KEGG   MODULE: M00375
Entry
M00375            Pathway   Module                                 
Name
Hydroxypropionate-hydroxybutylate cycle
Definition
(K01964+K15037+K15036) K15017 K15039 K15018 K15019 K15020 K05606 (K01848+K01849) (K15038,K15017) K14465 (K14466,K18861,K25774) K14534 K15016 K00626
Diagram
M00375  Hydroxypropionate-hydroxybutylate cycle
M00375

Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Other carbon fixation pathways
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Orthology
K01964,K15036  
acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] [RN:R00742 R01859]
K15037  
biotin carboxyl carrier protein [RN:R00742 R01859]
K15017  
malonyl-CoA reductase (NADPH) [EC:1.2.1.75] [RN:R00740]
K15039  
3-hydroxypropionate dehydrogenase (NADP+) [EC:1.1.1.298] [RN:R09289]
K15018  
3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36] [RN:R09286]
K15019  
3-hydroxypropionyl-coenzyme A dehydratase [EC:4.2.1.116] [RN:R03045]
K15020  
acryloyl-coenzyme A reductase [EC:1.3.1.84] [RN:R00919]
K05606  
methylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765]
K01848,K01849  
methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]
K15038,K15017  
succinyl-coA reductase [EC:1.2.1.76] [RN:R09280]
K14465  
succinate semialdehyde reductase [EC:1.1.1.-] [RN:R09281]
K14466,K18861,K25774  
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279]
K14534  
4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3] [RN:R10782]  
K15016  
3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
Complete
sto  Sulfurisphaera tokodaii
soh  Sulfurisphaera ohwakuensis
sjv  Sulfurisphaera javensis
sso  Saccharolobus solfataricus P2
sol  Saccharolobus solfataricus 98/2
ssoa  Saccharolobus solfataricus SULA
ssol  Saccharolobus solfataricus SARC-B
ssof  Saccharolobus solfataricus SARC-C
sshi  Saccharolobus shibatae
scas  Saccharolobus caldissimus
sis  Saccharolobus islandicus L.S.2.15
sia  Saccharolobus islandicus M.14.25
sim  Saccharolobus islandicus M.16.27
sid  Saccharolobus islandicus M.16.4
siy  Saccharolobus islandicus Y.G.57.14
sii  Saccharolobus islandicus L.D.8.5
sih  Saccharolobus islandicus HVE10/4
sir  Saccharolobus islandicus REY15A
sic  Saccharolobus islandicus LAL14/1
sula  Saccharolobus sp. A20
sule  Saccharolobus sp. E5-1-F
sai  Sulfolobus acidocaldarius DSM 639
sacn  Sulfolobus acidocaldarius N8
sacr  Sulfolobus acidocaldarius Ron12/I
sacs  Sulfolobus acidocaldarius SUSAZ
sulo  Sulfolobus sp. E11-6
sull  Sulfolobus sp. S-194
mse  Metallosphaera sedula DSM 5348
memj  Metallosphaera sedula MJ1HA
mcn  Metallosphaera cuprina
mhk  Metallosphaera hakonensis JCM 8857 = DSM 7519
mpru  Metallosphaera prunae
mten  Metallosphaera tengchongensis
mjn  Metallosphaera javensis
aho  Acidianus hospitalis
aman  Acidianus manzaensis
abri  Acidianus brierleyi
asul  Acidianus sulfidivorans
aamb  Acidianus ambivalens
acih  Acidianus sp. HS-5
sazo  Stygiolobus azoricus
csty  Stygiolobus caldivivus
step  Sulfuracidifex tepidarius
smet  Sulfuracidifex metallicus
 » show all
Reaction
R00742  
R00740  
R09289  
R09286  
R03045  
R00919  
R01859  
R02765  
R00833  
R09280  
R09281  
R09279  
R10782  
R03026  
R01975  
R00238  
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00222  3-Oxopropanoate
C01013  3-Hydroxypropanoate
C05668  3-Hydroxypropionyl-CoA
C00894  Propenoyl-CoA
C00100  Propanoyl-CoA
C00683  (S)-Methylmalonyl-CoA
C01213  (R)-Methylmalonyl-CoA
C00091  Succinyl-CoA
C00232  Succinate semialdehyde
C00989  4-Hydroxybutanoic acid
C11062  4-Hydroxybutyryl-CoA
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
RModule
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Comment
Organism group: crenarchaeota
Reference
PMID:19429610
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09
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