| Entry |
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| Name |
EBV BARF1 to intrinsic apoptotic pathway
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| Definition |
BARF1 -> BCL2 -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3 |
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| Expanded |
K22973 -> 596 -| (581,578) -> 54205 == 317 -> 842 -> 836 |
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| Class |
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| Type |
Pathogen
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| Pathway |
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| Disease |
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| Gene |
| 596 | BCL2; BCL2, apoptosis regulator |
| 581 | BAX; BCL2 associated X, apoptosis regulator |
| 578 | BAK1; BCL2 antagonist/killer 1 |
| 54205 | CYCS; cytochrome c, somatic |
| 317 | APAF1; apoptotic peptidase activating factor 1 |
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| Perturbant |
| K22973 (BARF1) | BARF1; EBV secreted protein BARF1 |
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| Reference |
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| Authors |
Fu Q, He C, Mao ZR |
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| Title |
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells. |
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| Journal |
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| Reference |
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| Authors |
Sheng W, Decaussin G, Sumner S, Ooka T |
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| Title |
N-terminal domain of BARF1 gene encoded by Epstein-Barr virus is essential for malignant transformation of rodent fibroblasts and activation of BCL-2. |
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| Journal |
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| Reference |
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| Authors |
Sheng W, Decaussin G, Ligout A, Takada K, Ooka T |
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| Title |
Malignant transformation of Epstein-Barr virus-negative Akata cells by introduction of the BARF1 gene carried by Epstein-Barr virus. |
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| Journal |
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| LinkDB |
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