KEGG   MODULE: M00925
Entry
M00925            Pathway   Module                                 
Name
Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
Definition
(K02303,K13542) (K03394,K13540) K02229 (K05934,K13540,K13541) K05936 K02228 K05895 K00595 K06042 K02224 K02230+K09882+K09883
Diagram
M00925

Orthology
cobA; uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [RN:R03194]
K03394  
cobI; precorrin-2 C20-methyltransferase [EC:2.1.1.130] [RN:R03948]
K13540  
cobIJ; precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase [EC:2.1.1.130 2.1.1.131] [RN:R03948 R05180]
K02229  
cobG; precorrin-3B synthase [EC:1.14.13.83] [RN:R05217]
cobJ; precorrin-3B C17-methyltransferase [EC:2.1.1.131] [RN:R05180]
K05936  
cobM; precorrin-4 C11-methyltransferase [EC:2.1.1.133] [RN:R05181]
K02228  
cobF; precorrin-6A synthase [EC:2.1.1.152] [RN:R05219]
K05895  
cobK; precorrin-6A reductase [EC:1.3.1.54] [RN:R05150]
K00595  
cobL; precorrin-6B C5,15-methyltransferase [EC:2.1.1.132] [RN:R05149]
K06042  
cobH; precorrin-8X methylmutase [EC:5.4.99.61] [RN:R05177]
K02224  
cobB; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9] [RN:R05224]
cobNST; cobaltochelatase CobNST [EC:6.6.1.2] [RN:R05227]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00860  Porphyrin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C01051  Uroporphyrinogen III
C02463  Precorrin 2
C05772  Precorrin 3A
C06406  Precorrin 3B
C06407  Precorrin 4
C06416  Precorrin 5
C06320  Precorrin 6X
C06319  Precorrin 6Y
C06408  Precorrin 8X
C06399  Hydrogenobyrinate
C06503  Hydrogenobyrinate a,c diamide
C06504  Cob(II)yrinate a,c diamide
Reference
  Authors
Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ
  Title
An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.
  Journal
Nat Chem Biol 8:933-40 (2012)
DOI:10.1038/nchembio.1086
Reference
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat Prod Rep 19:390-412 (2002)
DOI:10.1039/b108967f
Reference
  Authors
Bryant DA, Hunter CN, Warren MJ
  Title
Biosynthesis of the modified tetrapyrroles-the pigments of life.
  Journal
J Biol Chem 295:6888-6925 (2020)
DOI:10.1074/jbc.REV120.006194
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