KEGG ORTHOLOGY: K22937

ORTHOLOGY: K22937

Entry

K22937                      KO

Symbol

LYST, CHS1

Name

lysosomal-trafficking regulator

Disease

H02021

Chediak-Higashi syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K22937  LYST, CHS1; lysosomal-trafficking regulator
Membrane trafficking [BR:ko04131]
Endosome - Lysosome transport
  Others
   Others
    K22937  LYST, CHS1; lysosomal-trafficking regulator

Genes

HSA:	1130(LYST)

PTR:	457838(LYST)

PPS:	100981133(LYST)

GGO:	101142325(LYST)

PON:	100441491(LYST)

PPYG:

129012821(LYST)

NLE:	100597105(LYST)

HMH:	116457215(LYST)

SSYN:

129458787(LYST)

MCC:	718051(LYST)

MCF:	102143435(LYST)

MTHB:

126942616

MNI:	105474609(LYST)

CSAB:

103230802(LYST)

CATY:

105574893(LYST)

PANU:

101021324(LYST)

TGE:	112634929(LYST)

MLEU:

105546879

RRO:	104679176(LYST)

RBB:	108522221(LYST)

TFN:	117075556(LYST)

PTEH:

111545243(LYST)

CANG:

105507300(LYST)

CJC:	100410662(LYST)

SBQ:	101045715(LYST)

CIMI:

108302841(LYST)

ANAN:

105722391(LYST)

CSYR:

103255669(LYST)

MMUR:

105856486(LYST)

LCAT:

123627586(LYST)

PCOQ:

105823076(LYST)

OGA:	100940433(LYST)

MMU:	17101(Lyst)

MCAL:

110307810(Lyst)

MPAH:

110333788(Lyst)

RNO:	85419(Lyst)

MCOC:

116082523(Lyst)

ANU:	117713627(Lyst)

ASYL:

127665254(Lyst)

MUN:	110558138(Lyst)

CGE:	100768280(Lyst)

MAUA:

101842610(Lyst)

PROB:

127229770(Lyst)

PLEU:

114685175(Lyst)

MORG:

121432724(Lyst)

MFOT:

126501663

AAMP:

119817961(Lyst)

NGI:	103745128(Lyst)

HGL:	101707129(Lyst)

CPOC:

100730206(Lyst)

CCAN:

109692617(Lyst)

DORD:

105984383(Lyst)

DSP:	122113059(Lyst)

DMER:

138810808(Lyst)

PLOP:

125367326(Lyst)

NCAR:

124961500

MMMA:

107157926(Lyst)

ITI:	101963386(Lyst)

OCU:	100339012 103351034

OPI:	101531487(LYST)

OCZ:	121148130(LYST)

TUP:	102476987(LYST)

GVR:	103602784(LYST)

CFA:	479195(LYST)

CLUD:

112660910(LYST)

VVP:	112927369(LYST)

VLG:	121486691(LYST)

NPO:	129499091(LYST)

AML:	100468700(LYST)

UMR:	103661900(LYST)

UAH:	113259277(LYST)

UAR:	123783046(LYST)

ELK:

111160518

LLV:

125085143

MPUF:

101688558(LYST)

MNP:	132016145(LYST)

MLK:	131829050(LYST)

NVS:	122900571(LYST)

ORO:	101369082(LYST)

EJU:	114210357(LYST)

ZCA:	113918796(LYST)

MLX:	118012934(LYST)

NSU:	110586064(LYST)

LWW:	102748111(LYST)

FCA:	101081414(LYST)

PYU:	121023146(LYST)

PCOO:

112851575(LYST)

PBG:	122492708(LYST)

PVIV:

125148321(LYST)

LRUF:

124518689

LGF:	123576432(LYST)

AJU:

106982551

PTG:	102954281(LYST)

PPAD:

109248873(LYST)

PUC:

125932578

PLEZ:

122202712(LYST)

HHV:	120241807(LYST)

BTA:	281072(LYST)

BOM:	102279397(LYST)

BIU:	109553758(LYST)

BBUB:

102406137(LYST)

BBIS:

105003124(LYST)

CHX:	102170942(LYST)

OAS:	101115340(LYST)

BTAX:

128048031(LYST)

CSUM:

138087054(LYST)

ODA:	120860491 120865417

CCAD:

122446611(LYST)

MREE:

136159733(LYST)

OVR:	110124189(LYST)

MBEZ:

129555855(LYST)

SSC:	100049676(LYST)

CFR:	102510593(LYST)

CBAI:

105075112(LYST)

CDK:	105088844(LYST)

VPC:	102526760(LYST)

BACU:

103019897(LYST)

BMUS:

118882545(LYST)

LVE:	103082398(LYST)

OOR:	101271512(LYST)

LALB:

132507050(LYST)

GMF:	115843478(LYST)

DDP:	132440038(LYST)

DLE:	111163934(LYST)

PCAD:

102976128(LYST)

PSIU:

116741616(LYST)

PPHC:

136136335(LYST)

NASI:

112410740(LYST)

ECB:	100050724(LYST)

EPZ:	103547678(LYST)

EAI:	106834698(LYST)

MYB:	102240076(LYST)

MYD:	102763491(LYST)

MMYO:

118678722(LYST)

MLF:	102422439 102430474

MDT:	132222444(LYST)

MYUM:

138999198(LYST)

PKL:	118727680(LYST)

EFUS:

103293438(LYST)

MNA:	107527187(LYST)

DRO:	112305878(LYST)

SHON:

118980660(LYST)

AJM:	119065951(LYST)

PDIC:

114512237(LYST)

PHAS:

123804638(LYST)

MMF:	118640509(LYST)

PPAM:

129072100(LYST)

HAI:	109387716(LYST)

RFQ:	117018661(LYST)

PALE:

102897476(LYST)

PGIG:

120592625(LYST)

PVP:	105302727(LYST)

RAY:	107520047(LYST)

MJV:	108399461(LYST)

TOD:	119244583(LYST)

SARA:

101544214(LYST)

SFUM:

130022960(LYST)

SETR:

126030797(LYST)

LAV:	100664464(LYST)

TMU:

101357280

ETF:	101661440(LYST)

DNM:	101442148(LYST)

MDO:	100619622(LYST)

GAS:	123245616(LYST)

SHR:	100921256(LYST)

AFZ:

127559634

PCW:	110217881(LYST)

TVP:	118848405(LYST)

PBRV:

138143283(LYST)

MLAO:

141513279(LYST)

OAA:	100081827(LYST)

TACU:

119940576(LYST)

GGA:	421514(LYST)

PCOC:

116228355(LYST)

MGP:	100550123(LYST)

CJO:	107311369(LYST)

TPAI:

128075204(LYST)

LMUT:

125690200(LYST)

NMEL:

110396438(LYST)

APLA:

101802189(LYST)

ACYG:

106048818(LYST)

CATA:

118254120(LYST)

AFUL:

116487008(LYST)

TGU:	100230901(LYST)

LSR:	110468866(LYST)

SCAN:

103818522(LYST)

PMOA:

120501263(LYST)

OTC:	121341031(LYST)

PRUF:

121363298(LYST)

ATRC:

139592425(LYST)

GFR:	102040322(LYST)

FAB:	101812819(LYST)

OMA:	130251519(LYST)

PHI:	102112723(LYST)

PMAJ:

107201945(LYST)

CCAE:

111926851(LYST)

CCW:	104684285(LYST)

CBRC:

103624081(LYST)

ACOE:

138108134(LYST)

ETL:	114066546(LYST)

ZAB:	102066601(LYST)

ZLE:	135445652(LYST)

ACHL:

103800345(LYST)

SVG:	106852240(LYST)

MMEA:

130588788(LYST)

HRT:	120750117(LYST)

SATI:

136359243(LYST)

CCIC:

134041941(LYST)

FPG:	101910820(LYST)

FCH:	102046356(LYST)

CCRI:

104163758(LYST)

NNT:	104413522(LYST)

SHAB:

115614032(LYST)

ACUN:

113478535(LYST)

TALA:

104359026(LYST)

ACHC:

115349959(LYST)

HALD:

104314480(LYST)

HLE:	104828733(LYST)

AGEN:

126051822

HHAR:

128149827(LYST)

GCL:

127014160

CSTI:

104550600

LDI:	104354147(LYST)

MNB:	103770623(LYST)

DPUB:

104305228(LYST)

PPUS:

135183510

AVIT:

104271219

BRHI:

104491554(LYST)

EGZ:	104131014(LYST)

NNI:	104019869(LYST)

PCRI:

104038297(LYST)

PCAO:

104052799(LYST)

PADL:

103921231(LYST)

AFOR:

103900992(LYST)

FGA:	104078968(LYST)

CBOR:

142080675(LYST)

GSTE:

104256279(LYST)

CBOY:

140649352(LYST)

MAME:

142407004(LYST)

CLV:	102094920(LYST)

CNIC:

135986522(LYST)

PGUU:

104458637(LYST)

PLET:

104627529(LYST)

EHS:

104514676

CMAC:

104480416(LYST)

CUCA:

104060349(LYST)

TEO:	104380744(LYST)

BREG:

104640358(LYST)

OHA:	104328290(LYST)

ACAR:

104528482(LYST)

CPEA:

104388690(LYST)

CVF:	104287252(LYST)

RTD:	128907154(LYST)

CRID:

134513004(LYST)

LMIC:

141740789(LYST)

AAM:	106486815(LYST)

AROW:

112964539(LYST)

NPD:	112951933(LYST)

TGT:	104573818(LYST)

DNE:	112988997(LYST)

SCAM:

104148174(LYST)

ASN:	102374372(LYST)

AMJ:	102561444(LYST)

CPOO:

109319966(LYST)

GGN:	109304512(LYST)

PSS:	102460343(LYST)

CIZ:	142011146(LYST)

CMY:	102935852(LYST)

CCAY:

125633873(LYST)

DCC:	119852820(LYST)

CPIC:

101932873(LYST)

TST:	117875482(LYST)

CABI:

116821682(LYST)

MRV:	120400421(LYST)

ACS:	100557273(lyst)

ASAO:

132761202(LYST)

PVT:	110075654(LYST)

SUND:

121931456(LYST)

PBI:	103052064(LYST) 103057306 103058668

PMUR:

107288314(LYST)

CTIG:

120312348(LYST)

TSR:

106538195

PGUT:

117671969(LYST)

PCAE:

139308743(LYST)

APRI:

131189723(LYST)

PTEX:

113439372(LYST)

NSS:	113413291(LYST)

VKO:	123018156(LYST)

PMUA:

114594414(LYST)

PRAF:

128410832(LYST)

ZVI:	118081863(LYST)

HCG:	128346499(LYST)

GJA:	107117654(LYST)

STOW:

125426913(LYST)

EMC:	129326772(LYST)

XLA:

101027285

XTR:	779601(lyst)

NPR:	108788001(LYST)

RTEM:

120937424(LYST)

ACAT:

141140393(LYST)

BBUF:

120998673(LYST)

BGAR:

122935042(LYST)

DTC:	141072884(LYST)

PWL:	138296095(LYST)

MUO:	115465435(LYST)

GSH:	117356744(LYST)

DRE:	100150726(lysT)

SRX:	107728318 107730379

SANH:

107689764 107691204

SGH:	107557718(lyst) 107569426

CCAR:

109102661(lyst) 109112143

CAUA:

113056630(lyst) 113112320

CGIB:

127970404 128025860

PTET:

122356212(lyst)

LROH:

127175506(lyst)

GRF:

141325150

OMC:	131551775(lyst)

PPRM:

120461177(lyst)

RKG:	130068996(lyst)

MAMB:

125276474(lyst)

CIDE:

127525477

CERY:

137020315(lyst)

MASI:

127411909 127414352

TROS:

130559636(lyst)

TDW:	130431346(lyst)

MANU:

129415472(lyst)

PDAB:

135786711(lyst)

IPU:

108261076

IFU:	128605356(lyst)

PHYP:

113542007(lyst)

SMEO:

124396944(lyst)

TFD:	113644978(lyst)

TVC:	132847062(lyst)

CGAR:

128528888(lyst)

NGRA:

132889219(lyst)

TRN:	134314964(lyst)

AMEX:

103033034(lyst)

CMAO:

118810724(lyst)

EEE:	113577749(lyst)

CHAR:

105902255(lyst)

SPIL:

134064486(lyst)

ASAD:

121685443(lyst)

TRU:	101062501(lyst)

TFS:	130533369(lyst)

TNG:	GSTEN00030876G001

LCO:	104934546(lyst)

NCC:	104960297(lyst)

TBEN:

117499969(lyst)

CGOB:

115019746(lyst)

PGEO:

117459654(lyst)

GACU:

117553412(lyst)

EMAC:

134858823(lyst)

ELY:	117248040(lyst)

EFO:	125903361(lyst)

PLEP:

121954974(lyst)

SLUC:

116051130(lyst)

ECRA:

117960108(lyst)

ESP:	116705713(lyst)

PFLV:

114571715(lyst)

GAT:	120820343(lyst)

PPUG:

119213958(lyst)

AFB:	129091992(lyst)

CLUM:

117744409(lyst)

PSWI:

130207632(lyst)

CANA:

137779526(lyst)

CVE:	137883635(lyst)

MSAM:

119916997(lyst)

SCHU:

122884522(lyst)

CUD:	121511586(lyst)

SPUL:

138589053(lyst)

LMIX:

132975079(lyst)

HTC:	141794750(lyst)

ALAT:

119033414(lyst)

ASTR:

137603430(lyst)

MZE:	101476748(lyst)

ONL:	100694037(lyst)

OAU:	116318521(lyst)

OLA:	101170120(lyst)

OML:	112161466(lyst)

CSAI:

133463998(lyst)

XMA:	102234327(lyst)

XCO:	114137452(lyst)

XHE:	116713156(lyst)

PRET:

103477259(lyst)

PFOR:

103137661(lyst)

PLAI:

106949760(lyst)

PMEI:

106923826

GAF:	122842455(lyst)

PPRL:

129359630(lyst)

CVG:	107087804(lyst)

CTUL:

119782863(lyst)

GMU:	124859561(lyst)

NFU:	107375428(lyst)

KMR:	108240656(lyst)

ALIM:

106515873(lyst)

NWH:	119411192(lyst)

AOCE:

111573714(lyst)

EJA:	138195541(lyst)

BFRE:

138616069(lyst)

MCEP:

125018968(lysT)

CSEM:

103387614(lyst)

POV:	109630601(lyst) 109647567

SSEN:

122773164

SSOE:

131473755(lyst)

HHIP:

117775180(lyst)

HSP:	118118699(lyst)

PPLT:

128453085(lyst)

SMAU:

118283514(lyst)

LCF:

108885796

SDU:	111220560(lyst)

SLAL:

111658939(lyst)

XGL:	120796310(lyst)

HCQ:	109516216(lyst)

SSCV:

125978079(lyst)

SBIA:

133509752(lyst)

PEE:	133410216(lyst)

PTAO:

133485568(lyst)

BPEC:

110156774(lyst)

ENY:	140351228(lyst)

MALB:

109960817(lyst)

BSPL:

114870625(lyst)

SJO:	128372611(lyst)

SSCO:

133991534(lyst)

TTY:	137196798(lyst)

GMH:	115559801(lyst)

SASA:

106578744 106591199

STRU:

115155327(lyst)

OTW:	112236521 112237442

OMY:	110492789(lyst)

OGO:	124048031(lyst)

OKI:	109866052(lyst)

OKE:	118381102(lyst)

OMM:	135505291(lyst)

OCLA:

139367856

SALP:

112074671

SFON:

129863419(lyst)

CCLU:

121574315(lyst)

ELS:	105006092(lyst)

OEP:	134022802(lyst)

SFM:	108927089 108933602(lyst)

PKI:	111835683 111856370(lyst)

AANG:

118217551 118220324

AROT:

135245233 135249562

CCOG:

133114242 133118130

LOC:	102696080(lyst)

PSPA:

121316074 121317201(lyst)

ARUT:

117402875 117411061

PSEX:

120516289(lyst)

LCM:	102355328(LYST)

CMK:	103178879(lyst)

RTP:	109922054(lyst)

CPLA:

122542341(lyst)

HOC:	132833965(lyst)

SCAU:

119967689(lyst)

LERI:

129696992(lyst)

HAKA:

140733390(lyst)

PMRN:

116939665(LYST)

LRJ:	133347320(LYST)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LVG:

APLC:

SKO:

PFLL:

DME:	Dmel_CG42863(mv)

DER:

6545963

DSE:

6610432

DSI:	Dsimw501_GD13422(Dsim_GD13422)

DYA:	Dyak_GE20897

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12178

DAZ:

108612292

DNV:

108650895

DHE:

111603049

DVI:	6624309(mv)

CCAT:

BOD:

BDR:

AOQ:

ALUD:

TDA:

MDE:	101889306 131806483

SCAC:

106085788

LCQ:

111690865

LSQ:

119603680

CVJ:	135953291(mv)

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ005368

CPII:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108723393(mv)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139104439(Mv)

TLN:	139820583(Mv)

HST:

DQU:

CFO:

FEX:

PMEC:

138932580(Mv)

LHU:	105672150(mv)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209457

PMAC:

106712680 106712681

PXU:

106123368

BPHI:

137932923(mv)

PRAP:

111003661

ZCE:

119834276

AAGE:

121739343

HAW:	110376889(Mv)

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

LGLY:

CSTB:

CFUM:

141431710(mv)

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

106680353(mv)

NLU:

111046960

LDA:	142326746(mv)

PHU:	Phum_PHUM351440

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138706405(mv)

BROR:

134530338

IEL:

124157044

HAMR:

139687241(mv)

FCD:

110854100

DPX:	DAPPUDRAFT_195317 DAPPUDRAFT_316324

DMK:

DPZ:

AFRA:

PJA:

PCHN:

PMOO:

PCLA:

PTRU:

HAZT:

EAF:

LSM:	121125900(mv)

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

ABRU:

SDM:

LOA:	LOAG_16516

TSP:	Tsp_07712 Tsp_12811

HRO:	HELRODRAFT_191731

LGI:	LOTGIDRAFT_161637

PCAN:

BGT:

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MMER:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_162930

EGL:

EGR_03651

LLON:

135484461

NVE:	5507137 5518881

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

RES:

TAD:	TRIADDRAFT_26285

AQU:

100641459

DDI:	DDB_G0271504(lvsB)

DPP:	DICPUDRAFT_159064

DFA:	DFA_10070(lvsB)

ACAN:

ACA1_365070

» show all

Reference

PMID:8896560

Authors

Nagle DL, Karim MA, Woolf EA, Holmgren L, Bork P, Misumi DJ, McGrail SH, Dussault BJ Jr, Perou CM, Boissy RE, Duyk GM, Spritz RA, Moore KJ

Title

Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome.

Journal

Nat Genet 14:307-11 (1996)
DOI:10.1038/ng1196-307

Sequence

[hsa:1130]

LinkDB

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