KEGG   NETWORK: N00218
Entry
N00218                      Network                                
Name
FLT3LG-FLT3-RAS-PI3K signaling pathway
Definition
FLT3LG -> FLT3 -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -> MTOR
  Expanded
2323 -> 2322 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475
Class
nt06262 Pancreatic cancer
nt06275 Acute myeloid leukemia
nt06214 PI3K signaling (cancer)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
2323  FLT3LG; fms related tyrosine kinase 3 ligand
2322  FLT3; fms related tyrosine kinase 3
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26239344
  Authors
Gocek E, Studzinski GP
  Title
The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy.
  Journal
J Clin Med 4:504-34 (2015)
DOI:10.3390/jcm4040504
Reference
PMID:25239057
  Authors
Sun C, Bernards R
  Title
Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies.
  Journal
Trends Biochem Sci 39:465-74 (2014)
DOI:10.1016/j.tibs.2014.08.010
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