KEGG   ORTHOLOGY: K27884
Entry
K27884                      KO                                     
Symbol
pyrS
Name
two-component system, LytTR family, high-concentration pyruvate sensor kinase [EC:2.7.13.3]
Pathway
map02020  Two-component system
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K27884  pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K27884  pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase
  09183 Protein families: signaling and cellular processes
   02022 Two-component system
    K27884  pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.13  Protein-histidine kinases
    2.7.13.3  histidine kinase
     K27884  pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase
Protein kinases [BR:ko01001]
 Histidine kinases
  LytTR family [OT]
   K27884  pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase
Two-component system [BR:ko02022]
 LytTR family
  PyrS-PyrR (pyruvate reutilization)
   K27884  pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase
Other DBs
COG: COG3275
GO: 0000155
Genes
ECO: b2380(pyrS)
ECJ: JW5388(ypdA)
ECD: ECDH10B_2545(ypdA)
EBW: BWG_2148(ypdA)
ECOK: ECMDS42_1937(ypdA)
ECOC: C3026_13235
ECE: Z3645
ECS: ECs_3260(ypdA)
ECF: ECH74115_3612
ETW: ECSP_3330(ypdA)
ELX: CDCO157_3024
EOI: ECO111_3116(ypdA)
EOJ: ECO26_3440(ypdA)
EOH: ECO103_2905(ypdA)
ECOO: ECRM13514_3205
ECOH: ECRM13516_3067
ESL: O3K_07470
ESO: O3O_18165
ESM: O3M_07520
ECK: EC55989_2676(ypdA)
ECG: E2348C_2573(ypdA)
EOK: G2583_2913(ypdA)
ELR: ECO55CA74_14450
ELH: ETEC_2499
ECW: EcE24377A_2670
EUN: UMNK88_2980
ECP: ECP_2406
ENA: ECNA114_2462(ypdA)
ECOS: EC958_5001(ypdA)
ECV: APECO1_4157(ypdA)
ECOA: APECO78_15655
ECX: EcHS_A2517
ECM: EcSMS35_2532
ECY: ECSE_2677
ECR: ECIAI1_2446(ypdA)
ECQ: ECED1_2827(ypdA)
EUM: ECUMN_2710(ypdA)
ECT: ECIAI39_2524(ypdA)
EOC: CE10_2758(ypdA)
EBR: ECB_02290(ypdA)
ECOB: C3029_16020
EBL: ECD_02290(ypdA)
EBE: B21_02251(ypdA)
EBD: ECBD_1292
ECI: UTI89_C2712(ypdA)
EIH: ECOK1_2696
ECZ: ECS88_2575(ypdA)
ECC: c2919(ypdA)
ELO: EC042_2599
ELN: NRG857_11960
ESE: ECSF_2250
ECL: EcolC_1289
EKF: KO11_10860(ypdA)
EAB: ECABU_c27000(ypdA)
EDH: EcDH1_1277
EDJ: ECDH1ME8569_2319(ypdA)
ELU: UM146_04700
ELW: ECW_m2613(ypdA)
ELL: WFL_12820(ypdA)
ELC: i14_2716(ypdA)
ELD: i02_2716(ypdA)
ELP: P12B_c2499
ELF: LF82_3615(ypdA)
ECOL: LY180_12275
ECOI: ECOPMV1_02584(ypdA)
ECOJ: P423_13230
EFE: EFER_0788(ypdA)
EAL: EAKF1_ch3618c
EMA: C1192_23550
ESZ: FEM44_01950
ERUY: OSH18_19540(ypdA)
SFV: SFV_2438
SFE: SFxv_2693(ypdA)
SFN: SFy_3472
SFS: SFyv_3547
SFT: NCTC1_02683(ypdA)
SBO: SBO_2406
SBC: SbBS512_E2749
SDY: SDY_2579
SDZ: Asd1617_03475
SHQ: A0259_15655
SHIG: LXH19_07160(ypdA)
ENC: ECL_03724
ECLG: EC036_31810
ECLE: ECNIH2_16315
ECLN: ECNIH4_06835
ECLI: ECNIH5_15255
ECLX: LI66_15660
ECLY: LI62_17160
ECLZ: LI64_15090
EHM: AB284_09760
EXF: BFV63_15480
ECLA: ECNIH3_15345
ECLC: ECR091_15280
EAU: DI57_03315
EKB: BFV64_16025
ENO: ECENHK_15910
EEC: EcWSU1_03224(ypdA)
ELG: BH714_12255
ECAN: CWI88_06440
ERN: BFV67_15795
ECLS: LI67_017180
ECHG: FY206_17650
ESH: C1N69_16180
EPT: HWQ17_20065
ENT: Ent638_2919
EAS: Entas_3125
ENR: H650_07680
ENX: NI40_015930
ENF: AKI40_1506
LNI: CWR52_19110
EBG: FAI37_13155
END: A4308_20575
ENZ: G0034_16525
ENS: HWQ15_01240
ENK: LOC22_03800
EHU: D5067_0006830
EMOR: L6Y89_15480
ENB: ELK40_16320
EQU: OM418_15785
EPU: QVH39_16560
EDY: F0320_15450
EAX: AAHF05_16045
ESA: ESA_00854
CSK: ES15_1115
CSZ: CSSP291_04155
CSJ: CSK29544_02060
CCON: AFK62_14210
CDM: AFK67_14610
CSI: P262_01622
CMJ: AFK66_005210
CUI: AFK65_14085
CMW: AFK63_04190
CTU: CTU_29940(ypdA)
KPN: KPN_02736(ypdA)
KPU: KP1_3987(ypdA)
KPM: KPHS_38080
KPP: A79E_1365
KPH: KPNIH24_09645
KPZ: KPNIH27_18190
KPV: KPNIH29_19005
KPW: KPNIH30_19225
KPY: KPNIH31_18425
KPG: KPNIH32_19555
KPC: KPNIH10_18565
KPQ: KPR0928_18585
KPT: VK055_4776
KPO: KPN2242_16770
KPR: KPR_1968(ypdA)
KPJ: N559_1515
KPI: D364_13940
KPA: KPNJ1_01599
KPS: KPNJ2_01569
KPX: PMK1_00233(ypdA)
KPB: FH42_09795
KPNE: KU54_007370
KPNU: LI86_07375
KPNK: BN49_3952(ypdA)
KVA: Kvar_1314
KPE: KPK_1403
KPK: A593_03935
KVD: KR75_01230
KVQ: SP68_07760
KQU: AVR78_23245
KQV: B8P98_08040
KOX: KOX_26725
KOE: A225_4248
KOY: J415_10905
KOM: HR38_24855
KMI: VW41_16110
KOK: KONIH1_20935
KOC: AB185_15395
EAE: EAE_00255
EAR: CCG28871
KLL: BJF97_20895
KLW: DA718_08085
KAR: LGL98_07005
KGR: JJJ10_07840
KPAS: LUW96_27360
KLC: K7H21_07830
KLM: BWI76_20500
REE: electrica_01385(ypdA_1)
KLP: GUC22_07120
ROR: RORB6_00780
RON: TE10_20640
RAO: DSD31_07140
RTG: NCTC13098_01881(ypdA_1)
CRO: ROD_27951
CKO: CKO_00420
CFD: CFNIH1_23340
CBRA: A6J81_24445
CWE: CO701_05960
CYO: CD187_07355
CPOT: FOB25_18520
CSED: JY391_07095(ypdA)
CAMA: F384_13240
CAF: AL524_10205
CIF: AL515_16210
CFAR: CI104_17950
CIR: C2U53_28190
CIE: AN232_11805
CPAR: CUC49_12275
CTEL: GBC03_12070
CITZ: E4Z61_00640
CARS: E1B03_18870
CIX: M4I31_07215
CIB: HF677_007110
CENS: P2W74_07005(ypdA)
CITR: GUC46_07115
CIQ: FD428_06640
CIY: HAP28_18075
EBT: EBL_c11280(ypdA)
CNT: JT31_18770
CEM: LH23_22160
CEN: LH86_20690
CLAP: NCTC11466_01210(ypdA)
PGE: LG71_11495
ESC: Entcl_1359
KLE: AO703_15040
KSA: C813_22780
KOR: AWR26_07620
KRD: A3780_16340
KCO: BWI95_21675
KOT: EH164_06445
KPSE: IP581_15935
KOB: HF650_16920
KOO: O9K67_07445
KOU: C0557_17860
KCA: AAEY27_07010
KIE: NCTC12125_00324(ypdA)
KAS: KATP_12730(ypdA)
KLU: K7B04_22595
KCY: RIN60_06890
LAX: APT61_06485
LEI: C2U54_21550
LEH: C3F35_18475
LEE: DVA44_06600
LER: GNG29_16160
LEA: GNG26_16005
LPNU: KQ929_05650
LEY: DVA43_01330
LAZ: A8A57_15035
LEF: LJPFL01_2964
LEW: DAI21_11615
BUF: D8682_22065
BAGE: BADSM9389_11800
BFT: MNO13_06415
BSEL: RHD99_06320
AHN: NCTC12129_01447(ypdA_3)
ASUB: NLZ15_15710
YRE: HEC60_11290
SGOE: A8O29_006750
KIN: AB182_06455
PDZ: HHA33_09420
METY: MRY16398_14910
IZH: FEM41_22820
PSGC: G163CM_02510(ypdA)
SCOL: KFZ77_13840
PVJ: LMA04_18370
SUPE: P0H77_15240
TOE: QMG90_07095
AAPT: QNH14_05380
MPHG: MPHASIOC01_002679
FPUL: ACBV55_16480
EBF: D782_1268
EBC: C2U52_16450
EBU: CUC76_22615
EBB: F652_515(lytS)
PSTS: E05_18560
YEN: YE1228
YEP: YE105_C2884
YEY: Y11_00961
YEW: CH47_629
YEF: FORC2_1248
YEE: YE5303_09831
YAL: AT01_3665
YFR: AW19_394
YIN: CH53_501
YKR: CH54_1269
YRO: CH64_1321
YRU: BD65_922
YRB: UGYR_05190
YAK: ACZ76_03030
YMA: DA391_06595
YHI: D5F51_15455
YEL: LC20_03849
YCA: F0T03_06880
YMO: HRD69_19015
YAS: N0H69_09590
YKI: HRD70_11020
YEG: PL78_16160
SMAR: SM39_3014
SMAC: SMDB11_2806
SMW: SMWW4_v1c35240(ypdA)
SPE: Spro_3404
SRR: SerAS9_3596
SRL: SOD_c33190(ypdA)
SRY: M621_18040
SPLY: Q5A_017990(ypdA)
SRS: SerAS12_3597
SRA: SerAS13_3598
SMAF: D781_3185
SLQ: M495_17500
SERF: L085_11065
SFW: WN53_26350
SFG: AV650_22420
SRZ: AXX16_1884
SERM: CLM71_16830
SQU: E4343_23720
SFJ: SAMEA4384070_3535(ypdA)
SOF: NCTC11214_03270(ypdA)
SSUR: ATE40_014240
SURI: J0X03_06420
SRHZ: FO014_17415
SENP: KHA73_17200
SNEM: NLX84_17695
SNEV: OI978_14810
SGRI: SGBXF1_03472(ypdA)
SSAR: SSARUM_003391
SERN: GUC32_17530
SERT: TAN611_3388(ypdA)
SERH: GF111_20065
RAH: Rahaq_1132
RACE: JHW33_00025
RAQ: Rahaq2_1212
RAA: Q7S_05445
ROX: BV494_00960
RVC: J9880_13510
RBON: QNM34_05820
RIU: I2123_07725
GQU: AWC35_19175
EAME: GXP68_06215
RBAD: H2866_01940
RCB: O1V66_01385
CARU: P0E69_05630
NIG: C1N62_04635
ECA: ECA2432
PATR: EV46_11725
PATO: GZ59_21240
PCT: PC1_1878
PCC: PCC21_019380
PCV: BCS7_09715
PWA: Pecwa_2170
PPAR: A8F97_07760
PEC: W5S_2111
PWS: A7983_18280
PPOA: BJK05_04420
PBRA: B5S52_12285
PPUJ: E2566_10045
PARI: I2D83_10225
PAQU: DMB82_0011605
PVZ: OA04_23840(ypdA)
PPAV: LOZ86_09480
PQU: IG609_009280
PPOO: LW347_09825
PCAC: OI450_10205
PACB: M9782_11910
PARL: PEC302110_18760
PPEU: DUT67_11715
DDD: Dda3937_03817(ypdA)
DZE: Dd1591_2444
DDC: Dd586_2385
DZC: W909_08125
DSO: A4U42_18080
CED: LH89_03285
DFN: CVE23_09525
DDQ: DDI_1600
DAQ: DAQ1742_01975(ypdA)
DIC: Dpoa569_0002224
DLC: O1Q98_00310
DDA: Dd703_2358
BIZ: HC231_10135
LBQ: CKQ53_15695
LPOP: I6N93_09600
SOD: Sant_1272
ETA: ETA_11160
EBI: EbC_32490
EPE: CI789_02135
ERWI: GN242_05860
ERP: LJN55_16720
EPI: Q3V30_06205
ERWE: GKQ23_07670
ETO: RIN69_16130
EGE: EM595_2586(ypdA)
PAM: PANA_2742(ypdA)
PLF: PANA5342_1308(ypdA)
PAJ: PAJ_2026(ypdA)
PAQ: PAGR_g1283
PVA: Pvag_2177(ypdA)
PAGG: AL522_17955
PAO: Pat9b_2815
KLN: LH22_08530
PANT: PSNIH1_00840
PANP: PSNIH2_03845
PAGC: BEE12_01520
PSTW: DSJ_18160
PALH: B1H58_13180
PANS: FCN45_13625
PEY: EE896_05590
PDIS: D8B20_12125
PER: LAC65_11370
PJI: KTJ90_05540
PANO: OJ965_07870
KPIE: N5580_04955
PALF: K6R05_05645
PPHO: CTZ24_14515
PDIP: KFZ74_05945
PANE: P6287_13805
PAMT: IAI47_05565
PANZ: NR302_13480
PGZ: C2E15_15280
PCD: C2E16_14965
MINT: C7M51_02234(ypdA_2)
MTHI: C7M52_00623(ypdA_1)
MHAN: K6958_14395
TCI: A7K98_14190
TPTY: NCTC11468_02658(ypdA)
PMAK: PMPD1_3171
ETD: ETAF_2738
ETE: ETEE_1244(lytS)
ETR: ETAE_3010(lytS)
ETC: ETAC_14500
EDW: QY76_05305
EHO: A9798_02175
HAV: AT03_07395
HPAR: AL518_18190
OPO: DSM2777_12670
PPR: PBPRB1912(YPDA)
PDS: CAY62_04575
SALY: E8E00_13880
SCOT: HBA18_13820
SPRO: N7E60_15695
SBL: Sbal_4300
SBM: Shew185_0054
SBN: Sbal195_0059
SBP: Sbal223_0058
SBT: Sbal678_0063
SBS: Sbal117_4467
SBB: Sbal175_0062
SHE: Shewmr4_0056
SHM: Shewmr7_0054
SHEW: CKQ84_08495
SYK: KDN34_01725
SOG: RA178_00315
PSY: PCNPT3_04860
MMAA: FR932_13125
MLAU: ACEPPP_01980
AHA: AHA_0066
AHY: AHML_00375
AHD: AI20_19685
AHR: V428_00405
AHP: V429_00405
AHJ: V469_00330
AHH: RY45_00320
AHI: VU14_00525
AAJ: BOQ57_21950
ASA: ASA_0068
AEO: O23A_p3564
AVR: B565_0044
AVO: AMS64_00185
AMED: B224_5279
ASR: WL1483_3733(ypdA)
ADH: CK627_03615
ACAV: VI35_00305
AEM: CK911_17545
AEA: C2U39_22560
ARV: C7N77_03840
AES: C2U30_13645
AEL: NCTC12917_00053(ypdA)
AALL: I6G90_15545
AJD: I6H43_10935
ARIV: KYK33_00390
ASAA: KXJ75_00260
AEJ: E5E97_04005
ABES: IU367_00345
AERO: CK910_04335
AERZ: E5E96_07050
CDIZ: CEDIAZO_00858(ypdA)
CVI: CV_1771
CVC: BKX93_22045
CHRO: CXB49_13500
CHRI: DK842_16075
CHRB: DK843_21600
CRZ: D1345_15805
CHAE: CH06BL_12030
NEN: NCHU2750_31790
BIF: N288_25800
BACI: B1NLA3E_09445
BCIR: C2I06_23020
NTX: NQZ71_18630
NIL: L8T27_002945
NTGC: AB3U99_04465
BEO: BEH_23950
CGOT: J1899_21745
TAP: GZ22_12530
TAID: KS242_16735
NDT: L1999_16995
BCK: BCO26_2378
BAG: Bcoa_2045
BCOA: BF29_1520
STEA: C0679_04980
PPY: PPE_03532
PPM: PPSC2_18790(ypdA3)
PPO: PPM_3780(ypdA3)
PPOL: X809_34890
PPQ: PPSQR21_037670
PPOY: RE92_18445
PTA: HPL003_27495
PSAB: PSAB_01480
PDU: PDUR_01750
PBD: PBOR_01970
PGM: PGRAT_02220
POD: PODO_01780
PAEN: P40081_02290
PAEF: R50345_01755
PSTE: PSTEL_02220
PAEA: R70723_01685
PAEE: R70331_01645
PAEH: H70357_01885
PAEJ: H70737_01840
PIH: UB51_25675
PRI: PRIO_0493(ypdA1)
PPEO: ABE82_18770
PBV: AR543_17360
PXL: BS614_23600
PDH: B9T62_33895
PKB: B4V02_06765
PAIH: ASL14_19580
PBAC: HUB98_07375
PSOP: KP014_04940
PKA: PQ456_14850
PUI: PUW25_01120
PMAH: PTQ21_26490
PAMY: P9222_16480
PMAE: LMZ02_02745
PPOG: QPK24_01270
PHK: SK066_08470
PNK: AASFL403_04275
PPAB: KET34_23395
PLZH: C0638_14680
PEZZ: HW560_16330
PAUB: PUR_03450
SACA: FFV09_01875
CNO: NT01CX_1257
CBN: CbC4_0407
CPAS: Clopa_1850
CPAT: CLPA_c31340
CPAE: CPAST_c31340
CSB: CLSA_c19710(ypdA)
CCK: Ccar_06670
CCHV: BTM20_04635
CSEP: CP523_03050
CDY: F3K33_19475
CGAS: J1C67_15720
CCAA: KQH81_07830
CNN: CNEO_2182
CTAG: LL095_04595
HHW: NCTC503_00084(ypdA)
CALE: FDN13_11080
CRS: FQB35_00525
CPRF: K7H06_17950
CRAS: KVH43_05095
OCW: OW730_22985
PBIF: KXZ80_04215
PSOR: RSJ16_04175
CDF: CD630_26020
PDC: CDIF630_02856
CDC: CD196_2442
CDL: CDR20291_2489
PDF: CD630DERM_26020
RIL: CRIB_2013
RHOM: FRIFI_2291
TEM: JW646_06070
TGC: L0P85_02295
TMY: TEMA_36370(ypdA)
TPET: TPHSE_06540(ypdA)
TEB: T8CH_0892(pyrS)
THYR: P4S50_12630
IBR: NQ514_06210
CST: CLOST_1078(ypdA)
OCS: OF820_05770
FNU: FN0220
FNC: HMPREF0946_01463
FNT: HMPREF0405_01497
FUS: HMPREF0409_01232
FNE: FSDG_02127
FHW: RN87_11070
FPD: CTM68_09780
FVA: FV113G1_33020
FUL: C4N20_07490
FGO: C4N16_02030
FNF: BSQ88_10030
FPEI: C4N17_02960
FCI: I6I83_03900
FHO: H9Q81_06480
FPOL: ERS445057_00656(ypdA)
IPO: Ilyop_2498
CSOM: MKD34_06285
 » show all
Reference
PMID:30624637
  Authors
Miyake Y, Inaba T, Watanabe H, Teramoto J, Yamamoto K, Ishihama A
  Title
Regulatory roles of pyruvate-sensing two-component system PyrSR (YpdAB) in Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 366:5281236 (2019)
DOI:10.1093/femsle/fnz009
Reference
PMID:24659770
  Authors
Behr S, Fried L, Jung K
  Title
Identification of a novel nutrient-sensing histidine kinase/response regulator network in Escherichia coli.
  Journal
J Bacteriol 196:2023-9 (2014)
DOI:10.1128/JB.01554-14
Reference
PMID:23222720
  Authors
Fried L, Behr S, Jung K
  Title
Identification of a target gene and activating stimulus for the YpdA/YpdB histidine kinase/response regulator system in Escherichia coli.
  Journal
J Bacteriol 195:807-15 (2013)
DOI:10.1128/JB.02051-12
  Sequence
[eco:b2380]
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