| Entry |
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| Name |
Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM
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| Definition |
K11263+K27093+K27094+K27095
K12428 K12437 K27306 K18851
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| Diagram |
| M00887 | Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM |
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| Class |
Pathway modules; Lipid metabolism; Fatty acid metabolism
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| Pathway |
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| Orthology |
accA3+accD4+accD5+accE5; long-chain acyl-CoA carboxylase [EC:6.4.1.-] [RN: R13256] fadD32; fatty acyl-AMP ligase FadD32 [EC:6.2.1.-] [RN: R13274] pks13; polyketide synthase 13 [RN: R13275] cmrA; mycolic acid reductase [RN: R13276] |
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| Complete |
| mtu | Mycobacterium tuberculosis H37Rv |
| mtv | Mycobacterium tuberculosis H37Rv |
| mtc | Mycobacterium tuberculosis CDC1551 |
| mra | Mycobacterium tuberculosis H37Ra |
| mtf | Mycobacterium tuberculosis F11 |
| mtb | Mycobacterium tuberculosis KZN 1435 |
| mtk | Mycobacterium tuberculosis KZN 4207 |
| mtz | Mycobacterium tuberculosis KZN 605 |
| mtur | Mycobacterium tuberculosis CCDC5079 |
| mto | Mycobacterium tuberculosis CTRI-2 |
| mtd | Mycobacterium tuberculosis UT205 |
| mtn | Mycobacterium tuberculosis Erdman = ATCC 35801 |
| mtj | Mycobacterium tuberculosis Beijing/NITR203 |
| mtub | Mycobacterium tuberculosis 7199-99 |
| mtue | Mycobacterium tuberculosis EAI5/NITR206 |
| mtx | Mycobacterium tuberculosis EAI5 |
| mtul | Mycobacterium tuberculosis Haarlem |
| mtut | Mycobacterium tuberculosis BT1 |
| mtuu | Mycobacterium tuberculosis BT2 |
| mtq | Mycobacterium tuberculosis HKBS1 |
| mbo | Mycobacterium tuberculosis variant bovis AF2122/97 |
| mbb | Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2 |
| mbt | Mycobacterium tuberculosis variant bovis BCG Tokyo 172 |
| mbm | Mycobacterium tuberculosis variant bovis BCG Mexico |
| mbk | Mycobacterium tuberculosis variant bovis BCG Korea 1168P |
| mbx | Mycobacterium tuberculosis variant bovis BCG ATCC 35743 |
| mmic | Mycobacterium tuberculosis variant microti |
| mce | Mycobacterium canettii CIPT 140010059 |
| mcq | Mycobacterium canettii CIPT 140060008 |
| mcv | Mycobacterium canettii CIPT 140070008 |
| mcx | Mycobacterium canettii CIPT 140070010 |
| mcz | Mycobacterium canettii CIPT 140070017 |
| mory | Mycobacterium orygis |
| mle | Mycobacterium leprae TN |
| mlb | Mycobacterium leprae Br4923 |
| mpa | Mycobacterium avium subsp. paratuberculosis K-10 |
| mao | Mycobacterium avium subsp. paratuberculosis MAP4 |
| mavi | Mycobacterium avium subsp. paratuberculosis E1 |
| mavu | Mycobacterium avium subsp. paratuberculosis E93 |
| mav | Mycobacterium avium 104 |
| mavm | Mycobacterium avium subsp. avium |
| mit | Mycobacterium intracellulare MOTT-02 |
| mia | Mycobacterium intracellulare ATCC 13950 |
| mid | Mycobacterium intracellulare subsp. intracellulare |
| myo | Mycobacterium intracellulare subsp. yongonense |
| mchi | Mycobacterium intracellulare subsp. chimaera |
| mir | Mycobacterium paraintracellulare |
| mmal | Mycobacterium marseillense |
| mlp | Mycobacterium lepraemurium |
| mman | Mycobacterium mantenii |
| mser | Mycobacterium senriense |
| msa | Mycobacterium sp. JS623 |
| mul | Mycobacterium ulcerans |
| mmi | Mycobacterium marinum M |
| mmae | Mycobacterium marinum E11 |
| mli | Mycobacterium liflandii |
| mpse | Mycobacterium pseudoshottsii |
| msho | Mycobacterium shottsii |
| mmc | Mycobacterium sp. MCS |
| mkm | Mycobacterium sp. KMS |
| mjl | Mycobacterium sp. JLS |
| mmm | Mycobacterium sp. MOTT36Y |
| mkn | Mycobacterium kansasii ATCC 12478 |
| myv | Mycobacterium sp. VKM Ac-1817D |
| mye | Mycobacterium sp. EPa45 |
| mhad | Mycobacterium haemophilum |
| mdx | Mycobacterium dioxanotrophicus |
| mshg | Mycobacterium shigaense |
| mfj | Mycobacterium florentinum |
| msto | Mycobacterium stomatepiae |
| msim | Mycobacterium simiae |
| msak | Mycobacterium saskatchewanense |
| mku | Mycobacterium kubicae |
| mlw | Mycobacterium lentiflavum |
| mnv | Mycobacterium noviomagense |
| mpag | Mycobacterium paragordonae |
| mgor | Mycobacterium vicinigordonae |
| mcoo | Mycobacterium cookii |
| mbai | Mycobacterium basiliense |
| mseo | Mycobacterium seoulense |
| mhek | Mycobacterium heckeshornense |
| mgau | Mycobacterium gallinarum |
| mbrd | Mycobacterium branderi |
| mshj | Mycobacterium shinjukuense |
| mmam | Mycobacterium malmoense |
| mspg | Mycobacterium spongiae |
| mot | Mycobacterium ostraviense |
| mlm | Mycobacterium lepromatosis |
| mpaa | Mycobacterium paraterrae |
| mmeh | Mycobacterium methanotrophicum |
| madi | Mycobacterium adipatum |
| mwu | Mycobacterium wuenschmannii |
| myj | Mycobacterium sp. djl-10 |
| mhaf | Mycobacterium hainanense |
| msm | Mycolicibacterium smegmatis MC2 155 |
| msg | Mycolicibacterium smegmatis MC2 155 |
| msb | Mycolicibacterium smegmatis MC2 155 |
| msn | Mycolicibacterium smegmatis INHR1 |
| msh | Mycolicibacterium smegmatis INHR2 |
| mva | Mycolicibacterium vanbaalenii |
| maus | Mycolicibacterium austroafricanum |
| mgi | Mycolicibacterium gilvum PYR-GCK |
| msp | Mycolicibacterium gilvum Spyr1 |
| mcb | Mycolicibacterium chubuense |
| mne | Mycolicibacterium neoaurum VKM Ac-1815D |
| myn | Mycolicibacterium neoaurum NRRL B-3805 |
| mft | Mycolicibacterium fortuitum |
| mphl | Mycolicibacterium phlei |
| mvq | Mycolicibacterium vaccae |
| mll | Mycolicibacterium litorale |
| mrh | Mycolicibacterium rhodesiae |
| mthn | Mycolicibacterium thermoresistibile |
| mhas | Mycolicibacterium hassiacum |
| mdu | Mycolicibacterium duvalii |
| mdr | Mycolicibacterium doricum |
| mauu | Mycolicibacterium aurum |
| mmag | Mycolicibacterium madagascariense |
| mmor | Mycolicibacterium moriokaense |
| mfx | Mycolicibacterium fallax |
| maic | Mycolicibacterium aichiense |
| mij | Mycolicibacterium insubricum |
| malv | Mycolicibacterium alvei |
| mty | Mycolicibacterium tokaiense |
| mpsc | Mycolicibacterium psychrotolerans |
| marz | Mycolicibacterium arabiense |
| mgad | Mycolicibacterium gadium |
| mhev | Mycolicibacterium helvum |
| msar | Mycolicibacterium sarraceniae |
| many | Mycolicibacterium anyangense |
| maub | Mycolicibacterium aubagnense |
| mpof | Mycolicibacterium poriferae |
| mphu | Mycolicibacterium phocaicum |
| mmuc | Mycolicibacterium mucogenicum |
| mmat | Mycolicibacterium mageritense |
| mbok | Mycolicibacterium boenickei |
| mfg | Mycolicibacterium farcinogenes |
| msei | Mycolicibacterium sediminis |
| mflv | Mycolicibacterium flavescens |
| mcee | Mycolicibacterium celeriflavum |
| mbrm | Mycolicibacterium brumae |
| mmon | Mycolicibacterium monacense |
| mgo | Mycolicibacterium goodii |
| mhol | Mycolicibacterium holsaticum |
| msen | Mycolicibacterium senegalense |
| mpae | Mycolicibacterium pallens |
| mrf | Mycolicibacterium rufum |
| mdf | Mycolicibacterium diernhoferi |
| mcro | Mycolicibacterium crocinum |
| mgro | Mycolicibacterium grossiae |
| mfre | Mycolicibacterium frederiksbergense |
| mbug | Mycobacterium burgundiense |
| myq | Mycobacterium antarcticum |
| mflu | Mycolicibacterium fluoranthenivorans |
| myh | Mycolicibacterium sp. HK-90 |
| mpat | Mycolicibacterium parafortuitum |
| mkr | Mycolicibacillus koreensis |
| mpak | Mycolicibacillus parakoreensis |
| mab | Mycobacteroides abscessus ATCC 19977 |
| mmv | Mycobacteroides abscessus subsp. massiliense GO 06 |
| mabb | Mycobacteroides abscessus subsp. bolletii 50594 |
| mabl | Mycobacteroides abscessus subsp. massiliense CCUG 48898 = JCM 15300 |
| mche | Mycobacteroides chelonae |
| miz | Mycobacteroides immunogenum |
| mste | Mycobacteroides stephanolepidis |
| msao | Mycobacteroides saopaulense |
| msal | Mycobacteroides salmoniphilum |
| mjd | Mycolicibacter sinensis |
| mter | Mycolicibacter terrae |
| mmin | Mycolicibacter minnesotensis |
| mhib | Mycolicibacter hiberniae |
| mher | Mycolicibacter heraklionensis |
| mvm | Mycolicibacter virginiensis |
| cgl | Corynebacterium glutamicum ATCC 13032 (Kyowa Hakko) |
| cgb | Corynebacterium glutamicum ATCC 13032 (Bielefeld) |
| cgu | Corynebacterium glutamicum K051 |
| cgt | Corynebacterium glutamicum R |
| cgs | Corynebacterium glutamicum SCgG1 |
| cgg | Corynebacterium glutamicum SCgG2 |
| cgm | Corynebacterium glutamicum MB001 |
| cgj | Corynebacterium glutamicum ATCC 21831 |
| cgq | Corynebacterium glutamicum AR1 |
| cgx | Corynebacterium glutamicum B253 |
| cef | Corynebacterium efficiens |
| cdi | Corynebacterium diphtheriae NCTC 13129 |
| cdp | Corynebacterium diphtheriae 241 |
| cdh | Corynebacterium diphtheriae INCA 402 |
| cdt | Corynebacterium diphtheriae HC01 |
| cde | Corynebacterium diphtheriae HC02 |
| cdr | Corynebacterium diphtheriae HC03 |
| cda | Corynebacterium diphtheriae HC04 |
| cdz | Corynebacterium diphtheriae 31A |
| cdb | Corynebacterium diphtheriae BH8 |
| cds | Corynebacterium diphtheriae C7 (beta) |
| cdd | Corynebacterium diphtheriae CDCE 8392 |
| cdw | Corynebacterium diphtheriae PW8 |
| cdv | Corynebacterium diphtheriae VA01 |
| cdip | Corynebacterium diphtheriae NCTC11397 |
| car | Corynebacterium aurimucosum |
| cpu | Corynebacterium pseudotuberculosis FRC41 |
| cpl | Corynebacterium pseudotuberculosis 3/99-5 |
| cpg | Corynebacterium pseudotuberculosis 316 |
| cpp | Corynebacterium pseudotuberculosis P54B96 |
| cpk | Corynebacterium pseudotuberculosis 1002 |
| cpq | Corynebacterium pseudotuberculosis C231 |
| cpx | Corynebacterium pseudotuberculosis I19 |
| cpz | Corynebacterium pseudotuberculosis PAT10 |
| cor | Corynebacterium pseudotuberculosis 267 |
| cop | Corynebacterium pseudotuberculosis 31 |
| cod | Corynebacterium pseudotuberculosis 1/06-A |
| cos | Corynebacterium pseudotuberculosis 42/02-A |
| coi | Corynebacterium pseudotuberculosis CIP 52.97 |
| coe | Corynebacterium pseudotuberculosis 258 |
| cou | Corynebacterium pseudotuberculosis Cp162 |
| cpse | Corynebacterium pseudotuberculosis 48252 |
| cpsu | Corynebacterium pseudotuberculosis CS_10 |
| cpsf | Corynebacterium pseudotuberculosis Ft_2193/67 |
| cul | Corynebacterium ulcerans BR-AD22 |
| cuc | Corynebacterium ulcerans 809 |
| cue | Corynebacterium ulcerans 0102 |
| cun | Corynebacterium ulcerans 210932 |
| cuq | Corynebacterium ulcerans 210931 |
| cuz | Corynebacterium ulcerans 05146 |
| cuj | Corynebacterium ulcerans 131002 |
| cus | Corynebacterium ramonii FRC0011 |
| chn | Corynebacterium halotolerans |
| ccn | Corynebacterium callunae |
| cmd | Corynebacterium maris |
| caz | Corynebacterium argentoratense |
| ccg | Corynebacterium casei |
| cax | Corynebacterium atypicum |
| cii | Corynebacterium imitans |
| cuv | Corynebacterium ureicelerivorans |
| cdo | Corynebacterium doosanense |
| chm | Corynebacterium humireducens |
| csx | Corynebacterium singulare |
| cmq | Corynebacterium marinum |
| cku | Corynebacterium kutscheri |
| ccj | Corynebacterium camporealensis |
| cmv | Corynebacterium mustelae |
| cei | Corynebacterium epidermidicanis |
| cted | Corynebacterium testudinoris |
| cut | Corynebacterium uterequi |
| cdx | Corynebacterium deserti |
| csp | Corynebacterium simulans |
| csta | Corynebacterium stationis |
| ccjz | Corynebacterium crudilactis |
| cpho | Corynebacterium phocae |
| cfc | Corynebacterium flavescens |
| cgv | Corynebacterium glaucum |
| cstr | Corynebacterium striatum |
| caqu | Corynebacterium aquilae |
| csph | Corynebacterium sphenisci |
| camg | Corynebacterium ammoniagenes |
| cmin | Corynebacterium minutissimum |
| cpeg | Corynebacterium pelargi |
| cxe | Corynebacterium xerosis |
| cee | Corynebacterium endometrii |
| csan | Corynebacterium sanguinis |
| cgk | Corynebacterium geronticis |
| crf | Corynebacterium rouxii |
| ccho | Corynebacterium choanae |
| cpso | Corynebacterium pseudopelargi |
| csur | Corynebacterium suranareeae |
| ccys | Corynebacterium cystitidis |
| cmat | Corynebacterium matruchotii |
| cyz | Corynebacterium yudongzhengii |
| ckf | Corynebacterium kefirresidentii |
| clia | Corynebacterium liangguodongii |
| cprp | Corynebacterium propinquum |
| cglu | Corynebacterium glucuronolyticum |
| csil | Corynebacterium silvaticum |
| ctub | Corynebacterium tuberculostearicum |
| cluj | Corynebacterium lujinxingii |
| cqn | Corynebacterium qintianiae |
| ckw | Corynebacterium kalinowskii |
| ccoe | Corynebacterium comes |
| cok | Corynebacterium occultum |
| cmf | Corynebacterium macginleyi |
| cpoy | Corynebacterium poyangense |
| cacc | Corynebacterium accolens |
| cfy | Corynebacterium freneyi |
| cpsl | Corynebacterium pseudogenitalium |
| chin | Corynebacterium hindlerae |
| cjh | Corynebacterium jeddahense |
| cpsp | Corynebacterium pseudodiphtheriticum |
| cihu | Corynebacterium ihumii |
| ccoy | Corynebacterium coyleae |
| chad | Corynebacterium hadale |
| cfg | Corynebacterium freiburgense |
| caqm | Corynebacterium aquatimens |
| ccaw | Corynebacterium canis |
| caui | Corynebacterium auris |
| cfac | Corynebacterium faecale |
| cfou | Corynebacterium fournieri |
| cfeu | Corynebacterium felinum |
| catr | Corynebacterium atrinae |
| cdur | Corynebacterium durum |
| ccou | Corynebacterium confusum |
| cafe | Corynebacterium afermentans subsp. lipophilum |
| cgf | Corynebacterium guangdongense |
| cgoi | Corynebacterium gottingense |
| capp | Corynebacterium appendicis |
| csue | Corynebacterium suedekumii |
| crie | Corynebacterium riegelii |
| cik | Corynebacterium incognitum |
| corn | Corynebacterium sp. NML98-0116 |
| cgp | Corynebacterium genitalium |
| ches | Corynebacterium hesseae |
| cbel | Corynebacterium belfantii |
| cors | Corynebacterium sp. SCR221107 |
| core | Corynebacterium sp. Z-1 |
| crhn | Corynebacterium rhinophilum |
| bfv | Brevibacterium flavum |
| nfa | Nocardia farcinica IFM 10152 |
| nfr | Nocardia farcinica NCTC11134 |
| nbr | Nocardia brasiliensis |
| nod | Nocardia otitidiscaviarum |
| rop | Rhodococcus opacus B4 |
| roa | Rhodococcus opacus PD630 |
| rpy | Rhodococcus pyridinivorans SB3094 |
| rby | Rhodococcus pyridinivorans TG9 |
| rrt | Rhodococcus rhodochrous |
| rtm | Rhodococcus triatomae |
| rko | Rhodococcus koreensis |
| rgo | Rhodococcus globerulus |
| roz | Rhodococcus oxybenzonivorans |
| rpsk | Rhodococcus pseudokoreensis |
| rgor | Rhodococcus gordoniae |
| rhoo | Rhodococcus sp. DN22 |
| rhou | Rhodococcus sp. 11-3 |
| rhoj | Rhodococcus sp. JVH1 |
| rhos | Rhodococcus sp. M8-50 |
| rhoq | Rhodococcus sp. M8-33 |
| rhoy | Rhodococcus sp. AH-ZY2 |
| rhoh | Rhodococcus sp. H-CA8f |
| rhjs | Rhodococcus sp. JS3073 |
| rhzq | Rhodococcus sp. 21391 |
| rhpd | Rhodococcus sp. PD04 |
| rhon | Rhodococcus sp. NJ-530 |
| rhsq | Rhodococcus sp. SGAir0479 |
| rhwy | Rhodococcus sp. WAY2 |
| rhdm | Rhodococcus sp. DMU1 |
| rhwq | Rhodococcus sp. W8901 |
| rhrc | Rhodococcus sp. RCBS9 |
| rhny | Rhodococcus sp. NyZ502 |
| rhrd | Rhodococcus sp. RDE2 |
| whr | Williamsia herbipolensis |
| gpo | Gordonia polyisoprenivorans |
| gru | Gordonia rubripertincta |
| gav | Gordonia alkanivorans |
| ghn | Gordonia hongkongensis |
| tpr | Tsukamurella paurometabola |
| tsm | Tsukamurella tyrosinosolvens |
| tpul | Tsukamurella pulmonis |
| tsd | Tsukamurella sp. PLM1 |
| dit | Dietzia sp. oral taxon 368 |
| dpc | Dietzia psychralcaliphila |
| did | Dietzia sp. DQ12-45-1b |
| toy | Tomitella fengzijianii |
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| Reaction |
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| Compound |
| C20876 | Very-long-chain acyl-CoA |
| C22857 | Very-long-chain alpha-carboxyacyl-CoA |
| C22874 | Meromycoloyl-[acp Pks13] |
| C22875 | Trehalose mycolic-beta-ketoester |
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| Reference |
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| Authors |
Takayama K, Wang C, Besra GS. |
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| Title |
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. |
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| Journal |
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| Reference |
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| Authors |
Marrakchi H, Laneelle MA, Daffe M. |
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| Title |
Mycolic acids: structures, biosynthesis, and beyond. |
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| Journal |
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| Reference |
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| Authors |
Bazet Lyonnet B, Diacovich L, Gago G, Spina L, Bardou F, Lemassu A, Quemard A, Gramajo H |
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| Title |
Functional reconstitution of the Mycobacterium tuberculosis long-chain acyl-CoA carboxylase from multiple acyl-CoA subunits. |
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| Journal |
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| Reference |
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| Authors |
Matsunaga I, Naka T, Talekar RS, McConnell MJ, Katoh K, Nakao H, Otsuka A, Behar SM, Yano I, Moody DB, Sugita M. |
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| Title |
Mycolyltransferase-mediated glycolipid exchange in Mycobacteria. |
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| Journal |
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| LinkDB |
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