KEGG   MODULE: M00975
Entry
M00975            Pathway   Module                                 
Name
Betaine degradation, bacteria, betaine => pyruvate
Definition
K00479+K21832 (((K00309,K00315) (K00301,K00302+K00303+K00304+K00305)),K21833+K21834+K25960+K25961) K00600 (K01752,K01754)
Diagram
M00975

Orthology
K00479,K21832  
glycine betaine monooxygenase [EC:1.14.13.251] [RN:R13016]
K00309  
dimethylglycine oxidase [EC:1.5.3.10] [RN:R01564]
K00315  
dimethylglycine dehydrogenase [EC:1.5.8.4] [RN:R01565]
K00301  
sarcosine oxidase [EC:1.5.3.1] [RN:R00610]
K00302,K00303,K00304,K00305  
sarcosine oxidase [EC:1.5.3.24 1.5.3.1] [RN:R00610 R12967]
K21833,K21834,K25960,K25961  
N,N-dimethylglycine/sarcosine dehydrogenase [EC:1.5.7.3] [RN:R13028 R13029]
K00600  
glycine hydroxymethyltransferase [EC:2.1.2.1] [RN:R00945]
K01752  
L-serine dehydratase [EC:4.3.1.17] [RN:R00220]
K01754  
threonine dehydratase [EC:4.3.1.19] [RN:R00220]
Class
Pathway modules; Amino acid metabolism; Serine and threonine metabolism
Pathway
map00260  Glycine, serine and threonine metabolism
map01100  Metabolic pathways
Reaction
R13016  
R01564,R01565,R13028  
R00610,R12967,R13029  
R00945  
R00220  
Compound
C00719  Betaine
C01026  N,N-Dimethylglycine
C00213  Sarcosine
C00037  Glycine
C00065  L-Serine
C00022  Pyruvate
Reference
PMID:32631860
  Authors
Yang T, Shao YH, Guo LZ, Meng XL, Yu H, Lu WD.
  Title
Role of N,N-Dimethylglycine and Its Catabolism to Sarcosine in Chromohalobacter salexigens DSM 3043.
  Journal
Appl Environ Microbiol 86:e01186-20 (2020)
DOI:10.1128/AEM.01186-20
LinkDB

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