAD+ <=> Catechol + NADH + H+

Equation

C04091 + C00003 <=> C00090 + C00004 + C00080

Reaction class

RC00001

C00003_C00004

RC00386

C00090_C04091

Enzyme

1.3.1.19

Pathway

rn00361

Chlorocyclohexane and chlorobenzene degradation

rn00362

Benzoate degradation

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

rn01220

Degradation of aromatic compounds

Module

M00547

Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.19
     R00812  cis-1,2-Dihydrobenzene-1,2-diol + NAD+ <=> Catechol + NADH + H+

Orthology

K16269

cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase [EC:1.3.1.19 1.3.1.119]

Other DBs

RHEA:

15460

LinkDB

DBGET integrated database retrieval system