| Entry |
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| Name |
CXCL12-CXCR4-PKC-ERK signaling pathaway
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| Definition |
CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG) -> IP3 -> Ca2+ -> PKC -> RAF -> MEK -> ERK |
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| Expanded |
6387 -> 7852 -> 2776 -> (23236,5330,5331,5332,5335,5336) -> C01245 -> C00076 -> (5578,5579,5582) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 6387 | CXCL12; C-X-C motif chemokine ligand 12 |
| 7852 | CXCR4; C-X-C motif chemokine receptor 4 |
| 2776 | GNAQ; G protein subunit alpha q |
| 23236 | PLCB1; phospholipase C beta 1 |
| 5330 | PLCB2; phospholipase C beta 2 |
| 5331 | PLCB3; phospholipase C beta 3 |
| 5332 | PLCB4; phospholipase C beta 4 |
| 5335 | PLCG1; phospholipase C gamma 1 |
| 5336 | PLCG2; phospholipase C gamma 2 |
| 5578 | PRKCA; protein kinase C alpha |
| 5579 | PRKCB; protein kinase C beta |
| 5582 | PRKCG; protein kinase C gamma |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Metabolite |
| C01245 | D-myo-Inositol 1,4,5-trisphosphate |
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| Reference |
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| Authors |
Werry TD, Sexton PM, Christopoulos A |
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| Title |
"Ins and outs" of seven-transmembrane receptor signalling to ERK. |
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| Journal |
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| Reference |
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| Authors |
Cojoc M, Peitzsch C, Trautmann F, Polishchuk L, Telegeev GD, Dubrovska A |
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| Title |
Emerging targets in cancer management: role of the CXCL12/CXCR4 axis. |
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| Journal |
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| LinkDB |
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