KEGG   MODULE: M00982
Entry
M00982            Pathway   Module                                 
Name
Methylcitrate cycle
Definition
K01659 (K01720,(K20455 K09788)) (K01682,K27802) (K03417,K01637) (K00239+K00240+K00241-(K00242,K18859,K18860),K00244+K00245+K00246-K00247) (K01676,K01679,K01677+K01678) (K00024,K00116)
Diagram
M00982

Orthology
K01659  
2-methylcitrate synthase [EC:2.3.3.5] [RN:R00931]
K01720  
2-methylcitrate dehydratase [EC:4.2.1.79] [RN:R04424]
K20455  
2-methylcitrate dehydratase [EC:4.2.1.117] [RN:R11263]
K09788  
2-methylaconitate isomerase [EC:5.3.3.-] [RN:R11264]
K01682,K27802  
2-methylisocitrate dehydratase [EC:4.2.1.99] [RN:R04425]
K03417,K01637  
methylisocitrate lyase [EC:4.1.3.30] [RN:R00409]
K00239,K00240,K00241,K00242,K18859,K18860  
succinate dehydrogenase [EC:1.3.5.1] [RN:R02164]
K00244,K00245,K00246,K00247 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164]  
 
K01676,K01679,K01677,K01678  
fumarate hydratase [EC:4.2.1.2] [RN:R01082]
K00024  
malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
K00116  
malate dehydrogenase (quinone) [EC:1.1.5.4] [RN:R00361]
Class
Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
Pathway
map00640  Propanoate metabolism
map00020  Citrate cycle (TCA cycle)
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R00931  
R04424  
R11263  
R11264  
R04425  
R00409  
R02164  
R01082  
R00342,R00361  
Compound
C00036  Oxaloacetate
C00100  Propanoyl-CoA
C02225  2-Methylcitrate
C04225  (Z)-But-2-ene-1,2,3-tricarboxylate
C21250  2-Methyl-trans-aconitate
C04593  (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate
C00042  Succinate
C00122  Fumarate
C00149  (S)-Malate
Reference
PMID:29458664
  Authors
Dolan SK, Wijaya A, Geddis SM, Spring DR, Silva-Rocha R, Welch M
  Title
Loving the poison: the methylcitrate cycle and bacterial pathogenesis.
  Journal
Microbiology (Reading) 164:251-259 (2018)
DOI:10.1099/mic.0.000604
Reference
PMID:18048912
  Authors
Upton AM, McKinney JD
  Title
Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis.
  Journal
Microbiology (Reading) 153:3973-3982 (2007)
DOI:10.1099/mic.0.2007/011726-0
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