Entry |
|
Name |
HGF-MET-RAS-ERK signaling pathway
|
Definition |
HGF -> MET -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
Expanded |
3082 -> 4233 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
Class |
|
Type |
Reference
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Pathway |
|
Gene |
3082 | HGF; hepatocyte growth factor |
4233 | MET; MET proto-oncogene, receptor tyrosine kinase |
2885 | GRB2; growth factor receptor bound protein 2 |
6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
3265 | HRAS; HRas proto-oncogene, GTPase |
3845 | KRAS; KRAS proto-oncogene, GTPase |
4893 | NRAS; NRAS proto-oncogene, GTPase |
369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
5594 | MAPK1; mitogen-activated protein kinase 1 |
5595 | MAPK3; mitogen-activated protein kinase 3 |
|
Reference |
|
Authors |
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. |
Title |
Met, metastasis, motility and more. |
Journal |
|
Reference |
|
Authors |
Bradley CA, Salto-Tellez M, Laurent-Puig P, Bardelli A, Rolfo C, Tabernero J, Khawaja HA, Lawler M, Johnston PG, Van Schaeybroeck S |
Title |
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges. |
Journal |
|
Reference |
|
Authors |
Parikh RA, Wang P, Beumer JH, Chu E, Appleman LJ |
Title |
The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment. |
Journal |
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LinkDB |
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