KEGG   MODULE: M00979
Entry
M00979            Pathway   Module                                 
Name
Ajmaline biosynthesis, geissoschizine => ajmaline
Definition
K27776 K08233 K12694 K22326 K27777 K27778 K21026 K27779
Diagram
M00979  Ajmaline biosynthesis, geissoschizine => ajmaline
M00979

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K27776  
polyneuridine aldehyde synthase [EC:1.14.19.81] [RN:R05829]
K08233  
polyneuridine-aldehyde esterase [EC:3.1.1.78] [RN:R05825]
K12694  
vinorine synthase [EC:2.3.1.160] [RN:R05876]
K22326  
vinorine hydroxylase [EC:1.14.14.104] [RN:R05877]
K27777  
vomilenine reductase [EC:1.5.1.32] [RN:R05878]
K27778  
1,2-dihydrovomilenine reductase [EC:1.3.1.73] [RN:R05879]
K21026  
acetylajmaline esterase [EC:3.1.1.80] [RN:R05880]
K27779  
norajmaline N-methyltransferase [EC:2.1.1.392] [RN:R05881]
Complete
4060  Rauvolfia serpentina
Reaction
R05829  
R05825  
R05876  
R05877  
R05878  
R05879  
R05880  
R05881  
Compound
C02151  Geissoschizine
C11632  Polyneuridine aldehyde
C11633  16-Epivellosimine
C11807  Vinorine
C01761  Vomilenine
C11808  1,2-Dihydrovomilenine
C11809  17-O-Acetylnorajmaline
C11810  Norajmaline
C06542  Ajmaline
Reference
PMID:38212296
  Authors
Guo J, Gao D, Lian J, Qu Y
  Title
De novo biosynthesis of antiarrhythmic alkaloid ajmaline.
  Journal
Nat Commun 15:457 (2024)
DOI:10.1038/s41467-024-44797-z
LinkDB

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