KEGG   MODULE: M00375
Entry
M00375            Pathway   Module                                 
Name
Hydroxypropionate-hydroxybutylate cycle
Definition
(K01964+K15037+K15036) K15017 K15039 K15018 K15019 K15020 K05606 (K01848+K01849) (K15038,K15017) K14465 (K14466,K18861) K14534 K15016 K00626
Diagram
M00375

Orthology
acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] [RN:R00742 R01859]
K15037  
biotin carboxyl carrier protein [RN:R00742 R01859]
K15017  
malonyl-CoA reductase (NADPH) [EC:1.2.1.75] [RN:R00740]
K15039  
3-hydroxypropionate dehydrogenase (NADP+) [EC:1.1.1.298] [RN:R09289]
K15018  
3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36] [RN:R09286]
K15019  
3-hydroxypropionyl-coenzyme A dehydratase [EC:4.2.1.116] [RN:R03045]
K15020  
acryloyl-coenzyme A reductase [EC:1.3.1.84] [RN:R00919]
K05606  
methylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765]
methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]
succinyl-coA reductase [EC:1.2.1.76] [RN:R09280]
K14465  
succinate semialdehyde reductase [EC:1.1.1.-] [RN:R09281]
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279]
K14534  
4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3] [RN:R10782]  
K15016  
3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Carbon fixation pathways in prokaryotes
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00222  3-Oxopropanoate
C01013  3-Hydroxypropanoate
C05668  3-Hydroxypropionyl-CoA
C00894  Propenoyl-CoA
C00100  Propanoyl-CoA
C00683  (S)-Methylmalonyl-CoA
C01213  (R)-Methylmalonyl-CoA
C00091  Succinyl-CoA
C00232  Succinate semialdehyde
C00989  4-Hydroxybutanoic acid
C11062  4-Hydroxybutyryl-CoA
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
RModule
RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
Comment
Organism group: crenarchaeota
Reference
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09
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