KEGG   NETWORK: N00538
Entry
N00538                      Network                                
Name
Ca2+-PYK2-RAS-ERK signaling pathway
Definition
Ca2+ -> PTK2B -> SRC -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
C00076 -> 2185 -> 6714 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06263 Hepatocellular carcinoma
nt06162 Hepatitis B virus (HBV)
Type
Reference
Gene
2185  PTK2B; protein tyrosine kinase 2 beta
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Metabolite
C00076  Calcium cation
Reference
PMID:17158754
  Authors
Gudermann T, Roelle S
  Title
Calcium-dependent growth regulation of small cell lung cancer cells by neuropeptides.
  Journal
Endocr Relat Cancer 13:1069-84 (2006)
DOI:10.1677/erc.1.01302
Reference
PMID:20974046
  Authors
Fisar Z, Hroudova J
  Title
Intracellular signalling pathways and mood disorders.
  Journal
Folia Biol (Praha) 56:135-48 (2010)
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