KEGG   MODULE: M00957
Entry
M00957            Pathway   Module                                 
Name
Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA
Definition
K00468 K01506 (K14268,K07250) K00135 ((K15737 K15736),(K01041 K00252 (K01692,K01825,K01782) (K01825,K01782) K00626))
Diagram
M00957  Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA
M00957

Class
Pathway modules; Amino acid metabolism; Lysine metabolism
Pathway
map00310  Lysine degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Orthology
K00468  
lysine 2-monooxygenase [EC:1.13.12.2] [RN:R00449]
K01506  
5-aminopentanamidase [EC:3.5.1.30] [RN:R02273]
K14268,K07250  
5-aminovalerate aminotransferase [EC:2.6.1.48] [RN:R02274]
K00135  
glutarate-semialdehyde dehydrogenase [EC:1.2.1.20] [RN:R02401]
K15737  
glutarate dioxygenase [EC:1.14.11.64] [RN:R12216]
K15736  
(S)-2-hydroxyglutarate dehydrogenase [EC:1.1.5.13] [RN:R12217]
K01041  
glutaryl-CoA transferase [EC:2.8.3.-] [RN:R13035]
K00252  
glutaryl-CoA dehydrogenase [EC:1.3.8.6] [RN:R02488]
K01692,K01825,K01782  
enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03026]
K01825,K01782  
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] [RN:R01975]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
Complete
pre  Metapseudomonas resinovorans
pfuw  Metapseudomonas furukawaii
poj  Metapseudomonas otitidis
plal  Metapseudomonas lalkuanensis
pcq  Pseudomonas citronellolis
pmui  Pseudomonas multiresinivorans
pnt  Pseudomonas nitroreducens
ppu  Pseudomonas putida KT2440
ppf  Pseudomonas putida F1
ppg  Pseudomonas putida GB-1
ppw  Pseudomonas putida W619
ppt  Pseudomonas putida S16
ppb  Pseudomonas putida BIRD-1
ppi  Pseudomonas putida ND6
ppx  Pseudomonas putida DOT-T1E
ppuh  Pseudomonas putida HB3267
pput  Pseudomonas putida H8234
ppun  Pseudomonas putida NBRC 14164
ppud  Pseudomonas putida DLL-E4
pmon  Pseudomonas monteilii SB3078
pmot  Pseudomonas monteilii SB3101
ppj  Pseudomonas plecoglossicida
pmol  Pseudomonas mosselii
pald  Pseudomonas alloputida
pix  Pseudomonas inefficax
pmos  Pseudomonas soli
pst  Pseudomonas syringae pv. tomato DC3000
psb  Pseudomonas syringae pv. syringae B728a
psyr  Pseudomonas syringae CC1557
psav  Pseudomonas savastanoi pv. savastanoi
pamg  Pseudomonas amygdali
pci  Pseudomonas cichorii
pavl  Pseudomonas avellanae
pvd  Pseudomonas viridiflava
pcab  Pseudomonas cannabina pv. alisalensis
pcof  Pseudomonas coronafaciens pv. oryzae
ptre  Pseudomonas tremae
psyi  Pseudomonas syringae pv. tagetis
past  Pseudomonas asturiensis
plij  Pseudomonas lijiangensis
pfuv  Pseudomonas fuscovaginae
pfl  Pseudomonas protegens Pf-5
pprc  Pseudomonas protegens CHA0
ppro  Pseudomonas protegens Cab57
pfe  Pseudomonas ogarae F113
pza  Pseudomonas ogarae SWRI108
pfn  Pseudomonas fluorescens UK4
pfo  Pseudomonas fluorescens Pf0-1
pfs  Pseudomonas fluorescens SBW25
pfc  Pseudomonas fluorescens A506
ppz  Pseudomonas poae
pfb  Pseudomonas synxantha LBUM223
pman  Pseudomonas mandelii
ptv  Pseudomonas trivialis
pcg  Pseudomonas corrugata
pvr  Pseudomonas veronii
pazo  Pseudomonas azotoformans
poi  Pseudomonas orientalis
prx  Pseudomonas rhodesiae
pkr  Pseudomonas koreensis
pmud  Pseudomonas mucidolens
ptol  Pseudomonas tolaasii
pmab  Pseudomonas marginalis
pbre  Pseudomonas brenneri
pfw  Pseudomonas simiae PCL1751
pff  Pseudomonas simiae PICF7
pfx  Pseudomonas lurida
pen  Pseudomonas entomophila
pba  Pseudomonas brassicacearum subsp. brassicacearum NFM421
ppuu  Pseudomonas sp. UW4
pdr  Pseudomonas sp. ATCC 13867
psv  Pseudomonas sp. VLB120
psk  Pseudomonas gorinensis
pkc  Pseudomonas knackmussii
pch  Pseudomonas chlororaphis PA23
pcz  Pseudomonas chlororaphis PCL1606
pcp  Pseudomonas chlororaphis subsp. aurantiaca
pchp  Pseudomonas chlororaphis subsp. piscium
pfz  Pseudomonas fragi
plq  Pseudomonas lundensis
palk  Pseudomonas alkylphenolica
prh  Pseudomonas rhizosphaerae
psw  Pseudomonas cremoricolorata
ppv  Pseudomonas parafulva
pses  Pseudomonas sp. StFLB209
psem  Pseudomonas sp. MRSN12121
psec  Pseudomonas sp. CCOS 191
ppsy  Pseudomonas versuta
psos  Pseudomonas sp. Os17
pfk  Pseudomonas frederiksbergensis
panr  Pseudomonas antarctica
pset  Pseudomonas sp. TCU-HL1
psil  Pseudomonas silesiensis
pym  Pseudomonas yamanorum
pke  Pseudomonas kribbensis
pum  Pseudomonas umsongensis
pgg  Pseudomonas graminis
ppsh  Pseudomonas psychrophila
pgy  Pseudomonas glycinae
pvk  Pseudomonas viciae
pez  Pseudomonas eucalypticola
pbz  Pseudomonas bijieensis
pata  Pseudomonas atacamensis
pdw  Pseudomonas donghuensis
pze  Pseudomonas zeae
pmoe  Pseudomonas monsensis
psep  Pseudomonas sessilinigenes
ppii  Pseudomonas piscis
pvw  Pseudomonas vanderleydeniana
ptrt  Pseudomonas tritici
pxa  Pseudomonas xanthosomatis
psam  Pseudomonas salmasensis
ptz  Pseudomonas tensinigenes
pqi  Pseudomonas qingdaonensis
pshh  Pseudomonas shahriarae
pxn  Pseudomonas xantholysinigenes
phv  Pseudomonas hamedanensis
pprg  Pseudomonas promysalinigenes
panh  Pseudomonas anuradhapurensis
pasg  Pseudomonas asgharzadehiana
pfak  Pseudomonas fakonensis
pmuy  Pseudomonas muyukensis
pmam  Pseudomonas maumuensis
paze  Pseudomonas azerbaijanorientalis
palv  Pseudomonas alvandae SWRI17
pcas  Pseudomonas alvandae B21-020
pory  Pseudomonas oryziphila
ptk  Pseudomonas tructae
ptw  Pseudomonas tohonis
pie  Pseudomonas iranensis
ptae  Pseudomonas taetrolens
pgf  Pseudomonas germanica
pju  Pseudomonas juntendi
piz  Pseudomonas izuensis
ppeg  Pseudomonas pergaminensis
psii  Pseudomonas siliginis
psih  Pseudomonas sichuanensis
pfit  Pseudomonas fitomaticsae
pasi  Pseudomonas asiatica
pkm  Pseudomonas kermanshahensis
pnb  Pseudomonas nunensis
psoa  Pseudomonas solani
ptai  Pseudomonas taiwanensis
pkk  Pseudomonas kurunegalensis
pkj  Pseudomonas kielensis
phyg  Pseudomonas hygromyciniae
phom  Pseudomonas hormoni
pcuc  Pseudomonas cucumis
ptrl  Pseudomonas triclosanedens
ppae  Pseudomonas palleroniana
ppao  Pseudomonas phytophila
prhz  Pseudomonas rhizophila
psjy  Pseudomonas sp. JY-Q
psku  Pseudomonas sp. KUIN-1
pshs  Pseudomonas sp. HS6
phef  Pseudomonas hefeiensis
plis  Pseudomonas serboccidentalis
psnc  Pseudomonas sp. NC02
pfou  Pseudomonas fortuita
pbej  Pseudomonas beijingensis
pkv  Pseudomonas khavaziana
pskp  Pseudomonas sp. KU43P
pbam  Pseudomonas batumici
pdeu  Pseudomonas defluvii
pqe  Pseudomonas quebecensis
psdt  Pseudomonas sp. Stari2
pcaa  Pseudomonas canadensis
pbub  Pseudomonas bubulae
psml  Pseudomonas sp. ML2-2023-3
psmz  Pseudomonas sp. ML2-2023-6
psiv  Pseudomonas silvicola
pswo  Pseudomonas sp. W03
pmor  Pseudomonas moorei
pthv  Pseudomonas thivervalensis
pssx  Pseudomonas sp. SXM-1
pagb  Pseudomonas agarici
psns  Pseudomonas sp. NS1(2017)
psru  Pseudomonas sp. RU47
psny  Pseudomonas sp. NyZ201
pden  Pseudomonas denitrificans (nom. rej.)
plg  Paucimonas lemoignei
rmk  Rhodoferax mekongensis
htn  Hydrogenophaga taeniospiralis
suam  Sulfitobacter alexandrii
susq  Sulfitobacter sp. S190
parh  Priestia aryabhattai
src  Streptomyces rapamycinicus
sant  Streptomyces antimycoticus
sluo  Streptomyces luomodiensis
stid  Streptomyces sp. ID38640
amd  Amycolatopsis mediterranei U32
amn  Amycolatopsis mediterranei S699
amm  Amycolatopsis mediterranei S699
amz  Amycolatopsis mediterranei RB
 » show all
Reaction
R00449  
R02273  
R02274  
R02401  
R12216  
R12217  
R13035  
R02488  
R03026  
R01975  
R00238  
Compound
C00047  L-Lysine
C00990  5-Aminopentanamide
C00431  5-Aminopentanoate
C03273  5-Oxopentanoate
C00489  Glutarate
C00026  2-Oxoglutarate
C03196  (S)-2-Hydroxyglutarate
C00042  Succinate
C00527  Glutaryl-CoA
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
C00024  Acetyl-CoA
Reference
PMID:31064836
  Authors
Thompson MG, Blake-Hedges JM, Cruz-Morales P, Barajas JF, Curran SC, Eiben CB, Harris NC, Benites VT, Gin JW, Sharpless WA, Twigg FF, Skyrud W, Krishna RN, Pereira JH, Baidoo EEK, Petzold CJ, Adams PD, Arkin AP, Deutschbauer AM, Keasling JD.
  Title
Massively Parallel Fitness Profiling Reveals Multiple Novel Enzymes in Pseudomonas putida Lysine Metabolism.
  Journal
mBio 10:e02577-18 (2019)
DOI:10.1128/mBio.02577-18
LinkDB

DBGET integrated database retrieval system