KEGG   MODULE: M00937
Entry
M00937            Pathway   Module                                 
Name
Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Definition
K15316 K17643 K17644 K17645 K17652 K17646 K24440 K24855 K17648 K24439 K24856+K24438+K24857+K24858 K17649 K17650 K17651
Diagram
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
M00937

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other fungal compounds
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K15316  
noranthrone synthase [EC:2.3.1.221] [RN:R10239]
K17643  
noranthrone monooxygenase [EC:1.13.12.20] [RN:R10224]
K17644  
norsolorinic acid ketoreductase [EC:1.1.1.349] [RN:R10309]
K17645  
averantin hydroxylase [EC:1.14.14.116] [RN:R10317 R10318]
K17652  
5'-hydroxyaverantin dehydrogenase [EC:1.1.1.352] [RN:R10310 R10311]
K17646  
5'-oxoaverantin cyclase / versicolorin B synthase [EC:4.2.1.142 4.2.1.143] [RN:R10475 R10402]
K24440  
averufin monooxygenase [EC:1.14.-.-] [RN:R10476]
K24855  
hydroxyversicolorone monooxygenase [EC:1.14.13.-] [RN:R10477]
K17648  
versiconal hemiacetal acetate esterase [EC:3.1.1.94] [RN:R10401]
K24439  
versicolorin B desaturase [EC:1.14.-.-] [RN:R10479]
K24856  
NADPH-dependent reductase [RN:R10481]
K24438  
sterigmatocystin biosynthesis cytochrome P450 monooxygenase [RN:R10481]
K24857  
oxidoreductase AflX [RN:R10481]
K24858  
oxidoreductase AflY [RN:R10481]
K17649  
demethylsterigmatocystin 6-O-methyltransferase [EC:2.1.1.109] [RN:R03112]
K17650  
sterigmatocystin 8-O-methyltransferase [EC:2.1.1.110] [RN:R03111]
K17651  
aflatoxin B synthase [EC:1.14.14.117] [RN:R10319]
Complete
afv  Aspergillus flavus
Reaction
R10239  
R10224  
R10309  
R10317  
R10310  
R10318  
R10311  
R10475  
R10476  
R10477  
R10401  
R10402  
R10479  
R10481  
R03112  
R03111  
R10319  
Compound
C00083  Malonyl-CoA
C20453  Norsolorinic acid anthrone
C20452  Norsolorinic acid
C20499  (1'S)-Averantin
C20500  (1'S,5'S)-5'-Hydroxyaverantin
C20502  5'-Oxoaverantin
C20501  (1'S,5'R)-5'-Hydroxyaverantin
C20574  (1'S,5'S)-Averufin
C20503  1'-Hydroxyversicolorone
C20505  Versiconal hemiacetal acetate
C20507  Versiconal
C20575  Versicolorin B
C20583  Versicolorin A
C03683  6-Demethylsterigmatocystin
C00961  Sterigmatocystin
C03686  O-Methylsterigmatocystin
C06800  Aflatoxin B1
Reference
PMID:15006741
  Authors
Yu J, Chang PK, Ehrlich KC, Cary JW, Bhatnagar D, Cleveland TE, Payne GA, Linz JE, Woloshuk CP, Bennett JW
  Title
Clustered pathway genes in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 70:1253-62 (2004)
DOI:10.1128/AEM.70.3.1253-1262.2004
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