KEGG   MODULE: M00375
Entry
M00375            Pathway   Module                                 
Name
Hydroxypropionate-hydroxybutylate cycle
Definition
(K01964+K15037+K15036) K15017 K15039 K15018 K15019 K15020 K05606 (K01848+K01849) (K15038,K15017) K14465 (K14466,K18861,K25774) K14534 K15016 K00626
Diagram
M00375

Orthology
K01964,K15036  
acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] [RN:R00742 R01859]
K15037  
biotin carboxyl carrier protein [RN:R00742 R01859]
K15017  
malonyl-CoA reductase (NADPH) [EC:1.2.1.75] [RN:R00740]
K15039  
3-hydroxypropionate dehydrogenase (NADP+) [EC:1.1.1.298] [RN:R09289]
K15018  
3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36] [RN:R09286]
K15019  
3-hydroxypropionyl-coenzyme A dehydratase [EC:4.2.1.116] [RN:R03045]
K15020  
acryloyl-coenzyme A reductase [EC:1.3.1.84] [RN:R00919]
K05606  
methylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765]
K01848,K01849  
methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]
K15038,K15017  
succinyl-coA reductase [EC:1.2.1.76] [RN:R09280]
K14465  
succinate semialdehyde reductase [EC:1.1.1.-] [RN:R09281]
K14466,K18861,K25774  
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279]
K14534  
4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3] [RN:R10782]  
K15016  
3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Other carbon fixation pathways
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R00742  
R00740  
R09289  
R09286  
R03045  
R00919  
R01859  
R02765  
R00833  
R09280  
R09281  
R09279  
R10782  
R03026  
R01975  
R00238  
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00222  3-Oxopropanoate
C01013  3-Hydroxypropanoate
C05668  3-Hydroxypropionyl-CoA
C00894  Propenoyl-CoA
C00100  Propanoyl-CoA
C00683  (S)-Methylmalonyl-CoA
C01213  (R)-Methylmalonyl-CoA
C00091  Succinyl-CoA
C00232  Succinate semialdehyde
C00989  4-Hydroxybutanoic acid
C11062  4-Hydroxybutyryl-CoA
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
RModule
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Comment
Organism group: crenarchaeota
Reference
PMID:19429610
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09
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