KEGG   MODULE: M00957
Entry
M00957            Pathway   Module                                 
Name
Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA
Definition
K00468 K01506 (K14268,K07250) K00135 ((K15737 K15736),(K01041 K00252 (K01692,K01825,K01782) (K01825,K01782) K00626))
Diagram
M00957

Orthology
K00468  
lysine 2-monooxygenase [EC:1.13.12.2] [RN:R00449]
K01506  
5-aminopentanamidase [EC:3.5.1.30] [RN:R02273]
K14268,K07250  
5-aminovalerate aminotransferase [EC:2.6.1.48] [RN:R02274]
K00135  
glutarate-semialdehyde dehydrogenase [EC:1.2.1.20] [RN:R02401]
K15737  
glutarate dioxygenase [EC:1.14.11.64] [RN:R12216]
K15736  
(S)-2-hydroxyglutarate dehydrogenase [EC:1.1.5.13] [RN:R12217]
K01041  
glutaryl-CoA transferase [EC:2.8.3.-] [RN:R13035]
K00252  
glutaryl-CoA dehydrogenase [EC:1.3.8.6] [RN:R02488]
K01692,K01825,K01782  
enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03026]
K01825,K01782  
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] [RN:R01975]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
Class
Pathway modules; Amino acid metabolism; Lysine metabolism
Pathway
map00310  Lysine degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R00449  
R02273  
R02274  
R02401  
R12216  
R12217  
R13035  
R02488  
R03026  
R01975  
R00238  
Compound
C00047  L-Lysine
C00990  5-Aminopentanamide
C00431  5-Aminopentanoate
C03273  5-Oxopentanoate
C00489  Glutarate
C00026  2-Oxoglutarate
C03196  (S)-2-Hydroxyglutarate
C00042  Succinate
C00527  Glutaryl-CoA
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
C00024  Acetyl-CoA
Reference
PMID:31064836
  Authors
Thompson MG, Blake-Hedges JM, Cruz-Morales P, Barajas JF, Curran SC, Eiben CB, Harris NC, Benites VT, Gin JW, Sharpless WA, Twigg FF, Skyrud W, Krishna RN, Pereira JH, Baidoo EEK, Petzold CJ, Adams PD, Arkin AP, Deutschbauer AM, Keasling JD.
  Title
Massively Parallel Fitness Profiling Reveals Multiple Novel Enzymes in Pseudomonas putida Lysine Metabolism.
  Journal
mBio 10:e02577-18 (2019)
DOI:10.1128/mBio.02577-18
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