KEGG   MODULE: M00917
Entry
M00917            Pathway   Module                                 
Name
Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Definition
K01853 K00559 K14423 K23558 -- K08246 K05917 K00222 K01824 K08242
K14424 K00227 K00213 K09828
Diagram
M00917  Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
M00917

Class
Pathway modules; Lipid metabolism; Sterol biosynthesis
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K01853  
cycloartenol synthase [EC:5.4.99.8] [RN:R03200]
K00559  
sterol 24-C-methyltransferase [EC:2.1.1.41] [RN:R07481]
K14423  
plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase [EC:1.14.18.10] [RN:R12377]
K23558  
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase [EC:1.1.1.418] [RN:R12371 R12375 R12376]
K08246  
cycloeucalenol cycloisomerase [EC:5.5.1.9] [RN:R03775]
K05917  
sterol 14alpha-demethylase [EC:1.14.14.154] [RN:R05731]
K00222  
Delta14-sterol reductase [EC:1.3.1.70] [RN:R07483]
K01824  
cholestenol Delta-isomerase [EC:5.3.3.5] [RN:R07484]
K08242  
24-methylenesterol C-methyltransferase [EC:2.1.1.143] [RN:R05776]
K14424  
plant 4alpha-monomethylsterol monooxygenase [EC:1.14.18.11] [RN:R12378 R12379]
K00227  
Delta7-sterol 5-desaturase [EC:1.14.19.20] [RN:R07491 R07486]
K00213  
7-dehydrocholesterol reductase [EC:1.3.1.21] [RN:R07492 R07487]
K09828  
Delta24-sterol reductase [EC:1.3.1.72 1.3.1.-] [RN:R07493 R07488]
Complete
ath  Arabidopsis thaliana (thale cress)
aly  Arabidopsis lyrata (lyrate rockcress)
crb  Capsella rubella (pink shepherd's-purse)
csat  Camelina sativa (false flax)
eus  Eutrema salsugineum (saltwater cress)
brp  Brassica rapa (field mustard)
bna  Brassica napus (rape)
boe  Brassica oleracea (wild cabbage)
rsz  Raphanus sativus (radish)
thj  Tarenaya hassleriana (spider flower)
cit  Citrus sinensis (Valencia orange)
cic  Citrus x clementina (clementine)
pvy  Pistacia vera (pistachio)
minc  Mangifera indica (mango)
tcc  Theobroma cacao (cacao)
gra  Gossypium raimondii
ghi  Gossypium hirsutum (upland cotton)
gab  Gossypium arboreum (tree cotton)
hsyr  Hibiscus syriacus (Rose-of-Sharon)
dzi  Durio zibethinus (durian)
egr  Eucalyptus grandis (rose gum)
rarg  Rhodamnia argentea (silver malletwood)
gmx  Glycine max (soybean)
gsj  Glycine soja (wild soybean)
pvu  Phaseolus vulgaris (common bean)
vra  Vigna radiata (mung bean)
var  Vigna angularis (adzuki bean)
vun  Vigna unguiculata (cowpea)
vum  Vigna umbellata (ricebean)
ccaj  Cajanus cajan (pigeon pea)
aprc  Abrus precatorius (Indian licorice)
mtr  Medicago truncatula (barrel medic)
tpra  Trifolium pratense (red clover)
cam  Cicer arietinum (chickpea)
psat  Lathyrus oleraceus (garden pea)
vvo  Vicia villosa (hairy vetch)
lja  Lotus japonicus
adu  Arachis duranensis
aip  Arachis ipaensis
ahf  Arachis hypogaea (peanut)
lang  Lupinus angustifolius (narrow-leaved blue lupine)
pcin  Prosopis cineraria
qsa  Quillaja saponaria (soapbark tree)
fve  Fragaria vesca (woodland strawberry)
aans  Argentina anserina (silverweed cinquefoil)
rcn  Rosa chinensis (China rose)
pper  Prunus persica (peach)
pmum  Prunus mume (Japanese apricot)
pavi  Prunus avium (sweet cherry)
pdul  Prunus dulcis (almond)
mdm  Malus domestica (apple)
msyl  Malus sylvestris (European crab apple)
pcox  Pyrus communis (pear)
zju  Ziziphus jujuba (Chinese jujube)
mnt  Morus notabilis
csav  Cannabis sativa (hemp)
csv  Cucumis sativus (cucumber)
cmo  Cucumis melo (muskmelon)
bhj  Benincasa hispida (wax gourd)
mcha  Momordica charantia (bitter melon)
cmax  Cucurbita maxima (winter squash)
cmos  Cucurbita moschata (crookneck pumpkin)
cpep  Cucurbita pepo subsp. pepo (vegetable marrow)
rcu  Ricinus communis (castor bean)
hbr  Hevea brasiliensis (rubber tree)
mesc  Manihot esculenta (cassava)
pop  Populus trichocarpa (black cottonwood)
peu  Populus euphratica (Euphrates poplar)
palz  Populus alba (white poplar)
pnz  Populus nigra (Lombardy poplar)
jre  Juglans regia (English walnut)
cill  Carya illinoinensis (pecan)
cave  Corylus avellana (European hazelnut)
aglu  Alnus glutinosa (common alder)
qsu  Quercus suber (cork oak)
qlo  Quercus lobata (valley oak)
twl  Tripterygium wilfordii (thunder duke vine)
vvi  Vitis vinifera (wine grape)
sly  Solanum lycopersicum (tomato)
spen  Solanum pennellii
sot  Solanum tuberosum (potato)
sstn  Solanum stenotomum
sdul  Solanum dulcamara (climbing nightshade)
cann  Capsicum annuum (peppers)
lbb  Lycium barbarum (goji berry)
nta  Nicotiana tabacum (common tobacco)
nsy  Nicotiana sylvestris (wood tobacco)
nto  Nicotiana tomentosiformis
nau  Nicotiana attenuata (coyote tobacco)
ini  Ipomoea nil (Japanese morning glory)
itr  Ipomoea triloba (trilobed morning glory)
sind  Sesamum indicum (sesame)
oeu  Olea europaea var. sylvestris (wild olive)
egt  Erythranthe guttata (spotted monkey flower)
sspl  Salvia splendens (scarlet sage)
smil  Salvia miltiorrhiza (redroot sage)
apan  Andrographis paniculata
hpum  Henckelia pumila
phua  Primulina huaijiensis
pebu  Primulina eburnea
ptab  Primulina tabacum
han  Helianthus annuus (common sunflower)
ecad  Erigeron canadensis (horseweed)
lsv  Lactuca sativa (garden lettuce)
ccav  Cynara cardunculus var. scolymus (artichoke)
dcr  Daucus carota (carrot)
csin  Camellia sinensis (tea plant)
rvl  Rhododendron vialii
aew  Actinidia eriantha (wild kiwifruit)
bvg  Beta vulgaris (sugar beet)
soe  Spinacia oleracea (spinach)
cqi  Chenopodium quinoa (quinoa)
atri  Amaranthus tricolor (tampala)
slaf  Silene latifolia (white campion)
mof  Malania oleifera
nnu  Nelumbo nucifera (sacred lotus)
ming  Macadamia integrifolia (macadamia nut)
tss  Telopea speciosissima (New South Wales waratah)
psom  Papaver somniferum (opium poppy)
osa  Oryza sativa japonica (Japanese rice)
obr  Oryza brachyantha (malo sina)
ogl  Oryza glaberrima (African rice)
bdi  Brachypodium distachyon (stiff brome)
ats  Aegilops tauschii (wheat D)
tdc  Triticum dicoccoides (wild emmer wheat)
taes  Triticum aestivum (bread wheat)
tua  Triticum urartu (red wild einkorn wheat)
hvg  Hordeum vulgare subsp. vulgare (domesticated barley)
lper  Lolium perenne (perennial ryegrass)
lrd  Lolium rigidum (rigid ryegrass)
sbi  Sorghum bicolor (sorghum)
zma  Zea mays (maize)
sita  Setaria italica (foxtail millet)
svs  Setaria viridis (green foxtail)
pvir  Panicum virgatum (switchgrass)
phai  Panicum hallii (Hall's panicgrass)
paua  Phragmites australis (common reed)
tang  Typha angustifolia (narrow-leaf cattail)
pda  Phoenix dactylifera (date palm)
egu  Elaeis guineensis (African oil palm)
mus  Musa acuminata (dessert banana)
zof  Zingiber officinale (ginger)
dct  Dendrobium catenatum
aof  Asparagus officinalis (garden asparagus)
msin  Magnolia sinica
acak  Aristolochia californica
ncol  Nymphaea colorata (blue-petal water lily)
atr  Amborella trichopoda
cjf  Cryptomeria japonica (Japanese cedar)
smo  Selaginella moellendorffii
ppp  Physcomitrium patens (spreading earthmoss)
 » show all
Reaction
R03200  
R07481  
R12377  
R12371  
R12399  
R03775  
R05731  
R07483  
R07484  
R05776  
R12379  
R12376  
R12401  
R07486  
R07487  
R07488  
R12378  
R12375  
R12400  
R07491  
R07492  
R07493  
Compound
C01054  (S)-2,3-Epoxysqualene
C01902  Cycloartenol
C08830  24-Methylidenecycloartanol
C22116  3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate
C22121  Cycloeucalenone
C02141  Cycloeucalenol
C01943  Obtusifoliol
C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C15776  4alpha-Methylfecosterol
C11522  24-Methylenelophenol
C11523  24-Ethylidenelophenol
C22120  4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol
C22123  Avenastenone
C15782  Delta7-Avenasterol
C15783  5-Dehydroavenasterol
C08821  Isofucosterol
C01753  beta-Sitosterol
C22119  3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate
C22122  Episterone
C15777  Episterol
C15780  5-Dehydroepisterol
C15781  24-Methylenecholesterol
C01789  Campesterol
Reference
PMID:28005066
  Authors
Sonawane PD, Pollier J, Panda S, Szymanski J, Massalha H, Yona M, Unger T, Malitsky S, Arendt P, Pauwels L, Almekias-Siegl E, Rogachev I, Meir S, Cardenas PD, Masri A, Petrikov M, Schaller H, Schaffer AA, Kamble A, Giri AP, Goossens A, Aharoni A
  Title
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.
  Journal
Nat Plants 3:16205 (2016)
DOI:10.1038/nplants.2016.205
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