KEGG   MODULE: M00917
Entry
M00917            Pathway   Module                                 
Name
Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Definition
K01853 K00559 K14423 K23558 -- K08246 K05917 K00222 K01824 K08242
K14424 K00227 K00213 K09828
Diagram
M00917

Orthology
K01853  
cycloartenol synthase [EC:5.4.99.8] [RN:R03200]
K00559  
sterol 24-C-methyltransferase [EC:2.1.1.41] [RN:R07481]
K14423  
plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase [EC:1.14.18.10] [RN:R12377]
K23558  
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase [EC:1.1.1.418] [RN:R12371 R12375 R12376]
K08246  
cycloeucalenol cycloisomerase [EC:5.5.1.9] [RN:R03775]
K05917  
sterol 14alpha-demethylase [EC:1.14.14.154] [RN:R05731]
K00222  
Delta14-sterol reductase [EC:1.3.1.70] [RN:R07483]
K01824  
cholestenol Delta-isomerase [EC:5.3.3.5] [RN:R07484]
K08242  
24-methylenesterol C-methyltransferase [EC:2.1.1.143] [RN:R05776]
K14424  
plant 4alpha-monomethylsterol monooxygenase [EC:1.14.18.11] [RN:R12378 R12379]
K00227  
Delta7-sterol 5-desaturase [EC:1.14.19.20] [RN:R07491 R07486]
K00213  
7-dehydrocholesterol reductase [EC:1.3.1.21] [RN:R07492 R07487]
K09828  
Delta24-sterol reductase [EC:1.3.1.72 1.3.1.-] [RN:R07493 R07488]
Class
Pathway modules; Lipid metabolism; Sterol biosynthesis
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C01054  (S)-2,3-Epoxysqualene
C01902  Cycloartenol
C08830  24-Methylidenecycloartanol
C22116  3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate
C22121  Cycloeucalenone
C02141  Cycloeucalenol
C01943  Obtusifoliol
C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C15776  4alpha-Methylfecosterol
C11522  24-Methylenelophenol
C11523  24-Ethylidenelophenol
C22120  4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol
C22123  Avenastenone
C15782  Delta7-Avenasterol
C15783  5-Dehydroavenasterol
C08821  Isofucosterol
C01753  beta-Sitosterol
C22119  3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate
C22122  Episterone
C15777  Episterol
C15780  5-Dehydroepisterol
C15781  24-Methylenecholesterol
C01789  Campesterol
Reference
  Authors
Sonawane PD, Pollier J, Panda S, Szymanski J, Massalha H, Yona M, Unger T, Malitsky S, Arendt P, Pauwels L, Almekias-Siegl E, Rogachev I, Meir S, Cardenas PD, Masri A, Petrikov M, Schaller H, Schaffer AA, Kamble A, Giri AP, Goossens A, Aharoni A
  Title
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.
  Journal
Nat Plants 3:16205 (2016)
DOI:10.1038/nplants.2016.205
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