KEGG   MODULE: M00917
Entry
M00917            Pathway   Module                                 
Name
Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Definition
K01853 K00559 K14423 K23558 -- K08246 K05917 K00222 K01824 K08242
K14424 K00227 K00213 K09828
Diagram
M00917

Orthology
K01853  
cycloartenol synthase [EC:5.4.99.8] [RN:R03200]
K00559  
sterol 24-C-methyltransferase [EC:2.1.1.41] [RN:R07481]
K14423  
plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase [EC:1.14.18.10] [RN:R12377]
K23558  
plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase [EC:1.1.1.418] [RN:R12371 R12375 R12376]
K08246  
cycloeucalenol cycloisomerase [EC:5.5.1.9] [RN:R03775]
K05917  
sterol 14alpha-demethylase [EC:1.14.14.154] [RN:R05731]
K00222  
Delta14-sterol reductase [EC:1.3.1.70] [RN:R07483]
K01824  
cholestenol Delta-isomerase [EC:5.3.3.5] [RN:R07484]
K08242  
24-methylenesterol C-methyltransferase [EC:2.1.1.143] [RN:R05776]
K14424  
plant 4alpha-monomethylsterol monooxygenase [EC:1.14.18.11] [RN:R12378 R12379]
K00227  
Delta7-sterol 5-desaturase [EC:1.14.19.20] [RN:R07491 R07486]
K00213  
7-dehydrocholesterol reductase [EC:1.3.1.21] [RN:R07492 R07487]
K09828  
Delta24-sterol reductase [EC:1.3.1.72 1.3.1.-] [RN:R07493 R07488]
Class
Pathway modules; Lipid metabolism; Sterol biosynthesis
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R03200  
R07481  
R12377  
R12371  
R12399  
R03775  
R05731  
R07483  
R07484  
R05776  
R12379  
R12376  
R12401  
R07486  
R07487  
R07488  
R12378  
R12375  
R12400  
R07491  
R07492  
R07493  
Compound
C01054  (S)-2,3-Epoxysqualene
C01902  Cycloartenol
C08830  24-Methylidenecycloartanol
C22116  3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate
C22121  Cycloeucalenone
C02141  Cycloeucalenol
C01943  Obtusifoliol
C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C15776  4alpha-Methylfecosterol
C11522  24-Methylenelophenol
C11523  24-Ethylidenelophenol
C22120  4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol
C22123  Avenastenone
C15782  Delta7-Avenasterol
C15783  5-Dehydroavenasterol
C08821  Isofucosterol
C01753  beta-Sitosterol
C22119  3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate
C22122  Episterone
C15777  Episterol
C15780  5-Dehydroepisterol
C15781  24-Methylenecholesterol
C01789  Campesterol
Reference
PMID:28005066
  Authors
Sonawane PD, Pollier J, Panda S, Szymanski J, Massalha H, Yona M, Unger T, Malitsky S, Arendt P, Pauwels L, Almekias-Siegl E, Rogachev I, Meir S, Cardenas PD, Masri A, Petrikov M, Schaller H, Schaffer AA, Kamble A, Giri AP, Goossens A, Aharoni A
  Title
Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.
  Journal
Nat Plants 3:16205 (2016)
DOI:10.1038/nplants.2016.205
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