KEGG   MODULE: M00887
Entry
M00887            Pathway   Module                                 
Name
Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM
Definition
K11263+K27093+K27094+K27095
K12428 K12437 K27306 K18851
Diagram
M00887  Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM
M00887

Class
Pathway modules; Lipid metabolism; Fatty acid metabolism
Pathway
map00074  Mycolic acid biosynthesis
map01100  Metabolic pathways
Orthology
K11263+K27093+K27094+K27095  
accA3+accD4+accD5+accE5; long-chain acyl-CoA carboxylase [EC:6.4.1.-] [RN:R13256]
K12428  
fadD32; fatty acyl-AMP ligase FadD32 [EC:6.2.1.-] [RN:R13274]
K12437  
pks13; polyketide synthase 13 [RN:R13275]
K27306  
cmrA; mycolic acid reductase [RN:R13276]
K18851  
fbp; trehalose O-mycolyltransferase / mycolyltransferase Ag85 [EC:2.3.1.122 2.3.1.-] [RN:R13277 R13278 R13280]
Complete
mtu  Mycobacterium tuberculosis H37Rv
mtv  Mycobacterium tuberculosis H37Rv
mtc  Mycobacterium tuberculosis CDC1551
mra  Mycobacterium tuberculosis H37Ra
mtf  Mycobacterium tuberculosis F11
mtb  Mycobacterium tuberculosis KZN 1435
mtk  Mycobacterium tuberculosis KZN 4207
mtz  Mycobacterium tuberculosis KZN 605
mtur  Mycobacterium tuberculosis CCDC5079
mto  Mycobacterium tuberculosis CTRI-2
mtd  Mycobacterium tuberculosis UT205
mtn  Mycobacterium tuberculosis Erdman = ATCC 35801
mtj  Mycobacterium tuberculosis Beijing/NITR203
mtub  Mycobacterium tuberculosis 7199-99
mtue  Mycobacterium tuberculosis EAI5/NITR206
mtx  Mycobacterium tuberculosis EAI5
mtul  Mycobacterium tuberculosis Haarlem
mtut  Mycobacterium tuberculosis BT1
mtuu  Mycobacterium tuberculosis BT2
mtq  Mycobacterium tuberculosis HKBS1
mbo  Mycobacterium tuberculosis variant bovis AF2122/97
mbb  Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2
mbt  Mycobacterium tuberculosis variant bovis BCG Tokyo 172
mbm  Mycobacterium tuberculosis variant bovis BCG Mexico
mbk  Mycobacterium tuberculosis variant bovis BCG Korea 1168P
mbx  Mycobacterium tuberculosis variant bovis BCG ATCC 35743
mmic  Mycobacterium tuberculosis variant microti
mce  Mycobacterium canettii CIPT 140010059
mcq  Mycobacterium canettii CIPT 140060008
mcv  Mycobacterium canettii CIPT 140070008
mcx  Mycobacterium canettii CIPT 140070010
mcz  Mycobacterium canettii CIPT 140070017
mory  Mycobacterium orygis
mle  Mycobacterium leprae TN
mlb  Mycobacterium leprae Br4923
mpa  Mycobacterium avium subsp. paratuberculosis K-10
mao  Mycobacterium avium subsp. paratuberculosis MAP4
mavi  Mycobacterium avium subsp. paratuberculosis E1
mavu  Mycobacterium avium subsp. paratuberculosis E93
mav  Mycobacterium avium 104
mavm  Mycobacterium avium subsp. avium
mit  Mycobacterium intracellulare MOTT-02
mia  Mycobacterium intracellulare ATCC 13950
mid  Mycobacterium intracellulare subsp. intracellulare
myo  Mycobacterium intracellulare subsp. yongonense
mchi  Mycobacterium intracellulare subsp. chimaera
mir  Mycobacterium paraintracellulare
mmal  Mycobacterium marseillense
mlp  Mycobacterium lepraemurium
mman  Mycobacterium mantenii
mser  Mycobacterium senriense
msa  Mycobacterium sp. JS623
mul  Mycobacterium ulcerans
mmi  Mycobacterium marinum M
mmae  Mycobacterium marinum E11
mli  Mycobacterium liflandii
mpse  Mycobacterium pseudoshottsii
msho  Mycobacterium shottsii
mmc  Mycobacterium sp. MCS
mkm  Mycobacterium sp. KMS
mjl  Mycobacterium sp. JLS
mmm  Mycobacterium sp. MOTT36Y
mkn  Mycobacterium kansasii ATCC 12478
myv  Mycobacterium sp. VKM Ac-1817D
mye  Mycobacterium sp. EPa45
mhad  Mycobacterium haemophilum
mdx  Mycobacterium dioxanotrophicus
mshg  Mycobacterium shigaense
mfj  Mycobacterium florentinum
msto  Mycobacterium stomatepiae
msim  Mycobacterium simiae
msak  Mycobacterium saskatchewanense
mku  Mycobacterium kubicae
mlw  Mycobacterium lentiflavum
mxe  Mycobacterium xenopi
mnv  Mycobacterium noviomagense
mpag  Mycobacterium paragordonae
mnm  Mycobacterium novum
mgor  Mycobacterium vicinigordonae
mcoo  Mycobacterium cookii
mbai  Mycobacterium basiliense
mseo  Mycobacterium seoulense
mhek  Mycobacterium heckeshornense
mgau  Mycobacterium gallinarum
mlj  Mycobacterium lacus
mbrd  Mycobacterium branderi
mshj  Mycobacterium shinjukuense
mmam  Mycobacterium malmoense
mspg  Mycobacterium spongiae
mot  Mycobacterium ostraviense
mlm  Mycobacterium lepromatosis
mpaa  Mycobacterium paraterrae
mmeh  Mycobacterium methanotrophicum
madi  Mycobacterium adipatum
mwu  Mycobacterium wuenschmannii
myj  Mycobacterium sp. djl-10
msm  Mycolicibacterium smegmatis MC2 155
msg  Mycolicibacterium smegmatis MC2 155
msb  Mycolicibacterium smegmatis MC2 155
msn  Mycolicibacterium smegmatis INHR1
msh  Mycolicibacterium smegmatis INHR2
mva  Mycolicibacterium vanbaalenii
mgi  Mycolicibacterium gilvum PYR-GCK
msp  Mycolicibacterium gilvum Spyr1
mcb  Mycolicibacterium chubuense
mne  Mycolicibacterium neoaurum VKM Ac-1815D
myn  Mycolicibacterium neoaurum NRRL B-3805
mft  Mycolicibacterium fortuitum
mphl  Mycolicibacterium phlei
mvq  Mycolicibacterium vaccae
mll  Mycolicibacterium litorale
mrh  Mycolicibacterium rhodesiae
mthn  Mycolicibacterium thermoresistibile
mhas  Mycolicibacterium hassiacum
mdu  Mycolicibacterium duvalii
mdr  Mycolicibacterium doricum
mauu  Mycolicibacterium aurum
mmag  Mycolicibacterium madagascariense
mmor  Mycolicibacterium moriokaense
mfx  Mycolicibacterium fallax
maic  Mycolicibacterium aichiense
mij  Mycolicibacterium insubricum
malv  Mycolicibacterium alvei
mty  Mycolicibacterium tokaiense
mpsc  Mycolicibacterium psychrotolerans
marz  Mycolicibacterium arabiense
mgad  Mycolicibacterium gadium
mhev  Mycolicibacterium helvum
msar  Mycolicibacterium sarraceniae
many  Mycolicibacterium anyangense
maub  Mycolicibacterium aubagnense
mpof  Mycolicibacterium poriferae
mphu  Mycolicibacterium phocaicum
mmuc  Mycolicibacterium mucogenicum
mmat  Mycolicibacterium mageritense
mbok  Mycolicibacterium boenickei
mfg  Mycolicibacterium farcinogenes
msei  Mycolicibacterium sediminis
mflv  Mycolicibacterium flavescens
mcee  Mycolicibacterium celeriflavum
mbrm  Mycolicibacterium brumae
mmon  Mycolicibacterium monacense
mgo  Mycolicibacterium goodii
mhol  Mycolicibacterium holsaticum
msen  Mycolicibacterium senegalense
mpae  Mycolicibacterium pallens
mrf  Mycolicibacterium rufum
mdf  Mycolicibacterium diernhoferi
mcro  Mycolicibacterium crocinum
mgro  Mycolicibacterium grossiae
maus  Mycolicibacterium austroafricanum
mfre  Mycolicibacterium frederiksbergense
mbug  Mycobacterium burgundiense
myq  Mycolicibacterium sp. TUM20985
mflu  Mycolicibacterium fluoranthenivorans
myh  Mycolicibacterium sp. HK-90
mpat  Mycolicibacterium parafortuitum
mkr  Mycolicibacillus koreensis
mpak  Mycolicibacillus parakoreensis
mab  Mycobacteroides abscessus ATCC 19977
mmv  Mycobacteroides abscessus subsp. massiliense GO 06
mabb  Mycobacteroides abscessus subsp. bolletii 50594
mabl  Mycobacteroides abscessus subsp. massiliense CCUG 48898 = JCM 15300
mche  Mycobacteroides chelonae
miz  Mycobacteroides immunogenum
mste  Mycobacterium stephanolepidis
msao  Mycobacteroides saopaulense
msal  Mycobacteroides salmoniphilum
mjd  Mycolicibacter sinensis
mter  Mycolicibacter terrae
mmin  Mycolicibacter minnesotensis
mhib  Mycolicibacter hiberniae
mher  Mycolicibacter heraklionensis
mvm  Mycolicibacter virginiensis
cgl  Corynebacterium glutamicum ATCC 13032 (Kyowa Hakko)
cgb  Corynebacterium glutamicum ATCC 13032 (Bielefeld)
cgu  Corynebacterium glutamicum K051
cgt  Corynebacterium glutamicum R
cgs  Corynebacterium glutamicum SCgG1
cgg  Corynebacterium glutamicum SCgG2
cgm  Corynebacterium glutamicum MB001
cgj  Corynebacterium glutamicum ATCC 21831
cgq  Corynebacterium glutamicum AR1
cgx  Corynebacterium glutamicum B253
cef  Corynebacterium efficiens
cdi  Corynebacterium diphtheriae NCTC 13129
cdp  Corynebacterium diphtheriae 241
cdh  Corynebacterium diphtheriae INCA 402
cdt  Corynebacterium diphtheriae HC01
cde  Corynebacterium diphtheriae HC02
cdr  Corynebacterium diphtheriae HC03
cda  Corynebacterium diphtheriae HC04
cdz  Corynebacterium diphtheriae 31A
cdb  Corynebacterium diphtheriae BH8
cds  Corynebacterium diphtheriae C7 (beta)
cdd  Corynebacterium diphtheriae CDCE 8392
cdw  Corynebacterium diphtheriae PW8
cdv  Corynebacterium diphtheriae VA01
cdip  Corynebacterium diphtheriae NCTC11397
car  Corynebacterium aurimucosum
cpu  Corynebacterium pseudotuberculosis FRC41
cpl  Corynebacterium pseudotuberculosis 3/99-5
cpg  Corynebacterium pseudotuberculosis 316
cpp  Corynebacterium pseudotuberculosis P54B96
cpk  Corynebacterium pseudotuberculosis 1002
cpq  Corynebacterium pseudotuberculosis C231
cpx  Corynebacterium pseudotuberculosis I19
cpz  Corynebacterium pseudotuberculosis PAT10
cor  Corynebacterium pseudotuberculosis 267
cop  Corynebacterium pseudotuberculosis 31
cod  Corynebacterium pseudotuberculosis 1/06-A
cos  Corynebacterium pseudotuberculosis 42/02-A
coi  Corynebacterium pseudotuberculosis CIP 52.97
coe  Corynebacterium pseudotuberculosis 258
cou  Corynebacterium pseudotuberculosis Cp162
cpse  Corynebacterium pseudotuberculosis 48252
cpsu  Corynebacterium pseudotuberculosis CS_10
cpsf  Corynebacterium pseudotuberculosis Ft_2193/67
cul  Corynebacterium ulcerans BR-AD22
cuc  Corynebacterium ulcerans 809
cue  Corynebacterium ulcerans 0102
cun  Corynebacterium ulcerans 210932
cuq  Corynebacterium ulcerans 210931
cuz  Corynebacterium ulcerans 05146
cuj  Corynebacterium ulcerans 131002
cus  Corynebacterium ramonii FRC0011
chn  Corynebacterium halotolerans
ccn  Corynebacterium callunae
cmd  Corynebacterium maris
caz  Corynebacterium argentoratense
ccg  Corynebacterium casei
cvt  Corynebacterium vitaeruminis
cax  Corynebacterium atypicum
cii  Corynebacterium imitans
cuv  Corynebacterium ureicelerivorans
cdo  Corynebacterium doosanense
chm  Corynebacterium humireducens
csx  Corynebacterium singulare
cmq  Corynebacterium marinum
cku  Corynebacterium kutscheri
ccj  Corynebacterium camporealensis
cmv  Corynebacterium mustelae
cei  Corynebacterium epidermidicanis
cted  Corynebacterium testudinoris
cut  Corynebacterium uterequi
cdx  Corynebacterium deserti
csp  Corynebacterium simulans
csta  Corynebacterium stationis
ccjz  Corynebacterium crudilactis
cpho  Corynebacterium phocae
cfc  Corynebacterium flavescens
cgv  Corynebacterium glaucum
cstr  Corynebacterium striatum
caqu  Corynebacterium aquilae
csph  Corynebacterium sphenisci
camg  Corynebacterium ammoniagenes
cmin  Corynebacterium minutissimum
cpeg  Corynebacterium pelargi
cxe  Corynebacterium xerosis
cee  Corynebacterium endometrii
csan  Corynebacterium sanguinis
cgk  Corynebacterium geronticis
crf  Corynebacterium rouxii
ccho  Corynebacterium choanae
cpso  Corynebacterium pseudopelargi
csur  Corynebacterium suranareeae
ccys  Corynebacterium cystitidis
cmat  Corynebacterium matruchotii
cyz  Corynebacterium yudongzhengii
ckf  Corynebacterium kefirresidentii
clia  Corynebacterium liangguodongii
cprp  Corynebacterium propinquum
cglu  Corynebacterium glucuronolyticum
csil  Corynebacterium silvaticum
ctub  Corynebacterium tuberculostearicum
cluj  Corynebacterium lujinxingii
cqn  Corynebacterium qintianiae
ckw  Corynebacterium kalinowskii
ccoe  Corynebacterium comes
cok  Corynebacterium occultum
cmf  Corynebacterium macginleyi
cpoy  Corynebacterium poyangense
cacc  Corynebacterium accolens
cfy  Corynebacterium freneyi
cpsl  Corynebacterium pseudogenitalium
chin  Corynebacterium hindlerae
cjh  Corynebacterium jeddahense
cpsp  Corynebacterium pseudodiphtheriticum
cihu  Corynebacterium ihumii
ccoy  Corynebacterium coyleae
chad  Corynebacterium hadale
cfg  Corynebacterium freiburgense
caqm  Corynebacterium aquatimens
ccaw  Corynebacterium canis
caui  Corynebacterium auris
cfac  Corynebacterium faecale
cfou  Corynebacterium fournieri
cfeu  Corynebacterium felinum
catr  Corynebacterium atrinae
cdur  Corynebacterium durum
ccou  Corynebacterium confusum
cafe  Corynebacterium afermentans subsp. lipophilum
cgf  Corynebacterium guangdongense
cgoi  Corynebacterium gottingense
capp  Corynebacterium appendicis
csue  Corynebacterium suedekumii
crie  Corynebacterium riegelii
cik  Corynebacterium incognita
corn  Corynebacterium sp. NML98-0116
cgp  Corynebacterium genitalium
ches  Corynebacterium hesseae
cbel  Corynebacterium belfantii
cors  Corynebacterium sp. SCR221107
core  Corynebacterium sp. Z-1
crhn  Corynebacterium rhinophilum
bfv  Brevibacterium flavum
nfa  Nocardia farcinica IFM 10152
nfr  Nocardia farcinica NCTC11134
nbr  Nocardia brasiliensis
nno  Nocardia nova
nsr  Nocardia seriolae
nod  Nocardia otitidiscaviarum
nah  Nocardia arthritidis
nwl  Nocardia wallacei
nhu  Nocardia huaxiensis
nspu  Nocardia sputorum
nyu  Nocardia yunnanensis
nvu  Nocardia vulneris
rha  Rhodococcus jostii
rop  Rhodococcus opacus B4
roa  Rhodococcus opacus PD630
rpy  Rhodococcus pyridinivorans SB3094
rby  Rhodococcus pyridinivorans TG9
rrz  Rhodococcus ruber
rhq  Rhodococcus sp. p52
rrt  Rhodococcus rhodochrous
rtm  Rhodococcus triatomae
rko  Rhodococcus koreensis
rgo  Rhodococcus globerulus
roz  Rhodococcus oxybenzonivorans
rpsk  Rhodococcus pseudokoreensis
rgor  Rhodococcus gordoniae
rhop  Rhodococcus sp. P1Y
rhoo  Rhodococcus sp. DN22
rhou  Rhodococcus sp. 11-3
rhow  Rhodococcus sp. WB1
rhoj  Rhodococcus sp. JVH1
rhos  Rhodococcus sp. M8-50
rhoq  Rhodococcus sp. M8-33
rhoy  Rhodococcus sp. AH-ZY2
rhoh  Rhodococcus sp. H-CA8f
rhox  Rhodococcus sp. D-6
rhjs  Rhodococcus sp. JS3073
rsf  Rhodococcus sacchari
rhzq  Rhodococcus sp. 21391
rhzg  Rhodococcus sp. 2G
rhbh  Rhodococcus sp. BH4
rhpd  Rhodococcus sp. PD04
req  Prescottella equi
psow  Prescottella soli
whr  Williamsia herbipolensis
gbr  Gordonia bronchialis
gpo  Gordonia polyisoprenivorans
gor  Gordonia sp. KTR9
goq  Gordonia phthalatica
gta  Gordonia terrae
goc  Gordonia sp. YC-JH1
git  Gordonia iterans
gru  Gordonia rubripertincta
gom  Gordonia insulae
gav  Gordonia alkanivorans
god  Gordonia sp. 135
gos  Gordonia sp. SMJS1
goj  Gordonia sp. JH63
gam  Gordonia amarae
gpd  Gordonia pseudamarae
gji  Gordonia jinghuaiqii
goi  Gordonia otitidis
ghn  Gordonia hongkongensis
gami  Gordonia amicalis
gmg  Gordonia mangrovi
gsi  Gordonia sihwensis
goo  Gordonia sp. X0973
gop  Gordonia sp. PS3
spin  Skermania pinensis
tpr  Tsukamurella paurometabola
tsm  Tsukamurella tyrosinosolvens
tpul  Tsukamurella pulmonis
tsd  Tsukamurella sp. PLM1
dtm  Dietzia timorensis
dit  Dietzia sp. oral taxon 368
diz  Dietzia sp. JS16-p6b
dpc  Dietzia psychralcaliphila
dlu  Dietzia lutea
dkn  Dietzia kunjamensis
dcd  Dietzia cinnamea
toy  Tomitella fengzijianii
 » show all
Reaction
R13256  
R13274  
R13275  
R13276  
R13277  
R13278  
R13280  
Compound
C20876  Very-long-chain acyl-CoA
C22857  Very-long-chain alpha-carboxyacyl-CoA
C22873  Meromycolic acid
C22874  Meromycoloyl-[acp Pks13]
C01083  alpha,alpha-Trehalose
C22875  Trehalose mycolic-beta-ketoester
C22876  Trehalose monomycolate
C22877  Trehalose dimycolate
C22879  mAGP
C00031  D-Glucose
C22855  Glucose monomycolate
Reference
PMID:15653820
  Authors
Takayama K, Wang C, Besra GS.
  Title
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 18:81-101 (2005)
DOI:10.1128/CMR.18.1.81-101.2005
Reference
PMID:24374164
  Authors
Marrakchi H, Laneelle MA, Daffe M.
  Title
Mycolic acids: structures, biosynthesis, and beyond.
  Journal
Chem Biol 21:67-85 (2014)
DOI:10.1016/j.chembiol.2013.11.011
Reference
PMID:28222482
  Authors
Bazet Lyonnet B, Diacovich L, Gago G, Spina L, Bardou F, Lemassu A, Quemard A, Gramajo H
  Title
Functional reconstitution of the Mycobacterium tuberculosis long-chain acyl-CoA carboxylase from multiple acyl-CoA subunits.
  Journal
FEBS J 284:1110-1125 (2017)
DOI:10.1111/febs.14046
Reference
PMID:18703502
  Authors
Matsunaga I, Naka T, Talekar RS, McConnell MJ, Katoh K, Nakao H, Otsuka A, Behar SM, Yano I, Moody DB, Sugita M.
  Title
Mycolyltransferase-mediated glycolipid exchange in Mycobacteria.
  Journal
J Biol Chem 283:28835-41 (2008)
DOI:10.1074/jbc.M805776200
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