| Entry |
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| Name |
Amplified PDGFR to PLCG-CAMK signaling pathway
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| Definition |
PDGFR* -> PLCG -> IP3 -> Ca2+ -> CALM == CAMK |
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| Expanded |
5156v1 -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) == (8536,57118,57172,815,816,817,818,814) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 5156 | PDGFRA; platelet derived growth factor receptor alpha |
| 5335 | PLCG1; phospholipase C gamma 1 |
| 5336 | PLCG2; phospholipase C gamma 2 |
| 8536 | CAMK1; calcium/calmodulin dependent protein kinase I |
| 57118 | CAMK1D; calcium/calmodulin dependent protein kinase ID |
| 57172 | CAMK1G; calcium/calmodulin dependent protein kinase IG |
| 815 | CAMK2A; calcium/calmodulin dependent protein kinase II alpha |
| 816 | CAMK2B; calcium/calmodulin dependent protein kinase II beta |
| 817 | CAMK2D; calcium/calmodulin dependent protein kinase II delta |
| 818 | CAMK2G; calcium/calmodulin dependent protein kinase II gamma |
| 814 | CAMK4; calcium/calmodulin dependent protein kinase IV |
|
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| Variant |
5156v1 (PDGFR*) PDGFRA amplification
|
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| Metabolite |
| C01245 | D-myo-Inositol 1,4,5-trisphosphate |
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| Reference |
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| Authors |
Kapoor GS, O'Rourke DM. |
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| Title |
Mitogenic signaling cascades in glial tumors. |
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| Journal |
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| Reference |
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| Authors |
Khoshyomn S, Penar PL, Rossi J, Wells A, Abramson DL, Bhushan A |
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| Title |
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates. |
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| Journal |
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| Reference |
|
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| Authors |
Westermark B |
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| Title |
Platelet-derived growth factor in glioblastoma-driver or biomarker? |
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| Journal |
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| LinkDB |
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