KEGG   NETWORK: N00151
Entry
N00151                      Network                                
Name
TNF-NFKB signaling pathway
Definition
TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB
  Expanded
7124 -> 7132 -> (8737+8717+(7186,7188)) -> ((10454,23118,257397)+6885) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06516 TNF signaling
nt06263 Hepatocellular carcinoma
nt06223 TNF signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06163 Hepatitis C virus (HCV)
nt06167 Human cytomegalovirus (HCMV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
nt06180 Pathogenic Escherichia coli
nt06181 Salmonella
nt06182 Shigella
Type
Reference
Pathway
hsa04668  TNF signaling pathway
hsa04064  NF-kappa B signaling pathway
Gene
7124  TNF; tumor necrosis factor
7132  TNFRSF1A; TNF receptor superfamily member 1A
8737  RIPK1; receptor interacting serine/threonine kinase 1
8717  TRADD; TNFRSF1A associated via death domain
7186  TRAF2; TNF receptor associated factor 2
7188  TRAF5; TNF receptor associated factor 5
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
257397  TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Reference
PMID:22119011
  Authors
Verhelst K, Carpentier I, Beyaert R
  Title
Regulation of TNF-induced NF-kappaB activation by different cytoplasmic ubiquitination events.
  Journal
Cytokine Growth Factor Rev 22:277-86 (2011)
DOI:10.1016/j.cytogfr.2011.11.002
Reference
PMID:21232019
  Authors
Naude PJ, den Boer JA, Luiten PG, Eisel UL
  Title
Tumor necrosis factor receptor cross-talk.
  Journal
FEBS J 278:888-98 (2011)
DOI:10.1111/j.1742-4658.2011.08017.x
Reference
PMID:19489733
  Authors
Skaug B, Jiang X, Chen ZJ
  Title
The role of ubiquitin in NF-kappaB regulatory pathways.
  Journal
Annu Rev Biochem 78:769-96 (2009)
DOI:10.1146/annurev.biochem.78.070907.102750
Reference
PMID:21772278
  Authors
Oeckinghaus A, Hayden MS, Ghosh S
  Title
Crosstalk in NF-kappaB signaling pathways.
  Journal
Nat Immunol 12:695-708 (2011)
DOI:10.1038/ni.2065
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
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